Loop Quantum Cosmology: A Status Report

The goal of this article is to provide an overview of the current state of the art in loop quantum cosmology for three sets of audiences: young researchers interested in entering this area; the quantum gravity community in general; and, cosmologists who wish to apply loop quantum cosmology to probe modifications in the standard paradigm of the early universe. An effort has been made to streamline the material so that, as described at the end of section I, each of these communities can read only the sections they are most interested in, without a loss of continuity.Comment: 138 pages, 15 figures. Invited Topical Review, To appear in Classical and Quantum Gravity. Typos corrected, clarifications and references adde

The Trump foreign policy record and the concept of transformational change

While there has been debate about the extent to which US foreign policy has been transformed since President Trumpfirst took office in 2017, the concept of transformational policy change has not been defined with any degree of precision. The purpose of this article is, primarily, to establish such a definition. It does this by drawing upon a number of the literatures that address domestic policy processes, in particular the work of Karl Polanyi, to suggest that transformational change rests upon paradigmatic shifts, the reconfiguration of interests, large scale institutional re-ordering and changed logics. Application of the definition to the Trump foreign policy leads us to conclude that while the Trump foreign policy owes much to the militant internationalism of the Bush years its understanding of nations and“globalism”and abandonment of a defining moral purpose represent, although incipient, partial and variegated, the beginnings of transformational change

Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice

An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM ) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has been useful in predicting the functional classes of genes involved and pathways altered during the course of disease. To further understand the contribution of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules – CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM. We find that CD14 plays a predominant role in the induction of ECM and regulation of parasite density; deletion of the CD14 gene not only prevented the onset of disease in a majority of susceptible mice (only 21% of CD14-deficient compared to 80% of wildtype mice developed ECM, p<0.0004) but also had an ameliorating effect on parasitemia (a 2 fold reduction during the cerebral phase). Furthermore, deletion of the galectin-3 gene in susceptible C57BL/6 mice resulted in partial protection from ECM (47% of galectin-3-deficient versus 93% of wildtype mice developed ECM, p<0.0073). Subsequent adherence assays suggest that galectin-3 induced pathogenesis of ECM is not mediated by the recognition and binding of galectin-3 to P. berghei ANKA parasites. A previous study of ECM has demonstrated that brain infiltrating T cells are strongly activated and are CD44+CD62L− differentiated memory T cells [1]. We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4+ and CD8+ T cells accumulated in the brain vasculature is approximately equal

Geopolitics and Democracy:The Western Liberal Order from Foundation to Fracture

A large and widening gap has opened between Western democracies’ international ambitions and their domestic political capacity to support these objectives. Drawing on an array of cross-national data on Western governments, parties, and voters, Geopolitics and Democracy traces this ends-means divide back to decisions that Western governments made after the Cold War. The key decisions were to globalize markets and pool sovereignty at the supranational level, while at the same time reducing social protections and guarantees at home. This combination of foreign and domestic policies succeeded in expanding the Western liberal order in the quarter century after the Cold War, but at the cost of mounting public discontent and political fragmentation within the advanced industrial economies. The analysis reveals the large extent to which domestic support for international engagement during the long East-West geopolitical contest had rested on social protections within the Western democracies. At a time when problems of great power rivalry, spheres of influence, and reactionary nationalism have returned, Geopolitics and Democracy reminds us that the liberal order rose in an age of social democracy as well as Cold War. In the absence of a renewed commitment to those social purposes, Western democracies will struggle to find a collective grand strategy that their domestic publics will support

The Retreat of the West

The West is turning inward. Donald Trump’s presidency, Britain’s decision to leave the European Union, and the spread of populist parties in Europe are the most visible signs of this retreat. The shift is not as recent as these examples suggest, however. Drawing on an array of cross-national data for twenty-four industrialized democracies and hundreds of political parties in those democracies, we show that domestic support for liberal internationalism has been receding for twenty-five years across the West. We show that since the end of the Cold War a large and widening gap has opened up between Western democracies’ international ambitions and their domestic political capacity to support them. As Western governments came to rely increasingly on economic globalization, institutionalized cooperation, and multilateral governance, mainstream parties that backed these efforts lost electoral ground to parties on the radical-left and increasingly, the anti-globalist radical-right that have been the vehicles of the current backlash. We discuss the implications of these trends for the Western liberal international order and the strategies now on offer to repair it

The Retreat of the West

The West is turning inward. Donald Trump’s presidency, Britain’s decision to leave the European Union, and the spread of populist parties in Europe are the most visible signs of this retreat. The shift is not as recent as these examples suggest, however. Drawing on an array of cross-national data for twenty-four industrialized democracies and hundreds of political parties in those democracies, we show that domestic support for liberal internationalism has been receding for twenty-five years across the West. We show that since the end of the Cold War a large and widening gap has opened up between Western democracies’ international ambitions and their domestic political capacity to support them. As Western governments came to rely increasingly on economic globalization, institutionalized cooperation, and multilateral governance, mainstream parties that backed these efforts lost electoral ground to parties on the radical-left and increasingly, the anti-globalist radical-right that have been the vehicles of the current backlash. We discuss the implications of these trends for the Western liberal international order and the strategies now on offer to repair it