362 research outputs found
Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy
Metaphyseal chondrodysplasia, Schmid type (MCDS) is characterized by mild short stature and growth plate hypertrophic zone expansion, and caused by collagen X mutations. We recently demonstrated the central importance of ER stress in the pathology of MCDS by recapitulating the disease phenotype by expressing misfolding forms of collagen X (Schmid) or thyroglobulin (Cog) in the hypertrophic zone. Here we characterize the Schmid and Cog ER stress signaling networks by transcriptional profiling of microdissected mutant and wildtype hypertrophic zones. Both models displayed similar unfolded protein responses (UPRs), involving activation of canonical ER stress sensors and upregulation of their downstream targets, including molecular chaperones, foldases, and ER-associated degradation machinery. Also upregulated were the emerging UPR regulators Wfs1 and Syvn1, recently identified UPR components including Armet and Creld2, and genes not previously implicated in ER stress such as Steap1 and Fgf21. Despite upregulation of the Chop/Cebpb pathway, apoptosis was not increased in mutant hypertrophic zones. Ultrastructural analysis of mutant growth plates revealed ER stress and disrupted chondrocyte maturation throughout mutant hypertrophic zones. This disruption was defined by profiling the expression of wildtype growth plate zone gene signatures in the mutant hypertrophic zones. Hypertrophic zone gene upregulation and proliferative zone gene downregulation were both inhibited in Schmid hypertrophic zones, resulting in the persistence of a proliferative chondrocyte-like expression profile in ER-stressed Schmid chondrocytes. Our findings provide a transcriptional map of two chondrocyte UPR gene networks in vivo, and define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress during hypertrophy. Thus they provide important insights into ER stress signaling and its impact on cartilage pathophysiology
Virgo Detector Characterization and Data Quality during the O3 run
The Advanced Virgo detector has contributed with its data to the rapid growth
of the number of detected gravitational-wave signals in the past few years,
alongside the two LIGO instruments. First, during the last month of the
Observation Run 2 (O2) in August 2017 (with, most notably, the compact binary
mergers GW170814 and GW170817) and then during the full Observation Run 3 (O3):
an 11 months data taking period, between April 2019 and March 2020, that led to
the addition of about 80 events to the catalog of transient gravitational-wave
sources maintained by LIGO, Virgo and KAGRA. These discoveries and the manifold
exploitation of the detected waveforms require an accurate characterization of
the quality of the data, such as continuous study and monitoring of the
detector noise. These activities, collectively named {\em detector
characterization} or {\em DetChar}, span the whole workflow of the Virgo data,
from the instrument front-end to the final analysis. They are described in
details in the following article, with a focus on the associated tools, the
results achieved by the Virgo DetChar group during the O3 run and the main
prospects for future data-taking periods with an improved detector.Comment: 86 pages, 33 figures. This paper has been divided into two articles
which supercede it and have been posted to arXiv on October 2022. Please use
these new preprints as references: arXiv:2210.15634 (tools and methods) and
arXiv:2210.15633 (results from the O3 run
Virgo Detector Characterization and Data Quality: results from the O3 run
The Advanced Virgo detector has contributed with its data to the rapid growth
of the number of detected gravitational-wave (GW) signals in the past few
years, alongside the two Advanced LIGO instruments. First during the last month
of the Observation Run 2 (O2) in August 2017 (with, most notably, the compact
binary mergers GW170814 and GW170817), and then during the full Observation Run
3 (O3): an 11-months data taking period, between April 2019 and March 2020,
that led to the addition of about 80 events to the catalog of transient GW
sources maintained by LIGO, Virgo and now KAGRA. These discoveries and the
manifold exploitation of the detected waveforms require an accurate
characterization of the quality of the data, such as continuous study and
monitoring of the detector noise sources. These activities, collectively named
{\em detector characterization and data quality} or {\em DetChar}, span the
whole workflow of the Virgo data, from the instrument front-end hardware to the
final analyses. They are described in details in the following article, with a
focus on the results achieved by the Virgo DetChar group during the O3 run.
Concurrently, a companion article describes the tools that have been used by
the Virgo DetChar group to perform this work.Comment: 57 pages, 18 figures. To be submitted to Class. and Quantum Grav.
