Perfil cognitivo asociado al trastorno por estrés postraumático en víctimas de violencia armada

ABSTRACT: to determine the cognitiveprofile associated to the posttraumatic stress disorder (PTSD) in victims of armed violence in the state of Chocó - Colombia. Participants: 40 adults (70% women and 30% men). The instruments used were: M.I.N.I, CCE-TP and EEC-M. Procedure: A comparative analysis between groups was made, distributed as follows: group 1: exposed to violence with PTSD, n=15, and group 2: exposed to violence without PTSD n=25. Findings: 37% of participants presented PTSD. Significant differences were found between groups, with higher punctuations in the mean in group 1 in schizoid beliefs (p=.007; means 11.5 vs. 7.83) and professional support (p=.003; means 20.5 vs. 12.7), and lower punctuations in narcissistic beliefs (p=.001; means 7.8 vs. 10.46), religion (p=.002; means 28.12 vs. 35.8) and expression coping difficulty (p=.034; means 13.6 vs. 15.5). Conclusions: the cognitive profile associated to PTSD was characterized by affective distancing from others, search for professional support, low self-esteem, minor strategies related with religion and inhibition in expressing coping difficulties.RESUMEN: establecer el perfil cognitivo asociado al trastorno por estrés postraumático (TEPT) en víctimas de violencia armada en el departamento del Chocó - Colombia. Participantes: 40 adultos (70% mujeres y 30% hombres). Instrumentos: M.I.N.I., CCE-TP y EEC-M. Procedimiento: análisis comparativo entre grupos: grupo 1: expuestos con TEPT, n=15 y grupo 2: expuestos sin TEPT, n=25. Resultados: se encontraron diferencias significativas con puntuaciones mayores en la media estadística en el G1 en los esquemas referentes al trastorno de la personalidad esquizoide (p=.007; medias 11.5 vs. 7.83) y en la estrategia de afrontamiento Apoyo profesional (p=.003; medias 20.5 vs. 12.7), y puntuaciones inferiores en esquemas referentes al trastorno de la personalidad narcisistas (p=.001; medias 7.8 vs. 10.46), y las estrategias de afrontamiento del estrés Religión (p=.002; medias 28.12 vs. 35.8) y Expresión de la dificultad de afrontamiento (p=.034; medias 13.6 vs. 15.5). Conclusiones: el perfil cognitivo asociado al TEPT se caracterizó por distanciamiento afectivo hacia los otros, búsqueda del apoyo profesional, baja autoestima, menores estrategias relacionadas con la religión e inhibición para la expresión de las dificultades de afrontamiento

Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles

pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.Mas Font, N.; Galiana, I.; Hurtado, S.; Mondragón Martínez, L.; Bernardos Bau, A.; Sancenón Galarza, F.; Marcos Martínez, MD.... (2014). Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles. International Journal of Nanomedicine. 9:2597-2606. doi:10.2147/IJN.S59654S25972606

Diagnosis of Genetic White Matter Disorders by Singleton Whole-Exome and Genome Sequencing Using Interactome-Driven Prioritization

Background and Objectives Genetic white matter disorders (GWMD) are of heterogeneous origin, with >100 causal genes identified to date. Classic targeted approaches achieve a molecular diagnosis in only half of all patients. We aimed to determine the clinical utility of singleton whole-exome sequencing and whole-genome sequencing (sWES-WGS) interpreted with a phenotype- and interactome-driven prioritization algorithm to diagnose GWMD while identifying novel phenotypes and candidate genes. Methods A case series of patients of all ages with undiagnosed GWMD despite extensive standard-of-care paraclinical studies were recruited between April 2017 and December 2019 in a collaborative study at the Bellvitge Biomedical Research Institute (IDIBELL) and neurology units of tertiary Spanish hospitals. We ran sWES and WGS and applied our interactome-prioritization algorithm based on the network expansion of a seed group of GWMD-related genes derived from the Human Phenotype Ontology terms of each patient. Results We evaluated 126 patients (101 children and 25 adults) with ages ranging from 1 month to 74 years. We obtained a first molecular diagnosis by singleton WES in 59% of cases, which increased to 68% after annual reanalysis, and reached 72% after WGS was performed in 16 of the remaining negative cases. We identified variants in 57 different genes among 91 diagnosed cases, with the most frequent being RNASEH2B, EIF2B5, POLR3A, and PLP1, and a dual diagnosis underlying complex phenotypes in 6 families, underscoring the importance of genomic analysis to solve these cases. We discovered 9 candidate genes causing novel diseases and propose additional putative novel candidate genes for yet-to-be discovered GWMD. Discussion Our strategy enables a high diagnostic yield and is a good alternative to trio WES/WGS for GWMD. It shortens the time to diagnosis compared to the classical targeted approach, thus optimizing appropriate management. Furthermore, the interactome-driven prioritization pipeline enables the discovery of novel disease-causing genes and phenotypes, and predicts novel putative candidate genes, shedding light on etiopathogenic mechanisms that are pivotal for myelin generation and maintenance

