33 research outputs found
Spectrophotometric Observations of Blue Compact Dwarf Galaxies: Mrk 370
We present results from a detailed spectrophotometric analysis of the blue
compact dwarf galaxy (BCD) Mrk 370, based on deep UBVRI broad-band and Halpha
narrow-band observations, and long-slit and two-dimensional spectroscopy of its
brightest knots. The spectroscopic data are used to derive the internal
extinction, and to compute metallicities, electronic density and temperature in
the knots. By subtracting the contribution of the underlying older stellar
population, modeled by an exponential function, removing the contribution from
emission lines, and correcting for extinction, we can measure the true colors
of the young star-forming knots. We show that the colors obtained this way
differ significantly from those derived without the above corrections, and lead
to different estimates of the ages and star-forming history of the knots. Using
predictions of evolutionary synthesis models, we estimate the ages of both the
starburst regions and the underlying stellar component. We found that we can
reproduce the colors of all the knots with an instantaneous burst of star
formation and the Salpeter initial mass function with an upper mass limit of
100 solar masses. The resulting ages range between 3 and 6 Myrs. The colors of
the low surface brightness component are consistent with ages larger than 5
Gyr. The kinematic results suggest ordered motion around the major axis of the
galaxy.Comment: 26 pages with 14 figures; accepted for publication in Ap
SHARDS: A global view of the star formation activity at z~0.84 and z~1.23
In this paper, we present a comprehensive analysis of star-forming galaxies
(SFGs) at intermediate redshifts (z~1). We combine the ultra-deep optical
spectro-photometric data from the Survey for High-z Absorption Red and Dead
Sources (SHARDS) with deep UV-to-FIR observations in the GOODS-N field.
Exploiting two of the 25 SHARDS medium-band filters, F687W17 and F823W17, we
select [OII] emission line galaxies at z~0.84 and z~1.23 and characterize their
physical properties. Their rest-frame equivalent widths
(EW([OII])), line fluxes, luminosities, star formation rates
(SFRs) and dust attenuation properties are investigated. The evolution of the
EW([OII]) closely follows the SFR density evolution of the
universe, with a trend of EW([OII])(1+z) up to
redshift z~1, followed by a possible flattening. The SF properties of the
galaxies selected on the basis of their [OII] emission are compared with
complementary samples of SFGs selected by their MIR and FIR emission, and also
with a general mass-selected sample of galaxies at the same redshifts. We
demonstrate observationally that the UVJ diagram (or, similarly, a cut in the
specific SFR) is only partially able to distinguish the quiescent galaxies from
the SFGs. The SFR-M relation is investigated for the different samples,
yelding a logarithmic slope ~1, in good agreement with previous results. The
dust attenuations derived from different SFR indicators (UV(1600), UV(2800),
[OII], IR) are compared and show clear trends with respect to both the stellar
mass and total SFR, with more massive and highly star-forming galaxies being
affected by stronger dust attenuation.Comment: Replaced to match the accepted version (24 pages, 1 table, 17
figures). Published in ApJ, 812, 155 (2015):
http://stacks.iop.org/0004-637X/812/15
2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) : Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries
Endorsed by: the European Stroke Organization (ESO), The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)Peer reviewe
Design and rationale of a multicentre, randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of vitamin D on ventricular remodelling in patients with anterior myocardial infarction: the VITamin D in Acute Myocardial Infarction (VITDAMI) trial
Introduction:Decreased plasma vitamin D (VD) levels are linked to cardiovascular damage. However, clinical trials have not demonstrated a benefit of VD supplements on left ventricular (LV) remodelling. Anterior ST-elevation acute myocardial infarction (STEMI) is the best human model to study the effect of treatments on LV remodelling. We present a proof-of-concept study that aims to investigate whether VD improves LV remodelling in patients with anterior STEMI. Methods and analysis:The VITamin D in Acute Myocardial Infarction (VITDAMI) trial is a multicentre, randomised, double-blind, placebo-controlled trial. 144 patients with anterior STEMI will be assigned to receive calcifediol 0.266 mg capsules (Hidroferol SGC)/15 days or placebo on a 2:1 basis during 12 months. Primary objective:to evaluate the effect of calcifediol on LV remodelling defined as an increase in LV end-diastolic volume >= 10\% (MRI). Secondary objectives:change in LV end-diastolic and end-systolic volumes, ejection fraction, LV mass, diastolic function, sphericity index and size of fibrotic area; endothelial function; plasma levels of aminoterminal fragment of B-type natriuretic peptide, galectin-3 and monocyte chemoattractant protein-1; levels of calcidiol (VD metabolite) and other components of mineral metabolism (fibroblast growth factor-23 (FGF-23), the soluble form of its receptor klotho, parathormone and phosphate). Differences in the effect of VD will be investigated according to the plasma levels of FGF-23 and klotho. Treatment safety and tolerability will be assessed. This is the first study to evaluate the effect of VD on cardiac remodelling in patients with STEMI. Ethics and dissemination: This trial has been approved by the corresponding Institutional Review Board (IRB) and National Competent Authority (Agencia Espanola de Medicamentos y Productos Sanitarios (AEMPS)). It will be conducted in accordance with good clinical practice (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use-Good Clinical Practice (ICH-GCP)) requirements, ethical principles of the Declaration of Helsinki and national laws. The results will be submitted to indexed medical journals and national and international meetings.The VITDAMI trial is an investigator initiated study, sponsored by the Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS-FJD). Funding has been obtained from Fondo de Investigaciones Sanitarias (PI14/01567; http://www.isciii.es/) and Spanish Society of Cardiology (http://secardiologia.es/). In addition, the study medication has been provided freely by the pharmaceutical Company FAES FARMA S.A. (Leioa, Vizcaya, Spain; http://faesfarma.com/). This company was the only funder who collaborated in study design (IG-H).S
