A function-based typology for Earth’s ecosystems

As the United Nations develops a post-2020 global biodiversity framework for the Convention on Biological Diversity, attention is focusing on how new goals and targets for ecosystem conservation might serve its vision of ‘living in harmony with nature’1,2. Advancing dual imperatives to conserve biodiversity and sustain ecosystem services requires reliable and resilient generalizations and predictions about ecosystem responses to environmental change and management3. Ecosystems vary in their biota4, service provision5 and relative exposure to risks6, yet there is no globally consistent classification of ecosystems that reflects functional responses to change and management. This hampers progress on developing conservation targets and sustainability goals. Here we present the International Union for Conservation of Nature (IUCN) Global Ecosystem Typology, a conceptually robust, scalable, spatially explicit approach for generalizations and predictions about functions, biota, risks and management remedies across the entire biosphere. The outcome of a major cross-disciplinary collaboration, this novel framework places all of Earth’s ecosystems into a unifying theoretical context to guide the transformation of ecosystem policy and management from global to local scales. This new information infrastructure will support knowledge transfer for ecosystem-specific management and restoration, globally standardized ecosystem risk assessments, natural capital accounting and progress on the post-2020 global biodiversity framework

Dynamic multi-objective optimisation using deep reinforcement learning::benchmark, algorithm and an application to identify vulnerable zones based on water quality

Dynamic multi-objective optimisation problem (DMOP) has brought a great challenge to the reinforcement learning (RL) research area due to its dynamic nature such as objective functions, constraints and problem parameters that may change over time. This study aims to identify the lacking in the existing benchmarks for multi-objective optimisation for the dynamic environment in the RL settings. Hence, a dynamic multi-objective testbed has been created which is a modified version of the conventional deep-sea treasure (DST) hunt testbed. This modified testbed fulfils the changing aspects of the dynamic environment in terms of the characteristics where the changes occur based on time. To the authors’ knowledge, this is the first dynamic multi-objective testbed for RL research, especially for deep reinforcement learning. In addition to that, a generic algorithm is proposed to solve the multi-objective optimisation problem in a dynamic constrained environment that maintains equilibrium by mapping different objectives simultaneously to provide the most compromised solution that closed to the true Pareto front (PF). As a proof of concept, the developed algorithm has been implemented to build an expert system for a real-world scenario using Markov decision process to identify the vulnerable zones based on water quality resilience in São Paulo, Brazil. The outcome of the implementation reveals that the proposed parity-Q deep Q network (PQDQN) algorithm is an efficient way to optimise the decision in a dynamic environment. Moreover, the result shows PQDQN algorithm performs better compared to the other state-of-the-art solutions both in the simulated and the real-world scenario

Association of common genetic variants with brain microbleeds

OBJECTIVE: To identify common genetic variants associated with the presence of brain microbleeds (BMBs). METHODS: We performed geno

Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division

Modern medicinal plant drug discovery has provided pharmacologically active compounds targeted against a multitude of conditions and diseases, such as infection, inflammation, and cancer. To date, natural products from medicinal plants remain a solid niche as a source from which cancer therapies can be derived. Among other properties, one favorable characteristic of an anticancer drug is its ability to block the uncontrollable process of cell division, as cancer cells are notorious for their abnormal cell division. There are numerous other documented works on the potential anticancer activity of drugs derived from medicinal plants, and their effects on cell division are an attractive and growing therapeutic target. Despite this, there remains a vast number of unidentified natural products that are potentially promising sources for medical applications. This mini review aims to revise the current knowledge of the effects of natural plant products on cell division