Examining aging sexual stigma attitudes among adults by gender, age, and generational status

Objectives: Stigma related to later life sexuality could produce detrimental effects for older adults, through individual concerns and limited sexual health care for older adults. Identifying groups at risk for aging sexual stigma will help to focus interventions to reduce it. Accordingly, the purpose of this study was to examine cross-sectional trends in aging sexual stigma attitudes by age group, generational status, and gender. Method: An online survey was administered to a national sample of adults via a crowdsourcing tool, in order to examine aging sexual stigma across age groups, generational status, and gender (N = 962; 47.0% male, 52.5% female, and .5% other; mean age = 45 years). An aging sexual stigma index was formulated from the attitudinal items of the Aging Sexual Knowledge and Attitudes Scale. Results: This sample reported moderately permissive attitudes toward aging sexuality, indicating a low level of aging sexual stigma. Though descriptive data showed trends of stigma attitudes increasing with age and later generations, there were no significant differences between age groups or generations in terms of aging sexual stigma beliefs. Men, regardless of age and/or generation, were found to espouse significantly higher stigmatic beliefs than women or those reporting ‘other’ gender. Conclusions: Aging sexual stigma beliefs may not be prevalent among the general population as cohorts become more sexually liberal over time, though men appear more susceptible to these beliefs. However, in order to more comprehensively assess aging sexual stigma, future research may benefit from measuring explicit and implicit aging sexual stigma beliefs

A multi-layer extension of the stochastic heat equation

Motivated by recent developments on solvable directed polymer models, we define a 'multi-layer' extension of the stochastic heat equation involving non-intersecting Brownian motions.Comment: v4: substantially extended and revised versio

Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

Isolated peripheral blood CD4 cells from allergic individuals express CC chemokine receptor (CCR)3 and CCR4 after expansion in vitro. In addition, human T helper type 2 (Th2) cells polarized in vitro selectively express CCR3 and CCR4 at certain stages of activation/differentiation and respond preferentially to the ligands eotaxin and monocyte-derived chemokine (MDC). However, controversy arises when the in vivo significance of this distinct expression is discussed. To address the functional role of CCR3/eotaxin and CCR4/MDC during the in vivo recruitment of Th2 cells, we have transferred effector Th cells into naive mice to induce allergic airway disease. Tracking of these cells after repeated antigen challenge has established that both CCR3/eotaxin and CCR4/MDC axes contribute to the recruitment of Th2 cells to the lung, demonstrating the in vivo relevance of the expression of these receptors on Th2 cells. We have shown that involvement of the CCR3/eotaxin pathway is confined to early stages of the response in vivo, whereas repeated antigen stimulation results in the predominant use of the CCR4/MDC pathway. We propose that effector Th2 cells respond to both CCR3/eotaxin and CCR4/MDC pathways initially, but that a progressive increase in CCR4-positive cells results in the predominance of the CCR4/MDC axis in the long-term recruitment of Th2 cells in vivo

On the partition function of the six-vertex model with domain wall boundary conditions

The six-vertex model on an $N\times N$ square lattice with domain wall boundary conditions is considered. A Fredholm determinant representation for the partition function of the model is given. The kernel of the corresponding integral operator is of the so-called integrable type, and involves classical orthogonal polynomials. From this representation, a ``reconstruction'' formula is proposed, which expresses the partition function as the trace of a suitably chosen quantum operator, in the spirit of corner transfer matrix and vertex operator approaches to integrable spin models.Comment: typos correcte

A Matrix model for plane partitions

We construct a matrix model equivalent (exactly, not asymptotically), to the random plane partition model, with almost arbitrary boundary conditions. Equivalently, it is also a random matrix model for a TASEP-like process with arbitrary boundary conditions. Using the known solution of matrix models, this method allows to find the large size asymptotic expansion of plane partitions, to ALL orders. It also allows to describe several universal regimes.Comment: Latex, 41 figures. Misprints and corrections. Changing the term TASEP to self avoiding particle porces

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Minority Sexual Orientation, Gender Identity Status and Suicidal Behavior: Serial Indirect Effects of Hope, Hopelessness and Depressive Symptoms

Death by suicide, and suicidal behaviors, are a significant public mental health problem, and individuals who are lesbian, gay, bisexual, transgendered and questioning (LGBTQ), may be at increased risk. Potential underlying mechanisms of this association are unknown, but may involve the impact of LGBTQ status on future orientation and mood. Our purpose was to determine the influence of sexual identity, sequentially, on cognitive and emotional functioning, and consequent relation to suicidal behavior. In a sample of 349 college students, we used serial mediation models to investigate the relation between self-identification as LGBTQ and suicidal behavior, with hope and hopelessness as first-order mediators and depression as a second order mediator. Supporting hypotheses, we found that LGBTQ status was related to less hope and greater hopelessness and, in serial fashion, to depressive symptoms and consequent suicidal behavior. Our findings may have clinical implications. Resolution of hopelessness and depression, and promotion of hopefulness, perhaps via Motivational Interviewing and Cognitive Behavioral Therapy strategies, such as goal-setting, may reduce suicidal risk in LGBTQ young adults

Postelection Distress and Resiliency in LGBTQ Communities: An Overview of Real Data, Not Alternative Facts

As with every U.S. election cycle, the early 2016 election season was a roller-coaster experience, with positive and negative campaign messages emerging from both parties, and with high hopes and dashed hopes for both Democratic and Republican candidates. However, as Donald J. Trump emerged as the Republican candidate to challenge Democrat Hillary R. Clinton for the Office of President, the United States appeared to be equally bemused, horrified and confident in a Democratic victory — after all, how could someone so unorthodox as Donald Trump become the next president? His divisive campaign had become predictive, for many voters, of a clear victory for Clinton. However, those within vulnerable groups, including women, immigrants and the LGBTQ communities, along with many allies, noted the growing normalization of his micro- and macro-aggressions by the mainstream media, and the societal legitimization of his campaign

What the Trump?Anticipated Rejectionand Concern aboutRights are Associatedwith Suicide Risk inLGBTQ Communities,but Can ResilienceTrump Risk?

It is common knowledge that LGBTQ (lesbian, gay, bisexual, transgender, and queer) communities experience disparate rates of mental health concerns, including greater levels of self-reported depression, anxiety, substance abuse, and suicidal behavior (Bränström, Hatzenbuehler, & Pachankis, 2016). As an example, gay and bisexual men are four times as likely and lesbian and bisexual women are 2 times as likely, to attempt suicide compared to heterosexual counterparts (King et al., 2008). Between 25-43% of transgender persons have a lifetime history of suicide attempts, compared to 5% of the general US population (Nock & Kessler, 2006). Such poor mental health outcomes may be due, in part, to a lack of acceptance by society in the form of discrimination and unequal rights, and to rejection by family, friends and the self, including internalized homophobia, concealment and shame (Skerrett, Kõlves, & De Leo, 2016). LGBTQ persons are also more likely to have experienced trauma, including physical and sexual abuse, as well as interpersonal violence by intimate partners, family and strangers (LangenderferMagruder, Whitfeld, Walls, Kattari, & Ramos, 2016). LGBTQ communities, therefore, constitute a vulnerable and marginalized population, who are already at risk for rejection and abuse with consequent deleterious effects on physical and mental health, including risk for suicide