Deep Near Infrared Mapping of Young and Old Stars in Blue Compact Dwarf Galaxies
We analyze J, H and Ks near-infrared data for 9 Blue Compact Dwarf (BCD)
galaxies, selected from a larger sample that we have already studied in the
optical. We present contour maps, surface brightness and color profiles, as
well as color maps of the sample galaxies. The morphology of the BCDs in the
NIR has been found to be basically the same as in the optical. The inner
regions of these systems are dominated by the starburst component. At low
surface brightness levels the emission is due to the underlying host galaxy;
the latter is characterized by red, radially constant colors and isophotes well
fit by ellipses. We derive accurate optical near--infrared host galaxy colors
for eight of the sample galaxies; these colors are typical of an evolved
stellar population. Interestingly, optical near--infrared color maps reveal the
presence of a complex, large-scale absorption pattern in three of the sample
galaxies. We study the applicability of the Sersic law to describe the surface
brightness profiles of the underlying host galaxy, and find that, because of
the limited surface brightness interval over which the fit can be made, the
derived Sersic parameters are very sensitive to the selected radial interval
and to errors in the sky subtraction. Fitting an exponential model gives
generally more stable results, and can provide a useful tool to quantify the
structural properties of the host galaxy and compare them with those of other
dwarf classes as well as with those of star-forming dwarfs at higher redshifts.Comment: 49 pages, 9 figures, 10 tables, accepted for publication in the
Astrophysical Journa
Valoracion por ecocardiografia doppler color de la insuficiencia tricuspide croncia en pacientes con valvulopatia izquierda Estudio comparativo con la angiografia en el laboratorio de hemodinamica
Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai
Cinetoquimica de la oxidacion permanganica de aminoacidos en medio basico: glicina, alanina y fenilalanina
Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai
Drug-loaded PCL electrospun nanofibers as anti-pancreatic cancer drug delivery systems
Cancer is one of the main causes of death worldwide, being pancreatic cancer the second deadliest cancer in Western countries. Surgery, chemotherapy and radiotherapy form the basis of pancreatic cancer's current treatment. However, these techniques have several disadvantages, such as surgery complications, chemotherapy systemic side effects and cancer recurrence. Drug delivery systems can reduce side effects, increasing the effectivity of the treatment by a controlled release at the targeted tumor cells. In this context, coaxial electrospun fibers can increase the control on the release profile of the drug. The aim of this study was to encapsulate and release different anticancer drugs (5-Fluorouracil and Methotrexate) from a polymeric fiber mat. Different flows and ratios were used to test their effect on fiber morphology, FTIR spectrum, drug encapsulation and release. Good integration of the anticancer drugs was observed and the use of a desiccator for 24 h showed to be a key step to remove solvent remanence. Moreover, the results of this study demonstrated that the polymeric solution could be used to encapsulate and release different drugs to treat cancers. This makes coaxial electrospinning a promising alternative to deliver complex chemotherapies that involve more than one drug, such as FOLFIRINOX, used in pancreatic cancer treatment
Halothane induces oxidative stress and NF-kappa B activation in rat liver: Protective effect of propofol
We investigated the effects of propofol on markers of oxidative stress, nuclear factor kappa B (NF-kappa B) activation and inducible nitric oxide synthase (NOS) expression in liver of rats treated with halothane under hypoxic conditions. Male Wistar rats received halothane 1% oxygen 14%, oxygen 14%/propofol 60 mg kg(-1) i.p., or halothane 1% oxygen 14%/propofol 60 mg kg(-1) i.p. Morphological examination showed complete loss of architecture with massive necrosis of parenchyma in the halothane group, while only minor histological abnormalities were observed in rats receiving halothane plus propofol. the cytosolic concentration of TBARS and the hydroperoxide-initiated chemiluminescence increased significantly in the liver of animals from the halothane group (+62% and +40% versus controls, respectively), and this increase was abolished by propofol administration. Halothane induced a marked activation of NF-kappa B (+180%), and resulted in a significant decrease of the nonphosphorylated form of the inhibitor I kappa B alpha (-53%), while phosphorylated I kappa B alpha protein level was markedly increased (+ 146%). Propofol administration lowered these effects to +30% (NF-kappa B), -26% (nonphosphorylated I kappa B alpha), and +56% (phosphorylated I kappa B alpha). the increase of WOS protein level (+59%) induced by halothane was significantly reduced to +22% by additional administration of propofol. Results obtained show that administration of propofol inhibits oxidative stress, NF-kappa B nuclear traslocation and Nos overexpression in liver of rats receiving halothane. Propofol treatment, by inhibiting the NF-kappa B signal transduction pathway, might block the production of noxious mediators involved in the development of halothane-induced injury. (c) 2006 Elsevier Ireland Ltd. All rights reserved.Univ Leon, Dept Physiol, E-24071 Leon, SpainIrmandade Santa Casa Misericordia, Porto Alegre, RS, BrazilUniv Luterana Brasil, Porto Alegre, RS, BrazilUniversidade Federal de São Paulo, Dept Anesthesiol & Intens Care Med, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Anesthesiol & Intens Care Med, São Paulo, BrazilWeb of Scienc