ClinPrior: an algorithm for diagnosis and novel gene discovery by network-based prioritization

BackgroundWhole-exome sequencing (WES) and whole-genome sequencing (WGS) have become indispensable tools to solve rare Mendelian genetic conditions. Nevertheless, there is still an urgent need for sensitive, fast algorithms to maximise WES/WGS diagnostic yield in rare disease patients. Most tools devoted to this aim take advantage of patient phenotype information for prioritization of genomic data, although are often limited by incomplete gene-phenotype knowledge stored in biomedical databases and a lack of proper benchmarking on real-world patient cohorts.MethodsWe developed ClinPrior, a novel method for the analysis of WES/WGS data that ranks candidate causal variants based on the patient's standardized phenotypic features (in Human Phenotype Ontology (HPO) terms). The algorithm propagates the data through an interactome network-based prioritization approach. This algorithm was thoroughly benchmarked using a synthetic patient cohort and was subsequently tested on a heterogeneous prospective, real-world series of 135 families affected by hereditary spastic paraplegia (HSP) and/or cerebellar ataxia (CA).ResultsClinPrior successfully identified causative variants achieving a final positive diagnostic yield of 70% in our real-world cohort. This includes 10 novel candidate genes not previously associated with disease, 7 of which were functionally validated within this project. We used the knowledge generated by ClinPrior to create a specific interactome for HSP/CA disorders thus enabling future diagnoses as well as the discovery of novel disease genes.ConclusionsClinPrior is an algorithm that uses standardized phenotype information and interactome data to improve clinical genomic diagnosis. It helps in identifying atypical cases and efficiently predicts novel disease-causing genes. This leads to increasing diagnostic yield, shortening of the diagnostic Odysseys and advancing our understanding of human illnesses

Impacto de la gestión virtual por competencias que brinda la empresa Metrik Solutions S.A., a los colaboradores del Hospital Universitario de San Vicente Fundación, en el periodo comprendido entre el año 2008 y 2012

Ubicación en Biblioteca USB Medellín (San Benito): CD-2646t .-- Grupo de Investigación Interdisciplinario para el Desarrollo e Investigación Continua en Psicología del Trabajo y las Organizaciones PSICORGEl siguiente trabajo parte de la necesidad de la empresa Metrik Solutions como proveedor de un sistema virtual de valoración y desarrollo de Competencias y de su cliente, el Hospital Universitario de San Vicente Fundación, con el fin de determinar el impacto que el proceso virtual de Gestión por Competencias, ha tenido en sus colaboradores, luego de 5 años de estar implementando este proceso. Para determinar el impacto, se realizaron dos encuestas, una enfocada a las Jefes de Enfermería y otra a las Auxiliares de Enfermería. Fueron encuestadas 44 jefes y 311 Auxiliares. Además se compararon resultados en 294 colaboradores entre personal asistencial y administrativo que participaron en dos mediciones (2008 y 2010) y que realizaron en el 2009 el proceso de desarrollo virtual de Competencias.Especialización en convenio con la Católica del Norte Fundación Universitari

Selektiver, hoch empfindlicher und schneller Nachweis genomischer DNA mit gesteuerten materialien am beispiel von Mycoplasma

