8 research outputs found
Risk factors for mortality among children under 5 years of age with severe diarrhea in low- and middle-income countries: Findings from the WHO-coordinated Global Rotavirus and Pediatric Diarrhea Surveillance Networks.
- Author
- Antoni Sebastien
- Ashmony Hossam
- Batmunkh Nyambat
- Biey Joseph
- Cohen Adam L
- de Oliveira Lucia
- Fahmy Kamal
- Ghoniem Amany
- Grabovac Varja
- Hartman Rachel M
- Liyanage Jayantha
- Logronio Josephine
- Mwenda Jason
- Nakamura Tomoka
- Ortiz Claudia
- Rey Gloria
- Serhan Fatima
- Shaba Keith
- Sharifuzzaman Mohammed
- Singh Simarjit
- Tereza Maria
- Tondo Emmanuel
- Videbaek Dovile
- Weldegebriel Goitom
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 05/08/2022
- Field of study
BACKGROUND: Diarrhea is the second leading cause of death in children under five years of age globally. The burden of diarrheal mortality is concentrated in low-resource settings. Little is known about the risk factors for childhood death from diarrheal disease in low and middle-income countries. METHODS: Data from the WHO-coordinated Global Rotavirus and Pediatric Diarrhea Surveillance Networks, which are composed of active, sentinel, hospital-based surveillance sites, were analyzed to assess mortality in children less than five years of age who were hospitalized with diarrhea between 2008-2018. Case fatality risks were calculated, and multivariable logistic regression was performed to identify risk factors for mortality. RESULTS: This analysis is comprised of 234,781 cases, including 1,219 deaths, across 57 countries. The overall case fatality risk was found to be 0.5%. Risk factors for death in the multivariable analysis included younger age (for <6 months compared with older ages, OR = 3.54; 95% CI = 2.81-4.50), female sex (OR = 1.18; 95% CI= 1.06-1.81), presenting with persistent diarrhea (OR = 1.91; 95% CI= 1.01-3.25), no vomiting (OR = 1.13, 95% CI= 0.98-1.30), severe dehydration (OR = 3.79; 95% CI = 3.01-4.83), and being negative for rotavirus on an ELISA test (OR = 2.29; 95% CI= 1.92-2.74). Cases from the African Region had the highest odds of death compared with other WHO Regions (OR = 130.62 comparing the African Region to the European region; 95% CI= 55.72-422.73), while cases from the European region had the lowest odds of death. CONCLUSIONS: Our findings support known risk factors for childhood diarrheal mortality and highlight the need for interventions to address dehydration and rotavirus-negative diarrheal infections
The Global Landscape of Pediatric Bacterial Meningitis Data Reported to the World Health Organization-Coordinated Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2014-2019.
- Author
- Antoni Sebastien
- Antonio Martin
- Azmy Aya
- Bae Songmee
- Batmunkh Nyambat
- Biey Joseph NM
- Cohen Adam L
- Daniels Danni
- De Gouveia Linda
- de Oliveira Lucia
- Du Plessis Mignon
- Duarte Carolina
- Egorova Ekaterina
- El Gohary Samaa
- Fahmy Kamal
- Fox Kimberly
- Gamal Asmaa
- Ghoniem Amany
- Grabovac Varja
- Heffelfinger James
- Howden Ben
- Jung Sangoun
- Katsande Reggis
- Kwambana-Adams Brenda
- Litt David
- Liyanage Jayantha BL
- Logronio Josephine
- Mwenda Jason M
- Nakamura Tomoka
- Ortiz Claudia
- Ouattara Mahamoudou
- Rahman Hossam Abdel
- Rey-Benito Gloria
- Saha Samir
- Sait Michelle
- Schwartz Stephanie
- Seaton Shila
- Serhan Fatima
- Sharifuzzaman Mohammad
- Singh Simarjit
- Slack Mary
- Tondo Emmanuel
- Urban Yulia
- Van Beneden Chris
- Veeraraghavan Balaji
- Videbaek Dovile
- von Gottberg Anne
- Voropaeva Elena
- Wasley Annemarie
- Weldegebriel Goitom
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/09/2021
- Field of study
