Interannual variability of Alexandrium fundyense abundance and shellfish toxicity in the Gulf of Maine

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 52 (2005): 2843-2855, doi:10.1016/j.dsr2.2005.06.020.Six years of oceanographic surveys of Alexandrium fundyense concentrations in the Gulf of Maine are combined with shellfish toxicity records from coastal monitoring stations to assess covariations of these quantities on seasonal to interannual time scales. Annual mean gulf-wide cell abundance varies by less than one order of magnitude during the time interval examined (1993-2002). Fluctuations in gulf-wide annual mean cell abundance and shellfish toxicity are not related in a consistent manner. This suggests that interannual variations in toxicity may be regulated by transport and delivery of offshore cell populations, rather than the absolute abundance of the source populations themselves.We gratefully acknowledge the support of the US ECOHAB Program, sponsored by NOAA, NSF, EPA, NASA, and ONR

Spinning deformations of the D1-D5 system and a geometric resolution of Closed Timelike Curves

The SO(4) isometry of the extreme Reissner-Nordstrom black hole of N=1, D=5 supergravity can be partly broken, without breaking any supersymmetry, in two different ways. The ``right'' solution is a rotating black hole (BMPV); the ``left'' is interpreted as a black hole in a Godel universe. In ten dimensions, both spacetimes are described by deformations of the D1-D5-pp-wave system with the property that the non-trivial Closed Timelike Curves of the five dimensional manifold are absent in the universal covering space of the ten dimensional manifold. In the decoupling limit, the BMPV deformation is normalizable. It corresponds to the vev of an IR relevant operator of dimension \Delta=1. The Godel deformation is sub-leading in \alpha' unless we take an infinite vorticity limit; in such case it is a non-normalizable perturbation. It corresponds to the insertion of a vector operator of dimension \Delta=5. Thus we conclude that from the dual (1+1)-CFT viewpoint the SO(4) R-symmetry is broken `spontaneously' in the BMPV case and explicitly in the Godel case.Comment: 20 pages, no figures, LaTeX; v2: Minor improvements, to appear in Nucl. Phys.

Hormonal modulation of breast cancer gene expression: implications for intrinsic subtyping in premenopausal women

Clinics are increasingly adopting gene-expression profiling to diagnose breast cancer subtype, providing an intrinsic, molecular portrait of the tumor. For example, the PAM50- based Prosigna test quantifies expression of 50 key genes to classify breast cancer subtype, and this method of classification has been demonstrated to be superior over traditional immunohistochemical methods that detect proteins, to predict risk of disease recurrence. However, these tests were largely developed and validated using breast cancer samples from postmenopausal women. Thus, the accuracy of such tests has not been explored in the context of the hormonal fluctuations in estrogen and progesterone that occur during the menstrual cycle in premenopausal women. Concordance between traditional methods of subtyping and the new tests in premenopausal women is likely to depend on the stage of the menstrual cycle at which the tissue sample is taken and the relative effect of hormones on expression of genes versus proteins. The lack of knowledge around the effect of fluctuating estrogen and progesterone on gene expression in breast cancer patients raises serious concerns for intrinsic subtyping in premenopausal women, which comprise about 25% of breast cancer diagnoses. Further research on the impact of the menstrual cycle on intrinsic breast cancer profiling is required if premenopausal women are to benefit from the new technology of intrinsic subtyping.Sarah M. Bernhardt, Pallave Dasari, David Walsh, Amanda R. Townsend, Timothy J. Price, and Wendy V. Ingma

Flux-branes and the Dielectric Effect in String Theory

We consider the generalization to String and M-theory of the Melvin solution. These are flux p-branes which have (p+1)-dimensional Poincare invariance and are associated to an electric (p+1)-form field strength along their worldvolume. When a stack of Dp-branes is placed along the worldvolume of a flux (p+3)-brane it will expand to a spherical D(p+2)-brane due to the dielectric effect. This provides a new setup to consider the gauge theory/gravity duality. Compactifying M-theory on a circle we find the exact gravity solution of the type IIA theory describing the dielectric expansion of N D4-branes into a spherical bound state of D4-D6-branes, due to the presence of a flux 7-brane. In the decoupling limit, the deformation of the dual field theory associated with the presence of the flux brane is irrelevant in the UV. We calculate the gravitational radius and energy of the dielectric brane which give, respectively, a prediction for the VEV of scalars and vacuum energy of the dual field theory. Consideration of a spherical D6-brane probe with n units of D4-brane charge in the dielectric brane geometry suggests that the dual theory arises as the Scherk-Schwarz reduction of the M5-branes (2,0) conformal field theory. The probe potential has one minimum placed at the locus of the bulk dielectric brane and another associated to an inner dielectric brane shell.Comment: v2 Major Additions: dielectric radius in gravity solution matches exactly stable and unstable points of Myers probe potential, as well as the upper bound on D-brane charge. New section probing dielectric brane that clarifies dual field theory discussion and is consistent with Scherk-Schwarz reduction of (2,0) M5-brane theory. References added. 43 pages, 4 figure

Small Black Holes on Cylinders

We find the metric of small black holes on cylinders, i.e. neutral and static black holes with a small mass in d-dimensional Minkowski-space times a circle. The metric is found using an ansatz for black holes on cylinders proposed in hep-th/0204047. We use the new metric to compute corrections to the thermodynamics which is seen to deviate from that of the (d+1)-dimensional Schwarzschild black hole. Moreover, we compute the leading correction to the relative binding energy which is found to be non-zero. We discuss the consequences of these results for the general understanding of black holes and we connect the results to the phase structure of black holes and strings on cylinders.Comment: 23 pages, 1 figure. v2: typos corrected, introduction expanded, v3: presentation of sections 2 and 3 reordered and improved, explanatory remarks added, refs adde

