Evaluating the Effectiveness of a Commercial Portable Air Purifier in Homes with Wood Burning Stoves: A Preliminary Study

Wood burning for residential heating is prevalent in the Rocky Mountain regions of the United States. Studies have shown that wood stoves can be a significant source of PM2.5 within homes. In this study, the effectiveness of an electrostatic filter portable air purifier was evaluated (1) in a home where a wood stove was the sole heat source and (2) in a home where a wood stove was used as a supplemental heat source. Particle count concentrations in six particle sizes and particle mass concentrations in two particle sizes were measured for ten 12-hour purifier on and ten purifier off trials in each home. Particle count concentrations were reduced by 61–85 percent. Similar reductions were observed in particle mass concentrations. These findings, although limited to one season, suggest that a portable air purifier may effectively reduce indoor particulate matter concentrations associated with wood combustion during home heating

Unprecedented springtime retreat of Antarctic sea ice in 2016

During austral spring 2016 Antarctic sea ice extent (SIE) decreased at a record rate of 75 x 10(3) km(2) d(-1), which was 46% faster than the mean rate and 18% faster than in any previous spring season during the satellite era. The decrease of sea ice area was also exceptional and 28% greater than the mean. Anomalous negative retreat occurred in all sectors of the Antarctic but was greatest in the Weddell and Ross Seas. Record negative SIE anomalies for the day of year were recorded from 3 November 2016 to 9 April 2017. Rapid ice retreat in the Weddell Sea took place in strong northerly flow after an early maximum ice extent in late August. Rapid ice retreat occurred in November in the Ross Sea when surface pressure was at a record high level, with the Southern Annular Mode at its most negative for that month since 1968

The impacts of El Niño on the observed sea ice budget of West Antarctica

We assess the impact of El Niño-induced wind changes on seasonal West Antarctic sea ice concentrations using reanalysis data and sea ice observations. A novel ice budget analysis reveals that in autumn a previously identified east-west dipole of sea ice concentration anomalies is formed by dynamic and thermodynamic processes in response to El Niño-generated circulation changes. The dipole features decreased (increased) concentration in the Ross Sea (Amundsen and Bellingshausen Seas). Thermodynamic processes and feedback make a substantial contribution to ice anomalies in all seasons. The eastward propagation of this anomaly is partly driven by mean sea ice drift rather than anomalous winds. Our results demonstrate that linkages between sea ice anomalies and atmospheric variability are highly nonlocal in space and time. Therefore, we assert that caution should be applied when interpreting the results of studies that attribute sea ice changes without accounting for such temporally and spatially remote linkages

Hydraulic & Design Parameters in Full-Scale Constructed Wetland & Treatment Units: Six Case Studies

The efficiency of pond and constructed wetland (CW) treatment systems, is influenced by the internal hydrodynamics and mixing interactions between water and aquatic vegetation. In order to contribute to current knowledge of how emergent real vegetation affects solute mixing, and on what the shape and size effects are on the mixing characteristics, an understanding and quantification of those physical processes and interactions was evaluated. This paper presents results from tracer tests conducted during 2015-2016 in six full-scale systems in the UK under different flow regimes, operational depths, shapes and sizes, and in-/outlet configurations. The aim is to quantify the hydraulic performance and mixing characteristics of the treatment units, and to investigate the effect of size and shape on the mixing processes. Relative comparison of outlet configuration, inflow conditions, and internal features between the six different treatment units showed variations in residence times of up to a factor of 3. A key outcome of this study, demonstrated that the width is a more important dimension for the efficiency of the unit compared to the depth. Results underlined the importance of investigating hydrodynamics and physics of flow in full-size units to enhance treatment efficiency and predictions of water quality models

