Ruteo multicast mediante algoritmos genéticos

Los sistemas o redes de comunicación construidos teniendo en cuenta el modelo de referencia OSI (Open Systems lnterconection) o la arquitectura de Internet, fueron diseñados para soportar servicios o comunicaciones punto a punto, donde la información fluye entre dos usuarios únicamente. Uno de los tópicos en el cual las redes de computadoras actuales están poniendo mucho énfasis, proviene de las aplicaciones multicast o de grupo. Estas involucran más de dos usuarios (estos usuarios definen el grupo multicast) los cuales desean intercambiar información. Recientes avances en los medios de transmisión como la fibra óptica y en los equipos como ruutas o switch es, han logrado velocidades del orden de Gbps (Giga Bits por Segundo). Lo anterior sumado al trabajo en las nuevas tecnologías para almacenar datos, audio y video, han permitido el desarrollo de nuevas aplicaciones multimediales y/o servicios de tiempo real distribuidos, como por ejemplo Educación a Distancia, Video-Conferencia, entre otros, donde la red debería ser capaz de proveer el servicio de comunicación multicast.Eje: Sistemas inteligentes. Metaheurísticas.Red de Universidades con Carreras en Informática (RedUNCI

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Postoperative outcomes in oesophagectomy with trainee involvement

BACKGROUND: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. METHODS: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. RESULTS: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). CONCLUSION: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery

High Transmission Gain Antenna on SOI Substrate for VLSI wireless Interconnects

International audienc

Design and characterization of dipoles antenna on SOI-substrate for intra chip wireless interconnections

International audienc