The Faint End Slopes Of Galaxy Luminosity Functions In The COSMOS 2-Square Degree Field

We examine the faint-end slope of the rest-frame V-band luminosity function (LF), with respect to galaxy spectral type, of field galaxies with redshift z<0.5, using a sample of 80,820 galaxies with photometric redshifts in the Cosmic Evolution Survey (COSMOS) field. For all galaxy spectral types combined, the LF slope, alpha, ranges from -1.24 to -1.12, from the lowest redshift bin to the highest. In the lowest redshift bin (0.02<z<0.1), where the magnitude limit is M(V) ~ -13, the slope ranges from ~ -1.1 for galaxies with early-type spectral energy distributions (SEDs), to ~ -1.9 for galaxies with low-extinction starburst SEDs. In each galaxy SED category (Ell, Sbc, Scd/Irr, and starburst), the faint-end slopes grow shallower with increasing redshift; in the highest redshift bin (0.4<z<0.5), the slope is ~ -0.5 and ~ -1.3 for early-types and starbursts respectively. The steepness of alpha at lower redshift could be qualitatively explained by large numbers of faint dwarf galaxies, perhaps of low surface brightness, which are not detected at higher redshifts.Comment: 24 pages including 5 figures, accepted to ApJ

Public Health for the Internet φ Towards A New Grand Challenge for Information Management

Business incentives have brought us within a small factor of achieving the database community\u27s Grand Challenge set out in the Asilomar Report of 1998. This paper makes the case for a new, focused Grand Challenge: Public Health for the Internet. The goal of PHI (or φ) is to enable collectives of hosts on the Internet to jointly monitor and promote network health by sharing information on network conditions in a peer-to-peer fashion. We argue that this will be a positive effort for the research community for a variety of reasons, both in terms of its technical reach and its societal impact. This version of the φ vision is targeted at readers in the database research community, but the effort is clearly multidisciplinary. A more generalist version of this paper will be maintained at http://openphi.net

Longitudinal Effects of a 2-Year Meditation and Buddhism Program on Well-being, Quality of Life, and Valued Living

Objectives: Most research on mindfulness and meditation has focused on structured therapeutic interventions, such as mindfulness-based stress reduction, or meditation retreats. Such programs have received moderate empirical support for improving psychological outcomes in clinical and nonclinical populations, but there remains a paucity of research on intensive or long-term mindfulness or meditation programs for experienced practitioners, especially those that incorporate Buddhist teachings. The purpose of the current study was to investigate the effects of a long-term integrated mindfulness/meditation and Buddhism program, Dharma in Daily Life (DIDL). Methods: Well-being, quality of life, valued living, and theorized processes of change were measured using a naturalistic, quasi-experimental design over the course of the 2-year program and 6-month follow-up. Participants included 17 individuals enrolled in the program and 14 individuals recruited from community meditation groups. Results: Participation in the program predicted increases in subjective well-being and mindfulness over time compared to the control group. Regardless of condition, frequency of meditation predicted lower psychological inflexibility and higher mindfulness, well-being, and progress toward values. Length of meditation session predicted a greater ability to observe experience, and prior meditation experience predicted greater non-reactivity to experience. Conclusions: Although preliminary, results suggest that participation in a long-term integrated mindfulness/meditation and Buddhism program may positively impact mindfulness and general well-being. Frequency of meditation sessions appears to be a particularly important variable. These findings warrant further investigation of such programs and practice parameters, as well as how each may affect key outcomes

ISS Operations Cost Reductions Through Automation of Real-Time Planning Tasks

In 2007 the Johnson Space Center s Mission Operations Directorate (MOD) management team challenged their organizations to find ways to reduce the cost of operations for supporting the International Space Station (ISS) in the Mission Control Center (MCC). Each MOD organization was asked to define and execute projects that would help them attain cost reductions by 2012. The MOD Operations Division Flight Planning Branch responded to this challenge by launching several software automation projects that would allow them to greatly improve console operations and reduce ISS console staffing and intern reduce operating costs. These tasks ranged from improving the management and integration mission plan changes, to automating the uploading and downloading of information to and from the ISS and the associated ground complex tasks that required multiple decision points. The software solutions leveraged several different technologies including customized web applications and implementation of industry standard web services architecture; as well as engaging a previously TRL 4-5 technology developed by Ames Research Center (ARC) that utilized an intelligent agent-based system to manage and automate file traffic flow, archive data, and generate console logs. These projects to date have allowed the MOD Operations organization to remove one full time (7 x 24 x 365) ISS console position in 2010; with the goal of eliminating a second full time ISS console support position by 2012. The team will also reduce one long range planning console position by 2014. When complete, these Flight Planning Branch projects will account for the elimination of 3 console positions and a reduction in staffing of 11 engineering personnel (EP) for ISS

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its function. Unlike channels formed only with HERG, mixed complexes resemble native cardiac IKr channels in their gating, unitary conductance, regulation by potassium, and distinctive biphasic inhibition by the class III antiarrhythmic E-4031. Three missense mutations associated with long QT syndrome and ventricular fibrillation are identified in the gene for MiRP1. Mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. One variant, associated with clarithromycin-induced arrhythmia, increases channel blockade by the antibiotic. A mechanism for acquired arrhythmia is revealed: genetically based reduction in potassium currents that remains clinically silent until combined with additional stressors