This is the "Results" part of preprint arXiv:2205.01555 [gr-qc] which has
been split into two companion articles: one about the tools and methods, the
other about the analyses of the O3 Virgo dat
Virgo Detector Characterization and Data Quality: tools
Detector characterization and data quality studies -- collectively referred
to as {\em DetChar} activities in this article -- are paramount to the
scientific exploitation of the joint dataset collected by the LIGO-Virgo-KAGRA
global network of ground-based gravitational-wave (GW) detectors. They take
place during each phase of the operation of the instruments (upgrade, tuning
and optimization, data taking), are required at all steps of the dataflow (from
data acquisition to the final list of GW events) and operate at various
latencies (from near real-time to vet the public alerts to offline analyses).
This work requires a wide set of tools which have been developed over the years
to fulfill the requirements of the various DetChar studies: data access and
bookkeeping; global monitoring of the instruments and of the different steps of
the data processing; studies of the global properties of the noise at the
detector outputs; identification and follow-up of noise peculiar features
(whether they be transient or continuously present in the data); quick
processing of the public alerts. The present article reviews all the tools used
by the Virgo DetChar group during the third LIGO-Virgo Observation Run (O3,
from April 2019 to March 2020), mainly to analyse the Virgo data acquired at
EGO. Concurrently, a companion article focuses on the results achieved by the
DetChar group during the O3 run using these tools.Comment: 44 pages, 16 figures. To be submitted to Class. and Quantum Grav.
This is the "Tools" part of preprint arXiv:2205.01555 [gr-qc] which has been
split into two companion articles: one about the tools and methods, the other
about the analyses of the O3 Virgo dat
Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3
We report on the population properties of compact binary mergers inferred from gravitational-wave observations of these systems during the first three LIGO-Virgo observing runs. The Gravitational-Wave Transient Catalog 3 (GWTC-3) contains signals consistent with three classes of binary mergers: binary black hole, binary neutron star, and neutron star-black hole mergers. We infer the binary neutron star merger rate to be between 10 and 1700 Gpc-3 yr-1 and the neutron star-black hole merger rate to be between 7.8 and 140 Gpc-3 yr-1, assuming a constant rate density in the comoving frame and taking the union of 90% credible intervals for methods used in this work. We infer the binary black hole merger rate, allowing for evolution with redshift, to be between 17.9 and 44 Gpc-3 yr-1 at a fiducial redshift (z=0.2). The rate of binary black hole mergers is observed to increase with redshift at a rate proportional to (1+z)Îș with Îș=2.9-1.8+1.7 for zâČ1. Using both binary neutron star and neutron star-black hole binaries, we obtain a broad, relatively flat neutron star mass distribution extending from 1.2-0.2+0.1 to 2.0-0.3+0.3Mâ. We confidently determine that the merger rate as a function of mass sharply declines after the expected maximum neutron star mass, but cannot yet confirm or rule out the existence of a lower mass gap between neutron stars and black holes. We also find the binary black hole mass distribution has localized over- and underdensities relative to a power-law distribution, with peaks emerging at chirp masses of 8.3-0.5+0.3 and 27.9-1.8+1.9Mâ. While we continue to find that the mass distribution of a binary's more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above approximately 60Mâ, which would indicate the presence of a upper mass gap. Observed black hole spins are small, with half of spin magnitudes below Ïiâ0.25. While the majority of spins are preferentially aligned with the orbital angular momentum, we infer evidence of antialigned spins among the binary population. We observe an increase in spin magnitude for systems with more unequal-mass ratio. We also observe evidence of misalignment of spins relative to the orbital angular momentum
