12 research outputs found
RNA-binding proteins in human oogenesis:Balancing differentiation and self-renewal in the female fetal germline
Get PDFPrimordial germ cells undergo three significant processes on their path to becoming primary oocytes: the initiation of meiosis, the formation and breakdown of germ cell nests, and the assembly of single oocytes into primordial follicles. However at the onset of meiosis, the germ cell becomes transcriptionally silenced. Consequently translational control of pre-stored mRNAs plays a central role in coordinating gene expression throughout the remainder of oogenesis; RNA binding proteins are key to this regulation. In this review we examine the role of exemplars of such proteins, namely LIN28, DAZL, BOLL and FMRP, and highlight how their roles during germ cell development are critical to oogenesis and the establishment of the primordial follicle pool
RNA melting and RNA chaperone activities of plant cold shock domain proteins are not correlated
No full textDepletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives
No full textConcurrent treatment with simvastatin and NF-κB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-κB/LIN28/let-7 miRNA signaling pathway
No full textNucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line
No full textNatural variation in glycine-rich region of Brassica oleracea cold shock domain protein 5 (BoCSDP5) is associated with low temperature tolerance
No full textPersistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex
No full textRole and Regulation of Lin28 in Progenitor Cells During Central Nervous System Development
No full textMINT: a multivariate integrative method to identify reproducible molecular signatures across independent experiments and platforms
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