BACKGROUND: The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. The network was established to strengthen surveillance and laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. METHODS: Sentinel hospitals report cases of children 137 000 suspected meningitis cases were reported by 58 participating countries, with 44.6% (n = 61 386) reported from countries in the WHO African Region. More than half (56.6%, n = 77 873) were among children <1 year of age, and 4.0% (n = 4010) died among those with reported disease outcome. Among suspected meningitis cases, 8.6% (n = 11 798) were classified as probable bacterial meningitis. One of 3 bacterial pathogens was identified in 30.3% (n = 3576) of these cases, namely S. pneumoniae (n = 2177 [60.9%]), H. influenzae (n = 633 [17.7%]), and N. meningitidis (n = 766 [21.4%]). Among confirmed bacterial meningitis cases with outcome reported, 11.0% died; case fatality ratio varied by pathogen (S. pneumoniae, 12.2%; H. influenzae, 6.1%; N. meningitidis, 11.0%). Among the 277 children who died with confirmed bacterial meningitis, 189 (68.2%) had confirmed S. pneumoniae. The proportion of pneumococcal cases with pneumococcal conjugate vaccine (PCV) serotypes decreased as the number of countries implementing PCV increased, from 77.8% (n = 273) to 47.5% (n = 248). Of 397 H. influenzae specimens serotyped, 49.1% (n = 195) were type b. Predominant N. meningitidis serogroups varied by region. CONCLUSIONS: This multitier, global surveillance network has supported countries in detecting and serotyping the 3 principal invasive bacterial pathogens that cause pediatric meningitis. Streptococcus pneumoniae was the most common bacterial pathogen detected globally despite the growing number of countries that have nationally introduced PCV. The large proportions of deaths due to S. pneumoniae reflect the high proportion of meningitis cases caused by this pathogen. This global network demonstrated a strong correlation between PCV introduction status and reduction in the proportion of pneumococcal meningitis infections caused by vaccine serotypes. Maintaining case-based, active surveillance with laboratory confirmation for prioritized vaccine-preventable diseases remains a critical component of the global agenda in public health.The World Health Organization (WHO)-coordinated Invasive Bacterial Vaccine-Preventable Disease (IB-VPD) Surveillance Network reported data from 2014 to 2019, contributing to the estimates of the disease burden and serotypes of pediatric meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
- Author
- Abbey Selim
- Adragão Pedro
- Almroth Henrik
- Anic Ante
- Anselme Frédéric
- Arentz Thomas
- Asso Antonio
- Balasubramaniam Richard
- Baldinger Samuel H.
- Balsam Pawel
- Baran Jakub
- Beiert Thomas
- Bergau Leonard
- Bianchi Stefano
- Blaauw Yuri
- Bohnen Jan
- Boveda Serge
- Breitenstein Alexander
- Bulava Alan
- Chaumont Corentin
- Chierchia Gian Battista
- Chun Julian
- de Jong Jonas S.S.G.
- de Sousa João
- Defaye Pascal
- Dekker Lukas
- Della Rocca Domenico G.
- Deneke Thomas
- Duncker David
- Duytschaever Mattias
- Efremidis Michalis
- Ekanem Emmanuel
- Eschalier Romain
- Ewertsen Niels Christian
- Fareh Samir
- Ferrero Angel
- Fiala Martin
- Fink Thomas
- Frommeyer Gerrit
- Funasako Moritoshi
- Füting Anna
- Gandjbakhch Estelle
- García-Bolao Ignacio
- Geller Laszlo
- George Andrikopoulos
- Glowniak Andrzej
- Goette Andreas
- Gramlich Michael
- Gunawerdene Melanie
- Gupta Dhiraj
- Guyomar Yves
- Hansen Jim
- Hansen Peter Steen
- Iacopino Saverio
- Inkovaara Jaakko
- Jacobsen Peter Karl
- Jais Pierre
- Jauvert Gael
- Johannessen Arne
- Jurisic Zrinka
- Kautzner Joseph
- Keane David
- Kirstein Bettina
- Knecht Sebastien
- Koopman Pieter
- Kreis Ingo
- Kucera Pavel
- Küffer Thomas
- Laredo Mikael
- Latcu Decebal Gabriel
- Lehrmann Heiko
- Lepillier Antoine
- Linz Dominik
- Lozano-Granero Cristina
- Luik Armin
- Manninger Martin
- Martin Claire
- Massoullie Grégoire
- Mathew Shibu
- Maury Philippe
- Meininghaus Dirk Grosse
- Mellor Greg
- Metzner Andreas
- Moravec Ondrej
- Munoz Daniel Rodriguez
- Müller Patrick
- Nentwich Karin
- Neuzil Petr
- Neven Kars
- Olalla Juan José
- Osca Joaquin
- Osmancik Pavel
- O’Hare Daniel
- Parwani Abdul Shokor
- Peichl Petr
- Petru Jan
- Pierre Bertrand
- Pürerfellner Helmut
- Raczka Franck
- Ramos-Maqueda Javier
- Rana Obaida
- Reddy Vivek Y.
