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HP1 reshapes nucleosome core to promote phase separation of heterochromatin
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2. These diverse functions are proposed to arise in part from compaction of the underlying chromatin2. A major type of heterochromatin contains at its core the complex formed between HP1 proteins and chromatin that is methylated on histone H3, lysine 9 (H3K9me). HP1 is proposed to use oligomerization to compact chromatin into phase-separated condensates3-6. Yet, how HP1-mediated phase separation relates to chromatin compaction remains unclear. Here we show that chromatin compaction by the Schizosaccharomyces pombe HP1 protein Swi6 results in phase-separated liquid condensates. Unexpectedly, we find that Swi6 substantially increases the accessibility and dynamics of buried histone residues within a nucleosome. Restraining these dynamics impairs compaction of chromatin into liquid droplets by Swi6. Our results indicate that Swi6 couples its oligomerization to the phase separation of chromatin by a counterintuitive mechanism, namely the dynamic exposure of buried nucleosomal regions. We propose that such reshaping of the octamer core by Swi6 increases opportunities for multivalent interactions between nucleosomes, thereby promoting phase separation. This mechanism may more generally drive chromatin organization beyond heterochromatin
Study of in-medium meson properties in Ap, pA and AA collisions
We propose to investigate the in-medium properties of vector mesons
at the normal nuclear density in Ap(pA) collisions and at higher density in AA
collisions at the ITEP accelerator facility TWAC. Using of the inverse Ap
kinematics will permit us to study the meson production in a wide
momentum interval included the not yet explored range of small meson momenta
relative to the projectile nuclei where the mass modification effect in nuclear
matter is expected to be the strongest. Momentum dependence of the in-medium
meson width will be studied in the traditional pA kinematics. We
intend to use the electromagnetic calorimeter for reconstruction of the
meson invariant mass by detecting photons from the decay. The model calculations and simulations with
RQMD generator show feasibility of the proposed experiment. Available now
intensity of the ion beams provides a possibility to collect large statistics
and make decisive conclusion about the meson properties at density of
normal nuclei. At the second stage of the investigation the meson
properties will be studied in AA collisions at higher density. Interpretation
of these measurements will be based on the results obtained in Ap(pA)
interactions. Further investigation of the in-medium properties of light
unflavored and charmed mesons can be performed at ITEP and at GSI(FAIR) where
higher ion energies will be accessible in near future.Comment: 26 pages, 10 figures, 2 table
The spectral function of the omega meson in nuclear matter from a coupled-channel resonance model
We calculate the spectral function of the omega meson in nuclear matter at
zero temperature by means of the low-density theorem. The omega N forward
scattering amplitude is calculated within a unitary coupled-channel effective
Lagrangian model that has been applied successfully to the combined analysis of
pion- and photon-induced reactions. While the peak of the omega spectral
distribution is shifted only slightly, we find a considerable broadening of the
omega meson due to resonance-hole excitations. For omega mesons at rest with
respect to the surrounding nuclear medium, we find an additional width of about
60 MeV at saturation density.Comment: 26 pages, 10 figures, added short discussio
Measurement of the Beam Asymmetry in the Forward Direction for pi0 Photoproduction
Photoproduction of neutral pions has been studied with the CBELSA/TAPS
detector for photon energies between 0.92 and 1.68~GeV at the electron
accelerator ELSA. The beam asymmetry~ has been extracted for of the ~meson and for . The new beam asymmetry data improve the world database for
photon energies above 1.5~GeV and, by covering the very forward region, extend
previously published data for the same reaction by our collaboration. The
angular dependence of shows overall good agreement with the SAID
parameterization.Comment: 11 pages, 10 figures, published in Phys. Rev. C, included LEPS data
and MAID 2007 predictions for comparison with our dat
Photoproduction of Neutral Pions off Protons
Photoproduction of neutral pions has been studied with the CBELSA/TAPS
detector in the reaction for photon energies between 0.85
and 2.50 GeV. The mesons are observed in their dominant neutral decay
mode: . For the first time, the differential cross
sections cover the very forward region, . A
partial-wave analysis of these data within the Bonn-Gatchina framework observes
the high-mass resonances (2190), (2080), and (2070).Comment: 12 pages, 9 figures, minor modifications to PWA sectio
On the background in the reaction and mixed event simulation
In this paper we evaluate sources of background for the , with the detected through its decay channel, to
compare with the experiment carried out at ELSA. We find background from
followed by decay of a into two ,
recombining one and one , and from the reaction with subsequent decay of the into two photons. This
background accounts for the data at invariant masses beyond 700
MeV, but strength is missing at lower invariant masses which was attributed to
photon misidentification events, which we simulate to get a good reproduction
