Jill Graper Hernandez, Gabriel Marcel’s Ethic of Hope: Evil, God and Virtue

Review of Jill Graper Hernandez, Gabriel Marcel's Ethic of Hope: Evil, God, and Virtu

Emplotting Virtue: A Narrative Approach to Environmental Virtue Ethics

https://digitalcommons.lmu.edu/facultypubnight/1030/thumbnail.jp

Vitality: Carnal, Seraphic Bodies

This paper reflects on experiences of what i call vitality. Such experiences are neither idiosyncratic (they overlap major themes in Chinese philosophy, among other disciplines) nor mere romanticism (contemporary psychology lends credence to these accounts). Moreover, while some figures in continental philosophy do address the body—as perceiving, as sexed, as political—there has been almost no attention given to the active body of vitality. Drawing from the work of Michel Serres, this paper will uncover some of the significant features of such bodily experiences

Strong Linguistic Relativity: A Continental Sense of Language and Being

The theory of linguistic relativity can be divided into two hypotheses: the strong argument and the weak argument. The strong argument, often called linguistic determinism, posits that one’s native language determines one’s thought in an inescapable manner. The so-called “Sapir-Whorf Hypothesis” demonstrates this, though many modern linguists now believe this principle – and linguistic determinism in general – to be implausible. The weak argument for linguistic relativity states that one’s native language merely influences their worldview, such that it struggles to maintain a connection that is more than trivial. In this work, I seek a “third option” that is both a) plausible and b) non-trivial, such that it mediates these two hypotheses; I term this third option “strong linguistic relativity.” Through an analysis of the ideas of Hans-Georg Gadamer, Paul Ricoeur, and Martin Heidegger, I argue that modern hermeneutics and phenomenology lend themselves to strong linguistic relativity because they suggest that one’s native language influences one’s being-in-the-world in at least some non-trivial ways

AI-based game design patterns

This paper proposes a model for designing games around Artificial Intelligence (AI). AI-based games put AI in the foreground of the player experience rather than in a supporting role as is often the case in many commercial games. We analyze the use of AI in a number of existing games and identify design patterns for AI in games. We propose a generative ideation technique to combine a design pattern with an AI technique or capacity to make new AI-based games. Finally, we demonstrate this technique through two examples of AI-based game prototypes created using these patterns

Live, Attenuated Influenza A H5N1 Candidate Vaccines Provide Broad Cross-Protection in Mice and Ferrets

BACKGROUND: Recent outbreaks of highly pathogenic influenza A H5N1 viruses in humans and avian species that began in Asia and have spread to other continents underscore an urgent need to develop vaccines that would protect the human population in the event of a pandemic. METHODS AND FINDINGS: Live, attenuated candidate vaccines possessing genes encoding a modified H5 hemagglutinin (HA) and a wild-type (wt) N1 neuraminidase from influenza A H5N1 viruses isolated in Hong Kong and Vietnam in 1997, 2003, and 2004, and remaining gene segments derived from the cold-adapted (ca) influenza A vaccine donor strain, influenza A/Ann Arbor/6/60 ca (H2N2), were generated by reverse genetics. The H5N1 ca vaccine viruses required trypsin for efficient growth in vitro, as predicted by the modification engineered in the gene encoding the HA, and possessed the temperature-sensitive and attenuation phenotypes specified by the internal protein genes of the ca vaccine donor strain. More importantly, the candidate vaccines were immunogenic in mice. Four weeks after receiving a single dose of 10(6) 50% tissue culture infectious doses of intranasally administered vaccines, mice were fully protected from lethality following challenge with homologous and antigenically distinct heterologous wt H5N1 viruses from different genetic sublineages (clades 1, 2, and 3) that were isolated in Asia between 1997 and 2005. Four weeks after receiving two doses of the vaccines, mice and ferrets were fully protected against pulmonary replication of homologous and heterologous wt H5N1 viruses. CONCLUSIONS: The promising findings in these preclinical studies of safety, immunogenicity, and efficacy of the H5N1 ca vaccines against antigenically diverse H5N1 vaccines provide support for their careful evaluation in Phase 1 clinical trials in humans

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) exhibits lymphoid, myeloid, and stem cell features and is associated with a poor prognosis. Whole genome sequencing of human ETP-ALL cases has identified recurrent mutations in signaling, histone modification, and hematopoietic development genes but it remains to be determined which of these abnormalities are sufficient to initiate leukemia. We show that activating mutations in the interleukin-7 receptor identified in human pediatric ETP-ALL cases are sufficient to generate ETP-ALL in mice transplanted with primitive transduced thymocytes from p19(Arf-/-) mice. The cellular mechanism by which these mutant receptors induce ETP-ALL is the block of thymocyte differentiation at the double negative 2 stage at which myeloid lineage and T lymphocyte developmental potential coexist. Analyses of samples from pediatric ETP-ALL cases and our murine ETP-ALL model show uniformly high levels of LMO2 expression, very low to undetectable levels of BCL11B expression, and a relative lack of activating NOTCH1 mutations. We report that pharmacological blockade of Jak-Stat signaling with ruxolitinib has significant antileukemic activity in this ETP-ALL model. This new murine model recapitulates several important cellular and molecular features of ETP-ALL and should be useful to further define novel therapeutic approaches for this aggressive leukemia.Louise M. Treanor, Sheng Zhou, Laura Janke, Michelle L. Churchman, Zhijun Ma, Taihe Lu, Shann-Ching Chen, Charles G. Mullighan, Brian P. Sorrentin