Role of transverse excitations in the instability of Bose-Einstein condensates moving in optical lattices

The occurrence of energetic and dynamical instabilities in a Bose-Einstein condensate moving in a one-dimensional (1D) optical lattice is analyzed by means of the Gross-Pitaevskii theory. Results of full 3D calculations are compared with those of an effective 1D model, the nonpolynomial Schrodinger equation, pointing out the role played by transverse degrees of freedom. The instability thresholds are shown to be scarcely affected by transverse excitations, so that they can be accurately predicted by effective 1D models. Conversely, transverse excitations turn out to be important in characterizing the stability diagram and the occurrence of a complex radial dynamics above the threshold for dynamical instability. This analysis provides a realistic framework to discuss the dissipative dynamics observed in recent experiments.Comment: 9 pages, 11 figures; typos corrected, references updated, new Figure

Influence of the number of trials and the exercise to rest ratio in repeated sprint ability, with changes of direction and orientation

The purpose of this investigation was to determine if there were different trends in physical fatigue observed in 3 different sets, of 7 trials each, in repeated sprint training, performed in 3 different modes: straight sprinting over 30 m, shuttle sprinting over 15 + 15 m, and sprinting over 30 m with changes of direction. Recovery time among trials in the sets was administered according to the 1:5 exercise to rest ratio. The sets were performed on 3 different days, with at least 48 hours between each set. The study involved 17 trained male soccer players (height, 177.33 +/- 6.21 cm; body mass, 71.63 +/- 9.58 kg; body mass index, 23 +/- 2.39 kg<bold>m(</bold>-2); age, 21.94 +/- 3.58 years). To compare the different values of the time recorded, an index of fatigue was used. Significant differences among trials within each set (repeated measures analysis of variance; p < 0.05) and between the sets (factorial analysis of variance; p < 0.001) were found. Significant correlations between each test and countermovement jump and stiffness values recorded pre exercise were found (p < 0.05). Significant differences between countermovement jump and stiffness values recorded pre and post exercise were also found (p < 0.05). This study suggests that training sessions aimed at increasing the capacity of repeated sprint ability in nonlinear and multidirectional sprints (shuttle and change of direction), which might imply a different number of trials within the set or different exercise to rest ratios from the ones usually adopted for straight sprinting, to induce similar trends of fatigue. As practical applications, the estimated numbers of necessary trials in the different sets and the possible exercise to rest ratios, resulting from mathematical modeling, are provided for each investigated sprinting mode

Bogoliubov spectrum and Bragg spectroscopy of elongated Bose-Einstein condensates

The behavior of the momentum transferred to a trapped Bose-Einstein condensate by a two-photon Bragg pulse reflects the structure of the underlying Bogoliubov spectrum. In elongated condensates, axial phonons with different number of radial nodes give rise to a multibranch spectrum which can be resolved in Bragg spectroscopy, as shown by Steinhauer {\it et al.} [Phys. Rev. Lett. {\bf 90}, 060404 (2003)]. Here we present a detailed theoretical analysis of this process. We calculate the momentum transferred by numerically solving the time dependent Gross-Pitaevskii equation. In the case of a cylindrical condensate, we compare the results with those obtained by linearizing the Gross-Pitaevskii equation and using a quasiparticle projection method. This analysis shows how the axial-phonon branches affect the momentum transfer, in agreement with our previous interpretation of the observed data. We also discuss the applicability of this type of spectroscopy to typical available condensates, as well as the role of nonlinear effects.Comment: 8 pages, 7 figures, minor changes, typos correcte

Bragg spectroscopy of a superfluid Bose-Hubbard gas

Bragg spectroscopy is used to measure excitations of a trapped, quantum-degenerate gas of 87Rb atoms in a 3-dimensional optical lattice. The measurements are carried out over a range of optical lattice depths in the superfluid phase of the Bose-Hubbard model. For fixed wavevector, the resonant frequency of the excitation is found to decrease with increasing lattice depth. A numerical calculation of the resonant frequencies based on Bogoliubov theory shows a less steep rate of decrease than the measurements.Comment: 11 pages, 4 figure

O PERFIL DO PACIENTE CONTAMINADO PELO VÍRUS HIV/AIDS

Sabe-se que o número de infectados pelo Vírus da Imunodeficiência Humana (HIV) tem aumentado exacerbadamente nos últimos anos, o que tem desafiado a formulação de políticas de saúde,educação, desenvolvimento bem como de métodos de prevenção. Descobrir que se está com AIDS pode gerar um estado prolongado de estresse, trazendo medo e angústia. Pesquisas atuais indicam que aspectos comportamentais, psicológicos e sociais influenciam na evolução ou não da infecção por HIV, assim sendo, tem-se por objetivo identificar o perfil desses pacientes, desde a sua reação ao diagnóstico da AIDS com vistas compreender melhor o perfil do paciente soropositivo a fim de proporcionar melhores condições de vida aos mesmos. O objetivo desta pesquisa é verificar qual é o perfil da pessoa contaminada pelo vírus da imunodeficiência humana, (HIV que desenvolveu ou não a AIDS), incluindo a sua reação desde o diagnóstico até o momento no qual a pessoa se encontra. Critério de inclusão dos sujeitos: as pesquisadoras farão contatos com pessoas conhecidas contaminadas pelo vírus, do seu próprio relacionamento e convidarão quatro pessoas para participar espontaneamente da mesma. Esta pesquisa é de natureza qualitativa, e será realizada por meio da metodologia aplicada a estudos de casos. O enfoque da análise será psicossocial. Com esse tipo de abordagem as pesquisadoras interpretarão os dados e os fatos, procurando solução para o problema de pesquisa proposto. O roteiro para entrevista semiestruturada, será elaborado pela equipe pesquisadora. A pesquisa se encontra em andamento, e foi encaminhada para ser avaliada pela Comissão de Ética em Pesquisa do Cesumar, Pelo fato de ainda não se ter colhido os dados, não se obteve resultados até o dado momento

CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML.

An understanding of natural killer (NK) cell physiology in acute myeloid leukemia (AML) has led to the use of NK cell transfer in patients, demonstrating promising clinical results. However, AML is still characterized by a high relapse rate and poor overall survival. In addition to conventional NKs that can be considered the innate counterparts of CD8 T cells, another family of innate lymphocytes has been recently described with phenotypes and functions mirroring those of helper CD4 T cells. Here, in blood and tissues, we identified a CD56+ innate cell population harboring mixed transcriptional and phenotypic attributes of conventional helper innate lymphoid cells (ILCs) and lytic NK cells. These CD56+ ILC1-like cells possess strong cytotoxic capacities that are impaired in AML patients at diagnosis but are restored upon remission. Their cytotoxicity is KIR independent and relies on the expression of TRAIL, NKp30, NKp80, and NKG2A. However, the presence of leukemic blasts, HLA-E-positive cells, and/or transforming growth factor-β1 (TGF-β1) strongly affect their cytotoxic potential, at least partially by reducing the expression of cytotoxic-related molecules. Notably, CD56+ ILC1-like cells are also present in the NK cell preparations used in NK transfer-based clinical trials. Overall, we identified an NK cell-related CD56+ ILC population involved in tumor immunosurveillance in humans, and we propose that restoring their functions with anti-NKG2A antibodies and/or small molecules inhibiting TGF-β1 might represent a novel strategy for improving current immunotherapies

Early Immunotherapy and Longer Corticosteroid Treatment Are Associated With Lower Risk of Relapsing Disease Course in Pediatric MOGAD

Background and Objectives We sought to identify early factors associated with relapse and outcome in paediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD). Methods In a multicenter retrospective cohort of pediatric MOGAD (≤18 years), onset features and treatment were compared in patients with monophasic vs relapsing disease (including cases with follow-up ≥12 months after onset or relapse at any time) and in patients with final Expanded Disability Status Scale (EDSS) 0 vs ≥1 at last follow-up (including cases with followup >3 months after last event or EDSS0 at any time). Multivariable logistic regression models were used to evaluate factors associated with relapsing disease course and EDSS ≥ 1 at final follow-up. Results Seventy-five children were included (median onset age 7 years; median 30 months of follow-up). Presentation with acute disseminated encephalomyelitis was more frequent in children aged 8 years or younger (66.7%, 28/42) than in older patients (30.3%, 10/33) (p = 0.002), whereas presentation with optic neuritis was more common in children older than 8 years (57.6%, 19/33) than in younger patients (21.4%, 9/42) (p = 0.001). 40.0% (26/65) of patients relapsed. Time to first relapse was longer in children aged 8 years or younger than in older patients (median 18 vs 4 months) (p = 0.013). Factors at first event independently associated with lower risk of relapsing disease course were immunotherapy <7 days from onset (6.7-fold reduced odds of relapsing course, OR 0.15, 95% CI 0.03–0.61, p = 0.009), corticosteroid treatment for ≥5 weeks (6.7-fold reduced odds of relapse, OR 0.15, 95% CI 0.03–0.80, p = 0.026), and abnormal optic nerves on onset MRI (12.5-fold reduced odds of relapse, OR 0.08, 95% CI 0.01–0.50, p = 0.007). 21.1% (15/71) had EDSS ≥ 1 at final follow-up. Patients with a relapsing course had a higher proportion of final EDSS ≥ 1 (37.5%, 9/24) than children with monophasic disease (12.8%, 5/39) (p = 0.022, univariate analysis). Each 1-point increment in worst EDSS at onset was independently associated with 6.7-fold increased odds of final EDSS ≥ 1 (OR 6.65, 95% CI 1.33–33.26, p = 0.021). Discussion At first attack of pediatric MOGAD, early immunotherapy, longer duration of corticosteroid treatment, and abnormal optic nerves on MRI seem associated with lower risk of relapse, whereas higher disease severity is associated with greater risk of final disability (EDSS ≥ 1)

Data monitoring roadmap. The experience of the Italian Multiple Sclerosis and Related Disorders Register

Introduction Over the years, disease registers have been increasingly considered a source of reliable and valuable population studies. However, the validity and reliability of data from registers may be limited by missing data, selection bias or data quality not adequately evaluated or checked.This study reports the analysis of the consistency and completeness of the data in the Italian Multiple Sclerosis and Related Disorders Register.MethodsThe Register collects, through a standardized Web-based Application, unique patients.Data are exported bimonthly and evaluated to assess the updating and completeness, and to check the quality and consistency. Eight clinical indicators are evaluated.ResultsThe Register counts 77,628 patients registered by 126 centres. The number of centres has increased over time, as their capacity to collect patients.The percentages of updated patients (with at least one visit in the last 24 months) have increased from 33% (enrolment period 2000-2015) to 60% (enrolment period 2016-2022). In the cohort of patients registered after 2016, there were &gt;= 75% updated patients in 30% of the small centres (33), in 9% of the medium centres (11), and in all the large centres (2).Clinical indicators show significant improvement for the active patients, expanded disability status scale every 6 months or once every 12 months, visits every 6 months, first visit within 1 year and MRI every 12 months.ConclusionsData from disease registers provide guidance for evidence-based health policies and research, so methods and strategies ensuring their quality and reliability are crucial and have several potential applications