of the experimental background. Once this is done, we perform an event mixing
simulation to reproduce the calculated background and we find that the method
provides a good description of the background at low invariant
masses but fakes the background at high invariant masses, making background
events at low invariant masses, which are due to misidentification
events, responsible for the background at high invariant masses which is due to
the and reactions.Comment: 10 pages, 5 figure
Spectroscopic, Morphological and Mechanistic Investigation of the Solvent.Promoted Aggregation of Porphyrins Modified in meso-positions by Glucosylated steroids
Solvent-driven aggregation
of a series of porphyrin derivatives was
studied by UV/Vis and circular dichroism
spectroscopy. The porphyrins are
characterised by the presence in the
meso positions of steroidal moieties
further conjugated with glucosyl
groups. The presence of these groups
makes the investigated macrocycles
amphiphilic and soluble in aqueous solvent,
namely, dimethyl acetamide/
water. Aggregation of the macrocycles
is triggered by a change in bulk solvent
composition leading to formation of
large architectures that express supramolecular
chirality, steered by the presence
of the stereogenic centres on the
periphery of the macrocycles. The aggregation
behaviour and chiroptical
features of the aggregates are strongly
dependent on the number of moieties
decorating the periphery of the porphyrin
framework. In particular, experimental
evidence indicates that the
structure of the steroid linker dictates
the overall chirality of the supramolecular
architectures. Moreover, the porphyrin
concentration strongly affects
the aggregation mechanism and the
CD intensities of the spectra. Notably,
AFM investigations reveal strong differences
in aggregate morphology that
are dependent on the nature of the appended
functional groups, and closely
in line with the changes in aggregation
mechanism. The suprastructures
formed at lower concentration show a
network of long fibrous structures
spanning over tens of micrometres,
whereas the aggregates formed at
higher concentration have smaller rodshaped
structures that can be recognised
as the result of coalescence of
smaller globular structures. The fully
steroid substituted derivative forms
globular structures over the whole concentration
range explored. Finally, a rationale
for the aggregation phenomena
was given by semiempirical calculations
at the PM6 level
On different lagrangian formalisms for vector resonances within chiral perturbation theory
We study the relation of vector Proca field formalism and antisymmetric
tensor field formalism for spin-one resonances in the context of the large N_C
inspired chiral resonance Lagrangian systematically up to the order O(p6) and
give a transparent prescription for the transition from vector to antisymmetric
tensor Lagrangian and vice versa. We also discuss the possibility to describe
the spin-one resonances using an alternative "mixed" first order formalism,
which includes both types of fields simultaneously, and compare this one with
the former two. We also briefly comment on the compatibility of the above
lagrangian formalisms with the high-energy constraints for concrete VVP
correlator.Comment: 34 pages, 3 figure
Photoproduction of meson pairs: First measurement of the polarization observable I^s
The polarization observable I^s, a feature exclusive to the acoplanar
kinematics of multi-meson final states produced via linearly polarized photons,
has been measured for the first time. Results for the reaction g p -> p pi0 eta
are presented for incoming photon energies between 970 MeV and 1650 MeV along
with the beam asymmetry I^c. The comparably large asymmetries demonstrate a
high sensitivity of I^s to the dynamics of the reaction. Fits using
Bonn-Gatchina partial wave analysis demonstrate that the new polarization
observables carry significant information on the contributing partial waves.Comment: 11 pages, 6 figures, v2 to appear in Phys. Lett.
Unification of Residues and Grassmannian Dualities
The conjectured duality relating all-loop leading singularities of n-particle
N^(k-2)MHV scattering amplitudes in N=4 SYM to a simple contour integral over
the Grassmannian G(k,n) makes all the symmetries of the theory manifest. Every
residue is individually Yangian invariant, but does not have a local space-time
interpretation--only a special sum over residues gives physical amplitudes. In
this paper we show that the sum over residues giving tree amplitudes can be
unified into a single algebraic variety, which we explicitly construct for all
NMHV and N^2MHV amplitudes. Remarkably, this allows the contour integral to
have a "particle interpretation" in the Grassmannian, where higher-point
amplitudes can be constructed from lower-point ones by adding one particle at a
time, with soft limits manifest. We move on to show that the connected
prescription for tree amplitudes in Witten's twistor string theory also admits
a Grassmannian particle interpretation, where the integral over the
Grassmannian localizes over the Veronese map from G(2,n) to G(k,n). These
apparently very different theories are related by a natural deformation with a
parameter t that smoothly interpolates between them. For NMHV amplitudes, we
use a simple residue theorem to prove t-independence of the result, thus
establishing a novel kind of duality between these theories.Comment: 56 pages, 11 figures; v2: typos corrected, minor improvement
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