- Reichlin Tobias
- Reil Peter
- Rillig Andreas
- Rivero Maximo
- Rollin Anne
- Rossillo Antonio
- Rosso Raphael
- Roux Antoine
- Russo Antonio Dello
- Scherr Daniel
- Schmidt Boris
- Schreieck Jürgen
- Skala Tomas
- Solimene Francesco
- Sommer Philipp
- Spitzer Stefan
- Steven Daniel
- Sticherling Christian
- Stix Günter
- Sultan Arian
- Szeplaki Gabor
- Szumowski Lukasz
- Tabrizi Fariborz
- Themistoclakis Sakis
- Thomas Olivier
- Tilz Roland
- Timo Gottschling
- Tondo Claudio
- Turagam Mohit K.
- Tzeis Stylianos
- van der Voort Pepijn
- Van Opstal Jurren
- Vijgen Johan
- Wakili Reza
- Willems Stephan
- Wong Tom
- Zhao Alexandre
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.Peer reviewe
Refining criteria for a neurodevelopmental sub-phenotype of bipolar disorders: a FondaMental Advanced Centers of Expertise for Bipolar Disorders study
- Author
- Alda Martin
- Aouizerate Bruno
- Aubin Valérie
- Auzias Guillaume
- Belzeaux Raoul
- Contu Martina
- Courtet Philippe
- Dansou Yecodji
- Deruelle Christine
- Dubertret Caroline
- Etain Bruno
- Godin Ophélia
- Haffen Emmanuel
- Jamain Stéphane
- Januel Dominique
- Leboyer Marion
- Lefrere Antoine
- Llorca Pierre Michel
- Manchia Mirko
- Marlinge Emeline
- Neilson Samantha
- Olié Emilie
- Paribello Pasquale
- Pinna Marco
- Polosan Mircea
- Rey Romain
- Roux Paul
- Samalin Ludovic
- Schwan Raymund
- Tondo Leonardo
- Tzavara Eleni
- Walter Michel
- Publication venue
- Elsevier
- Publication date
- 01/10/2024
- Field of study
International audienceBackground: Bipolar disorder (BD) is a complex and heterogeneous psychiatric disorder. Neurodevelopmental factors were suggested to contribute to the etiology of BD, yet a specific neurodevelopmental phenotype of the disorder remains unidentified. Our objective was to define and characterize a neurodevelopmental phenotype (NDP) in BD and validate its associations with clinical outcomes, polygenic risk scores (PGS), and treatment responses.Method: We analyzed the FACE-BD cohort of 4,468 BD patients, a validation cohort of 101 BD patients, and two independent replication datasets of 274 and 89 BD patients. Using factor analyses, we identified a set of criteria for defining NDP. We next developed a scoring system for NDP-load and assessed its association with prognosis, neurological soft signs, polygenic risk scores for neurodevelopmental disorders, and responses to treatment using multiple regressions, adjusted for age and sex with bootstrap replications.Results: Our study established a NDP in BD consisting of nine clinical features: advanced paternal age, advanced maternal age, childhood maltreatment, attention deficit hyperactivity disorder (ADHD), early onset of BD, early onset of substance use disorders, early onset of anxiety disorders, early onset of eating disorders, specific learning disorders. Patients with higher NDP-load showed a worse prognosis and increased neurological soft signs. Notably, these individuals exhibited a poorer response to lithium treatment. Furthermore, a significant positive correlation was observed between the NDP-load and PGS for ADHD suggesting potential overlapping genetic factors or pathophysiological mechanisms between BD and ADHD.Conclusions: The proposed NDP constitutes a promising clinical tool for patient stratification in BD
“Research participants want to feel they are better off than they were before research was introduced to them”: engaging cameroonian rural plantation populations in HIV research
- Author
- AR Sheon
- BA Koblin
- DD Celentano
- DHS Cameroon
- DJ Jackson
- E Mills
- E Mills
- EA Suter
- Eleanor McLellan-Lemal
- Emmanuel Kiawi
- FNA Dodoo
- J Kiwanuka-Tondo
- J Mooney-Somers
- JB Averill
- Jembia Mosoko
- JJ Mosoko
- JP Spradley
- K Longfield
- Kata Chillag
- KM MacQueen
- LK Murray
- M Minkler