Germline EPHB2 Receptor Variants in Familial Colorectal Cancer

Familial clustering of colorectal cancer occurs in 15–20% of cases, however recognized cancer syndromes explain only a small fraction of this disease. Thus, the genetic basis for the majority of hereditary colorectal cancer remains unknown. EPHB2 has recently been implicated as a candidate tumor suppressor gene in colorectal cancer. The aim of this study was to evaluate the contribution of EPHB2 to hereditary colorectal cancer. We screened for germline EPHB2 sequence variants in 116 population-based familial colorectal cancer cases by DNA sequencing. We then estimated the population frequencies and characterized the biological activities of the EPHB2 variants identified. Three novel nonsynonymous missense alterations were detected. Two of these variants (A438T and G787R) result in significant residue changes, while the third leads to a conservative substitution in the carboxy-terminal SAM domain (V945I). The former two variants were found once in the 116 cases, while the V945I variant was present in 2 cases. Genotyping of additional patients with colorectal cancer and control subjects revealed that A438T and G787R represent rare EPHB2 alleles. In vitro functional studies show that the G787R substitution, located in the kinase domain, causes impaired receptor kinase activity and is therefore pathogenic, whereas the A438T variant retains its receptor function and likely represents a neutral polymorphism. Tumor tissue from the G787R variant case manifested loss of heterozygosity, with loss of the wild-type allele, supporting a tumor suppressor role for EPHB2 in rare colorectal cancer cases. Rare germline EPHB2 variants may contribute to a small fraction of hereditary colorectal cancer

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia

A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/MIC were evaluated in a "real-world" context by following a cohort of 182 patients with S. aureus bacteremia (SAB) and analyzing these parameters within the critical first 96 h of vancomycin therapy. The median vancomycin trough level at this time point was 19.5 mg/liter. There was a significant difference in vancomycin AUC/MIC when using broth microdilution (BMD) compared with Etest MIC (medians of 436.1 and 271.5, respectively; P373, derived using classification and regression tree analysis, was associated with reduced mortality (P=0.043) and remained significant in a multivariable model. This study demonstrated that we obtained vancomycin trough levels in the target therapeutic range early during the course of therapy and that obtaining a higher vancomycin AUC/MIC (in this case, >373) within 96 h was associated with reduced mortality. The MIC test method has a significant impact on vancomycin AUC/MIC estimation. Clinicians should be aware that the current target AUC/MIC of ≥400 was derived using the reference BMD method, so adjustments to this target need to be made when calculating AUC/MIC ratio using other MIC testing methods. Copyrigh

Layered control architectures in robots and vertebrates

We revieiv recent research in robotics, neuroscience, evolutionary neurobiology, and ethology with the aim of highlighting some points of agreement and convergence. Specifically, we com pare Brooks' (1986) subsumption architecture for robot control with research in neuroscience demonstrating layered control systems in vertebrate brains, and with research in ethology that emphasizes the decomposition of control into multiple, intertwined behavior systems. From this perspective we then describe interesting parallels between the subsumption architecture and the natural layered behavior system that determines defense reactions in the rat. We then consider the action selection problem for robots and vertebrates and argue that, in addition to subsumption- like conflict resolution mechanisms, the vertebrate nervous system employs specialized selection mechanisms located in a group of central brain structures termed the basal ganglia. We suggest that similar specialized switching mechanisms might be employed in layered robot control archi tectures to provide effective and flexible action selection

Accumulation in coastal West Antarctic ice core records and the role of cyclone activity

Cyclones are an important component of Antarctic climate variability, yet quantifying their impact on the polar environment is challenging. We assess how cyclones which pass through the Bellingshausen Sea affect accumulation over Ellsworth Land, West Antarctica, where we have two ice core records. We use self-organizing maps (SOMs), an unsupervised machine learning technique, to group cyclones into nine SOM nodes differing by their trajectories (1980–2015). The annual frequency of cyclones associated with the first SOM node (SOM1, which generally originate from lower latitudes over the South Pacific Ocean) is significantly (p < 0.001) correlated with annual accumulation, with the highest seasonal correlations (p < 0.001) found during autumn. While significant (p < 0.01) increases in vertically integrated water vapor over the South Pacific Ocean coincide with this same group of cyclones, we find no indication that this has led to an increase in moisture advection into, nor accumulation over, Ellsworth Land over this short time period