The purified extract from the medicinal plant Bacopa monnieri, bacopaside II, inhibits growth of colon cancer cells in vitro by inducing cell cycle arrest and apoptosis

Published: 21 July 2018Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. The aim of this study was to further elucidate the anti-tumour potential of bacopaside II in colon cancer cells. Expression of AQP1 in HT-29, SW480, SW620 and HCT116 was determined by quantitative PCR and western immunoblot. Cells were treated with bacopaside II, and morphology, growth, autophagy, cell cycle and apoptosis assessed by time-lapse microscopy, crystal violet, acridine orange, propidium iodide (PI) and annexin V/PI staining respectively. AQP1 expression was significantly higher in HT-29 than SW480, SW620 and HCT116. Bacopaside II significantly reduced growth at ≥20 µM for HT-29 and ≥15 µM for SW480, SW620 and HCT116. Inhibition of HT-29 at 20 µM was primarily mediated by G0/G1 cell cycle arrest, and at 30 µM by G2/M arrest and apoptosis. Inhibition of SW480, SW620 and HCT116 at ≥15 µM was mediated by G2/M arrest and apoptosis. These results are the first to show that bacopaside II inhibits colon cancer cell growth by inducing cell cycle arrest and apoptosis.Eric Smith, Helen M. Palethorpe, Yoko Tomita, Jinxin V. Pei, Amanda R. Townsend, Timothy J. Price, Joanne P. Young, Andrea J. Yool and Jennifer E. Hardingha

Phase evolution in the CaZrTi2O7–Dy2Ti2O7 system : a potential host phase for minor actinide immobilization

Zirconolite is considered to be a suitable wasteform material for the immobilization of Pu and other minor actinide species produced through advanced nuclear separations. Here, we present a comprehensive investigation of Dy3+ incorporation within the self-charge balancing zirconolite Ca1–xZr1–xDy2xTi2O7 solid solution, with the view to simulate trivalent minor actinide immobilization. Compositions in the substitution range 0.10 ≤ x ≤ 1.00 (Δx = 0.10) were fabricated by a conventional mixed oxide synthesis, with a two-step sintering regime at 1400 °C in air for 48 h. Three distinct coexisting phase fields were identified, with single-phase zirconolite-2M identified only for x = 0.10. A structural transformation from zirconolite-2M to zirconolite-4M occurred in the range 0.20 ≤ x ≤ 0.30, while a mixed-phase assemblage of zirconolite-4M and cubic pyrochlore was evident at Dy concentrations 0.40 ≤ x ≤ 0.50. Compositions for which x ≥ 0.60 were consistent with single-phase pyrochlore. The formation of zirconolite-4M and pyrochlore polytype phases, with increasing Dy content, was confirmed by high-resolution transmission electron microscopy, coupled with selected area electron diffraction. Analysis of the Dy L3-edge XANES region confirmed that Dy was present uniformly as Dy3+, remaining analogous to Am3+. Fitting of the EXAFS region was consistent with Dy3+ cations distributed across both Ca2+ and Zr4+ sites in both zirconolite-2M and 4M, in agreement with the targeted self-compensating substitution scheme, whereas Dy3+ was 8-fold coordinated in the pyrochlore structure. The observed phase fields were contextualized within the existing literature, demonstrating that phase transitions in CaZrTi2O7–REE3+Ti2O7 binary solid solutions are fundamentally controlled by the ratio of ionic radius of REE3+ cations

Star Models with Dark Energy

We have constructed star models consisting of four parts: (i) a homogeneous inner core with anisotropic pressure (ii) an infinitesimal thin shell separating the core and the envelope; (iii) an envelope of inhomogeneous density and isotropic pressure; (iv) an infinitesimal thin shell matching the envelope boundary and the exterior Schwarzschild spacetime. We have analyzed all the energy conditions for the core, envelope and the two thin shells. We have found that, in order to have static solutions, at least one of the regions must be constituted by dark energy. The results show that there is no physical reason to have a superior limit for the mass of these objects but for the ratio of mass and radius.Comment: 20 pages, 1 figure, references and some comments added, typos corrected, in press GR

Individual Confidence-Weighting and Group Decision-Making

Group-living species frequently pool individual information so as to reach consensus decisions such as when and where to move, or whether a predator is present. Such opinion-pooling has been demonstrated empirically, and theoretical models have been proposed to explain why group decisions are more reliable than individual decisions. Behavioural ecology theory frequently assumes that all individuals have equal decision-making abilities, but decision theory relaxes this assumption and has been tested in human groups. We summarise relevant theory and argue for its applicability to collective animal decisions. We consider selective pressure on confidence-weighting in groups of related and unrelated individuals. We also consider which species and behaviours may provide evidence of confidence-weighting, paying particular attention to the sophisticated vocal communication of cooperative breeders

Black Holes in Higher-Dimensional Gravity

These lectures review some of the recent progress in uncovering the phase structure of black hole solutions in higher-dimensional vacuum Einstein gravity. The two classes on which we focus are Kaluza-Klein black holes, i.e. static solutions with an event horizon in asymptotically flat spaces with compact directions, and stationary solutions with an event horizon in asymptotically flat space. Highlights include the recently constructed multi-black hole configurations on the cylinder and thin rotating black rings in dimensions higher than five. The phase diagram that is emerging for each of the two classes will be discussed, including an intriguing connection that relates the phase structure of Kaluza-Klein black holes with that of asymptotically flat rotating black holes.Comment: latex, 49 pages, 5 figures. Lectures to appear in the proceedings of the Fourth Aegean Summer School, Mytiline, Lesvos, Greece, September 17-22, 200