Evaluating family physicians’ willingness to prescribe PrEP

International audienceIntroduction: We assessed family physicians' (FP) willingness to integrate PrEP into their clinical practice in Montpellier and its surroundings.Method: We aimed to randomly assess 92 FPs.Results: Ninety-six FPs were interviewed from May to December 2018: 78% (95% CI [69; 86]) were willing to integrate PrEP, 65% to be trained, and 52% to be the first providers. Of the 65 (6%) with some knowledge of PrEP, 21 were not aware of targeted populations and 39 never talked about PrEP with their patients. Nearly all FPs declared HIV prevention as part of their job and felt at ease talking about sexuality. Considering HIV prevention as part of their job was associated with increased likelihood to integrate PrEP into their practice (P=0.015).Conclusions: Most FPs were willing to integrate and be trained on PrEP. Lack of PrEP prescription seemed related to a lack of knowledge

Phenotypic prediction based on metabolomic data on the growing pig from three main European breeds.

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "International audiencePredicting phenotypes is a statistical and biotechnical challenge, both in medicine (predicting an illness) and animal breeding (predicting the carcass economical value on a young living animal). High-throughput fine phenotyping is possible using metabolomics, which describes the global metabolic status of an individual, and is the closest to the terminal phenotype. The purpose of this work was to quantify the prediction power of metabolomic profiles for commonly used production phenotypes from a single blood sample from the growing pig. Several statistical approaches were investigated and compared on the basis of cross validation: raw data vs. signal preprocessing (wavelet transformation), with a single-feature selection method. The best results in terms of prediction accuracy were obtained when data were preprocessed using wavelet transformations on the Daubechies basis. The phenotypes related to meat quality were not well predicted because the blood sample was taken some time prior to slaughter, and slaughter is known to have a strong influence on these traits. In contrast, phenotypes of potential economic interest (e.g., lean meat percentage and ADFI) were well predicted (R(2) = 0.7; P < 0.0001) using metabolomic data

Le metabolome, un moyen pour trouver de nouveaux biomarqueurs ?

Cette étude visait à quantifier le pouvoir prédictif du métabolome sur des phénotypes de production dans la filière porcine. Des données métabolomiques ont été obtenues par Résonance Magnétique Nucléaire à partir d’une prise de sang réalisée pendant la période de croissance de l’animal. Selon le type de phénotype considéré, un spectre métabolomique peut être envisagé comme une source de biomarqueurs intéressants. Ainsi, le taux de muscle des pièces de la carcasse a pu être correctement prédit à partir des mesures prises sur des prélèvements réalisés à environ 60 kg.This study was aimed at quantifying the predictive power of metabolomic data on production phenotypes in the pig. Metabolomic data were obtained by Nuclear Magnetic Resonance from one blood sample during the growing period of the animals. Depending on the phenotype, a metabolomic spectrum can be envisioned as a source of suitable biomarkers. In particular, the lean meat percentage was correctly predicted from samples taken at around 60 k

Correlation of nailfold capillaroscopy findings with history of digital ulcer on same finger: Results of SCLEROCAP study

International audienceSystemic sclerosis may be complicated by digital ulcers. Nailfold capillaroscopy on one finger might reflect an increased risk of digital ulcer (DU). In the present study we studied the correlations between a history of ulcer and capillary findings on the finger.Method: This study is part of Sclerocap, a multicenter study aiming at validating prospectively the prognostic value of Maricq's and Cutolo's capillaroscopic classifications during a three-year longitudinal follow-up. A history of past or present digital ulcer was recorded at inclusion and nailfold capillaroscopy was performed. Elementary findings as well as Cutolo and Maricq's classifications were assessed.Results: 387 patients were included in Sclerocap (327 females, 60 males) and 3096 fingers were examined by capillaroscopy at inclusion: 316 fingers (10%) belonging to 113 patients had a history of DU. Late Cutolo's stage was statistically correlated with a history of DU, both by univariate: OR 2.08 [1.09-3.96] and multivariate analysis: OR 1.97 [1.06-3.63]. Among the elemental abnormalities, only edema and decreased capillary density were correlated with a history of DU by multivariate analysis: respectively OR 1.92 [1.17-3.16] and 0.65 [0.49-0.85].Conclusion: This cross-sectional study in a large cohort of patients with systemic sclerosis shows a correlation between a history of digital ulcer and edema, a decrease in capillary density and the late stage in Cutolo's classification. The extent of capillary abnormalities on one finger is associated with a history of local digital ulcer. Capillaroscopy might be used to predict the risk of DU but these results need first to be confirmed by prospective studies

Diversité et biologie intégrative : des pistes à explorer pour combler le gap entre diversité génétique et diversité phénotypique

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Diversité et biologie intégrative : des pistes à explorer pour combler le gap entre diversité génétique et diversité phénotypique

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