120 research outputs found
The Link Between the Hidden Broad Line Region and the Accretion Rate in Seyfert 2 Galaxies
In the past few years more and more pieces of evidence have been presented
for a revision of the widely accepted Unified Model of Active Galactic Nuclei.
A model based solely on orientation cannot explain all the observed
phenomenology. In the following, we will present evidence that accretion rate
is also a key parameter for the presence of Hidden Broad Line Regions in
Seyfert 2 galaxies. Our sample consists of 21 sources with polarized Hidden
Broad Lines and 18 sources without Hidden Broad Lines. We use stellar velocity
dispersions from several studies on the CaII and Mg b triplets in Seyfert 2
galaxies, to estimate the mass of the central black holes via the
Mbh-{\sigma}\ast relation. The ratio between the bolometric luminosity, derived
from the intrinsic (i.e. unabsorbed) X-ray luminosity, and the Eddington
luminosity is a measure of the rate at which matter accretes onto the central
supermassive black hole. A separation between Compton-thin HBLR and non-HBLR
sources is clear, both in accretion rate (log Lbol/LEdd = -1.9) and in
luminosity (log Lbol = 43.90). When, properly luminosity-corrected,
Compton-thick sources are included, the separation between HBLR and non-HBLR is
less sharp but no HBLR source falls below the Eddington ratio threshold. We
speculate that non-HBLR Compton-thick sources with accretion rate higher than
the threshold, do possess a BLR, but something, probably related to their heavy
absorption, is preventing us from observing it even in polarized light. Our
results for Compton-thin sources support theoretical expectations. In a model
presented by Nicastro (2000), the presence of broad emission lines is
intrinsically connected with disk instabilities occuring in proximity of a
transition radius, which is a function of the accretion rate, becoming smaller
than the innermost stable orbit for very low accretion rates and therefore
luminosities.Comment: 23 pages, 4 figure
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Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher organisms has, however, been hindered by a scarcity of tools for controlled DSB induction. Here, we describe a mouse model that allows for both tissue-specific and temporally controlled DSB formation at ∼140 defined genomic loci. Using this model, we show that DSBs promote a DNA damage signaling-dependent decrease in gene expression in primary cells specifically at break-bearing genes, which is reversed upon DSB repair. Importantly, we demonstrate that restoration of gene expression can occur independently of cell cycle progression, underlining its relevance for normal tissue maintenance. Consistent with this, we observe no evidence for persistent transcriptional repression in response to a multi-day course of continuous DSB formation and repair in mouse lymphocytes in vivo. Together, our findings reveal an unexpected capacity of primary cells to maintain transcriptome integrity in response to DSBs, pointing to a limited role for DNA damage as a mediator of cell-autonomous epigenetic dysfunction
Interacting Galaxies in the A901/902 Supercluster with STAGES
We present a study of galaxy mergers and the influence of environment in the
Abell 901/902 supercluster at z~0.165. We use HST ACS F606W data from the
STAGES survey, COMBO-17, Spitzer 24um, and XMM-Newton X-ray data. Our analysis
utilizes both a visual classification system, and quantitative CAS parameters
to identify systems which show evidence of a recent or ongoing merger of mass
ratio >1/10. Our results are: (1) After visual classification and minimizing
the contamination from false projection pairs, we find that the merger fraction
f_merge is 0.023+/-0.007. The estimated fractions of likely major mergers,
likely minor mergers, and ambiguous cases are 0.01+/-0.004, 0.006+/-0.003, and
0.007+/-0.003, respectively. (2) The mergers lie outside the cluster core of
radius R < 0.25 Mpc: the lack of mergers in the core is likely due to the large
galaxy velocity dispersion in the core. Mergers populate the region (0.25 Mpc <
R <= 2 Mpc) between the core and outskirt. In this region, the estimated
frequency of mergers is similar to those seen at typical group overdensities.
