Türkiye'de koroner yoğun bakım ünitelerindeki hastane içi mortalite (MORCOR-TURK) çalışmasında hasta temel karakteristikleri ve öngördürücüleri

OBJECTIVE: The MORtality in CORonary Care Units in Türkiye (MORCOR-TURK) trial is a national registry evaluating predictors and rates of in-hospital mortality in coronary care unit (CCU) patients in Türkiye. This report describes the baseline demographic characteristics of patients recruited for the MORCOR-TURK trial. METHODS: The study is a multicenter, cross-sectional, prospective national registry that included 50 centers capable of 24-hour CCU service, selected from all seven geographic regions of Türkiye. All consecutive patients admitted to CCUs with cardiovascular emergencies between September 1-30, 2022, were prospectively enrolled. Baseline demographic characteristics, admission diagnoses, laboratory data, and cardiovascular risk factors were recorded. RESULTS: A total of 3,157 patients with a mean age of 65 years (range: 56-73) and 2,087 (66.1%) males were included in the analysis. Patients with arterial hypertension [1,864 patients (59%)], diabetes mellitus (DM) [1,184 (37.5%)], hyperlipidemia [1,120 (35.5%)], and smoking [1,093 (34.6%)] were noted. Non-ST elevation myocardial infarction (NSTEMI) was the leading cause of admission [1,187 patients (37.6%)], followed by ST elevation myocardial infarction (STEMI) in 742 patients (23.5%). Other frequent diagnoses included decompensated heart failure (HF) [339 patients (10.7%)] and arrhythmia [272 patients (8.6%)], respectively. Atrial fibrillation (AF) was the most common pathological rhythm [442 patients (14%)], and chest pain was the most common primary complaint [2,173 patients (68.8%)]. CONCLUSION: The most common admission diagnosis was acute coronary syndrome (ACS), particularly NSTEMI. Hypertension and DM were found to be the two leading risk factors, and AF was the most commonly seen pathological rhythm in all hospitalized patients. These findings may be useful in understanding the characteristics of patients admitted to CCUs and thus in taking precautions to decrease CCU admissions

The ectoparasite mites spinturnicid and macronysid (acari: mesostigmata, spinturnicidae, macronyssidae) of the Akdeniz region bats

Bu çalışma, 2008-2011 yılları arasında Akdeniz Bölgesinden yakalanan 1079 yarasa örneğinden elde edilen 1402 akar örneğine dayanmaktadır. Çalışma neticesinde incelenen 24 farklı türdeki yarasalardan, Spinturnicidae familyasına ait Eyndhovenia euryalis euryalis, E. euryalis ahi, Spinturnix acuminatus, S. myoti, S. psi, S. kolenatii, S. bakeri, S. marginatus, S. helvetiae, S. mystacinus, S. verutus, Paraperiglischrus rhinolophinus, Ancystropus zeleborii, Meristaspis lateralis ve Macronyssidae familyasına ait Steatonyssus noctulus, S. periblepharus, S. spinosus, S. sudanensis, Ornithonyssus desultorius, Ichoronyssus scutatus, Macronyssus aristippe, M. flavus, M. granulosus, M. kolenatii, M. rhinolophi, akar türleri tespit edilmiştir. Eyndhovenia euryalis euryalis, E. euryalis ahi, Spinturnix kolenatii, S. bakeri, S. emarginatus, S. helvetiae, S. mystacinus, S. verutus, Paraperiglischrus rhinolophinus, Ancystropus zeleborii, Meristaspis lateralis ve Macronyssidae familyasına ait Steatonyssus noctulus, S. spinosus, S. sudanensis, Ornithonyssus desultorius, Ichoronyssus scutatus, Macronyssus aristippe, M. flavus, M. granulosus, M. kolenatii, M. rhinolophi türleri Türkiye akar faunası için yeni tür kaydıdır. Ayrıca Meristaspis, Paraperiglischrus, Ornthonyssus ve Ichoronyssus cins düzeyinde ilk defa bu çalışmada tespit edilmiştir. Tespit edilen türlerin morfolojik özellikleri detaylı olarak verilmiştir.This study is based on 1402 Acari specimens from 1079 bat specimens collected between the years 2008 and 2011. As a result of the study, Eyndhovenia euryalis euryalis, E. euryalis ahi, Spinturnix acuminatus, S. myoti, S. psi, S. kolenatii, S. bakeri, S. emarginatus, S. helvetiae, S. mystacinus, S. verutus, Paraperiglischrus rhinolophinus, Ancystropus zeleborii, Meristaspis lateralis and family of Macronyssidae Steatonyssus noctulus, S. periblepharus, S. spinosus, S. sudanensis, Ornithonyssus desultorius, Ichoronyssus scutatus, Macronyssus aristippe, M. flavus, M. granulosus, M. kolenatii, M. rhinolophi, species were determined. Of these species Eyndhovenia euryalis euryalis, E. euryalis ahi, Spinturnix kolenatii, S. bakeri, S. emarginatus, S. helvetiae, S. mystacinus, S. verutus, Paraperiglischrus rhinolophinus, Ancystropus zeleborii, Meristaspis lateralis and family of Macronyssidae Steatonyssus noctulus, S. spinosus, S. sudanensis, Ornithonyssus desultorius, Ichoronyssus scutatus, Macronyssus aristippe, M. flavus, M. granulosus, M. kolenatii, M. rhinolophi are new records for the Turkish acar fauna. In addition, Meristaspis, Paraperiglischrus, Ornthonyssus and Ichoronyssus genus level have been identified in this study for the first time Morphological features of the determined species were given in details