Search of the early O3 LIGO data for continuous gravitational waves from the Cassiopeia A and Vela Jr. supernova remnants
partially_open1412sĂŹWe present directed searches for continuous gravitational waves from the neutron stars in the Cassiopeia A (Cas A) and Vela Jr. supernova remnants. We carry out the searches in the LIGO detector data from the first six months of the third Advanced LIGO and Virgo observing run using the weave semicoherent method, which sums matched-filter detection-statistic values over many time segments spanning the observation period. No gravitational wave signal is detected in the search band of 20â976 Hz for assumed source ages greater than 300 years for Cas A and greater than 700 years for Vela Jr. Estimates from simulated continuous wave signals indicate we achieve the most sensitive results to date across the explored parameter space volume, probing to strain magnitudes as low as
âŒ6.3Ă10^â26 for Cas A and âŒ5.6Ă10^â26 for Vela Jr. at frequencies near 166 Hz at 95% efficiency.openAbbott, R.; Abbott, T.âD.; Acernese, F.; Ackley, K.; Adams, C.; Adhikari, N.; Adhikari, R.âX.; Adya, V.âB.; Affeldt, C.; Agarwal, D.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O.âD.; Aiello, L.; Ain, A.; Ajith, P.; Albanesi, S.; Allocca, A.; Altin, P.âA.; Amato, A.; Anand, C.; Anand, S.; Ananyeva, A.; Anderson, S.âB.; Anderson, W.âG.; Andrade, T.; Andres, N.; AndriÄ, T.; Angelova, S.âV.; Ansoldi, S.; Antelis, J.âM.; Antier, S.; Appert, S.; Arai, K.; Araya, M.âC.; Areeda, J.âS.; ArĂšne, M.; Arnaud, N.; Aronson, S.âM.; Arun, K.âG.; Asali, Y.; Ashton, G.; Assiduo, M.; Aston, S.âM.; Astone, P.; Aubin, F.; Austin, C.; Babak, S.; Badaracco, F.; Bader, M.âK.âM.; Badger, C.; Bae, S.; Baer, A.âM.; Bagnasco, S.; Bai, Y.; Baird, J.; Ball, M.; Ballardin, G.; Ballmer, S.âW.; Balsamo, A.; Baltus, G.; Banagiri, S.; Bankar, D.; Barayoga, J.âC.; Barbieri, C.; Barish, B.âC.; Barker, D.; Barneo, P.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Barton, M.âA.; Bartos, I.; Bassiri, R.; Basti, A.; Bawaj, M.; Bayley, J.âC.; Baylor, A.âC.; Bazzan, M.; BĂ©csy, B.; Bedakihale, V.âM.; Bejger, M.; Belahcene, I.; Benedetto, V.; Beniwal, D.; Bennett, T.âF.; Bentley, J.âD.; BenYaala, M.; Bergamin, F.; Berger, B.âK.; Bernuzzi, S.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Beveridge, D.; Bhandare, R.; Bhardwaj, U.; Bhattacharjee, D.; Bhaumik, S.; Bilenko, I.âA.; Billingsley, G.; Bini, S.; Birney, R.; Birnholtz, O.; Biscans, S.; Bischi, M.; Biscoveanu, S.; Bisht, A.; Biswas, B.; Bitossi, M.; Bizouard, M.-A.; Blackburn, J.âK.; Blair, C.âD.; Blair, D.âG.; Blair, R.âM.; Bobba, F.; Bode, N.; Boer, M.; Bogaert, G.; Boldrini, M.; Bonavena, L.âD.; Bondu, F.; Bonilla, E.; Bonnand, R.; Booker, P.; Boom, B.âA.; Bork, R.; Boschi, V.; Bose, N.; Bose, S.; Bossilkov, V.; Boudart, V.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P.âR.; Bramley, A.; Branch, A.; Branchesi, M.; Brau, J.âE.; Breschi, M.; Briant, T.; Briggs, J.âH.; Brillet, A.; Brinkmann, M.; Brockill, P.; Brooks, A.âF.; Brooks, J.; Brown, D.âD.; Brunett, S.; Bruno, G.; Bruntz, R.; Bryant, J.; Bulik, T.; Bulten, H.