Differences in Relationship Between Emotional Intelligence and self-Acceptance as Function of Gender and Ibasho (a Person Who Eases the Mind) of Japanese Undergraduates

The present study examined the differences in the relationship between emotional intelligence (EI) and self-acceptance as a function of gender and ibasho (ibasyo), a Japanese concept of \u27home\u27 or \u27refuge\u27. Here, the ibasho represents the person who eases one\u27s mind. The participants were 244 Japanese undergraduates who were asked to complete the Japanese version of the Emotional Intelligence Skills and Competence Questionnaire (J-ESCQ; Toyota, Morita, & Takšić, 2007), a question related to ibasho (Who is the person that eases the mind) and self-acceptance scales (Itatsu, 1989). Positive correlations between all sub-abilities in EI: (perceiving and understanding emotion (PU), expressing and labeling emotion (EL), managing and regulating emotion (MR), and self-acceptance) were found in females whereas in males, the only positive correlation was found between MR and self-acceptance. For participants who report that \u27lover\u27 is a person who eases their mind, PU has a negative correlation with self-acceptance. Both EL and MR have a strong correlation with self-acceptance in all types of groups. These results indicate that the effect of each sub-ability in EI on self-acceptance is determined by gender and the presence of the person who provides a sense of ibasho and also suggest that these determinants should be considered to clarify individual differences in adaptation

Differences in Relationship Between Emotional Intelligence and self-Acceptance as Function of Gender and Ibasho (a Person Who Eases the Mind) of Japanese Undergraduates

The present study examined the differences in the relationship between emotional intelligence (EI) and self-acceptance as a function of gender and ibasho (ibasyo), a Japanese concept of \u27home\u27 or \u27refuge\u27. Here, the ibasho represents the person who eases one\u27s mind. The participants were 244 Japanese undergraduates who were asked to complete the Japanese version of the Emotional Intelligence Skills and Competence Questionnaire (J-ESCQ; Toyota, Morita, & Takšić, 2007), a question related to ibasho (Who is the person that eases the mind) and self-acceptance scales (Itatsu, 1989). Positive correlations between all sub-abilities in EI: (perceiving and understanding emotion (PU), expressing and labeling emotion (EL), managing and regulating emotion (MR), and self-acceptance) were found in females whereas in males, the only positive correlation was found between MR and self-acceptance. For participants who report that \u27lover\u27 is a person who eases their mind, PU has a negative correlation with self-acceptance. Both EL and MR have a strong correlation with self-acceptance in all types of groups. These results indicate that the effect of each sub-ability in EI on self-acceptance is determined by gender and the presence of the person who provides a sense of ibasho and also suggest that these determinants should be considered to clarify individual differences in adaptation

Efficient total syntheses of natural pterin glycosides: limipterin and tepidopterin

The key, versatile precursors N-2-(N,N-dimethylaminomethylene)-1'-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (29a) and its ciliapterin analog (29b) were prepared, respectively, from D-xylose (in 14 steps) and L-xylose (in 11 steps). Treatment of 29a and 29b with 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-beta-D-glucopyranosyl bromide in the presence of silver triflate and tetramethylurea, followed by removal of the protecting groups, led to the first selective syntheses of limipterin (3) and tepidopterin (5), respectively

Risk Factors for Infection in Patients with Remitted Rheumatic Diseases Treated with Glucocorticoids

It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR＝4.50, 95%CI＝1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids

Precise Prediction of Right Atrium Position within Expiratory Phase Thorax

Fifteen patients who underwent CT during both the inspiratory and expiratory phases were retrospectively reviewed. The anterior posterior (AP) diameter of the thorax, the largest vertical distance from the uppermost RA level to the back surface (RA height), and the ratio of RA height to AP diameter of the thorax (RA thorax ratio) were determined. We then attempted to predict the expiratory RA height using the following 2 methods. Formula 1: Predicted expiratory RA height = Average inspiratory RA thorax ratio × Expiratory AP diameter of thorax. Formula 2: Predicted expiratory RA height = Each inspiratory RA thorax ratio × Expiratory AP diameter of thorax. In a Bland-Altman plot with Formula 1, the bias was –0.34 mm and limit of agreement ranged from –19.44 to 18.75 mm, whereas those were –1.31 mm and –9.72 to 7.10 mm with Formula 2. Our findings indicate that inspiratory CT imaging and expiratory phase thorax diameter can be used to precisely predict expiratory phase RA height in individual patients

Epigenetic biomarkers for prediction of sensitivity to chemotherapeutic drugs in multiple myeloma

Multiple myeloma continues to be a lethal malignancy despite the development of treatments such as high-dose chemotherapy combined with stem cell transplantation. Multiple myeloma arises through an accumulation of multiple genetic anges, including immunoglobulin gene rearrangements involved in Cyclin D. The main difficulties in multiple myeloma treatments are drug-resistance. DNA methylation of the5\u27 CpG islands of genes is often found in multiple myeloma. To screen for he genes involved in tumorigenesis of multiple myeloma, which are silenced by DNA methylation, we performed cDNA microarray analysis using multiple myeloma cell lines treated with demethylating agent5-aza-2-deoxycytidine (DAC), and entified RASD1, a dexamethasone (Dex)-inducible gene, as one of the targets of epigenetic changes. Inactivation of RASD1 was found to correlate with resistance to Dex, and treatment of multiple myeloma cells with DAC restored sensitivity to Dex. These findings suggest the involvement of epigenetic gene silencing in multiple myeloma progression and drug-resistance, and the usefulness of demethylation therapy for multiple myeloma treatment. Furthermore, DNA methylation can be an epigenetic biomarker for multiple myeloma

Synthetic studies on pterin glycosides: the first synthesis of 2′-O-(α-d-glucopyranosyl)biopterin

L-Rhamnose was led, in a 14-step-sequence, to N2-(N,N-dimethylaminomethylene)-1′-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (23), an appropriately protected precursor for 2′-O-glycosylation, while 4,6-di-O-acetyl-2,3-di-O-(4-methoxybenzyl)-α-d-glucopyranosyl bromide (32), a novel glycosyl donor, was efficiently prepared from d-glucose in 8 steps. The first synthesis of 2′-O-(α-d-glucopyranosyl)biopterin (2a) was achieved by treatment of the key intermediate 23 with 32 in the presence of silver triflate and tetramethylurea, followed by successive removal of the protecting groups

Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development

Juvenile hormone (JH) are a family of multifunctional hormones regulating larval development, molting, metamorphosis, reproduction, and phenotypic plasticity in arthropods. Based on its importance in arthropod life histories, many insect growth regulators (IGRs) mimicking JH have been designed to control harmful insects in agriculture and aquaculture. These JH analogs (JHAs) may also pose hazards to nontarget species by causing unexpected endocrine-disrupting (ED) effects such as molting and metamorphosis defects, larval lethality, and disruption of the sexual identity. This critical review summarizes the current knowledge of the JH-mediated effects in the freshwater cladoceran crustaceans such as Daphnia species on JHA-triggered endocrine disruptive outputs to establish a systematic understanding of JHA effects. Based on the current knowledge, adverse outcome pathways (AOPs) addressing the JHA-mediated ED effects in cladoceran leading to male offspring production and subsequent population decline were developed. The weight of evidence (WoE) of AOPs was assessed according to established guidelines. The review and AOP development aim to present the current scientific understanding of the JH pathway and provide a robust reference for the development of tiered testing strategies and new risk assessment approaches for JHAs in future ecotoxicological research and regulatory processes.publishedVersionacceptedVersio