Building with wildlife: project geographies and cosmopolitics in infrastructure construction

Across many construction projects, and especially infrastructure projects, efforts to mitigate potential loss of biodiversity and habitat are significant concerns, and at times politically controversial. And yet, thus far, very little research has addressed the interplay of humans and animals within construction projects. Instead those interested in the politics and ethics of human-animal relations, or animal studies, have arguably focused far more on more stable and contained sites, whether organizations like zoos, farms or laboratories, or other places like homes and parks. These largely ethnographic studies inevitably perhaps downplay the unplanned, unexpected and highly politically and ethically charged, collision of hitherto rather separate human and animal geographies. Yet it is often within such colliding spaces, where animal geographies are unexpectedly found at the heart of human projects, that we formulate our respect and response to both animals and indeed other humans. We develop an examination of such encounters, with conceptual reference to actor-network theory, and documented empirically through case studies of two infrastructure projects; the findings of our research are relevant to both construction project management and future animal studies

Invitation from Mr. and Mrs. Andrew Tryggestad, Viroqua, Wisconsin, to Mr. and Mrs. Hans Hanson, March 2, 1923

This item is from the Cornelia and Hans Hanson Papers, which contains letters written by various friends and relatives. The letters mainly discuss news of family members and acquaintances: illnesses, births, and deaths. There are also wedding and shower invitations and a Christmas card. Letters were mostly written from various places in Wisconsin, with one letter from friends in Gary, South Dakota

Invitation from Mr. and Mrs. Andrew Tryggestad, Viroqua, Wisconsin, to Mr. and Mrs. Hans Hanson, September 27, 1919

This item is from the Cornelia and Hans Hanson Papers, which contains letters written by various friends and relatives. The letters mainly discuss news of family members and acquaintances: illnesses, births, and deaths. There are also wedding and shower invitations and a Christmas card. Letters were mostly written from various places in Wisconsin, with one letter from friends in Gary, South Dakota

Organizing space and time through relational human–animal boundary work: Exclusion, invitation and disturbance

https://scholars.carroll.edu/romansarcophagus_file3/1129/thumbnail.jp

Development of a Novel Preclinical Pancreatic Cancer Research Model: Bioluminescence Image-Guided Focal Irradiation and Tumor Monitoring of Orthotopic Xenografts1

PURPOSE: We report on a novel preclinical pancreatic cancer research model that uses bioluminescence imaging (BLI)-guided irradiation of orthotopic xenograft tumors, sparing of surrounding normal tissues, and quantitative, noninvasive longitudinal assessment of treatment response. MATERIALS AND METHODS: Luciferase-expressing MiaPaCa-2 pancreatic carcinoma cells were orthotopically injected in nude mice. BLI was compared to pathologic tumor volume, and photon emission was assessed over time. BLI was correlated to positron emission tomography (PET)/computed tomography (CT) to estimate tumor dimensions. BLI and cone-beam CT (CBCT) were used to compare tumor centroid location and estimate setup error. BLI and CBCT fusion was performed to guide irradiation of tumors using the small animal radiation research platform (SARRP). DNA damage was assessed by γ-H2Ax staining. BLI was used to longitudinally monitor treatment response. RESULTS: Bioluminescence predicted tumor volume (R = 0.8984) and increased linearly as a function of time up to a 10-fold increase in tumor burden. BLI correlated with PET/CT and necropsy specimen in size (P < .05). Two-dimensional BLI centroid accuracy was 3.5 mm relative to CBCT. BLI-guided irradiated pancreatic tumors stained positively for γ-H2Ax, whereas surrounding normal tissues were spared. Longitudinal assessment of irradiated tumors with BLI revealed significant tumor growth delay of 20 days relative to controls. CONCLUSIONS: We have successfully applied the SARRP to a bioluminescent, orthotopic preclinical pancreas cancer model to noninvasively: 1) allow the identification of tumor burden before therapy, 2) facilitate image-guided focal radiation therapy, and 3) allow normalization of tumor burden and longitudinal assessment of treatment response