âJ.; Buonanno, A.; Buscicchio, R.; Buskulic, D.; Buy, C.; Byer, R.âL.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Bustillo, J. CalderĂłn; Callaghan, J.âD.; Callister, T.âA.; Calloni, E.; Cameron, J.; Camp, J.âB.; Canepa, M.; Canevarolo, S.; Cannavacciuolo, M.; Cannon, K.âC.; Cao, H.; Capote, E.; Carapella, G.; Carbognani, F.; Carlin, J.âB.; Carney, M.âF.; Carpinelli, M.; Carrillo, G.; Carullo, G.; Carver, T.âL.; Diaz, J. Casanueva; Casentini, C.; Castaldi, G.; Caudill, S.; CavagliĂ , M.; Cavalier, F.; Cavalieri, R.; Ceasar, M.; Cella, G.; CerdĂĄ-DurĂĄn, P.; Cesarini, E.; Chaibi, W.; Chakravarti, K.; Subrahmanya, S. Chalathadka; Champion, E.; Chan, C.-H.; Chan, C.; Chan, C.âL.; Chan, K.; Chandra, K.; Chanial, P.; Chao, S.; Charlton, P.; Chase, E.âA.; Chassande-Mottin, E.; Chatterjee, C.; Chatterjee, Debarati; Chatterjee, Deep; Chaturvedi, M.; Chaty, S.; Chen, H.âY.; Chen, J.; Chen, X.; Chen, Y.; Chen, Z.; Cheng, H.; Cheong, C.âK.; Cheung, H.âY.; Chia, H.âY.; Chiadini, F.; Chiarini, G.; Chierici, R.; Chincarini, A.; Chiofalo, M.âL.; Chiummo, A.; Cho, G.; Cho, H.âS.; Choudhary, R.âK.; Choudhary, S.; Christensen, N.; Chu, Q.; Chua, S.; Chung, K.âW.; Ciani, G.; Ciecielag, P.; CieĆlar, M.; Cifaldi, M.; Ciobanu, A.âA.; Ciolfi, R.; Cipriano, F.; Cirone, A.; Clara, F.; Clark, E.âN.; Clark, J.âA.; Clarke, L.; Clearwater, P.; Clesse, S.; Cleva, F.; Coccia, E.; Codazzo, E.; Cohadon, P.-F.; Cohen, D.âE.; Cohen, L.; Colleoni, M.; Collette, C.âG.; Colombo, A.; Colpi, M.; Compton, C.âM.; Constancio, M.; Conti, L.; Cooper, S.âJ.; Corban, P.; Corbitt, T.âR.; Cordero-CarriĂłn, I.; Corezzi, S.; Corley, K.âR.; Cornish, N.; Corre, D.; Corsi, A.; Cortese, S.; Costa, C.âA.; Cotesta, R.; Coughlin, M.âW.; Coulon, J.-P.; Countryman, S.âT.; Cousins, B.; Couvares, P.; Coward, D.âM.; Cowart, M.âJ.; Coyne, D.âC.; Coyne, R.; Creighton, J.âD.âE.; Creighton, T.âD.; Criswell, A.âW.; Croquette, M.; Crowder, S.âG.; Cudell, J.âR.; Cullen, T.âJ.; Cumming, A.; Cummings, R.; Cunningham, L.; Cuoco, E.; CuryĆo, M.; Dabadie, P.; Canton, T. Dal; DallâOsso, S.; DĂĄlya, G.; Dana, A.; DaneshgaranBajastani, L.âM.; DâAngelo, B.; Danilishin, S.; DâAntonio, S.; Danzmann, K.; Darsow-Fromm, C.; Dasgupta, A.; Datrier, L.âE.âH.; Datta, S.; Dattilo, V.; Dave, I.; Davier, M.; Davies, G.âS.; Davis, D.; Davis, M.âC.; Daw, E.âJ.; Dean, R.; DeBra, D.; Deenadayalan, M.; Degallaix, J.; De Laurentis, M.; DelĂ©glise, S.; Del Favero, V.; De Lillo, F.; De Lillo, N.; Del Pozzo, W.; DeMarchi, L.âM.; De Matteis, F.; DâEmilio, V.; Demos, N.; Dent, T.; Depasse, A.; De Pietri, R.; De Rosa, R.; De Rossi, C.; DeSalvo, R.; De Simone, R.; Dhurandhar, S.; DĂaz, M.âC.; Diaz-Ortiz, M.; Didio, N.âA.; Dietrich, T.; Di Fiore, L.; Di Fronzo, C.; Di Giorgio, C.; Di Giovanni, F.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Ding, B.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Divakarla, A.âK.; Dmitriev, A.; Doctor, Z.; DâOnofrio, L.; Donovan, F.; Dooley, K.âL.; Doravari, S.; Dorrington, I.; Drago, M.; Driggers, J.âC.; Drori, Y.; Ducoin, J.-G.; Dupej, P.; Durante, O.; DâUrso, D.; Duverne, P.-A.; Dwyer, S.âE.; Eassa, C.; Easter, P.âJ.; Ebersold, M.; Eckhardt, T.; Eddolls, G.; Edelman, B.; Edo, T.âB.; Edy, O.; Effler, A.; Eichholz, J.; Eikenberry, S.âS.; Eisenmann, M.; Eisenstein, R.âA.; Ejlli, A.; Engelby, E.; Errico, L.; Essick, R.âC.; EstellĂ©s, H.; Estevez, D.; Etienne, Z.; Etzel, T.; Evans, M.; Evans, T.âM.; Ewing, B.âE.; Fafone, V.; Fair, H.; Fairhurst, S.; Farah, A.âM.; Farinon, S.; Farr, B.; Farr, W.âM.; Farrow, N.âW.; Fauchon-Jones, E.âJ.; Favaro, G.; Favata, M.; Fays, M.; Fazio, M.; Feicht, J.; Fejer, M.âM.; Fenyvesi, E.; Ferguson, D.âL.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, T.