1,890 research outputs found
Suicide Screening in Primary Care: Use of an Electronic Screener to Assess Suicidality and Improve Provider Follow-Up for Adolescents
Purpose
The purpose of this study was to assess the feasibility of using an existing computer decision support system to screen adolescent patients for suicidality and provide follow-up guidance to clinicians in a primary care setting. Predictors of patient endorsement of suicidality and provider documentation of follow-up were examined.
Methods
A prospective cohort study was conducted to examine the implementation of a CDSS that screened adolescent patients for suicidality and provided follow-up recommendations to providers. The intervention was implemented for patients aged 12–20 years in two primary care clinics in Indianapolis, Indiana.
Results
The sample included 2,134 adolescent patients (51% female; 60% black; mean age = 14.6 years [standard deviation = 2.1]). Just over 6% of patients screened positive for suicidality. A positive endorsement of suicidality was more common among patients who were female, depressed, and seen by an adolescent−medicine board-certified provider as opposed to general pediatric provider. Providers documented follow-up action for 83% of patients who screened positive for suicidality. Documentation of follow-up action was correlated with clinic site and Hispanic race. The majority of patients who endorsed suicidality (71%) were deemed not actively suicidal after assessment by their provider.
Conclusions
Incorporating adolescent suicide screening and provider follow-up guidance into an existing computer decision support system in primary care is feasible and well utilized by providers. Female gender and depressive symptoms are consistently associated with suicidality among adolescents, although not all suicidal adolescents are depressed. Universal use of a multi-item suicide screener that assesses recency might more effectively identify suicidal adolescents
Collective behavior of interacting self-propelled particles
We discuss biologically inspired, inherently non-equilibrium self-propelled
particle models, in which the particles interact with their neighbours by
choosing at each time step the local average direction of motion. We summarize
some of the results of large scale simulations and theoretical approaches to
the problem
Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans
Comorbidity (COM) is an important issue in aging. Cardiovascular disease (CVD) and osteoarthritis separately and together may modify the trajectories of functional decline. This analysis examines whether specific and unrelated COMs influence functional change differently and vary by gender
Intergenerational education mobility and depressive symptoms in a population of Mexican origin
Low educational attainment has been associated with depression among Latinos. However, few studies have collected intergenerational data to assess mental health effects of educational mobility across generations
KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here, we found that knock-down of KLF9, an axon growth suppressor that is normally upregulated 250-fold in RGC development, promotes long-distance optic nerve regeneration in adult rats of both sexes. We identified a novel binding partner, MAPK10/JNK3 kinase, and found that JNK3 (c-Jun N-terminal kinase 3) is critical for KLF9\u27s axon-growth-suppressive activity. Interfering with a JNK3-binding domain or mutating two newly discovered serine phosphorylation acceptor sites, Ser106 and Ser110, effectively abolished KLF9\u27s neurite growth suppression in vitro and promoted axon regeneration in vivo. These findings demonstrate a novel, physiologic role for the interaction of KLF9 and JNK3 in regenerative failure in the optic nerve and suggest new therapeutic strategies to promote axon regeneration in the adult CNS
Expanded Mutation Profiling in Appendix Peritoneal Metastasis Has Prognostic and Therapeutic Utility When Managed with Cytoreductive Surgery/ Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC)
Constraints on the Ultra-High Energy Neutrino Flux from Gamma-Ray Bursts from a Prototype Station of the Askaryan Radio Array
We report on a search for ultra-high-energy (UHE) neutrinos from gamma-ray
bursts (GRBs) in the data set collected by the Testbed station of the Askaryan
Radio Array (ARA) in 2011 and 2012. From 57 selected GRBs, we observed no
events that survive our cuts, which is consistent with 0.12 expected background
events. Using NeuCosmA as a numerical GRB reference emission model, we estimate
upper limits on the prompt UHE GRB neutrino fluence and quasi-diffuse flux from
to GeV. This is the first limit on the prompt UHE GRB
neutrino quasi-diffuse flux above GeV.Comment: 14 pages, 8 figures, Published in Astroparticle Physics Journa
First Constraints on the Ultra-High Energy Neutrino Flux from a Prototype Station of the Askaryan Radio Array
The Askaryan Radio Array (ARA) is an ultra-high energy ( eV) cosmic
neutrino detector in phased construction near the South Pole. ARA searches for
radio Cherenkov emission from particle cascades induced by neutrino
interactions in the ice using radio frequency antennas ( MHz)
deployed at a design depth of 200 m in the Antarctic ice. A prototype ARA
Testbed station was deployed at m depth in the 2010-2011 season and
the first three full ARA stations were deployed in the 2011-2012 and 2012-2013
seasons. We present the first neutrino search with ARA using data taken in 2011
and 2012 with the ARA Testbed and the resulting constraints on the neutrino
flux from eV.Comment: 26 pages, 15 figures. Since first revision, added section on
systematic uncertainties, updated limits and uncertainty band with
improvements to simulation, added appendix describing ray tracing algorithm.
Final revision includes a section on cosmic ray backgrounds. Published in
Astropart. Phys.
Alcohol use among adolescents in India: a systematic review
Abstract
Background
Alcohol use is typically established during adolescence and initiation of use at a young age poses risks for short- and long-term health and social outcomes. However, there is limited understanding of the onset, progression and impact of alcohol use among adolescents in India. The aim of this review is to synthesise the evidence about prevalence, patterns and correlates of alcohol use and alcohol use disorders in adolescents from India.
Methods
Systematic review was conducted using relevant online databases, grey literature and unpublished data/outcomes from subject experts. Inclusion and exclusion criteria were developed and applied to screening rounds. Titles and abstracts were screened by two independent reviewers for eligibility, and then full texts were assessed for inclusion. Narrative synthesis of the eligible studies was conducted.
Results
Fifty-five peer-reviewed papers and one report were eligible for inclusion in this review. Prevalence of ever or lifetime alcohol consumption ranged from 3.9% to 69.8%; and prevalence of alcohol consumption at least once in the past year ranged from 10.6% to 32.9%. The mean age for initiation of drinking ranged from 14.4 to 18.3 years. Some correlates associated with alcohol consumption included being male, older age, academic difficulties, parental use of alcohol or tobacco, non-contact sexual abuse and perpetuation of violence.
Conclusion
The evidence base for alcohol use among adolescents in India needs a deeper exploration. Despite gaps in the evidence base, this synthesis provides a reasonable understanding of alcohol use among adolescents in India and can provide direction to policymakers.
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