Increasing energy efficiency in Smart Building through Internet of Things retrofitting intervention

Buildings are responsible for 40% of energy consumption in Europe, and 75% of them are energy inefficient. In this context, the opportunities enabled by improved management and conservation of energy in buildings are huge. There is a clear need to accelerate and finance building renovation investments and leverage smart, energy-efficient technologies if the EU wants to reach climate neutrality by 2050. IoT components enable new possibilities for improving efficiency in Smart Buildings, both in commercial and residential spaces. However, the literature misses some contributions aimed at evaluating the investment in IoT technologies used for improving the energy efficiency of a building used for different purposes. Thus, the objective of the present study is to provide an assessment of the main costs and benefits stemming from IoT technologies installation through retrofitting intervention and evaluate the sustainability of the investment. Data to feed the model were retrieved from academic literature and secondary sources. The results show that the investment can be recovered in the medium-short term. In particular, buildings with high consumption rates are the ones that benefit the most from this solution. The present study contributes to the academic literature by providing a model that considers a mixed building and multiple technologies at the same time. It also provides useful insights to whoever is interested in the application of IoT technologies to make a building smart, enabling the comprehension of necessary investment and economic returns

A comprehensive view of intelligent transport systems for urban smart mobility

Information accuracy and decision-making speed are of paramount importance in managing today’s mobility of goods and people inside the city. Intelligent Transport Systems (ITS) can provide road users with updated information and forecasts on both traffic and weather conditions. The result is a higher efficiency in the use of resources and a better management of physical flows. The purpose of this paper is to conduct an in-depth review on the role of ITS supporting urban Smart Mobility, in order to identify the main gaps in the literature and propose future research streams. In total, 71 papers have been thoroughly analysed: they are mainly focused on technology, with limited attention to value creation. Even though some benefits have been examined, a general lack of quantitative models emerged. Eventually, there is a lack of contributions considering both people and freight transport, even if they are strongly related, especially in an urban environment

Supply chain finance: a literature review

Purpose – The purpose of this paper is twofold: to classify the research to-date on supply chain finance (SCF) according to the main themes and methods, and to propose directions for future research. Design/methodology/approach – The review is based on 119 papers mainly published from 2000 to 2014 in international peer-reviewed journals and in the proceedings of international conferences. Findings – The articles that provide a definition of SCF reflect two major perspectives: the “finance oriented” perspective – focused on short-term solutions provided by financial institutions, addressing accounts payable and receivable – and the “supply chain oriented” perspective – which might not involve a financial institution, and is focused on working capital optimisation in terms of accounts payable, receivable, inventories, and sometimes even on fixed asset financing. Research limitations/implications – While efforts were made to be all-inclusive, significant research efforts may have been inadvertently omitted. However, the authors believe that this review is an accurate representation of the body of research on SCF published during the specified time frame, and feel that confidence may be placed on the resulting assessments. Originality/value – The paper presents a comprehensive summary of previous research on this topic and identifies the most important issues that need to be addressed in future research. On the basis of the identified gaps in the literature, four key issues have been highlighted which should be addressed in future research

Supply Chain Finance: Modelling a Dynamic Discounting Programme

In the last 10 years, new financing opportunities (known as “Supply Chain Finance” or SCF) arose, exploiting the strength of new ICTs and supply chain links to optimise the working capital and create value for the organisations involved. One of the solutions within the SCF landscape, called Dynamic Discounting (DD), utilises trade process visibility granted by an ICT platform to allow the dynamic settlement of invoices in a buyer-supplier relation: for every day of payment in advance with respect to a pre- defined baseline, the supplier grants to the buyer a discount on the invoice nominal value. DD is a supply management tool for which a cash-rich anchor buyer can let suppliers (especially SMEs) fast-access cash, while gaining a relatively high rate of return. This paper aims to estimate, through the development of an analytical model, the potential benefit sof using a DD model in a buyer-supplier relation. After a brief review of relevant literature, the paper presents amodel that compares, for the supplier, the cost of granting a discount to the buyer with the benefit of an early payment, whereas for the buyer, the benefit of receiving a discount with the financial cost of an early settlement. This paper fills the gap in literature related to the definition of the processes underlying the adoption of DD, and more broadly the need for models to assess the benefits of the most innovative SCF schemas

Risk Factors and Outcomes Related to Pediatric Intensive Care Unit Admission after Hematopoietic Stem Cell Transplantation: A Single-Center Experience