âA.; Fidecaro, F.; Figura, P.; Fiori, I.; Fishbach, M.; Fisher, R.âP.; Fittipaldi, R.; Fiumara, V.; Flaminio, R.; Floden, E.; Fong, H.; Font, J.âA.; Fornal, B.; Forsyth, P.âW.âF.; Franke, A.; Frasca, S.; Frasconi, F.; Frederick, C.; Freed, J.âP.; Frei, Z.; Freise, A.; Frey, R.; Fritschel, P.; Frolov, V.âV.; FronzĂ©, G.âG.; Fulda, P.; Fyffe, M.; Gabbard, H.âA.; Gadre, B.âU.; Gair, J.âR.; Gais, J.; Galaudage, S.; Gamba, R.; Ganapathy, D.; Ganguly, A.; Gaonkar, S.âG.; Garaventa, B.; GarcĂa-NĂșñez, C.; GarcĂa-QuirĂłs, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gayathri, V.; Gemme, G.; Gennai, A.; George, J.; Gerberding, O.; Gergely, L.; Gewecke, P.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, Shaon; Ghosh, Shrobana; Giacomazzo, B.; Giacoppo, L.; Giaime, J.âA.; Giardina, K.âD.; Gibson, D.âR.; Gier, C.; Giesler, M.; Giri, P.; Gissi, F.; Glanzer, J.; Gleckl, A.âE.; Godwin, P.; Goetz, E.; Goetz, R.; Gohlke, N.; Goncharov, B.; GonzĂĄlez, G.; Gopakumar, A.; Gosselin, M.; Gouaty, R.; Gould, D.âW.; Grace, B.; Grado, A.; Granata, M.; Granata, V.; Grant, A.; Gras, S.; Grassia, P.; Gray, C.; Gray, R.; Greco, G.; Green, A.âC.; Green, R.; Gretarsson, A.âM.; Gretarsson, E.âM.; Griffith, D.; Griffiths, W.; Griggs, H.âL.; Grignani, G.; Grimaldi, A.; Grimm, S.âJ.; Grote, H.; Grunewald, S.; Gruning, P.; Guerra, D.; Guidi, Gianluca; Guimaraes, A.âR.; GuixĂ©, G.; Gulati, H.âK.; Guo, H.-K.; Guo, Y.; Gupta, Anchal; Gupta, Anuradha; Gupta, P.; Gustafson, E.âK.; Gustafson, R.; Guzman, F.; Haegel, L.; Halim, O.; Hall, E.âD.; Hamilton, E.âZ.; Hammond, G.; Haney, M.; Hanks, J.; Hanna, C.; Hannam, M.âD.; Hannuksela, O.; Hansen, H.; Hansen, T.âJ.; Hanson, J.; Harder, T.; Hardwick, T.; Haris, K.; Harms, J.; Harry, G.âM.; Harry, I.âW.; Hartwig, D.; Haskell, B.; Hasskew, R.âK.; Haster, C.-J.; Haughian, K.; Hayes, F.âJ.; Healy, J.; Heidmann, A.; Heidt, A.; Heintze, M.âC.; Heinze, J.; Heinzel, J.; Heitmann, H.; Hellman, F.; Hello, P.; Helmling-Cornell, A.âF.; Hemming, G.; Hendry, M.; Heng, I.âS.; Hennes, E.; Hennig, J.; Hennig, M.âH.; Hernandez, A.âG.; Vivanco, F. Hernandez; Heurs, M.; Hild, S.; Hill, P.; Hines, A.âS.; Hochheim, S.; Hofman, D.; Hohmann, J.âN.; Holcomb, D.âG.; Holland, N.âA.; Hollows, I.âJ.; Holmes, Z.âJ.; Holt, K.; Holz, D.âE.; Hopkins, P.; Hough, J.; Hourihane, S.; Howell, E.âJ.; Hoy, C.âG.; Hoyland, D.; Hreibi, A.; Hsu, Y.; Huang, Y.; HĂŒbner, M.âT.; Huddart, A.âD.; Hughey, B.; Hui, V.; Husa, S.; Huttner, S.âH.; Huxford, R.; Huynh-Dinh, T.; Idzkowski, B.; Iess, A.; Ingram, C.; Isi, M.; Isleif, K.; Iyer, B.âR.; JaberianHamedan, V.; Jacqmin, T.; Jadhav, S.âJ.; Jadhav, S.âP.; James, A.âL.; Jan, A.âZ.; Jani, K.; Janquart, J.; Janssens, K.; Janthalur, N.âN.; Jaranowski, P.; Jariwala, D.; Jaume, R.; Jenkins, A.âC.; Jenner, K.; Jeunon, M.; Jia, W.; Johns, G.âR.; Jones, A.âW.; Jones, D.âI.; Jones, J.âD.; Jones, P.; Jones, R.; Jonker, R.âJ.âG.; Ju, L.; Junker, J.; Juste, V.; Kalaghatgi, C.âV.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J.âB.; Kao, Y.; Kapadia, S.âJ.; Kapasi, D.âP.; Karat, S.; Karathanasis, C.; Karki, S.; Kashyap, R.; Kasprzack, M.; Kastaun, W.; Katsanevas, S.; Katsavounidis, E.; Katzman, W.; Kaur, T.; Kawabe, K.; KĂ©fĂ©lian, F.; Keitel, D.; Key, J.âS.; Khadka, S.; Khalili, F.âY.; Khan, S.; Khazanov, E.âA.; Khetan, N.; Khursheed, M.; Kijbunchoo, N.; Kim, C.; Kim, J.âC.; Kim, K.; Kim, W.âS.; Kim, Y.-M.; Kimball, C.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J.âS.; Kleybolte, L.; Klimenko, S.; Knee, A.âM.; Knowles, T.âD.; Knyazev, E.; Koch, P.; Koekoek, G.; Koley, S.; Kolitsidou, P.; Kolstein, M.; Komori, K.; Kondrashov, V.; Kontos, A.; Koper, N.; Korobko, M.; Kovalam, M.; Kozak, D.