Measurement of HO2 and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 KM

The major events and results to date of the ongoing program of measuring stratospheric composition by the technique of far-infrared Fourier-transform spectroscopy from a balloon-borne platform are reviewed. The highlights of this period were the two balloon flight campaigns which were performed at Palestine, Texas, both of which produced large amounts of scientifically useful data

Measurement of H2O and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 km

Data analysis results from the 1983 BIC 1 and 2 balloon flights are presented, with emphasis on H2O2, OH, HCL, O3, O2, and H2O. A 2 sigma limit on H2O2 abundance was set, as a function of altitude. This is comparable to or less than the theoretically predicted winter abundances from the 2-D models of Dupont, with a large enough summer maximum to facilitate concentration profile measurements. There is a definite drop in OH concentration from day to night following two model profiles. There was general agreement between HF measurements. The dominant role of the far wings of H2O lines in low altitude spectra was recognized. The strength of these wings exceeds that of many molecular line cores, including O3 and O2, especially near the long wavelength end of the spectra (100 cm (-1)). Newly measured positions for O3 and H2O were obtained

Measurement of H2O and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 KM

The highlights of the stratospheric program were reviewed for the past 2.5 years. The major efforts were analysis of the data from the BIC-2 campaign, and the building or new instrumentation to replace that lost at the end of BIC-2. For clarity, the review will be done by topic, rather than chronologically: construction of the initial far-infrared spectrometer, balloon slight program, laboratory measurement, data analysis, and duplicate stabilized platform

Astrometric jitter of the sun as a star

The daily variation of the solar photocenter over some 11 years is derived from the Mount Wilson data reprocessed by Ulrich et al. 2010 to closely match the surface distribution of solar irradiance. The standard deviations of astrometric jitter are 0.52 $\mu$AU and 0.39 $\mu$AU in the equatorial and the axial dimensions, respectively. The overall dispersion is strongly correlated with the solar cycle, reaching $0.91 \mu$AU at the maximum activity in 2000. The largest short-term deviations from the running average (up to 2.6 $\mu$AU) occur when a group of large spots happen to lie on one side with respect to the center of the disk. The amplitude spectrum of the photocenter variations never exceeds 0.033 $\mu$AU for the range of periods 0.6--1.4 yr, corresponding to the orbital periods of planets in the habitable zone. Astrometric detection of Earth-like planets around stars as quiet as the Sun is not affected by star spot noise, but the prospects for more active stars may be limited to giant planets.Comment: Accepted in Ap

Dynamically-Coupled Oscillators -- Cooperative Behavior via Dynamical Interaction --

We propose a theoretical framework to study the cooperative behavior of dynamically coupled oscillators (DCOs) that possess dynamical interactions. Then, to understand synchronization phenomena in networks of interneurons which possess inhibitory interactions, we propose a DCO model with dynamics of interactions that tend to cause 180-degree phase lags. Employing an approach developed here, we demonstrate that although our model displays synchronization at high frequencies, it does not exhibit synchronization at low frequencies because this dynamical interaction does not cause a phase lag sufficiently large to cancel the effect of the inhibition. We interpret the disappearance of synchronization in our model with decreasing frequency as describing the breakdown of synchronization in the interneuron network of the CA1 area below the critical frequency of 20 Hz.Comment: 10 pages, 3 figure

Measurement of HO2 and Other Trace Gases in the Stratosphere using a High Resolution Far-Infrared Spectrometer

This report is a continuation of the analysis of data from past flights, exploring issues such as radical partitioning, stratospheric transport, and the ozone budget

Starspot Jitter in Photometry, Astrometry and Radial Velocity Measurements

Analytical relations are derived for the amplitude of astrometric, photometric and radial velocity perturbations caused by a single rotating spot. The relative power of the star spot jitter is estimated and compared with the available data for $\kappa^1$ Ceti and HD 166435, as well as with numerical simulations for $\kappa^1$ Ceti and the Sun. A Sun-like star inclined at i=90\degr at 10 pc is predicted to have a RMS jitter of 0.087 \uas in its astrometric position along the equator, and 0.38 m s$^{-1}$ in radial velocities. If the presence of spots due to stellar activity is the ultimate limiting factor for planet detection, the sensitivity of SIM Lite to Earth-like planets in habitable zones is about an order of magnitude higher that the sensitivity of prospective ultra-precise radial velocity observations of nearby stars.Comment: accepted in ApJ Letters, Nov. 200

Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum

Hookworm disease is a major global public health concern, annually affecting 500-700 million of the world's poorest people. The World Health Organization is targeting the elimination of hookworm as a public health problem by 2030 using a strategy of mass drug administration (MDA) to at-risk human populations. However, in Southeast Asia and the Pacific the zoonotic hookworm species, Ancylostoma ceylanicum, is endemic in dogs and commonly infects people. This presents a potential impediment to the effectiveness of MDA that targets only humans. Here, we develop a novel multi-host (dog and human) transmission model of A. ceylanicum and compare the effectiveness of human-only and "One Health" (human plus dog) MDA strategies under a range of eco-epidemiological assumptions. We show that One Health interventions-targeting both dogs and humans-could suppress prevalence in humans to ≤ 1% by the end of 2030, even with only modest coverage (25-50%) of the animal reservoir. With increasing coverage, One Health interventions may even interrupt transmission. We discuss key unresolved questions on the eco-epidemiology of A. ceylanicum, the challenges of delivering MDA to animal reservoirs, and the growing importance of One Health interventions to human public health

Risk profiling and efficacy of albendazole against the hookworms Necator americanus and Ancylostoma ceylanicum in Cambodia to support control programs in Southeast Asia and the Western Pacific

Background: Hookworm disease is endemic throughout many parts of the Asia Pacific, despite targeted control programs of at-risk populations. The success of these programs has been hindered by the limited efficacy of widely-used mebendazole, rapid re-infection rates linked to persistent reservoirs of untreated people and dogs, and the low sensitivity of conventional coprodiagnostic techniques employed. Methods: Here, we used standard faecal flotation (SFF) and a multiplex qPCR (mqPCR) assay to calculate and compare species-specific cure and egg reduction rates of single dose albendazole (400 mg) against hookworm infections at community level. Data from a cross-sectional survey in 1,232 people from Cambodia were used to inform a generalised linear mixed model to identify risk factors linked to hookworm infection(s) at baseline. Furthermore, we calculated risk factors associated to the probability of being cured after albendazole administration. Findings: Overall, 13.5% of all 1,232 people tested by SFF were positive for hookworm infection(s). Most (80.1%) infected people were >12 years of age, hence above the age targeted by the WHO control program. We estimate that as age increases, the odds of being infected increases at a faster rate for females than for males. We revealed a substantial difference in cure rate of hookworm infection(s) following albendazole treatment using the SFF (81.5%) and mqPCR (46.4%) assays, and provide the first data on the efficacy of this drug against the zoonotic hookworm Ancylostoma ceylanicum. We estimated that as age increases by one year, the odds of being cured decreases by 0.4%-3.7%. Similarly, the odds of being cured for people who boiled drinking water was estimated to be between 1.02 and 6.82. Interpretation: These findings show that the adoption of refined diagnostic techniques is central to monitoring hookworm infection(s) and the success of control strategies, which can ultimately aid in reducing associated morbidity in human populations. The approach taken is likely to be directly applicable to other parts of Southeast Asia and the Western Pacific, where specific epidemiological conditions might hamper the success of targeted treatment programs. Funding: Faculty of Veterinary and Agricultural Sciences Strategic Research Funds, The University of Melbourne

Strengthening Synergies: How Action to Achieve Post-2020 Global Biodiversity Conservation Targets Can Contribute to Mitigating Climate Change

The essential contribution of nature to addressing climate change provides an opportunity to strengthen the links between the United Nations Framework Convention on Climate Change and the Convention on Biological Diversity. As we move towards the next Conferences of the Parties of both Conventions, there is a need to assess explicitly the role of nature in helping to meet the goals of these agreements efficiently and effectively. This series of reports aims to shed light on this topic by assessing the potential contribution that achieving biodiversity conservation targets can make to climate change mitigation. By doing so, it aims to provide both context and mandate for discussions under both Conventions on the role of nature-based solutions in climate change mitigation and links to biodiversity conservation action