Sertaconazole antifungal profile determined by a microdilution method versus nine topical substances against dermatophyte fungi

Antifungal activity and in vitro inhibition time for sertaconazole (STZ) and 9 other topical drugs, namely amorolfine, bifonazole, clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, terbinafine, and tioconazole were determined against 124 clinical isolates of dermatophyte (12 species) fungi by the microdilution method in a liquid medium and the measurement of optical density. STZ's antifungal activity was not always affected by the tested dermatophyte genus, as was the case with the remaining antifungals. In vitro antifungal activity was at the same level for all the studied azole derivatives, but, in terms of partial inhibitory concentrations, STZ starts its in vitro inhibitory activity in a shorter time than the other tested substances, particularly in those incubation periods when the growth of the dermatophyte fungi was more developed.Fil: Carrillo Muñoz, A. J.. No especifíca;Fil: Tur Tur, C.. No especifíca;Fil: Cárdenes, D.. No especifíca;Fil: Rojas, Florencia Dinorah. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentin

Els cnidaris bentònics

En aquest treball es presenten 85 espècies de cnidaris bentònics trobats als fons que envolten l'Arxipèlag de Cabrera. També es fa esment de la distribució bionòmica de les espècies més representatives i es compara la fauna trobada amb la de la immediata costa de Mallorca, la costa catalana, i, en general, les del litoral de la Mediterrània central i occidental.A check-list of the benthic Cnidaria inhabiting the Archipelago of Cabrera is presented, with comments on the bionomic distribution of the most representative species. The faunistic composition and the species distribution is very similar to the other Balearic islands and the species pool is representative of the coastal Mediterranean Cnidarian fauna

A high efficiency, low background detector for measuring pair-decay branches in nuclear decay

We describe a high efficiency detector for measuring electron-positron pair transitions in nuclei. The device was built to be insensitive to gamma rays and to accommodate high overall event rates. The design was optimized for total pair kinetic energies up to about 7 MeV.Comment: Accepted for publication by Nucl. Inst. & Meth. in Phys. Res. A (NIM A

Effective balancing error and user effort in interactive handwriting recognition

This is the author’s version of a work that was accepted for publication in Pattern Recognition Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pattern Recognition Letters, Volume 37, 1 February 2014, Pages 135–142 DOI 10.1016/j.patrec.2013.03.010[EN] Transcription of handwritten text documents is an expensive and time-consuming task. Unfortunately, the accuracy of current state-of-the-art handwriting recognition systems cannot guarantee fully-automatic high quality transcriptions, so we need to revert to the computer assisted approach. Although this approach reduces the user effort needed to transcribe a given document, the transcription of handwriting text documents still requires complete manual supervision. An especially appealing scenario is the interactive transcription of handwriting documents, in which the user defines the amount of errors that can be tolerated in the final transcribed document. Under this scenario, the transcription of a handwriting text document could be obtained efficiently, supervising only a certain number of incorrectly recognised words. In this work, we develop a new method for predicting the error rate in a block of automatically recognised words, and estimate how much effort is required to correct a transcription to a certain user-defined error rate. The proposed method is included in an interactive approach to transcribing handwritten text documents, which efficiently employs user interactions by means of active and semi-supervised learning techniques, along with a hypothesis recomputation algorithm based on constrained Viterbi search. Transcription results, in terms of trade-off between user effort and transcription accuracy, are reported for two real handwritten documents, and prove the effectiveness of the proposed approach.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under Grant agreement No 287755 (transLectures). Also supported by the EC (FEDER, FSE), the Spanish Government (MICINN, MITyC, "Plan E", under grants MIPRCV "Consolider Ingenio 2010", MITTRAL (TIN2009-14633-C03-01), iTrans2 (TIN2009-14511), and FPU (AP2007-02867), and the Generalitat Valenciana (Grants Prometeo/2009/014 and GV/2010/067). Special thanks to Jesus Andres for his fruitful discussions.Serrano Martinez Santos, N.; Civera Saiz, J.; Sanchis Navarro, JA.; Juan Císcar, A. (2014). Effective balancing error and user effort in interactive handwriting recognition. Pattern Recognition Letters. 37(1):135-142. https://doi.org/10.1016/j.patrec.2013.03.010S13514237

Entrepreneurial Orientation and Firm Performance in the Context of Upper Echelon Theory

Entrepreneurial Orientation (EO) is a firm-level phenomenon, which involves the firm’s prospects to take risks, be proactive, and be innovative. Most of the research assumes a positive EO-performance relationship adopting the EO-as-advantage perspective without providing enough theoretical foundations of the way EO enhances performance. This paper provides insights into the EO and firm performance relationship looking into the EO-as-experimentation perspective. Through EO-as-experimentation perspective, we argue for the importance of looking into the differential effects of each of the EO dimensions on firm performance in active and inactive firms. We hypothesized that the effect of each of the proactiveness and innovativeness dimension of EO on firm performance is positive among active firms and negative among inactive firms. Whereas risk taking dimension of EO is negative among active and inactive firms. Based on the results of firm fixed effect regression some empirical support for the hypotheses is presented and discussed

Canonical description of ideal magnetohydrodynamic flows and integrals of motion

In the framework of the variational principle the canonical variables describing ideal magnetohydrodynamic (MHD) flows of general type (i.e., with spatially varying entropy and nonzero values of all topological invariants) are introduced. The corresponding complete velocity representation enables us not only to describe the general type flows in terms of single-valued functions, but also to solve the intriguing problem of the ``missing'' MHD integrals of motion. The set of hitherto known MHD local invariants and integrals of motion appears to be incomplete: for the vanishing magnetic field it does not reduce to the set of the conventional hydrodynamic invariants. And if the MHD analogs of the vorticity and helicity were discussed earlier for the particular cases, the analog of Ertel invariant has been so far unknown. It is found that on the basis of the new invariants introduced a wide set of high-order invariants can be constructed. The new invariants are relevant both for the deeper insight into the problem of the topological structure of the MHD flows as a whole and for the examination of the stability problems. The additional advantage of the proposed approach is that it enables one to deal with discontinuous flows, including all types of possible breaks.Comment: 16 page

Spectroscopy of 13B via the 13C(t,3He) reaction at 115 AMeV

Gamow-Teller and dipole transitions to final states in 13B were studied via the 13C(t,3He) reaction at Et = 115 AMeV. Besides the strong Gamow-Teller transition to the 13B ground state, a weaker Gamow-Teller transition to a state at 3.6 MeV was found. This state was assigned a spin-parity of 3/2- by comparison with shell-model calculations using the WBP and WBT interactions which were modified to allow for mixing between nhw and (n+2)hw configurations. This assignment agrees with a recent result from a lifetime measurement of excited states in 13B. The shell-model calculations also explained the relatively large spectroscopic strength measured for a low-lying 1/2+ state at 4.83 MeV in 13B. The cross sections for dipole transitions up to Ex(13B)= 20 MeV excited via the 13C(t,3He) reaction were also compared with the shell-model calculations. The theoretical cross sections exceeded the data by a factor of about 1.8, which might indicate that the dipole excitations are "quenched". Uncertainties in the reaction calculations complicate that interpretation.Comment: 11 pages, 6 figure

Predicting disability progression and cognitive worsening in multiple sclerosis using patterns of grey matter volumes

OBJECTIVE: In multiple sclerosis (MS), MRI measures at the whole brain or regional level are only modestly associated with disability, while network-based measures are emerging as promising prognostic markers. We sought to demonstrate whether data-driven patterns of covarying regional grey matter (GM) volumes predict future disability in secondary progressive MS (SPMS). METHODS: We used cross-sectional structural MRI, and baseline and longitudinal data of Expanded Disability Status Scale, Nine-Hole Peg Test (9HPT) and Symbol Digit Modalities Test (SDMT), from a clinical trial in 988 people with SPMS. We processed T1-weighted scans to obtain GM probability maps and applied spatial independent component analysis (ICA). We repeated ICA on 400 healthy controls. We used survival models to determine whether baseline patterns of covarying GM volume measures predict cognitive and motor worsening. RESULTS: We identified 15 patterns of regionally covarying GM features. Compared with whole brain GM, deep GM and lesion volumes, some ICA components correlated more closely with clinical outcomes. A mainly basal ganglia component had the highest correlations at baseline with the SDMT and was associated with cognitive worsening (HR=1.29, 95% CI 1.09 to 1.52, p<0.005). Two ICA components were associated with 9HPT worsening (HR=1.30, 95% CI 1.06 to 1.60, p<0.01 and HR=1.21, 95% CI 1.01 to 1.45, p<0.05). ICA measures could better predict SDMT and 9HPT worsening (C-index=0.69-0.71) compared with models including only whole and regional MRI measures (C-index=0.65-0.69, p value for all comparison <0.05). CONCLUSIONS: The disability progression was better predicted by some of the covarying GM regions patterns, than by single regional or whole-brain measures. ICA, which may represent structural brain networks, can be applied to clinical trials and may play a role in stratifying participants who have the most potential to show a treatment effect

The 150^{150}Nd(3^3He,tt) and 150^{150}Sm(tt,3^3He) reactions with applications to ββ\beta\beta decay of 150^{150}Nd

The $^{150}$Nd($^3$He,$t$) reaction at 140 MeV/u and $^{150}$Sm($t$,$^3$He) reaction at 115 MeV/u were measured, populating excited states in $^{150}$Pm. The transitions studied populate intermediate states of importance for the (neutrinoless) $\beta\beta$ decay of $^{150}$Nd to $^{150}$Sm. Monopole and dipole contributions to the measured excitation-energy spectra were extracted by using multipole decomposition analyses. The experimental results were compared with theoretical calculations obtained within the framework of Quasiparticle Random-Phase Approximation (QRPA), which is one of the main methods employed for estimating the half-life of the neutrinoless $\beta\beta$ decay ($0\nu\beta\beta$) of $^{150}$Nd. The present results thus provide useful information on the neutrino responses for evaluating the $0\nu\beta\beta$ and $2\nu\beta\beta$ matrix elements. The $2\nu\beta\beta$ matrix element calculated from the Gamow-Teller transitions through the lowest $1^{+}$ state in the intermediate nucleus is maximally about half of that deduced from the half-life measured in $2\nu\beta\beta$ direct counting experiments and at least several transitions through $1^{+}$ intermediate states in $^{150}$Pm are required to explain the $2\nu\beta\beta$ half-life. Because Gamow-Teller transitions in the $^{150}$Sm($t$,$^3$He) experiment are strongly Pauli-blocked, the extraction of Gamow-Teller strengths was complicated by the excitation of the $2\hbar\omega$, $\Delta L=0$, $\Delta S=1$ isovector spin-flip giant monopole resonance (IVSGMR). However, the near absence of Gamow-Teller transition strength made it possible to cleanly identify this resonance, and the strength observed is consistent with the full exhaustion of the non-energy-weighted sum rule for the IVSGMR.Comment: 18 pages, 13 figures, 2 table