Hypercoiling and hydrophobically associating polymers : interfacial synthesis, surface properties and pharmaceutical applications

The objective of the work described was to identify and synthesize a range of biodegradable hypercoiling or hydrophobically associating polymers to mimic natural apoproteins, such as those found in lung surfactant or plasma apolipoproteins. Stirred interfacial polymerization was used to synthesize potentially biodegradable aromatic polyamides (Mw of 12,000-26,000) based on L-Iysine, L-Iysine ethyl ester, L-ornithine and DL-diaminopropionic acid, by reaction with isophthaloyl chloride. A similar technique was used to synthesize aliphatic polyamides based on L-Iysine ethyl ester and either adipoyl chloride or glutaryl chloride resulting in the synthesis of poly(lysine ethyl ester adipamide) [PLETESA] or poly(lysine ethyl ester glutaramide) (Mw of 126,000 and 26,000, respectively). PLETESA was found to be soluble in both polar and non-polar solvents and the hydrophobic/hydrophilic balance could be modified by partial saponification (66-75%) of the ethyl ester side chains. Surface or interfacial tension/pH profiles were used to assess the conformation of both the poly(isophthalamides) and partially saponified PLETESA in aqueous solution. The results demonstrated that a loss of charge from the polymer was accompanied by an initial fall in surface activity, followed by a rise in activity, and ultimately, by polymer precipitation. These observations were explained by a collapse of the polymer chains into non-surface active intramolecular coils, followed by a transition to an amphipathic conformation, and finally to a collapsed hydrophobe. 2-Dimensional NMR analysis of polymer conformation in polar and non-polar solvents revealed intramolecular associations between the hydrophobic groups within partially saponified PLETESA. Unsaponified PLETESA appeared to form a coiled structure in polar solvents where the ethyl ester side chains were contained within the polymer coil. The implications of the secondary structure of PLETESA and potential biomedical applications are discussed

Three-dimensional simulations of laser-plasma interactions at ultrahigh intensities

Three-dimensional (3D) particle-in-cell (PIC) simulations are used to investigate the interaction of ultrahigh intensity lasers ($> 10^{20}$ W/cm$^{-2}$) with matter at overcritical densities. Intense laser pulses are shown to penetrate up to relativistic critical density levels and to be strongly self-focused during this process. The heat flux of the accelerated electrons is observed to have an annular structure when the laser is tightly focused, showing that a large fraction of fast electrons is accelerated at an angle. These results shed light into the multi-dimensional effects present in laser-plasma interactions of relevance to fast ignition of fusion targets and laser-driven ion acceleration in plasmas.Comment: 2 pages, 1 figur

Molecular structure of S-ethylthioacrylate Combined vibrational spectroscopic and abinitioSCF-MO study

Ab initio 6-31G* SCF-MO calculations have been carried out on S-ethyl thioacrylate [CH2CHC(O)SCH2CH3]. Fully optimized geometries, relative stabilities, dipole moments and harmonic force fields for several conformers of this molecule have been determined and the results compared with those for similar molecules. Together with FTIR and Raman spectroscopic data, the theoretical results demonstrate that S-ethyl thioacrylate exists in two different conformations about the Cα–C bond (the s-cis and s-trans forms, with CC–CO dihedral angles equal to 0° and 180°, respectively); the s-cis conformation being more stable than the s-trans form by ca. 6 kJ mol-1 for the isolated molecule. Comparison of the experimental and theoretical vibrational spectra confirms that, as concluded from our previous study on the analogous trans-S-ethyl thiocrotonate molecule (R. Fausto, P. J. Tonge and P. R. Carey, J. Chem. Soc., FaradayTrans., 1994, 90, 3491), the presence of the s-trans isomer of an α,β-unsaturated thioester can be successfully monitored by the IR band at ca. 1170 cm-1, ascribed to the Cα–C stretching mode of this form. In addition, we were also able to identify some IR bands sensitive to the conformation of the ethyl group that may be used as spectroscopic probes to study conformational equilibria associated with this internal degree of freedom in more complex S-ethyl thioester

A global simulation for laser driven MeV electrons in 50μm50\mu m-diameter fast ignition targets

The results from 2.5-dimensional Particle-in-Cell simulations for the interaction of a picosecond-long ignition laser pulse with a plasma pellet of 50-$\mu m$ diameter and 40 critical density are presented. The high density pellet is surrounded by an underdense corona and is isolated by a vacuum region from the simulation box boundary. The laser pulse is shown to filament and create density channels on the laser-plasma interface. The density channels increase the laser absorption efficiency and help generate an energetic electron distribution with a large angular spread. The combined distribution of the forward-going energetic electrons and the induced return electrons is marginally unstable to the current filament instability. The ions play an important role in neutralizing the space charges induced by the the temperature disparity between different electron groups. No global coalescing of the current filaments resulted from the instability is observed, consistent with the observed large angular spread of the energetic electrons.Comment: 9 pages, 6 figures, to appear in Physics of Plasmas (May 2006