âB.; Kringel, V.; Krishnendu, N.âV.; KrĂłlak, A.; Kuehn, G.; Kuei, F.; Kuijer, P.; Kumar, A.; Kumar, P.; Kumar, Rahul; Kumar, Rakesh; Kuns, K.; Kuwahara, S.; Lagabbe, P.; Laghi, D.; Lalande, E.; Lam, T.âL.; Lamberts, A.; Landry, M.; Lane, B.âB.; Lang, R.âN.; Lange, J.; Lantz, B.; La Rosa, I.; Lartaux-Vollard, A.; Lasky, P.âD.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lecoeuche, Y.âK.; Lee, H.âM.; Lee, H.âW.; Lee, J.; Lee, K.; Lehmann, J.; LemaĂźtre, A.; Leroy, N.; Letendre, N.; Levesque, C.; Levin, Y.; Leviton, J.âN.; Leyde, K.; Li, A.âK.âY.; Li, B.; Li, J.; Li, T.âG.âF.; Li, X.; Linde, F.; Linker, S.âD.; Linley, J.âN.; Littenberg, T.âB.; Liu, J.; Liu, K.; Liu, X.; Llamas, F.; Llorens-Monteagudo, M.; Lo, R.âK.âL.; Lockwood, A.; London, L.âT.; Longo, A.; Lopez, D.; Portilla, M. Lopez; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lott, T.âP.; Lough, J.âD.; Lousto, C.âO.; Lovelace, G.; Lucaccioni, J.âF.; LĂŒck, H.; Lumaca, D.; Lundgren, A.âP.; Lynam, J.âE.; Macas, R.; MacInnis, M.; Macleod, D.âM.; MacMillan, I.âA.âO.; Macquet, A.; Hernandez, I. Magaña; MagazzĂč, C.; Magee, R.âM.; Maggiore, R.; Magnozzi, M.; Mahesh, S.; Majorana, E.; Makarem, C.; Maksimovic, I.; Maliakal, S.; Malik, A.; Man, N.; Mandic, V.; Mangano, V.; Mango, J.âL.; Mansell, G.âL.; Manske, M.; Mantovani, M.; Mapelli, M.; Marchesoni, F.; Marion, F.; Mark, Z.; MĂĄrka, S.; MĂĄrka, Z.; Markakis, C.; Markosyan, A.âS.; Markowitz, A.; Maros, E.; Marquina, A.; Marsat, S.; Martelli, F.; Martin, I.âW.; Martin, R.âM.; Martinez, M.; Martinez, V.âA.; Martinez, V.; Martinovic, K.; Martynov, D.âV.; Marx, E.âJ.; Masalehdan, H.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T.âJ.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Mateu-Lucena, M.; Matichard, F.; Matiushechkina, M.; Mavalvala, N.; McCann, J.âJ.; McCarthy, R.; McClelland, D.âE.; McClincy, P.âK.; McCormick, S.; McCuller, L.; McGhee, G.âI.; McGuire, S.âC.; McIsaac, C.; McIver, J.; McRae, T.; McWilliams, S.âT.; Meacher, D.; Mehmet, M.; Mehta, A.âK.; Meijer, Q.; Melatos, A.; Melchor, D.âA.; Mendell, G.; Menendez-Vazquez, A.; 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Rana, J.; Rapagnani, P.; Rapol, U.âD.; Ray, A.; Raymond, V.; Raza, N.; Razzano, M.; Read, J.; Rees, L.âA.; Regimbau, T.; Rei, L.; Reid, S.; Reid, S.âW.; Reitze, D.âH.; Relton, P.; Renzini, A.; Rettegno, P.; Rezac, M.; Ricci, F.; Richards, D.; Richardson, J.âW.; Richardson, L.; Riemenschneider, G.; Riles, K.; Rinaldi, S.; Rink, K.; Rizzo, M.; Robertson, N.âA.; Robie, R.; Robinet, F.; Rocchi, A.; Rodriguez, S.; Rolland, L.; Rollins, J.âG.; Romanelli, M.; Romano, R.; Romel, C.âL.; Romero-RodrĂguez, A.; Romero-Shaw, I.âM.; Romie, J.âH.; Ronchini, S.; Rosa, L.; Rose, C.âA.; RosiĆska, D.; Ross, M.âP.; Rowan, S.; Rowlinson, S.âJ.; Roy, S.; Roy, Santosh; Roy, Soumen; Rozza, D.; Ruggi, P.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadiq, J.; Sakellariadou, M.; Salafia, O.âS.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sanchez, E.âJ.; Sanchez, J.âH.; Sanchez, L.âE.; Sanchis-Gual, N.; Sanders, J.âR.; Sanuy, A.; Saravanan, T.âR.; Sarin, N.; Sassolas, B.; Satari, H.; Sathyaprakash, B.âS.; Sauter, O.; Savage, R.âL.; Sawant, D.; Sawant, H.âL.; Sayah, S.; Schaetzl, D.; Scheel, M.; Scheuer, J.; Schiworski, M.; Schmidt, P.; Schmidt, S.; Schnabel, R.; Schneewind, M.; Schofield, R.âM.âS.; Schönbeck, A.; Schulte, B.âW.; Schutz, B.âF.; Schwartz, E.; Scott, J.; Scott, S.âM.; Seglar-Arroyo, M.; Sellers, D.; Sengupta, A.âS.; Sentenac, D.; Seo, E.âG.; Sequino, V.; Sergeev, A.; Setyawati, Y.; Shaffer, T.; Shahriar, M.âS.; Shams, B.; Sharma, A.; Sharma, P.; Shawhan, P.; Shcheblanov, N.