288 research outputs found
Conformal Collineations and Ricci Inheritance Symmetry in String Cloud and String Fluids
Conformal collineations (a generalization of conformal motion) and Ricci
inheritance collineations, defined by , for
string cloud and string fluids in general relativity are studied. By
investigating the kinematical and dynamical properties of such fluids and using
the field equations, some recent studies on the restrictions imposed by
conformal collineations are extended, and new results are found.Comment: 12 pages, LaTeX, no figures, to appear in Int. J. Mod. Phys.
Prediction of peptides binding to MHC class I and II alleles by temporal motif mining
Background: MHC (Major Histocompatibility Complex) is a key player in the immune response of most vertebrates. The computational prediction of whether a given antigenic peptide will bind to a specific MHC allele is important in the development of vaccines for emerging pathogens, the creation of possibilities for controlling immune response, and for the applications of immunotherapy. One of the problems that make this computational prediction difficult is the detection of the binding core region in peptides, coupled with the presence of bulges and loops causing variations in the total sequence length. Most machine learning methods require the sequences to be of the same length to successfully discover the binding motifs, ignoring the length variance in both motif mining and prediction steps. In order to overcome this limitation, we propose the use of time-based motif mining methods that work position-independently.
Results: The prediction method was tested on a benchmark set of 28 different alleles for MHC class I and 27 different alleles for MHC class II. The obtained results are comparable to the state of the art methods for both MHC classes, surpassing the published results for some alleles. The average prediction AUC values are 0.897 for class I, and 0.858 for class II.
Conclusions: Temporal motif mining using partial periodic patterns can capture information about the sequences well enough to predict the binding of the peptides and is comparable to state of the art methods in the literature. Unlike neural networks or matrix based predictors, our proposed method does not depend on peptide length and can work with both short and long fragments. This advantage allows better use of the available training data and the prediction of peptides of uncommon lengths
Performance of Some Forages Species (\u3cem\u3eFestuca arundinacea\u3c/em\u3e L., \u3cem\u3eChloris gayana\u3c/em\u3e var. Katambora, \u3cem\u3eLotus corniculatus\u3c/em\u3e L. and \u3cem\u3eMedicago sativa\u3c/em\u3e L.) in Saline Soil
Salinity is a soil degradation process which reduces plant diversity and agricultural productivity, decreases fertility and devalues the land in regions with arid and semi-arid climate. This process inhibits water and nutrient intake of plants from soil due to changeable nitrogen percentage and/or the intensity of soluble salt concentration. When the fact that agricultural lands are limited around the world and that the need for nutrition increases incrementally is taken into consideration, it is obvious that available lands should be used more effectively. Hence, it is quite crucial to reclaim saline soil and utilize it more economically (Woods 1996)
Testing robustness of relative complexity measure method constructing robust phylogenetic trees for Galanthus L. Using the relative complexity measure
Background: Most phylogeny analysis methods based on molecular sequences use multiple alignment where the quality of the alignment, which is dependent on the alignment parameters, determines the accuracy of the resulting trees. Different parameter combinations chosen for the multiple alignment may result in different phylogenies. A new non-alignment based approach, Relative Complexity Measure (RCM), has been introduced to tackle this problem and proven to work in fungi and mitochondrial DNA.
Result: In this work, we present an application of the RCM method to reconstruct robust phylogenetic trees using sequence data for genus Galanthus obtained from different regions in Turkey. Phylogenies have been analyzed using nuclear and chloroplast DNA sequences. Results showed that, the tree obtained from nuclear ribosomal RNA gene sequences was more robust, while the tree obtained from the chloroplast DNA showed a higher degree of variation.
