Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

Early neurological deterioration (END) is progressive neurological deterioration with an increase in NIHSS score of 2 points or more in the first 72 hours from the onset of acute ischemic stroke. END increases the risk of poor clinical outcomes at day 90 of ischemic stroke. We will study the frequency, predictors, and outcomes of patients with END in a case-control study at a comprehensive stroke centre in Vietnam. of the design is a descriptive observational study, longitudinal follow-up of patients with minor stroke hospitalized at the Stroke Center of Bach Mai Hospital from December 1, 2023, to December 1, 2024. Minor stroke patients characterized by NIHSS score ≤ 5 hospitalized within 24 hours of symptom onset will be recruited. The estimated END rate is about 30%, relative accuracy ε = 0.11, 95% reliability, expected 5% of patients lost data or follow-up, and an estimated sample size of 779 patients. This study will help determine the END rate in patients with minor stroke and related factors, thereby building a prognostic model for END. Our study determined the END rate in patients with minor stroke in Vietnam and also proposed risk factors for minor stroke management and treatment

Liquid pumping and mixing by PZT synthetic jet

In this paper, a PZT synthetic jet that can function as both an efficient pumping and mixing device is developed. Compare with the conventional design where the practice of controlling the internal flow is undertaken by microvalves structure, this approach promotes the durability and allows the device to work with different liquids at high Reynold number without losing of backflow from the diffuser, therefore provides efficient mixing. The pumping performance is applicable for commercialized counterparts while the homogeneous medium was obtained at downstream in the experiments, which was further confirmed by simulation. Notably, the chaotic mixing feature of the device is also applicable for immiscible liquids with the micro-droplet formation result at the outlet

Chemical composition and antibacterial property of Eclipta prostrata (L.) L.

Eclipta prostrata (L.) L. belonging to the Astearaceae family has been long used worldwide by various communities as a traditional medicine. We studied the antibacterial activity of different extracts from Eclipta prostrata (L.) L. against Aeromonas hydrophila, Aeromonas dhakensis, and Vibrio parahaemolyticus . The processing of this extract using repeated column and thin layer chromatographic techniques resulted in the isolation of three compounds including luteolin (1), kaempferol (2), and kaempferol-3-O-α-L-rhamnopyranoside (3), which were identified by NMR. Among them, kaempfreol-3-O-α-L-rhamnopyranoside was isolated for the first time and shows good antibacterial activity against Aeromonas hydrophila which is major pathogen for the aquaculture industry. The results demonstrate the beneficial effects of E. prostrata as an antimicrobial and bioactive compound for medicinal usages.

The 80-year development of Vietnam mathematical research: Preliminary insights from the SciMath database on mathematicians, their works and their networks

Starting with the first international publication of Le Van Thiem (Lê Văn Thiêm) in 1947, modern mathematics in Vietnam is a longstanding research field. However, what is known about its development usually comes from discrete essays such as anecdotes or interviews of renowned mathematicians. We introduce SciMath—a database on publications of Vietnamese mathematicians. To ensure this database covers as many publications as possible, data entries are manually collected from scientists’ publication records, journals’ websites, universities, and research institutions. Collected data went through various verification steps to ensure data quality and minimize errors. At the time of this report, the database covered 8372 publications, profiles of 1566 Vietnamese, and 1492 foreign authors since 1947. We found a growing capability in mathematics research in Vietnam in various aspects: scientific output, publications on influential journals, or collaboration. The database and preliminary results were presented to the Scientific Council of Vietnam Institute for Advanced Study in Mathematics (VIASM) on November 13th, 2020

Effects of water scarcity awareness and climate change belief on recycled water usage willingness: Evidence from New Mexico, United States

The global water crisis is being exacerbated by climate change, even in the United States. Recycled water is a feasible alternative to alleviate the water shortage, but it is constrained by humans’ perceptions. The current study examines how residents’ water scarcity awareness and climate change belief influence their willingness to use recycled water directly and indirectly. Bayesian Mindsponge Framework (BMF) analytics was employed on a dataset of 1831 residents in Albuquerque, New Mexico, an arid inland region in the US. We discovered that residents’ willingness to use direct recycled potable water is positively affected by their awareness of water scarcity, but the effect is conditional on their belief in the impacts of climate change on the water cycle. Meanwhile, the willingness to use indirect recycled potable water is influenced by water scarcity awareness, and the belief in climate change further enhances this effect. These findings implicate that fighting climate change denialism and informing the public of the water scarcity situation in the region can contribute to the effectiveness and sustainability of long-term water conservation and climate change alleviation efforts

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Interactive course materials using multi-touch interfaces

The increase in popularity of mobile devices in recent years has greatly risen the need for mobile programming. Nowadays, mobile applications can be found in various topics, from academic fields such as economics or education to ordinary services like delivery or entertainment. Applications in the education field have introduced a new educational paradigm called "Mobile Learning", which offers more freedom for learning since it allows students to study anywhere, anytime. One excellent and beneficial application of education introduced by mobile devices is interactive eBook - which does not simply provide the readers with written contents but also clear, concise and meaningful explanation. Interactive eBook is also proven to be capable of improving the reading experience and fostering the student's learning spirit. Inspired by the benefits of interactive eBook, this project aims to enhance the learning experience at NTU by converting the course materials into an interactive eBook application. Specifically, this project uses the course material of the course CZ2004 Human - Computer Interaction, but the ultimate goal is to make it applicable to all courses in NTU. The interactive eBook application is implemented using React Native, a cross-platform mobile application framework created by Facebook.Bachelor of Engineering (Computer Science

On-chip Silicon Photonic Controllable 2 × 2 Four-mode Waveguide Switch

Multimode optical switch is a key component of mode division multiplexing in modern high-speed optical signal processing. In this paper, we introduce for the first time a novel 2 × 2 multimode switch design and demonstrate in the proof-of-concept. The device composes of four Y-multijunctions and 2 × 2 multimode interference coupler using silicon-on-insulator material with four controllable phase shifters. The shifters operate using thermo-optic effects utilizing Ti heaters enabling simultaneous switching of the optical signal between the output ports on four quasi-transverse electric modes with the electric power consumption is in order of 22.5 mW and the switching time is 5.4 µs. The multimode switch exhibits a low insertion loss and a low crosstalk below − 3 dB and − 19 dB, respectively, in 50 nm bandwidth in the third telecom window from 1525 to 1575 nm. With a compact footprint of 10 µm × 960 µm, this device exhibits a relatively large width tolerance of ± 20 nm and a height tolerance of ± 10 nm. Furthermore, the conceptual principle of the proposed multimode switch can be reconfigurable and scalable in multifunctional on-chip mode-division multiplexing optical interconnects

Three-mode multiplexer and demultiplexer utilizing trident and multimode couplers

In this paper, a simultaneous three-mode silicon (de)multiplexer using a trident coupler and a 3 x 3 multimode interference (MMI) is presented. The fundamental (TE0), first-order (TE1), and second-order (TE2) modes at the input are successfully demultiplexed and converted to three uniform fundamental modes (TE0) at the output ports. The device is designed and optimized by numerical simulation using three-dimensional beam propagation method together with effective index method. The three-mode (de)multiplexing is achieved over the whole C-band with small insertion loss ( dB) and crosstalk ( dB). The proposed device also features with a small footprint ( ) and a large fabrication tolerance against chip-size variations while maintaining the desired optical performance.This research is funded by Vietnam Ministry of Education and Training, Viet Nam under project number B2018.DNA.05