âS.; Shikauchi, M.; Shoemaker, D.âH.; Shoemaker, D.âM.; ShyamSundar, S.; Sieniawska, M.; Sigg, D.; Singer, L.âP.; Singh, D.; Singh, N.; Singha, A.; Sintes, A.âM.; Sipala, V.; Skliris, V.; Slagmolen, B.âJ.âJ.; Slaven-Blair, T.âJ.; Smetana, J.; Smith, J.âR.; Smith, R.âJ.âE.; Soldateschi, J.; Somala, S.âN.; Son, E.âJ.; Soni, K.; Soni, S.; Sordini, V.; Sorrentino, F.; Sorrentino, N.; Soulard, R.; Souradeep, T.; Sowell, E.; Spagnuolo, V.; Spencer, A.âP.; Spera, M.; Srinivasan, R.; Srivastava, A.âK.; Srivastava, V.; Staats, K.; 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The population of merging compact binaries inferred using gravitational waves through GWTC-3
We report on the population properties of 76 compact binary mergers detected with gravitational waves below a false alarm rate of 1 per year through GWTC-3. The catalog contains three classes of binary mergers: BBH, BNS, and NSBH mergers. We infer the BNS merger rate to be between 10 and 1700 and the NSBH merger rate to be between 7.8 and 140 , assuming a constant rate density versus comoving volume and taking the union of 90% credible intervals for methods used in this work. Accounting for the BBH merger rate to evolve with redshift, we find the BBH merger rate to be between 17.9 and 44 at a fiducial redshift (z=0.2). We obtain a broad neutron star mass distribution extending from to . We can confidently identify a rapid decrease in merger rate versus component mass between neutron star-like masses and black-hole-like masses, but there is no evidence that the merger rate increases again before 10 . We also find the BBH mass distribution has localized over- and under-densities relative to a power law distribution. While we continue to find the mass distribution of a binary's more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above . The rate of BBH mergers is observed to increase with redshift at a rate proportional to with for . Observed black hole spins are small, with half of spin magnitudes below . We observe evidence of negative aligned spins in the population, and an increase in spin magnitude for systems with more unequal mass ratio
Snowmass Neutrino Frontier: DUNE Physics Summary
The Deep Underground Neutrino Experiment (DUNE) is a next-generation long-baseline neutrino oscillation experiment with a primary physics goal of observing neutrino and antineutrino oscillation patterns to precisely measure the parameters governing long-baseline neutrino oscillation in a single experiment, and to test the three-flavor paradigm. DUNE's design has been developed by a large, international collaboration of scientists and engineers to have unique capability to measure neutrino oscillation as a function of energy in a broadband beam, to resolve degeneracy among oscillation parameters, and to control systematic uncertainty using the exquisite imaging capability of massive LArTPC far detector modules and an argon-based near detector. DUNE's neutrino oscillation measurements will unambiguously resolve the neutrino mass ordering and provide the sensitivity to discover CP violation in neutrinos for a wide range of possible values of ÎŽCP. DUNE is also uniquely sensitive to electron neutrinos from a galactic supernova burst, and to a broad range of physics beyond the Standard Model (BSM), including nucleon decays. DUNE is anticipated to begin collecting physics data with Phase I, an initial experiment configuration consisting of two far detector modules and a minimal suite of near detector components, with a 1.2 MW proton beam. To realize its extensive, world-leading physics potential requires the full scope of DUNE be completed in Phase II. The three Phase II upgrades are all necessary to achieve DUNE's physics goals: (1) addition of far detector modules three and four for a total FD fiducial mass of at least 40 kt, (2) upgrade of the proton beam power from 1.2 MW to 2.4 MW, and (3) replacement of the near detector's temporary muon spectrometer with a magnetized, high-pressure gaseous argon TPC and calorimeter
