Detection efficiency and photometry in supernova surveys - the Stockholm VIMOS Supernova Survey I

The aim of the work presented in this paper is to test and optimise supernova detection methods based on the optimal image subtraction technique. The main focus is on applying the detection methods to wide field supernova imaging surveys and in particular to the Stockholm VIMOS Supernova Survey (SVISS). We have constructed a supernova detection pipeline for imaging surveys. The core of the pipeline is image subtraction using the ISIS 2.2 package. Using real data from the SVISS we simulate supernovae in the images, both inside and outside galaxies. The detection pipeline is then run on the simulated frames and the effects of image quality and subtraction parameters on the detection efficiency and photometric accuracy are studied. The pipeline allows efficient detection of faint supernovae in the deep imaging data. It also allows controlling and correcting for possible systematic effects in the SN detection and photometry. We find such a systematic effect in the form of a small systematic flux offset remaining at the positions of galaxies in the subtracted frames. This offset will not only affect the photometric accuracy of the survey, but also the detection efficiencies. Our study has shown that ISIS 2.2 works well for the SVISS data. We have found that the detection efficiency and photometric accuracy of the survey are affected by the stamp selection for the image subtraction and by host galaxy brightness. With our tools the subtraction results can be further optimised, any systematic effects can be controlled and photometric errors estimated, which is very important for the SVISS, as well as for future SN searches based on large imaging surveys such as Pan-STARRS and LSST.Comment: 17 pages, 10 figure, accepted for publication in A&

Sample Handling and Chemical Kinetics in an Acoustically Levitated Drop Microreactor

Accurate measurement of enzyme kinetics is an essential part of understanding the mechanisms of biochemical reactions. The typical means of studying such systems use stirred cuvettes, stopped-flow apparatus, microfluidic systems, or other small sample containers. These methods may prove to be problematic if reactants or products adsorb to or react with the container’s surface. As an alternative approach, we have developed an acoustically-levitated drop reactor eventually intended to study enzyme-catalyzed reaction kinetics related to free radical and oxidative stress chemistry. Microliter-scale droplet generation, reactant introduction, maintenance, and fluid removal are all important aspects in conducting reactions in a levitated drop. A three capillary bundle system has been developed to address these needs. We report kinetic measurements for both luminol chemiluminescence and the reaction of pyruvate with nicotinamide adenine dinucleotide, catalyzed by lactate dehydrogenase, to demonstrate the feasibility of using a levitated drop in conjunction with the developed capillary sample handling system as a microreactor

The discovery and classification of 16 supernovae at high redshifts in ELAIS-S1 - the Stockholm VIMOS Supernova Survey II

Supernova surveys can be used to study a variety of subjects such as: (i) cosmology through type Ia supernovae (SNe), (ii) star-formation rates through core-collapse SNe, and (iii) supernova properties and their connection to host galaxy characteristics. The Stockholm VIMOS Supernova Survey (SVISS) is a multi-band imaging survey aiming to detect supernovae at redshift ~0.5 and derive thermonuclear and core-collapse supernova rates at high redshift. In this paper we present the supernovae discovered in the survey along with light curves and a photometric classification into thermonuclear and core-collapse types. To detect the supernovae in the VLT/VIMOS multi-epoch images, we used difference imaging and a combination of automatic and manual source detection to minimise the number of spurious detections. Photometry for the found variable sources was obtained and careful simulations were made to estimate correct errors. The light curves were typed using a Bayesian probability method and Monte Carlo simulations were used to study misclassification. We detected 16 supernovae, nine of which had a core-collapse origin and seven had a thermonuclear origin. The estimated misclassification errors are quite small, in the order of 5%, but vary with both redshift and type. The mean redshift of the supernovae is 0.58. Additionally, we found a variable source with a very extended light curve that could possibly be a pair instability supernova.Comment: 30 pages, 15 figures, Accepted for publication in A&A. Version with high resolution images available at: http://www.astro.su.se/~jens/sviss_sne.pd

Clonal Hematopoiesis Before, During, and After Human Spaceflight.

Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation propagate faster than others. These mutations confer a risk for hematological cancers and cardiovascular disease. Here, we analyze CH in blood samples from a pair of twin astronauts over 4 years in bulk and fractionated cell populations using a targeted CH panel, linked-read whole-genome sequencing, and deep RNA sequencing. We show CH with distinct mutational profiles and increasing allelic fraction that includes a high-risk, TET2 clone in one subject and two DNMT3A mutations on distinct alleles in the other twin. These astronauts exhibit CH almost two decades prior to the mean age at which it is typically detected and show larger shifts in clone size than age-matched controls or radiotherapy patients, based on a longitudinal cohort of 157 cancer patients. As such, longitudinal monitoring of CH may serve as an important metric for overall cancer and cardiovascular risk in astronauts