Infrastructure for Detector Research and Development towards the International Linear Collider

The EUDET-project was launched to create an infrastructure for developing and testing new and advanced detector technologies to be used at a future linear collider. The aim was to make possible experimentation and analysis of data for institutes, which otherwise could not be realized due to lack of resources. The infrastructure comprised an analysis and software network, and instrumentation infrastructures for tracking detectors as well as for calorimetry.Comment: 54 pages, 48 picture

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Design and characterization of an analogue amplifier for the readout of micro-pattern gaseous detectors

This doctorate deals with the development of integrated analog preamplifiers for the readout of micro pattern gaseous detectors. Because of the small detector signals the noise performance of the readout electronics is of greatest significance. The design of analog preamplifiers constitutes a trade-off between bandwidth, noise, power consumption, radiation hardness and chip area. A prototype IC consisting of 12 channels was produced in a 0.13 um CMOS technology. Each channel is comprised of a single ended preamplifier followed by a fully differential shaping amplifier that produces a 4th order semi Gaussian pulse. Channels with different peaking time, conversion gain and preamplifier architectures were implemented. Among these a novel rail to rail preamplifier architecture for low voltage operation. Part of the thesis work was the design of a printed circuit test board and the characterization of the prototype ICs. The measurements show very good correlation with the simulated values and the circuit fulfills all given specifications. New R&D is needed to develop cost-effective single chip solutions with a higher degree of integration and programmability and reduction of power consumption. Starting from the prototype IC, a programmable 16 channel preamplifier/shaping amplifier was designed as analog frontend for a general purpose charge readout chip

Complex- Valued Data Estimation : second-order statistics and widely linear estimators

Stefan TrampitschKlagenfurt, Alpen-Adria-Univ., Master-Arb., 2013(VLID)241392

A single ended low Noise Rail to Rail CMOS Preamplifier

The CMOS scaling process that is mainly driven by the need to improve digital performance poses critical problems in terms of dynamic range to analog design. Conventional preamplifier-architectures that are considered as optimum design practice have proven useful for many decades. To overcome some of the new constraints a variety of components is available. This increases the number of necessary masks and therefore the cost of circuit fabrication. In order to cope with the constraints of today's low supply voltages a rail to rail charge sensitive preamplifier designed in a 0.13 mum process is presented. A comparison is made of the proposed design with conventional architectures. Design parameters like output swing ability, gain, bandwidth, power consumption and noise performance are investigated. Finally, experimental results from a prototype submission are presented

Investment in ordinary shares : fundamental and technical analysis

Thesis (M. Comm.) -- University of Stellenbosch, 1970.Full text to be digitised and attached to bibliographic record

Außerschulische Erziehung im Nationalsozialismus unter besonderer Berücksichtigung der Hitlerjugend

Klaus TrampitschKlagenfurt, Alpen-Adria-Univ., Dipl.-Arb., 2011(VLID)241024

Pharmazeutisch relevante Aspekte der Hantaviruserkrankungen

Das Hantavirus ist ein behülltes Einzelstrang-RNA-Virus und kommt weltweit vor. Die natürlichen Wirte dieses Virus sind unterschiedliche Nagetiere, welche spezifisch für die übertragenen Hantavirusspezies sind. Die Übertragung auf den Menschen erfolgt über den Kontakt mit den Ausscheidungen infizierter Nagetiere. Besonders gefährdet sind Menschen, die durch ihre Lebens- oder Berufsumstände mit solchen Tieren in Kontakt kommen. Verschiedene Hantavirusspezies lösen unterschiedliche Hantaviruserkrankungen in verschiedenen Schweregraden, nämlich das Hämorrhagische Fieber mit Nierensyndrom und das HantavirusCardiopulmonary-Syndrom, aus. Die Symptomatik ist nicht eindeutig und ähnelt anfangs einer Grippeerkrankung, daher ist die Diagnose oft schwierig zu stellen. Eine rasche Diagnose ist sehr wichtig, um frühzeitig mit der Therapie zu beginnen. Derzeit ist man ausschließlich auf die Behandlung der Symptome beschränkt, dies ist die einzige in Europa zugelassene Form der Therapie. Es wird aber intensiv an vielversprechenden Ansätzen für eine Virustatikatherapie mit Ribavirin, Interferon-ß und neueren Verbindungen geforscht. In einigen Teilen der Welt (zB. Asien) gibt es bereits zugelassene Impfungen als Hantaviruserkrankungsprophylaxe. In Europa hingegen wurden bisher nur Studien zur Impfstoffentwicklung veröffentlicht. Die Expositionsprophylaxe ist die momentan einzige Möglichkeit sich vor einer Hantavirusinfektion zu schützen. In erster Linie ist es wichtig den Kontakt mit infizierten Nagetieren zu meiden, bzw. wenn dies nicht möglich ist, muss man als Schutzmaßnahme Atemschutzmaske und Handschuhe tragen.The hantavirus is an enveloped single-stranded RNA virus and can be found globally. The natural hosts of those viruses are various rodents, which are specific for the transmitted hantavirus species. The transmission to humans happens via contact with the excretion of infected rodents. It is in particular humans being in contact with those animals through their living and working circumstances who are at risk. Different hantavirus species trigger hantavirus diseases of varying degrees of severity, i.e. the hemorrhagic fever with renal syndrome and the hantavirus cardio-pulmonary syndrome. Symptoms are ambiguous and initially resemble a flu, which is why it is often difficult to make a diagnosis. However, a prompt diagnosis is highly important in order to start early with a therapy. Although the symptomatic treatment to date remains the only approved therapy in Europe, intensive research is being conducted on promising approaches for an antiviral therapy with Ribavirin, Interferon-ß and newer combinations. In some regions, such as Asia, approved vaccines for a hantavirus disease prophylaxis are available. In Europe, in contrast, so far only studies on vaccine development have been published. Thus, exposure prophylaxis is currently the only way to protect oneself against infection with the hantavirus. First and foremost, it is important to avoid contact with infected rodents, or, if not possible, respirators and gloves must be worn.Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüftAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinKarl-Franzens-Universität Graz, Diplomarbeit, 2019(VLID)438354