Conclusions: Phylogenies generated by Relative Complexity Measure were found to be robust and results of RCM were more reliable than the compared techniques. Particularly, to overcome MSA-based problems, RCM seems to be a reasonable way and a good alternative to MSA-based phylogenetic analysis. We believe our method will become a mainstream phylogeny construction method especially for the highly variable sequence families where the accuracy of the MSA heavily depends on the alignment parameters
THE EFFECT OF 8 WEEK TENNIS TECHNICAL TRAINING AND GAMES ON REACTION TIME IN 10-12 YEAR OLD BOYS
The aim of this study is to assess the effect of tennis technique training and games on reaction times of 10-12 years old boys. For this study, 40 subjects who did not perform any physical activity volunteered. Subjects randomly assigned two groups: Experimental group: 20, control group: 20. The experimental group was subjected to 8 week three days a week and 60 minute per session tennis and education with games training program modified according to relevant age group. The control group did not participate any physical activity. Visual, auditory and mix reaction times were measured by Newtest 1000 reaction timer. Subjects’ reaction times were measured twice before and after training program. SPSS 22.0 package program was used for analysis of the data obtained from the study. Independent Sample T test was used for comparison between groups, and paired samples t test was analyzed at p <0.05 significance level. As a result of the study, there was no difference in the control group, and after eight weeks of tenement-specific games and technical training, the research group revealed significant changes between auditory, visual and mixed reaction times in both hands. Article visualizations
İZMİR METROSUNUN KONUT FİYATLARI ÜZERİNDEKİ ETKİLERİNİN HEDONİK FİYAT YÖNTEMİ İLE MODELLENMESİ
Bu çalışmada İzmir metrosu örneğinde, metro yatırımının konut-yerleşim birimlerinin değeri üzerine etkileri incelenmektedir. Yer seçimi teorisi, bir kentte ulaşım altyapısındaki yatırımın gayrimenkul değerleri üzerine kapitalize olacağını söylemektedir. Buna göre, bir ulaşım yatırımı, ev ile iş arasında gidip gelme zamanında ve ulaşım maliyetinde azalmaya neden olması beklenmektedir. Dolayısıyla, transit istasyonuna yakın konumlanmış gayrimenkul birimlerinin değerinin, artan erişilebilirlik faktöründen dolayı daha yüksek olması beklenmektedir. Çalışmada hedonik fiyat modeli, ulaşım yatırımının konut fiyatına olan etkisinin ölçülmesinde kullanılmıştır. Model iki farklı fonksiyonel form altında (lineer ve log-lineer) uygulanmıştır. Model sonuçları ulaşım altyapısında ki yatırımın konut fiyatlarını, etki alanı içinde arttırdığını göstermektedir
Social achievement goals, needs satisfaction, and coping among adolescents
In a sample of Turkish adolescents (N = 1614), we investigated whether pursuing social demonstration-approach goals (to attain popularity), next to social development goals (to cultivate meaningful relationships), explains differences in need satisfaction and frustration and coping. Cluster analysis showed that students who favored social development over social demonstration-approach goals reported less need frustration and defensive coping than students who favored both goals. These results were replicated with a prospective analysis with part of the initial sample (N = 425) as students who endorsed both goals reported more defensive coping five months later than students who mainly favored social development goals over social demonstration-approach goals. © 2016 Elsevier Ltd
Cytotoxic activities of certain medicinal plants on different cancer cell lines
Objectives: In recent years, the use of plants for the prevention and treatment of cancer is gaining more attention due to their diverse range of phytochemical constituents and fewer adverse effects. In this study, four medicinal plant species from the Kars province of Turkey were investigated for their cytotoxic potential against six different cancer cell lines and one normal cell line. Materials and Methods: MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide] assay was performed to assess cytotoxic activity and apoptotic effect was determined using flow cytometry and caspase-3 analyses. Results: Significant cytotoxicity (≥70%) was observed with the leaf extract of Artemisia absinthium on A-549, CCC-221, K-562, MCF-7, PC-3 cells, whereas seed extracts caused significant cytotoxicity (≥70%) on CCC-221, K-562, MCF-7, PC-3 cells. Selective cytotoxicity was obtained with leaf extract on A-549 and K-562 cells; and with seed extract on K-562, MCF-7 and PC-3 cells compared with normal Beas-2B cells. The levels of cytotoxicity for both extracts were time- and dose-dependent at lower concentrations. Moreover, selective cytotoxicity (78%) was detected on A-549 cells with the seed extract of Plantago major. Cytotoxicity of extracts from Hyoscyamus niger and Amaranthus retrosa ranged between 10% and 30%. Conclusion: A. absinthium extracts and P. major seed extract have potential for development as therapeutic agents for cytotoxicity on certain cancer cells following further investigation. © Turk J Pharm Sci, Published by Galenos Publishing House
ANKOS publisher application system and its impact on the e-resource evaluation process
The Publisher Application System (PAS) is a Web-based archiving and online evaluation system developed by the Database Evaluation Group (DEG), one of the working groups formed within the Anatolian University Libraries Consortium (ANKOS). The DEG was formed in 2008 to inquire and evaluate e-resources suited to the needs of the consortium; to follow up similar consortial activities worldwide as well as developments in connection with the scientific publishing industry; and to determine, implement, and improve pricing models in accordance with the prevailing economic, legal, and academic system. Development of the PAS was essential to ensure standardization and sustainability towards a more detailed and effective analysis of e-resources qualifying for evaluation by ANKOS. The PAS played an important part not only in establishing and defining the workflow of the DEG, but also in creating an archive of both the e-resources submitted to the consortium and the applicant publishers/agents submitting these resources. This article outlines the process that started with the foundation of the DEG through the formation of the PAS as well as the present setup of the system. It is also hoped that this case study will have a positive contribution to the processes being followed by the persons and the groups engaged in similar activities.pre-prin
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