Contributions on the southern distribution of Vespertilio murinus Linnaeus, 1758 (Chiroptera: Vespertilionidae) from Türkiye

Vespertilio murinus Linnaeus, 1758, has a wide distribution from France to Japan, and from Iran in the south to Scandinavia and Russia in the north. The only records of the parti-coloured bat, Vespertilio murinus known from Turkey so far were based on subfossils, remains from owl pellets, and ultrasound recordings. We present the first records of live individuals from two Turkish provinces, Ardahan and Bayburt. Additionally, based on echolocation call records, its known distribution in the Anatolian Peninsula was proved to be wider. The global distribution of the species has been mapped by using ecological niche modelling. The results revealed that its distribution is highly influenced by precipitation dynamics. Although no cases of domestic cat predation on bats have previously been documented in Turkey, this paper also provides the first case study of V. murinus predated by a domestic cat in Ardahan, in November 2003. © 2022, Turkiye Klinikleri. All rights reserved

Investigating the Activity of Indole-2-on Derivative Src Kinase Inhibitors Against Chronic Myeloid Leukemia Cells

Background Src family tyrosine kinases play a potential role in Bcr-Abl-induced leukemogenesis. Src kinase inhibitors are reported as selective inhibitors of chronic myeloid leukemia. Objective Since Src kinase inhibitors have an inhibitive effect on chronic myeloid leukemia, indole derivatives (C-1, C-2, C-3) previously found as potent inhibitors of Src kinase were tested against chronic myeloid leukemia in this study. Methods Cell viability of K562 and R/K562 cells, antiproliferative and antioxidant effects, and inhibition profiles of Bcr-Abl kinase of indole derivatives were determined compared to dasatinib and imatinib. Results The results showed that compounds affected cell proliferation and decreased the levels of Bcr/Abl. These results confirmed that the antileukemic activity of compounds was related to Bcr/Abl expression. Docking studies also presented that compounds are inhibitors of both Src and Abl kinases. Calculation of drug-like properties showed that compounds could be potential drug candidates. Conclusion Among indole-2-on derivatives, previously identified as Src kinase inhibitors, C-2 has been discovered to be a strong anticancer drug that is active against susceptible and resistant K562 cell lines and induces apoptosis

Wildfire Susceptibility Mapping Using Five Boosting Machine Learning Algorithms: The Case Study of the Mediterranean Region of Turkey

Forest fires caused by different environmental and human factors are responsible for the extensive destruction of natural and economic resources. Modern machine learning techniques have become popular in developing very accurate and precise susceptibility maps of various natural disasters to help reduce the occurrence of such calamities. The present study has applied and tested multiple algorithms to map the areas susceptible to wildfire in the Mediterranean Region of Turkey. Besides, the performance of XGBoost, CatBoost, Gradient Boost, AdaBoost, and LightGBM methods for wildfire susceptibility mapping is also examined. The results have revealed the higher testing accuracy of CatBoost (95.47%) algorithm, followed by LightGBM (94.70%), XGBoost (88.8%), AdaBoost (86.0%), and GBM (84.48%) algorithms. Resultant wildfire susceptibility maps provide proper inventories for forest engineers, planners, and local governments for future policies regarding disaster management in Turkey

