Growth, yield and phenology of 2 hybrid papayas (Carica papaya L.) as influenced by method of water application

Highly variable, outcrossed papaya lines irrigated with overhead sprinklers were grown at Yarwun (151.3˚E, 23.75˚S) in Queensland, Australia. The inherent variability made scientifically based comparative studies impractical. The advent of uniform hybrid papaya lines allowed the testing of 2 of these hybrids under 3 irrigation methods, 2 of which had the potential to greatly reduce water use compared with overhead sprinklers. Yields of 92 t/ha.year were achieved by both papaya Hybrids 29 and 1E. Water application method did not influence yield. About 26% of plants were lost due to the phytoplasma diseases dieback, yellow crinkle and mosaic over the life of the trial. Downward yield fluctuations were related to poor fruit set in winter when pollinators (Family Sphingidae) were not present and growth was slow due to hot dry periods affecting fruit set. The resultant fruit (about 6 months later) were small and reduced in number. Irrigation with overhead sprinklers using saline water (1400–4000 S/cm) damaged leaves and reduced growth of plants. Winter spot was most severe in July, August and September, in Hybrid 29 with overhead irrigation. Height of plants 13 weeks after planting was greater under trickle irrigation due to less damage from the saline water supply than in the overhead sprinkler treatment. Hybrid 29 set fruit at 94.3 cm above ground compared with 117.6 cm for Hybrid 1E

The protocols for the 10/66 dementia research group population-based research programme

BACKGROUND: Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with dementia that live in developing countries and the less than one tenth of population-based research carried out in those settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress this imbalance. METHODS/DESIGN: Cross-sectional comprehensive one phase surveys have been conducted of all residents aged 65 and over of geographically defined catchment areas in ten low and middle income countries (India, China, Nigeria, Cuba, Dominican Republic, Brazil, Venezuela, Mexico, Peru and Argentina), with a sample size of between 1000 and 3000 (generally 2000). Each of the studies uses the same core minimum data set with cross-culturally validated assessments (dementia diagnosis and subtypes, mental disorders, physical health, anthropometry, demographics, extensive non communicable disease risk factor questionnaires, disability/functioning, health service utilisation, care arrangements and caregiver strain). Nested within the population based studies is a randomised controlled trial of a caregiver intervention for people with dementia and their families (ISRCTN41039907; ISRCTN41062011; ISRCTN95135433; ISRCTN66355402; ISRCTN93378627; ISRCTN94921815). A follow up of 2.5 to 3.5 years will be conducted in 7 countries (China, Cuba, Dominican Republic, Venezuela, Mexico, Peru and Argentina) to assess risk factors for incident dementia, stroke and all cause and cause-specific mortality; verbal autopsy will be used to identify causes of death. DISCUSSION: The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that the health and social care needs of older people are anticipated and met

What will B will B: identifying molecular determinants of diverse B-cell fate decisions through systems biology

B-cells are the poster child for cellular diversity and heterogeneity. The diverse repertoire of B lymphocytes, each expressing unique antigen receptors, provides broad protection against pathogens. However, B-cell diversity goes beyond unique antigen receptors. Side-stepping B-cell receptor (BCR) diversity through BCR-independent stimuli or engineered organisms with monoclonal BCRs still results in seemingly identical B-cells reaching a wide variety of fates in response to the same challenge. Identifying to what extent the molecular state of a B-cell determines its fate is key to gaining a predictive understanding of B-cells and consequently the ability to control them with targeted therapies. Signals received by B-cells through transmembrane receptors converge on intracellular molecular signaling networks, which control whether each B-cell divides, dies, or differentiates into a number of antibody-secreting distinct B-cell subtypes. The signaling networks that interpret these signals are well known to be susceptible to molecular variability and noise, providing a potential source of diversity in cell fate decisions. Iterative mathematical modeling and experimental studies have provided quantitative insight into how B-cells achieve distinct fates in response to pathogenic stimuli. Here, we review how systems biology modeling of B-cells, and the molecular signaling networks controlling their fates, is revealing the key determinants of cell-to-cell variability in B-cell destiny

An essay on Percy Bysshe Shelley,

Errata slip inserted."Five hundred copies have been printed." This copy on hand-made paper.Mode of access: Internet