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Background The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Environmental temperature is a key signal which regulates virulence of the bacterium. The bacterium normally grows outside the human host at 28 °C. Therefore, understanding the mechanisms that the bacterium used to adapt to a mammalian host at 37 °C is central to the development of vaccines or drugs for the prevention or treatment of human disease. Results Using a library of over 1 million Y. pestis CO92 random mutants and transposon-directed insertion site sequencing, we identified 530 essential genes when the bacteria were cultured at 28 °C. When the library of mutants was subsequently cultured at 37 °C we identified 19 genes that were essential at 37 °C but not at 28 °C, including genes which encode proteins that play a role in enabling functioning of the type III secretion and in DNA replication and maintenance. Using genome-scale metabolic network reconstruction we showed that growth conditions profoundly influence the physiology of the bacterium, and by combining computational and experimental approaches we were able to identify 54 genes that are essential under a broad range of conditions. Conclusions Using an integrated computational-experimental approach we identify genes which are required for growth at 37 °C and under a broad range of environments may be the best targets for the development of new interventions to prevent or treat plague in humans

INFLATE : a protocol for a randomised controlled trial comparing nasal balloon autoinflation to no nasal balloon autoinflation for otitis media with effusion in Aboriginal and Torres Strait Islander children

Background: Otitis media with effusion (OME) is common and occurs at disproportionately higher rates among Indigenous children. Left untreated, OME can negatively affect language, development, learning, and health and wellbeing throughout the life-course. Currently, OME care includes observation for 3 months followed by consideration of surgical ventilation tube insertion. The use of a non-invasive, low-cost nasal balloon autoinflation device has been found beneficial in other populations but has not been investigated among Aboriginal and Torres Strait Islander children. Methods/design: This multi-centre, open-label, randomised controlled trial will determine the effectiveness of nasal balloon autoinflation compared to no nasal balloon autoinflation, for the treatment of OME among Aboriginal and Torres Strait Islander children in Australia. Children aged 3–16 years with unilateral or bilateral OME are being recruited from Aboriginal Health Services and the community. The primary outcome is the proportion of children showing tympanometric improvement of OME at 1 month. Improvement is defined as a change from bilateral type B tympanograms to at least one type A or C1 tympanogram, or from unilateral type B tympanogram to type A or C1 tympanogram in the index ear, without deterioration (type A or C1 to type C2, C3, or B tympanogram) in the contralateral ear. A sample size of 340 children (170 in each group) at 1 month will detect an absolute difference of 15% between groups with 80% power at 5% significance. Anticipating a 15% loss to follow-up, 400 children will be randomised. The primary analysis will be by intention to treat. Secondary outcomes include tympanometric changes at 3 and 6 months, hearing at 3 months, ear health-related quality of life (OMQ-14), and cost-effectiveness. A process evaluation including perspectives of parents or carers, health care providers, and researchers on trial implementation will also be undertaken. Discussion: INFLATE will answer the important clinical question of whether nasal balloon autoinflation is an effective and acceptable treatment for Aboriginal and Torres Strait Islander children with OME. INFLATE will help fill the evidence gap for safe, low-cost, accessible OME therapies. Trial registration: Australia New Zealand Clinical Trials Registry ACTRN12617001652369. Registered on 22 December 2017. The Australia New Zealand Clinical Trials Registry is a primary registry of the WHO ICTRP network and includes all items from the WHO Trial Registration data set. Retrospective registration.</p

The faint-end slopes of galaxy luminosity functions in the COSMOS field

We examine the faint-end slope of the rest-frame V-band luminosity function (LF), with respect to galaxy spectral type, of field galaxies with redshift z < 0.5, using a sample of 80,820 galaxies with photometric redshifts in the 2 deg^2 Cosmic Evolution Survey (COSMOS) field. For all galaxy spectral types combined, the LF slope ranges from –1.24 to –1.12, from the lowest redshift bin to the highest. In the lowest redshift bin (0.02 < z < 0.1), where the magnitude limit is MV ≾ − 13, the slope ranges from α ~ − 1.1 for galaxies with early-type spectral energy distributions (SEDs) to α ~ − 1.9 for galaxies with low-extinction starburst SEDs. In each galaxy SED category (early-type, Sbc, Scd+Irr, and starburst), the faint-end slopes grow shallower with increasing redshift; in the highest redshift bin (0.4 < z < 0.5), α ~ − 0.5 and –1.3 for early types and starbursts, respectively. The steepness of α at lower redshifts could be qualitatively explained by LF evolution, or by large numbers of faint dwarf galaxies, perhaps of low surface brightness, that are not detected at higher redshifts

Nanopore native RNA sequencing of a human poly(A) transcriptome

High-throughput complementary DNA sequencing technologies have advanced our understanding of transcriptome complexity and regulation. However, these methods lose information contained in biological RNA because the copied reads are often short and modifications are not retained. We address these limitations using a native poly(A) RNA sequencing strategy developed by Oxford Nanopore Technologies. Our study generated 9.9 million aligned sequence reads for the human cell line GM12878, using thirty MinION flow cells at six institutions. These native RNA reads had a median length of 771 bases, and a maximum aligned length of over 21,000 bases. Mitochondrial poly(A) reads provided an internal measure of read-length quality. We combined these long nanopore reads with higher accuracy short-reads and annotated GM12878 promoter regions to identify 33,984 plausible RNA isoforms. We describe strategies for assessing 3′ poly(A) tail length, base modifications and transcript haplotypes