Effect of Sleep Quality on Hemodynamic Response to Exercise and Heart Rate Recovery in Apparently Healthy Individuals

Purpose: Poor sleep quality has an unfavorable impact on autonomic nervous system activity, especially that of the cardiovascular (CV) system. The heart rate (HR) and blood pressure (BP) at rest and during exercise, along with the heart rate recovery (HRR), were examined in poor sleepers and compared with individuals with good sleep quality. Methods: A total of 113 healthy individuals were enrolled to the study. All participants performed treadmill stress testing. Sleep quality of participants was assessed by using the Pittsburgh Sleep Quality Index (PSQI) questionnaire: 48 subjects were categorized as ‘poor sleepers’ (PSQI score > 6 points), and the rest were grouped as ‘good sleepers’. Results: The poor sleepers showed higher resting HR (

Türkiye’de nonvalvüler atriyum fibrilasyonlu hastalarda vitamin K antagonisti ve yeni oral antikoagülan kullanımı uygulamalarını değerlendirmek için epidemiyolojik çalışma - AFTER*-2 çalışması dizaynı

Amaç: Atriyum fibrilasyonu (AF) önlenebilir iskemik inmenin en sık nedenlerinden biri olup artmış kardiyovasküler morbidite ve mortaliteyle ilişkilidir. Ülkemizde yeni oral antikoagülan kullanım sıklığı, vitamin K antagonisti kullanan hastalarda Uluslararası Düzeltme Oranı’nın (INR) etkin düzeyde kalma oranı ve AF tedavi yönetimi ile ilgili büyük bir çalışma mevcut değildir. Bu çok merkezli çalışmada amacımız nonvalvüler AF hastalarında epidemiyolojik verilerin analizi, takibi ve değerlendirilmesidir. Çalışma planı: Kırk iki merkezden elektrokardiyografisinde en az bir defa AF atağı tespit edilmiş ardışık 4100 erişkin hasta çalışmaya alınacaktır. Romatizmal mitral darlığı ve protez kapak hastalığı olan AF hastaları çalışmaya alınmayacaktır. Hastalar birinci yılın sonunda majör kardiyak sonlanım noktaları (ölüm, geçici iskemik atak, inme, sistemik tromboembolizm, majör kanama ve hastane yatışı) açısından değerlendirilecektir. Bulgular: İlk sonuçlar Haziran 2015 yılında bekleniyor. Majör kardiyak sonlanım noktaları açısından veriler Ocak 2016’da elde edilecektir. Sonuç: AFTER-2 çalışması ile ülkemizdeki non-valvüler AF hastalarının oral antikoagülan tedavi kullanım sıklığı ve çeşidi, varfarin alan hastalarda etkin INR düzeylerinde kalma oranı ve benimsenen tedavi yönetimi belirlenecektir. Ayrıca, ülkemizde AF’li hastalarda majör istenmeyen olay sıklığı ve bu olayların bağımsız belirteçleri de ortaya çıkarılacaktır (AFTER-2 Study ClinicalTrials.gov number, NCT02354456). Anahtar Kelimeler: Antikoagülan ilaç; atriyum fibrilasyonu/epidemiyoloji; ilaç kullanımı; elektrokardiyografi; uluslararası düzeltme oranı; varfarin.Objectives: Atrial fibrillation (AF) is one of the most common causes opreventable ischemic stroke and is related to increased cardiovasculamorbidity and mortality. There is a lack of data in Turkey on the use onew oral anticoagulants (NOACs), and time in therapeutic INR range (TTR) in vitamin K antagonist users and AF management modalityIn this multi-center trial, we aimed to analyze, follow and evaluate the epidemiological data in non-valvular AF patients. Study design: Four thousand one hundred consecutive adulpatients from 42 centers with at least one AF attack identified on electrocardiography will be included in the study. Patients with rheumatic mitral valve stenosis and prosthetic valve disease will be excluded from the study. At the end of one year, the patients will be evaluated in terms of major cardiac end points (death, transient ischemic attack, strokesystemic thromboembolism, major bleeding and hospitalization). Results: First results are expected in June 2015. Data about majocardiovascular end-points will be available in January 2016. Conclusion: The rates and kind of oral anticoagulant use, TTR in vitamin K antagonist users and main management modality applied in non-valvular AF patients will be determined by AFTER-2 studyIn addition, the rate of major adverse events (MACEs) and the independent predictors of these MACEs will be detected (AFTER-2 Study ClinicalTrials.gov number, NCT02354456.)