[DE] Mit DNA verschlossene und mit Farbstoff beladene mesoporöse Siliciumdioxid-Nanopartikel wurden zum Nachweis von Mycoplasma bis zu einer Nachweisgrenze von ca. 70 genomischen DNA-Kopien pro mu-L in real kontaminierten Zellkulturmedien ohne die Hilfe von PCR-Techniken eingesetzt.Diese Arbeit wurde durch die Spanische Regierung (MAT2009-14564-C04-01 und SAF2010 15512) und die Generalitat Valenciana (PROMETEO/2009/016 und 2010/005) unterstützt. E.C. dankt dem Spanischen Bildungsministerium für ein StipendiumCliment Terol, E.; Mondragón Martínez, L.; Martínez Mañez, R.; Sancenón Galarza, F.; Marcos Martínez, MD.; Murguía Ibáñez, JR.; Amoros Del Toro, P.... (2013). Selektiver, hoch empfindlicher und schneller Nachweis genomischer DNA mit gesteuerten materialien am beispiel von Mycoplasma. Angewandte Chemie. 125(34):9106-9110. https://doi.org/10.1002/ange.201302954S9106911012534Goodman, R. P. (2005). Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication. 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Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of Guests. Journal of the American Chemical Society, 131(46), 16614-16615. doi:10.1021/ja9061085Bernardos, A., Mondragón, L., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., … Amorós, P. (2010). Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with «Saccharides». ACS Nano, 4(11), 6353-6368. doi:10.1021/nn101499dWang, C., Li, Z., Cao, D., Zhao, Y.-L., Gaines, J. W., Bozdemir, O. A., … Stoddart, J. F. (2012). Stimulated Release of Size-Selected Cargos in Succession from Mesoporous Silica Nanoparticles. Angewandte Chemie, 124(22), 5556-5561. doi:10.1002/ange.201107960Wang, C., Li, Z., Cao, D., Zhao, Y.-L., Gaines, J. W., Bozdemir, O. A., … Stoddart, J. F. (2012). Stimulated Release of Size-Selected Cargos in Succession from Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 51(22), 5460-5465. doi:10.1002/anie.201107960Coll, C., Bernardos, A., Martínez-Máñez, R., & Sancenón, F. (2012). Gated Silica Mesoporous Supports for Controlled Release and Signaling Applications. Accounts of Chemical Research, 46(2), 339-349. doi:10.1021/ar3001469Luo, Z., Cai, K., Hu, Y., Zhao, L., Liu, P., Duan, L., & Yang, W. (2010). Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery. Angewandte Chemie, 123(3), 666-669. doi:10.1002/ange.201005061Luo, Z., Cai, K., Hu, Y., Zhao, L., Liu, P., Duan, L., & Yang, W. (2010). Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery. Angewandte Chemie International Edition, 50(3), 640-643. doi:10.1002/anie.201005061Porta, F., Lamers, G. E. M., Zink, J. I., & Kros, A. (2011). Peptide modified mesoporous silica nanocontainers. Physical Chemistry Chemical Physics, 13(21), 9982. doi:10.1039/c0cp02959aPopat, A., Ross, B. P., Liu, J., Jambhrunkar, S., Kleitz, F., & Qiao, S. Z. (2012). Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres. Angewandte Chemie, 124(50), 12654-12657. doi:10.1002/ange.201206416Popat, A., Ross, B. P., Liu, J., Jambhrunkar, S., Kleitz, F., & Qiao, S. Z. (2012). Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres. Angewandte Chemie International Edition, 51(50), 12486-12489. doi:10.1002/anie.201206416Climent, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Soto, J., Maquieira, A., & Amorós, P. (2010). Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie, 122(40), 7439-7441. doi:10.1002/ange.201001847Climent, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Soto, J., Maquieira, A., & Amorós, P. (2010). Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 49(40), 7281-7283. doi:10.1002/anie.201001847Schlossbauer, A., Warncke, S., Gramlich, P. M. E., Kecht, J., Manetto, A., Carell, T., & Bein, T. (2010). Ein programmierbares, DNA-basiertes molekulares Ventil für kolloidales, mesoporöses Siliciumoxid. Angewandte Chemie, 122(28), 4842-4845. doi:10.1002/ange.201000827Schlossbauer, A., Warncke, S., Gramlich, P. M. E., Kecht, J., Manetto, A., Carell, T., & Bein, T. (2010). A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica. Angewandte Chemie International Edition, 49(28), 4734-4737. doi:10.1002/anie.201000827Zhu, C.-L., Lu, C.-H., Song, X.-Y., Yang, H.-H., & Wang, X.-R. (2011). Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate. Journal of the American Chemical Society, 133(5), 1278-1281. doi:10.1021/ja110094gÖzalp, V. C., & Schäfer, T. (2011). Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery. Chemistry - A European Journal, 17(36), 9893-9896. doi:10.1002/chem.201101403Ruiz-Hernández, E., Baeza, A., & Vallet-Regí, M. (2011). Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates. ACS Nano, 5(2), 1259-1266. doi:10.1021/nn1029229Zhang, Y., Yuan, Q., Chen, T., Zhang, X., Chen, Y., & Tan, W. (2012). DNA-Capped Mesoporous Silica Nanoparticles as an Ion-Responsive Release System to Determine the Presence of Mercury in Aqueous Solutions. Analytical Chemistry, 84(4), 1956-1962. doi:10.1021/ac202993pHe, D., He, X., Wang, K., Cao, J., & Zhao, Y. (2012). A Photon-Fueled Gate-Like Delivery System Using i-Motif DNA Functionalized Mesoporous Silica Nanoparticles. Advanced Functional Materials, 22(22), 4704-4710. doi:10.1002/adfm.201201343Chen, Z., Li, Z., Lin, Y., Yin, M., Ren, J., & Qu, X. (2013). Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery. 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The Determination of Methylmercury in Real Samples Using Organically Capped Mesoporous Inorganic Materials Capable of Signal Amplification. Angewandte Chemie, 121(45), 8671-8674. doi:10.1002/ange.200904243Climent, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., Rurack, K., & Amorós, P. (2009). The Determination of Methylmercury in Real Samples Using Organically Capped Mesoporous Inorganic Materials Capable of Signal Amplification. Angewandte Chemie International Edition, 48(45), 8519-8522. doi:10.1002/anie.200904243Choi, Y. L., Jaworski, J., Seo, M. L., Lee, S. J., & Jung, J. H. (2011). Controlled release using mesoporous silica nanoparticles functionalized with 18-crown-6 derivative. Journal of Materials Chemistry, 21(22), 7882. doi:10.1039/c1jm11334hCui, Y., Dong, H., Cai, X., Wang, D., & Li, Y. (2012). Mesoporous Silica Nanoparticles Capped with Disulfide-Linked PEG Gatekeepers for Glutathione-Mediated Controlled Release. 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Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups

[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. In the first step, the pores of an inorganic MCM-41 support (in the form of nanoparticles) were loaded with [Ru(bipy) 3]Cl 2 complex, and then, in the second step, the pore outlets were functionalized with ester glycol moieties that acted as molecular caps. In the absence of an enzyme, release of the complex from aqueous suspensions of S1 at pH 8.0 is inhibited due to the steric hindrance imposed by the bulky ester glycol moieties. Upon addition of esterase enzyme, delivery of the ruthenium complex was observed due to enzymatic hydrolysis of the ester bond in the anchored ester glycol derivative, inducing the release of oligo(ethylene glycol) fragments. Hydrolysis of the ester bond results in size reduction of the appended group, therefore allowing delivery of the entrapped cargo. The S1 nanoparticles were not toxic for cells, as demonstrated by cell viability assays with HeLa and MCF-7 cell lines, and were found to be associated with lysosomes, as shown by confocal microscopy. However, when S1 nanoparticles were filled with the cytotoxic drug camptothecin (S1-CPT), S1-CPT-treated cells undergo cell death as a result of S1-CPT cell internalization and subsequent cellular enzyme-mediated hydrolysis and aperture of the molecular gate that induced the release of the camptothecin cargo. These findings point to a possible therapeutic application of these nanoparticles. © 2012 American Chemical Society.We thank the Spanish Government (Projects MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valencia (Project PROMETEO/2009/016) for support. A.A. and L.M. thank the Generalitat Valenciana for their Santiago Grisolia fellowship and VALI+D postdoctoral contract, respectively. We thank Eva Maria Lafuente Villarreal from the confocal microscopy service from CIPF for technical support.Agostini, A.; Mondragón Martínez, L.; Pascual Vidal, L.; Aznar Gimeno, E.; Coll Merino, MC.; Martínez Mañez, R.; Sancenón Galarza, F.... (2012). Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups. Langmuir. 28:14766-14776. https://doi.org/10.1021/la303161eS14766147762

Leaf habit affects the distribution of drought sensitivity but not water transport efficiency in the tropics

<p>Considering the global intensification of aridity in tropical biomes due to climate change, we need to understand what shapes the distribution of drought sensitivity in tropical plants. We conducted a pantropical data synthesis representing 1117 species to test whether xylem-specific hydraulic conductivity (K<sub>S</sub>), water potential at leaf turgor loss (Ψ<sub>TLP</sub>), and water potential at 50% loss of K<sub>S</sub> (ΨP50) varied along climate gradients. The Ψ<sub>TLP</sub> and ΨP<sub>50</sub> increased with climatic moisture only for evergreen species, but K<sub>S</sub> did not. Species with high Ψ<sub>TLP</sub> and Ψ<sub>P50</sub> values were associated with both dry and wet environments. However, drought-deciduous species showed high Ψ<sub>TLP</sub> and ΨP<sub>50</sub> values regardless of water availability whereas evergreen species only in wet environments. All three traits showed a weak phylogenetic signal and a short half-life. These results suggest that environmental controls on trait variance, which in turn is modulated by leaf habit along climatic moisture gradients in the tropics.</p><p>Funding provided by: University of Minnesota<br>Crossref Funder Registry ID: https://ror.org/017zqws13<br>Award Number: Doctoral Dissertation Fellowship to GVG</p><p>Funding provided by: Interdisciplinary Center for the Study of Global Change, University of Minnesota*<br>Crossref Funder Registry ID: <br>Award Number: ICGC scholar fellowship to GVG</p><p>Funding provided by: National Science Foundation<br>Crossref Funder Registry ID: https://ror.org/021nxhr62<br>Award Number: DEB-1753810</p><p>Funding provided by: United States Department of Energy<br>Crossref Funder Registry ID: https://ror.org/01bj3aw27<br>Award Number: DE-SC0020344</p&gt