Abstract To describe incidence, causes, and outcomes related to pediatric intensive care unit (PICU) admission for patients undergoing hematopoietic stem cell transplantation (HSCT), we investigated the risk factors predisposing to PICU admission and prognostic factors in terms of patient survival. From October 1998 to April 2015, 496 children and young adults (0 to 23 years) underwent transplantation in the HSCT unit. Among them, 70 (14.1%) were admitted to PICU. The 3-year cumulative incidence of PICU admission was 14.3%. The main causes of PICU admission were respiratory failure (36%), multiple organ failure (16%), and septic shock (13%). The overall 90-day cumulative probability of survival after PICU admission was 34.3% (95% confidence interval, 24.8% to 47.4%). In multivariate analysis, risk factors predisposing to PICU admission were allogeneic HSCT (versus autologous HSCT, P  = .030) and second or third HSCT ( P  = .018). Characteristics significantly associated with mortality were mismatched HSCT ( P  = .011), relapse of underlying disease before PICU admission ( P P  = .012), hepatic failure at admission ( P  = .021), and need for invasive ventilation during PICU course (

Serum Extracellular Vesicle-Derived microRNAs as Potential Biomarkers for Pleural Mesothelioma in a European Prospective Study

Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive and still incurable cancer. There is an urgent need to identify effective and reliable tools for detecting and diagnosing the early onset of MPM. In our study, we investigated the whole miRNAs expression profile from serum extracellular vesicles to identify early changes related to MPM development. miR-11400, miR-148a-3p, and miR-409-3p levels were increased in pre-clinical MPM patients up to five years before their diagnosis. The three-miRNA pattern showed a good discrimination capacity to distinguish pre-clinical MPM from cancer-free controls. The three miRNAs also displayed high diagnostic capabilities for differentiating between MPM patients and controls. This study identified a potential EV miRNA signature in preclinical MPM up to five years before diagnosis and raises the possibility of early intervention. Malignant pleural mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Early therapeutic interventions could improve patient outcomes. We aimed to identify a pattern of microRNAs (miRNAs) as potential early non-invasive markers of MPM. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort, we screened the whole miRNome in serum extracellular vesicles (EVs) of preclinical MPM cases. In a subgroup of 20 preclinical samples collected five years prior MPM diagnosis, we observed an upregulation of miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01), miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC = 1.5, p-value = 0.04) relative to matched controls. The 3-miRNA panel showed a good classification capacity with an area under the receiver operating characteristic curve (AUC) of 0.81 (specificity = 0.75, sensitivity = 0.70). The diagnostic ability of the model was also evaluated in an independent retrospective cohort, yielding a higher predictive power (AUC = 0.86). A signature of EV miRNA can be detected up to five years before MPM; moreover, the identified miRNAs could provide functional insights into the molecular changes related to the late carcinogenic process, preceding MPM development

Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. RESULTS: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. CONCLUSIONS: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear

Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990–2015)

Objective: In many Western countries, survival from vulvar squamous cell carcinoma (VSCC) has been stagnating for decades or has increased insufficiently from a clinical perspective. In Italy, previous studies on cancer survival have not taken vulvar cancer into consideration or have pooled patients with vulvar and vaginal cancer. To bridge this knowledge gap, we report the trend in survival from vulvar cancer between 1990 and 2015. (2) Methods: Thirty-eight local cancer registries covering 49% of the national female population contributed the records of 6274 patients. Study endpoints included 1- and 2-year net survival (NS) calculated using the Pohar-Perme estimator and 5-year NS conditional on having survived two years (5|2-year CNS). The significance of survival trends was assessed with the Wald test on the coefficient of the period of diagnosis, entered as a continuous regressor in a Poisson regression model. (3) Results: The median patient age was stable at 76 years. One-year NS decreased from 83.9% in 1990–2001 to 81.9% in 2009–2015 and 2-year NS from 72.2% to 70.5%. Five|2-year CNS increased from 85.7% to 86.7%. These trends were not significant. In the age stratum 70–79 years, a weakly significant decrease in 2-year NS from 71.4% to 65.7% occurred. Multivariate analysis adjusting for age group at diagnosis and geographic area showed an excess risk of death at 5|2-years, of borderline significance, in 2003–2015 versus 1990–2002. (4) Conclusions: One- and 2-year NS and 5|2-year CNS showed no improvements. Current strategies for VSCC control need to be revised both in Italy and at the global level

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke