Importance of Childhood Maltreatment on Borderline Personality in Adults: Meta-analysis

Early childhood maltreatment (CM) is a risk factor for later psychopathology specifically Borderline Personality Disorder (BPD). CM has been found to negatively affect social, emotional, and psychological development as well as the ability to foster and sustain interpersonal relationships throughout all stages of life. There are evidence-based interventions for different kinds of CM including Trauma-Focused Cognitive-Behavior Therapy (TF-CBT), Alternatives for Families - Cognitive Behavioral Therapy (AF-CBT), relaxation training, and social skills training. The current study is a meta-analysis of published research into CM as it contributes to BPD in adults and is designed to examine the effect size of childhood maltreatment as it contributes to adults diagnosed with BPD. Glaser’s theory of emotional abuse and neglect and Linehan’s theory of etiology of impulsivity form the theoretical framework for understanding the definition and recognition of emotional abuse and neglect, and the etiology of impulsivity in the developmental path leading to BPD, respectively. A widespread literature search strategy and coding plan for studies was developed, and utilizing Comprehensive Meta-Analysis, version 3 software assisted in managing the data from the studies, calculating effect sizes, and heterogeneity of studies in the sample. The overall correlation between CM and BPD is positive and medium range with an effect size of 0.34, meaning that all studies with presence or absence of CM and BPD reported a significant association. Outcomes from this study may play a role in positive social change by identifying how each form of CM contributes to BPD may improve the effectiveness of mental health treatment for children by focusing on which form of childhood abuse should be treated first and foremost. Future research needs were identified based upon the results of the meta-analysis

English-language reading in the Netherlands and its consequences on Dutch-language publishing

English-language proficiency, and thus the number of consumers able to read in English, is rapidly growing in Europe. Concomitantly, digitization and online retailing make English-language books readily available to consumers.Whilst representing an opportunity for Anglophone publishers to export to non-Anglophone markets, this constitutes a significant threat to local publishers, as they must face competition from English-language editions. Perhaps due to the relatively recent upsurge in this trend, this phenomenon and its consequences on local-language publishing have been little studied. This thesis helps fill this gap by undertaking an empirical study on English-language reading in one of the European countries with the highest level of English proficiency: the Netherlands.Drawing on the theoretical framework of field theory, two methodological approaches are adopted in this study: 1) quantification of the scale of the phenomenon by gathering statistics on English-language sales in Europe and the Netherlands; and 2) investigation of how Dutch publishing and translation professionals are affected by this issue through in-depth qualitative interviews.The quantitative results show a steady rise in English-language books sold in the Netherlands between 1976 and 2018, when they accounted for 15% of the trade book market. The qualitative results show that the main defence strategy used by Dutch publishers is to release translations simultaneously with English-language originals. However, through acceleration of publication rhythms, simultaneous publication was felt to exert significant pressure on publishers and translators. Also, Dutch publishers indicated they increasingly concentrated on publishing Dutch originals and non-Anglophone books.This study enhances Dutch publishing professionals’ awareness of this phenomenon and lays the foundations for self-reflection. Moreover, its findings set the basis for further research into this topic in the Netherlands as well as in other markets and fields facing similar challenges

Dealing with the Competition of English-language Export Editions: Voices from the Dutch Trade Book Market

This project explores the responses of the Dutch trade book market to the ever-increasing influx of Anglophone publications. Based on in-depth interviews (n?=?42) carried out between 2015 and 2017 with Dutch publishing professionals, this research identifies the approaches and strategies they adopt to defend their market from the competition of English-language editions. Findings show that the main defence strategy used is to release translations simultaneously with English-language originals, but that this creates significant pressures on both publishers and translators. Concomitantly, there has been an increasing focus on Dutch originals and non-Anglophone books. The strategies and approaches documented in this study may be of interest for scholars and practitioners in relation to other book markets and linguistic areas facing similar circumstances

Enhancing Open Access publishing @University of Groningen and @University Medical Center Groningen

The University of Groningen (UG) and the University Medical Centre Groningen (UMCG) have committed themselves to the Dutch National Open Science Plan. In addition, external research funders are increasingly demanding that research articles are published open access (e.g. through Plan S). In 2018, 50% of UG/UMCG-scientific articles were published open access. However, have we used all options for publishing open access in venues chosen by researchers, thereby maintaining the researchers’ quality standards, and reducing the costs as much as possible? The answer is "no." To maximize the open access uptake, while making the workflow as smooth as possible for researchers, the University Library and Central Medical Library have started an Open Access Services (OAS) project with the following objectives: Implementation of services for the provision of practical information and advice for researchers Establish communication channels to increase the overall visibility of open access services and to issue regular updates on changes and innovations in scholarly communication and open science; Provide information on available options, costs, copyright, licences, re-use rights and funders’ requirements, pre-funded open access deals and submission workflows; Establishment of expert networks for the provision of strategic information and advice: open access ambassadors (academic staff and/or research policy officers) within faculties to multiply  and disseminate between the OAS project team and individual researchers, research committees and faculty boards; support staff (research policy officers, funding officers, financial controllers), e.g. to include open access budgeting in grant applications; open access experts to identify obstacles to publish open access, and advise to eliminate them and advocate for policy changes with regard to research evaluation practices. Establishment of an open access training programme for young researchers Create and implement a programme of regular presentations and tutorials for young researchers about publication strategies and open access; Development of optimal workflows for monitoring and registering open access uptake and expenditures Registration of open access expenditures, including cost of pre-funded deals, support for diamond OA initiatives, unnecessary paid APCs and reimbursed by funders (grant budgets). Identification of missed opportunities to publish open access using pre-funded read and publish deals and repair them retroactively whenever possible. Improvement of standards for the registration of open access publications in the university’s CRIS system. Organization of UG’s participation in the Taverne Amendment pilot project i.e. the implementation of Article 25fa of the Dutch Copyright Act. Provision of extra support for open access publishing services offered by the UG Press Professionalize and improve the publishing services offered, to support diamond open access initiatives, with special emphasis on the humanities and social sciences. We will present on the main outcomes of this project

Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice

Aliment Pharmacol Ther 2010; 32: 1192–1202Although irritable bowel syndrome (IBS) is a multisymptom disorder, abdominal pain drives illness severity more than other symptoms. Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain.To determine whether combining information from multiple pain dimensions may capture the IBS illness experience more effectively than the approach of measuring ‘pain predominance’ or pain intensity alone.Irritable bowel syndrome patients rated dimensions of pain, including intensity, frequency, constancy, predominance, predictability, duration, speed of onset and relationship to bowel movements. We evaluated the impact of each dimension on illness severity using multivariable regression techniques.Among the pain dimensions, intensity, frequency, constancy and predictability were strongly and independently associated with illness severity; the other dimensions had weaker associations. The clinical definition of ‘pain predominance’, in which patients define pain as their most bothersome symptom, was insufficient to categorize patients by illness severity.Irritable bowel disease pain is multifaceted; some pain dimensions drive illness more than others. IBS trials should measure various pain dimensions, including intensity, constancy, frequency and predictability; this may improve upon the customary use of measuring pain as a unidimensional symptom in IBS.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79350/1/j.1365-2036.2010.04443.x.pd

Risk factors for pulmonary air leak and clinical prognosis in patients with COVID-19 related acute respiratory failure: a retrospective matched control study.

Background- The role of excessive inspiratory effort in promoting alveolar and pleural rupture resulting in air leak (AL) in patients with SARS-CoV-2 induced acute respiratory failure (ARF) while on spontaneous breathing is undetermined. Methods- Among all patients with COVID-19 related ARF admitted to a respiratory intensive care unit (RICU) and receiving non-invasive respiratory support, those developing an AL were and matched 1:1 (by means of PaO2/FiO2 ratio, age, body mass index-BMI and subsequent organ failure assessment [SOFA]) with a comparable population who did not (NAL group). Esophageal pressure (ΔPes) and dynamic transpulmonary pressure (ΔPL) swings were compared between groups. Risk factors affecting AL onset were evaluated. The composite outcome of ventilator-free-days (VFD) at day 28 (including ETI, mortality, tracheostomy) was compared between groups. Results- AL and NAL groups (n=28) showed similar ΔPes, whereas AL had higher ΔPL (20 [16‐21] and 17 [11‐20], p=0.01 respectively). Higher ΔPL (OR=1.5 95%CI[1‐1.8], p=0.01), positive end‐expiratory pressure (OR=2.4 95%CI[1.2‐5.9], p=0.04) and pressure support (OR=1.8 95%CI[1.1-3.5], p=0.03), D-dimer on admission (OR=2.1 95%CI[1.3-9.8], p=0.03), and features suggestive of consolidation on computed tomography scan (OR=3.8 95%CI[1.1-15], p= 0.04) were all significantly associated with AL. A lower VFD score resulted in a higher risk (HR=3.7 95%CI [1.2-11.3], p=0.01) in the AL group compared with NAL. RICU stay and 90-day mortality were also higher in the AL group compared with NAL. Conclusions- In spontaneously breathing patients with COVID‐19 related ARF, higher levels of ΔPL, blood D‐dimer, NIV delivery pressures and a consolidative lung pattern were associated with AL onset

Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults

Laryngotracheal stenosis (LTS) is a complex and heterogeneous disease whose pathogenesis remains unclear. LTS is considered to be the result of aberrant wound-healing process that leads to fibrotic scarring, originating from different aetiology. Although iatrogenic aetiology is the main cause of subglottic or tracheal stenosis, also autoimmune and infectious diseases may be involved in causing LTS. Furthermore, fibrotic obstruction in the anatomic region under the glottis can also be diagnosed without apparent aetiology after a comprehensive workup; in this case, the pathological process is called idiopathic subglottic stenosis (iSGS). So far, the laryngotracheal scar resulting from airway injury due to different diseases was considered as inert tissue requiring surgical removal to restore airway patency. However, this assumption has recently been revised by regarding the tracheal scarring process as a fibroinflammatory event due to immunological alteration, similar to other fibrotic diseases. Recent acquisitions suggest that different factors, such as growth factors, cytokines, altered fibroblast function and genetic susceptibility, can all interact in a complex way leading to aberrant and fibrotic wound healing after an insult that acts as a trigger. However, also physiological derangement due to LTS could play a role in promoting dysregulated response to laryngo-tracheal mucosal injury, through biomechanical stress and mechanotransduction activation. The aim of this narrative review is to present the state-of-the-art knowledge regarding molecular mechanisms, as well as mechanical and physio-pathological features behind LTS

Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials

Aliment Pharmacol Ther 2010; 32: 1275–1291There is uncertainty about how to measure patient-reported outcomes (PROs) in IBS. The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework.To perform qualitative analyses to inform a new conceptual framework for IBS symptoms.Following FDA guidance, we searched the literature for extant IBS questionnaires. We then performed interviews in IBS patients to learn about the illness experience in their own words. We cultivated vocabulary to inform a conceptual framework depicted with domains, sub-domains, and item categories, per FDA guidance.We identified 13 questionnaires with items encompassing 18 symptoms. We recruited 123 IBS patients for cognitive interviews. Major themes included: pain and discomfort are different – asking about discomfort is nonspecific and should be avoided in future PROs; bowel urgency is multifaceted – PROs should measure bowel immediacy, controllability, and predictability; and PROs should divide bloating into how it feels vs. how it looks. Symptom experience may be determined by 35-item categories within five domains: (i) pain; (ii) gas/bloat; (iii) diarrhoea; (iv) constipation; and (v) extraintestinal symptoms.We applied FDA guidance to develop a framework that can serve as the foundation for developing a PRO for IBS clinical trials.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79156/1/j.1365-2036.2010.04464.x.pd