Leaf habit affects the distribution of drought sensitivity but not water transport efficiency in the tropics

Considering the global intensification of aridity in tropical biomes due to climate change, we need to understand what shapes the distribution of drought sensitivity in tropical plants. We conducted a pantropical data synthesis representing 1117 species to test whether xylem-specific hydraulic conductivity (KS), water potential at leaf turgor loss (ΨTLP) and water potential at 50% loss of KS (ΨP50) varied along climate gradients. The ΨTLP and ΨP50 increased with climatic moisture only for evergreen species, but KS did not. Species with high ΨTLP and ΨP50 values were associated with both dry and wet environments. However, drought-deciduous species showed high ΨTLP and ΨP50 values regardless of water availability, whereas evergreen species only in wet environments. All three traits showed a weak phylogenetic signal and a short half-life. These results suggest strong environmental controls on trait variance, which in turn is modulated by leaf habit along climatic moisture gradients in the tropics.ISSN:1461-023XISSN:1461-024

Carta de Psicología No. 54

El capital psicológico y el engagement en el trabajo: revisión teórica / Angie Lorena Escobar Giraldo, Carol Valentina Londoño Pantoja y Laura Valentina Rojas Montealegre. Relación entre clima organizacional y engagement desde una mirada del modelo de Avalores en competencia / Karol Sunev Encinales y Angie Julieth Riaño. Relación de los estilos de liderazgo transformacional y transaccional en el clima organizacional: una revisión de la literatura / Leidy Tatiana Javela Avila y Angie Johana Maldonado Bejarano. El bienestar organizacional: una revisión teórica desde lo hedónico y lo eudaimónico / Astrid Carolina Rodríguez Prieto, Daniela Sthefania Pérez Arango y Laura Jimena Mondragón. Estudio comparativo de la normatividad en torno al acoso laboral / Magda Cardozo y Paola Andrea Rubiano. Análisis del estilo lingüístico prosocial y altruista / Luis Fernando Benedetti, Luisa Fernanda Martínez y Juan Camilo Carvajal-Builes. Violencia intrafamiliar como una problemática juvenil en Colombia / María José Saavedra Vargas y Daniela Barbosa Ardila. Análisis psicológico de la trata de personas con fines / María José Saavedra Vargas y Daniela Barbosa Ardila. Sobre el reciclaje: su debida ejecución y su importancia para el medio ambiente / María Camila Londoño Fernández y Camilo Jesús Alejandro Vivas Becerra. Estrategias de aprendizaje espacial con apoyo virtual en hombres y mujeres desde una visión evolutiva / Natalia Pareja Henao, J. Jacobo Pinto Galindo, Esteban Ayala Vargas, Ivonne Edith Alejo Castañeda y Tatiana Manrique Zuluaga. La música favorece la atención en niños / Manuela María del Rocío Pinzón, Laura Geraldine Cortés, Tatiana Manrique Zuluaga e Ivonne Edith Alejo Castañeda. La autorregulación y la autonomía, un abordaje desde la psicología del desarrollo infantil / Diana Paola Pardo Galvis, Lizeth Tatiana Herrera Toro y Julieth María Ospina Osorio. Importancia e incidencia de la vocación y la profesión en el sector social LGBTIQ / Lieen D. Guevara G. Sistema de Responsabilidad Penal para Niños o Adolescentes (SRPA) en Colombia / Diana Paola Pardo Galvis, Lizeth Tatiana Herrera Toro y Erika Natalia Algarra Martínez. Breve revisión de la importancia del desarrollo de los niños, niñas y adolescentes (NNA) y sus derechos de participación dentro del contexto sociopolítico / Daniela Barbosa Ardila y María José Saavedra Vargas. “Verdad y mentira”: conceptos relacionados con el ejercicio de la psicología del testimonio / María Paula Castro y Juan Camilo Carvajal-Builes. Comportamientos de violencia conyugal naturalizados por jóvenes universitarios de Bogotá / Daniela Alejandra Martínez Sarmiento, María Fernanda Nieto Ramírez, Laura Andrea Torres Pulido, María Emily Triana Jiménez y Darío León Rincó