Low exposure long-baseline neutrino oscillation sensitivity of the DUNE experiment
The Deep Underground Neutrino Experiment (DUNE) will produce world-leading
neutrino oscillation measurements over the lifetime of the experiment. In this
work, we explore DUNE's sensitivity to observe charge-parity violation (CPV) in
the neutrino sector, and to resolve the mass ordering, for exposures of up to
100 kiloton-megawatt-years (kt-MW-yr). The analysis includes detailed
uncertainties on the flux prediction, the neutrino interaction model, and
detector effects. We demonstrate that DUNE will be able to unambiguously
resolve the neutrino mass ordering at a 3 (5) level, with a 66
(100) kt-MW-yr far detector exposure, and has the ability to make strong
statements at significantly shorter exposures depending on the true value of
other oscillation parameters. We also show that DUNE has the potential to make
a robust measurement of CPV at a 3 level with a 100 kt-MW-yr exposure
for the maximally CP-violating values \delta_{\rm CP}} = \pm\pi/2.
Additionally, the dependence of DUNE's sensitivity on the exposure taken in
neutrino-enhanced and antineutrino-enhanced running is discussed. An equal
fraction of exposure taken in each beam mode is found to be close to optimal
when considered over the entire space of interest
Snowmass Neutrino Frontier: DUNE Physics Summary
The Deep Underground Neutrino Experiment (DUNE) is a next-generation
long-baseline neutrino oscillation experiment with a primary physics goal of
observing neutrino and antineutrino oscillation patterns to precisely measure
the parameters governing long-baseline neutrino oscillation in a single
experiment, and to test the three-flavor paradigm. DUNE's design has been
developed by a large, international collaboration of scientists and engineers
to have unique capability to measure neutrino oscillation as a function of
energy in a broadband beam, to resolve degeneracy among oscillation parameters,
and to control systematic uncertainty using the exquisite imaging capability of
massive LArTPC far detector modules and an argon-based near detector. DUNE's
neutrino oscillation measurements will unambiguously resolve the neutrino mass
ordering and provide the sensitivity to discover CP violation in neutrinos for
a wide range of possible values of . DUNE is also uniquely
sensitive to electron neutrinos from a galactic supernova burst, and to a broad
range of physics beyond the Standard Model (BSM), including nucleon decays.
DUNE is anticipated to begin collecting physics data with Phase I, an initial
experiment configuration consisting of two far detector modules and a minimal
suite of near detector components, with a 1.2 MW proton beam. To realize its
extensive, world-leading physics potential requires the full scope of DUNE be
completed in Phase II. The three Phase II upgrades are all necessary to achieve
DUNE's physics goals: (1) addition of far detector modules three and four for a
total FD fiducial mass of at least 40 kt, (2) upgrade of the proton beam power
from 1.2 MW to 2.4 MW, and (3) replacement of the near detector's temporary
muon spectrometer with a magnetized, high-pressure gaseous argon TPC and
calorimeter.Comment: Contribution to Snowmass 202
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