Neutrino oscillations and Lorentz Invariance Violation in a Finslerian Geometrical model

Neutrino oscillations are one of the first evidences of physics beyond the Standard Model (SM). Since Lorentz Invariance is a fundamental symmetry of the SM, recently also neutrino physics has been explored to verify the eventual modification of this symmetry and its potential magnitude. In this work we study the consequences of the introduction of Lorentz Invariance Violation (LIV) in the high energy neutrinos propagation and evaluate the impact of this eventual violation on the oscillation predictions. An effective theory explaining these physical effects is introduced via Modified Dispersion Relations. This approach, originally introduced by Coleman and Glashow, corresponds in our model to a modification of the special relativity geometry. Moreover, the generalization of this perspective leads to the introduction of a maximum attainable velocity which is specific of the particle. This can be formalized in Finsler geometry, a more general theory of space-time. In the present paper the impact of this kind of LIV on neutrino phenomenology is studied, in particular by analyzing the corrections introduced in neutrino oscillation probabilities for different values of neutrino energies and baselines of experimental interest. The possibility of further improving the present constraints on CPT-even LIV coefficients by means of our analysis is also discussed.Comment: Accepted for publication with minor revisions, will appear on European Physics Journal

Fast method for the determination of short-chain-length polyhydroxyalkanoates (scl-PHAs) in bacterial samples by In Vial-Thermolysis (IVT)

none8siA new method based on the GC–MS analysis of thermolysis products obtained by treating bacterial samples at a high temperature (above 270 C) has been developed. This method, here named “In-Vial- Thermolysis” (IVT), allowed for the simultaneous determination of short-chain-length polyhydrox- yalkanoates (scl-PHA) content and composition. The method was applied to both single strains and microbial mixed cultures (MMC) fed with different carbon sources. The IVT procedure provided similar analytical performances compared to previous Py-GC–MS and Py- GC-FID methods, suggesting a similar application for PHA quantitation in bacterial cells. Results from the IVT procedure and the traditional methanolysis method were compared; the correlation between the two datasets was fit for the purpose, giving a R2 of 0.975. In search of further simplification, the rationale of IVT was exploited for the development of a “field method” based on the titration of thermolyzed samples with sodium hydrogen carbonate to quantify PHA inside bacterial cells. The accuracy of the IVT method was fit for the purpose. These results lead to the possibility for the on-line measurement of PHA productivity. Moreover, they allow for the fast and inexpensive quantification/characterization of PHA for biotechnological process control, as well as investigation over various bacterial communities and/or feeding strategies.mixedF. Abbondanzi; G. Biscaro; G. Carvalho; L. Favaro; P. Lemos; M. Paglione; C. Samorì; C. TorriF. Abbondanzi; G. Biscaro; G. Carvalho; L. Favaro; P. Lemos; M. Paglione; C. Samorì; C. Torr

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Background Eribulin mesylate (E) is indicated for metastatic breast cancer patients previously treated with anthracycline and taxane. We argued that E could also benefit patients eligible for neoadjuvant chemotherapy. Methods Patients with primary triple negative breast cancer 2 cm received doxorubicin 60 mg/m2 and paclitaxel 200 mg/m2 x 4 cycles (AT) followed by E 1.4 mg/m2 x 4 cycles. Primary endpoint was pathological complete response (pCR) rate; secondary and explorative endpoints included clinical/metabolic response rates and safety, and biomarker analysis, respectively. Using a two-stage Simon design, 43 patients were to be included provided that 4 of 13 patients had achieved pCR in the first stage of the study. Results In stage I of the study 13 women were enrolled, median age 43 years, tumor size 2–5 cm in 9/13 (69%), positive nodal status in 8/13 (61%). Main grade 3 adverse event was neutropenia (related to AT and E in 4 and 2 cases, respectively). AT followed by E induced clinical complete + partial responses in 11/13 patients (85%), pCR in 3/13 (23%). Median measurements of maximum standardized uptake value (SUVmax) resulted 13, 3, and 1.9 at baseline, after AT and E, respectively. Complete metabolic response (CMR) occurred after AT and after E in 2 and 3 cases, respectively. Notably, 2 of the 5 (40%) patients with CMR achieved pCR at surgery. Immunostaining of paired pre-/post-treatment tumor specimens showed a reduction of β-catenin, CyclinD1, Zeb-1, and c-myc expression, in the absence of N-cadherin modulation. The study was interrupted at stage I due to the lack of the required patients with pCR. Conclusions Despite the early study closure, preoperative E following AT showed clinical and biological activity in triple negative breast cancer patients. Furthermore, the modulation of β-catenin pathway core proteins, supposedly outside the domain of epithelial–mesenchymal transition, claims for further investigation. Trial registration EU Clinical Trial Register, EudraCT number 2012-004956-12

Corrigendum to “Pollen-based paleoenvironmental and paleoclimatic change at Lake Ohrid (south-eastern Europe) during the past 500 ka” published in Biogeosciences, 13, 1423–1437, 2016

In this corrigendum we report an updated pollen record from the Lake Ohrid DEEP site spanning the past 500 ka whereby we have reprocessed and re-analyzed 104 samples affected by chemical procedure problems that occurred in one palynological laboratory. Firstly, these samples were affected by the use of wrong containers, causing in- adequate settling of particles at the set centrifuging speed. Secondly, HCl and HF treatments were combined without the prescribed intermediate centrifuging and decanting steps. The inaccuracy in the protocol resulted in the loss of smaller pollen grains and in the overrepresentation of bisaccate ones in most of the re-analyzed samples. We therefore provide an updated set of figures with the new data and have revised the description of the results, discussion and conclusions re- ported in Sadori et al. (2016) where necessary. We stress that the majority of the original results and conclusions remain valid, while the records’ reliability and resolution have improved as 12 samples that had been omitted in the original study because of low count sums are now included in the revised dataset (Sadori et al., 2018)

The potential of permanent gullies in Europe as geomorphosites

Geotourism is a useful way to educate societies in the field of geomorphology and natural hazards. Geosites, including geomorphosites, represent the basis for the development of this type of tourism. This study describes twelve representative gully regions within nine European countries. The characteristics of 42 permanent gullies, gully systems and badland landscapes are presented and a geotouristic assessment of these gullies was made, based on scientific, educational, functional and touristic indicators. This assessment demonstrates a large difference between the selected gully sites, particularly with regard to functional and tourist values. The geotouristic potential of gullies is the highest in Italy and Spain and the lowest in Romania and Latvia. In some countries, permanent gullies are not regarded as geotouristic attractions at all, while in others they constitute a significant element of their tourism development strategy. Based on the analysis of scientific values of the gully sites, educational lessons to be learned were identified that are mainly related to i) gullies as a geological window, ii) present-day geomorphological processes, and iii) stages of historical gully erosion reflecting past human-environment interactions. These must be part of a broader strategy for the development of geotourism in gully regions. Gullies are potential geosites within existing or planned geoparks. Values of gullies for other forms of tourism (active, cultural, nature), should be also emphasized

M2-Branes and Fano 3-folds

A class of supersymmetric gauge theories arising from M2-branes probing Calabi-Yau 4-folds which are cones over smooth toric Fano 3-folds is investigated. For each model, the toric data of the mesonic moduli space is derived using the forward algorithm. The generators of the mesonic moduli space are determined using Hilbert series. The spectrum of scaling dimensions for chiral operators is computed.Comment: 128 pages, 39 figures, 42 table

Effects of early dark energy on strong cluster lensing

We use the semi-analytic method developed by Fedeli et al. for computing strong-lensing optical depths to study the statistics of gravitational arcs in four dark-energy cosmologies. Specifically, we focus on models with early dark energy and compare them to more conventional models. Merger trees are constructed for the cluster population because strong cluster lensing is amplified by factors of two to three during mergers. We find that the optical depth for gravitational arcs in the early dark-energy models is increased by up to a factor of about 3 compared to the other models because of the modified dynamics of cluster formation. In particular, the probability for gravitational arcs in high-redshift clusters is considerably increased, which may offer an explanation for the unexpectedly high lensing efficiency of distant clusters.Comment: 10 pages, 9 figures, accepted for publication on A&

The strongest gravitational lenses: I. The statistical impact of cluster mergers

For more than a decade now, it has been controversial whether or not the high rate of giant gravitational arcs and the largest observed Einstein radii are consistent with the standard cosmological model. Recent studies indicate that mergers provide an efficient mechanism to substantially increase the strong-lensing efficiency of individual clusters. Based on purely semi-analytic methods, we investigated the statistical impact of cluster mergers on the distribution of the largest Einstein radii and the optical depth for giant gravitational arcs of selected cluster samples. Analysing representative all-sky realizations of clusters at redshifts z < 1 and assuming a constant source redshift of z_s = 2.0, we find that mergers increase the number of Einstein radii above 10 arcsec (20 arcsec) by ~ 35 % (~ 55 %). Exploiting the tight correlation between Einstein radii and lensing cross sections, we infer that the optical depth for giant gravitational arcs with a length-to-width ratio > 7.5 of those clusters with Einstein radii above 10 arcsec (20 arcsec) increases by ~ 45 % (85 %). Our findings suggest that cluster mergers significantly influence in particular the statistical lensing properties of the strongest gravitational lenses. We conclude that semi-analytic studies must inevitably take these events into account before questioning the standard cosmological model on the basis of the largest observed Einstein radii and the statistics of giant gravitational arcs.Comment: 23 pages, 18 figures; accepted for publication in Astronomy and Astrophysics; v2: minor corrections (added clarifying comments; added Fig. 19) to match the accepted versio

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels

Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these parasites. As a model for understanding the co-ordination of these genomes, we have examined the regulation and mitochondrial import of a nuclear-encoded component of the cytochrome oxidase complex, cytochrome oxidase subunit VI (COXVI). By generating transgenic trypanosomes expressing intact or mutant forms of this protein, we demonstrate that COXVI is not imported using a conventional cleaved presequence and show that sequences at the N-terminus of the protein are necessary for correct mitochondrial sorting. Analyses of endogenous and transgenic COXVI mRNA and protein expression in parasites undergoing developmental stage differentiation demonstrates a temporal order of control involving regulation in the abundance of, first, mRNA and then protein. This represents the first dissection of the regulation and import of a nuclear-encoded protein into the cytochrome oxidase complex in these organisms, which were among the earliest eukaryotes to possess a mitochondrion