This suggests ongoing growth of the clusters via accretion of group and field
galaxies. (3) We compare our observed merger fraction with those reported in
other clusters and groups out to z~0.4. Existing data points on the merger
fraction for L<= L* galaxies in clusters allow for a range of evolutionary
scenarios. (4) The fraction of mergers, which lie on the blue cloud is
80%+/-18% versus 34%+/-7% for non-interacting galaxies, implying that
interacting galaxies are preferentially blue. (5) The average SFR, based on UV
or UV+IR data, is enhanced by a factor of ~1.5 to 2 in mergers compared to
non-interacting galaxies. However, mergers in the clusters contribute only a
small fraction (between 10% and 15%) of the total SFR density.(Abridged)Comment: Accepted for publication in ApJ. 34 pages, 16 figures. Version with
full resolution figures available at: http://www.as.utexas.edu/~alh/apj/int/
; updated abridged abstrac
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
Mechanical signals from the extracellular microenvironment have been implicated in tumor and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis susceptibility gene for human estrogen receptor positive (ER+) breast cancer and a cellular mechanosensor. Nup210 depletion suppresses lung metastasis in mouse models of breast cancer. Mechanistically, NUP210 interacts with LINC complex protein SUN2 which connects the nucleus to the cytoskeleton. In addition, the NUP210/SUN2 complex interacts with chromatin via the short isoform of BRD4 and histone H3.1/H3.2 at the nuclear periphery. In Nup210 knockout cells, mechanosensitive genes accumulate H3K27me3 heterochromatin modification, mediated by the polycomb repressive complex 2 and differentially reposition within the nucleus. Transcriptional repression in Nup210 knockout cells results in defective mechanotransduction and focal adhesion necessary for their metastatic capacity. Our study provides an important role of nuclear pore protein in cellular mechanosensation and metastasis
Spore-FP1 tuberculosis mucosal vaccine candidate is highly protective in guinea pigs but fails to improve on BCG-conferred protection in non-human primates
Physical activity and nutrition behaviour outcomes of a cluster-randomized controlled trial for adults with metabolic syndrome in Vietnam
Background: Metabolic syndrome is prevalent among Vietnamese adults, especially those aged 50-65 years. This study evaluated the effectiveness of a 6 month community-based lifestyle intervention to increase physical activity levels and improve dietary behaviours for adults with metabolic syndrome in Vietnam. Methods: Ten communes, involving participants aged 50-65 years with metabolic syndrome, were recruited from Hanam province in northern Vietnam. The communes were randomly allocated to either the intervention (five communes, n = 214) or the control group (five communes, n = 203). Intervention group participants received a health promotion package, consisting of an information booklet, education sessions, a walking group, and a resistance band. Control group participants received one session of standard advice during the 6 month period. Data were collected at baseline and after the intervention to evaluate programme effectiveness. The International Physical Activity Questionnaire - Short Form and a modified STEPS questionnaire were used to assess physical activity and dietary behaviours, respectively, in both groups. Pedometers were worn by the intervention participants only for 7 consecutive days at baseline and post-intervention testing. To accommodate the repeated measures and the clustering of individuals within communes, multilevel mixed regression models with random effects were fitted to determine the impacts of intervention on changes in outcome variables over time and between groups. Results: With a retention rate of 80.8%, the final sample comprised 175 intervention and 162 control participants. After controlling for demographic and other confounding factors, the intervention participants showed significant increases in moderate intensity activity (P = 0.018), walking (P < 0.001) and total physical activity (P = 0.001), as well as a decrease in mean sitting time (P < 0.001), relative to their control counterparts. Significant improvements in dietary behaviours were also observed, particularly reductions in intake of animal internal organs (P = 0.001) and in using cooking oil for daily meal preparation (P = 0.001). Conclusions: The prescribed community-based physical activity and nutrition intervention programme successfully improved physical activity and dietary behaviours for adults with metabolic syndrome in Vietnam. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12614000811606. Registered on 31 July 201
Long-term sustainability of a physical activity and nutrition intervention for rural adults with or at risk of metabolic syndrome.
OBJECTIVE: To determine longer-term (18-month) sustainability of a six-month physical activity and nutrition intervention for 50-69-year-olds with or at risk of metabolic syndrome residing in a rural Australian community.
METHODS: Participants (n=151) were followed-up at 12 and 18 months post-intervention. Changes in nutrition behaviours (fat and fibre barometer); physical activity behaviours (IPAQ); anthropometry (waist-hip ratio, weight, BMI), blood pressure, blood parameters (triglycerides, glucose, LDL-, HDL-, non-HDL, total-cholesterol) were analysed using t-tests and repeated measures ANOVA.
RESULTS: Across three time points (6, 12 and 18 months) marginal decrease was observed for waist circumference (p=0.001), a modest increase was observed for diastolic blood pressure (p=0.010) and other outcome measures remained stable.
CONCLUSION: Maintenance and ongoing improvement of health behaviours in the longer-term is challenging. Future studies must look for ways to embed interventions into communities so they are sustainable and investigate new approaches to reduce the risk of chronic disease. Implications for public health: Metabolic syndrome is a major health issue in Australia and worldwide. Early identification and management are required to prevent the progression to chronic disease. This 18-month follow-up showed that outcomes measures remained relatively stable; however, there is a need to investigate opportunities for embedded community interventions to support long-term health behaviour change
Normal Human Pluripotent Stem Cell Lines Exhibit Pervasive Mosaic Aneuploidy
Human pluripotent stem cell (hPSC) lines have been considered to be homogeneously euploid. Here we report that normal hPSC – including induced pluripotent - lines are karyotypic mosaics of euploid cells intermixed with many cells showing non-clonal aneuploidies as identified by chromosome counting, spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) of interphase/non-mitotic cells. This mosaic aneuploidy resembles that observed in progenitor cells of the developing brain and preimplantation embryos, suggesting that it is a normal, rather than pathological, feature of stem cell lines. The karyotypic heterogeneity generated by mosaic aneuploidy may contribute to the reported functional and phenotypic heterogeneity of hPSCs lines, as well as their therapeutic efficacy and safety following transplantation
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