Heartbeat and Temperature Monitoring System for Remote Patients using Arduino

This paper describes the working of a wireless heartbeat and temperature monitoring system based on a microcontroller ATmega328 (arduino uno). Most monitoring systems that are in use in today\u27s world works in offline mode but our system is designed such that a patient can be monitored remotely in real time. The proposed approach consists of sensors which measures heartbeat and body temperature of a patient which is controlled by the microcontroller. Both the readings are displayed in LCD monitor. Wireless system is used to transmit the measured data from the remote location. The heartbeat sensor counts the heartbeat for specific interval of time and estimates Beats per Minute while the temperature sensor measures the temperature and both the data are sent to the microcontroller for transmission to receiving end. Finally, the data are displayed at the receiving end. This system could be made available at a reasonable cost with great effect

New members as party modernisers: The case of the Democratic Unionist Party in Northern Ireland

Amid the literature on members of political parties, surprisingly little has been written on the potential or actual impacts that can be made upon party strategy or policies of a rapid influx of new members. New members may have different outlooks and desires than long-standing members. Although already sympathetic to the party they are joining, new arrivals, if arriving in large numbers, may hold sufficiently revisionist views to be able to re-orientate a political party in a direction not previously taken. Using data from the first-ever membership survey of the Democratic Unionist Party (DUP) in Northern Ireland, the largest party in the Northern Ireland Assembly since 2003 and the fourth largest UK parliamentary party since 2005, this article analyses whether more recent joiners of the Party have brought greater pragmatism and moderation to an organisation previously dominated by hardline political, religious and ethnic attitudes. Modernisation from outsiders who become insiders can be a key aspect of party development. The DUP offers one of the stiffest tests of modernisation, given its history of opposition to moderation. This article shows that newer members have tempered beliefs in one of the most robustly ethno-religious parties in Europe

Weibel-instability-mediated collisionless shocks in the laboratory with ultraintense lasers

WOS:000305032100015The formation of nonrelativistic collisionless shocks in the laboratory with ultrahigh intensity lasers is studied via ab initio multidimensional particle-in-cell simulations. The microphysics behind shock formation and dissipation and the detailed shock structure are analyzed, illustrating that the Weibel instability plays a crucial role in the generation of strong subequipartition magnetic fields that isotropize the incoming flow and lead to the formation of a collisionless shock, similar to what occurs in astrophysical scenarios. The possibility of generating such collisionless shocks in the laboratory opens the way to the direct study of the physics associated with astrophysical shocks

DESIGNING AND TESTING A PARK-BASED VISITOR SURVEY

This technical report is part of a broader national project ‘Systematic and strategic collection and use of visitor information in protected area management’, funded by Sustainable Tourism Cooperative Research Centre (STCRC), and conducted in partnership with protected area agencies across Australia. The aim of this report is to provide a systematic approach to using a set of core variables to collect data in a way that can be consistently applied across Australian protected areas. This information is most relevant to park-level management, but is also of central interest for corporate reporting. An associated aim was to develop and test a questionnaire for collecting these data. The questionnaire was developed and tested in collaboration with the WA Department of Environment and Conservation (WA DEC) and Parks Australia (PA). Surveys were conducted in Yanchep National Park, a moderately sized peri-urban park managed by WA DEC, in April 2008 and in Booderee National Park, NSW, which encompasses marine features and a botanic garden, and is managed by Parks Australia (PA), in January 2009. In WA following the survey, a focus group was held with staff to obtain their feedback on the efficacy of the questionnaire. The following recommendations are based on statistical analyses of the results, feedback from the focus group, and the observations of the researchers conducting the surveys

Enhanced stopping of macro-particles in particle-in-cell simulations

We derive an equation for energy transfer from relativistic charged particles to a cold background plasma appropriate for finite-size particles that are used in particle-in-cell simulation codes. Expressions for one-, two-, and three-dimensional particles are presented, with special attention given to the two-dimensional case. This energy transfer is due to the electric field of the wake set up in the background plasma by the relativistic particle. The enhanced stopping is dependent on the q(2)/m, where q is the charge and m is the mass of the relativistic particle, and therefore simulation macro-particles with large charge but identical q/m will stop more rapidly. The stopping power also depends on the effective particle shape of the macro-particle. These conclusions are verified in particle-in-cell simulations. We present 2D simulations of test particles, relaxation of high-energy tails, and integrated fast ignition simulations showing that the enhanced drag on macro-particles may adversely affect the results of these simulations in a wide range of high-energy density plasma scenarios. We also describe a particle splitting algorithm which can potentially overcome this problem and show its effect in controlling the stopping of macro-particles.info:eu-repo/semantics/publishedVersio