- NE Mpoudi
- P Nyambi
- PR Ulin
- Pratima L Raghunathan
- R Power
- R Strotman
- RA Jenkins
- RB Hays
- RH Needle
- RP Strauss
- S Lahiri
- SM Manson
- Publication venue
- BMC
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>During a period of evolving international consensus on how to engage communities in research, facilitators and barriers to participation in HIV prevention research were explored in a rural plantation community in the coastal region of Cameroon.</p> <p>Methods</p> <p>A formative rapid assessment using structured observations, focus group discussions (FGD), and key informant interviews (KIIs) was conducted with a purposive non-probabilistic sample of plantation workers and their household members. Eligibility criteria included living or working >1 year within the plantation community and age >18 years. Both rapid and in-depth techniques were used to complete thematic analysis.</p> <p>Results</p> <p>Sixty-five persons participated in the study (6 FGDs and 12 KIIs). Participants viewed malaria and gastrointestinal conditions as more common health concerns than HIV. They identified three factors as contributing to HIV risk: concurrent sexual relationships, sex work, and infrequent condom use. Interviewees perceived that the community would participate in HIV research if it is designed to: (1) improve community welfare, (2) provide comprehensive health services and treatment for illnesses, (3) protect the personal information of participants, especially those who test positive for HIV, (4) provide participant incentives, (5) incorporate community input, and (6) minimize disruptions to “everyday life”. Barriers to participation included: (1) fear of HIV testing, (2) mistrust of researchers given possible disrespect or intolerance of plantation community life and lack of concern for communication, (3) time commitment demands, (3) medical care and treatment that would be difficult or costly to access, and (4) life disruptions along with potential requirements for changes in behaviour (i.e., engage in or abstain from alcohol use and sex activities).</p> <p>Conclusions</p> <p>Consistent with UNAIDS guidelines for good participatory practice in HIV prevention research, study participants placed a high premium on researchers’ politeness, trust, respect, communication, tolerance and empathy towards their community. Plantation community members viewed provision of comprehensive health services as an important community benefit likely to enhance HIV research participation.</p
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF
- Author
- Abd El-Aziz Ahmed
- Abdel-Qader Muwafeg
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Abou Seif Seif Kamal
- Abraham Sunitha
- Accogli Michele
- Acikel Sadik
- ACourt Christine
- Adachi Sen
- Adachi Susumu
- Adalberto Di Paola Leonel
- Adam Matthew
- Adriaansen Henk
- Agata Jun
- Ageta Masato
- Agnelli Giancarlo
- Agrawal Amrish
- Aguilar Juan
- Ahmad Shahid
- Ahmed Fayzal
- Ahuad Guerrero Rodolfo Andres
- Ainsworth Paul
- Akahane Kunio
- Akiyama Masahiro
- Akutsu Mitsuyuki
- Al Mahmeed Wael
- Al Naeemi Abdullah
- Alban Fabio
- Alberto Berli Mario
- Alberto Sambadaro Gustavo
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alfredo Fernandez Alberto
- Alfredo Sinisi Victor
- Ali Amar
- Almeida Fernandez Carlos Alexandre
- Alomairi Munther
- Altun Armagan
- Alvarez Garcia Pere
- Alvarez Lopez Humberto
- Alves Costa Fernando Augusto
- Amano Toshio
- Amarenco Pierre
- Ambrosio Giuseppe
- Andersson Agneta
- Andersson Lars
- Ando Hiroshi
- Ando Shinichi
- Angaran Paul
- Angchaisuksiri Pantep
- Anne Wim
- Anno Takafumi
- Anti Roberto S.
- Aoki Kenji
- Aoyama Takuma
- Arai Hidekazu
- Aranha Rosito Guido Bernardo
- Aras Dursun
- Arasaki Osamu
- Arcocha Tones Maria Fe
- Argena Antonio
- Arima Shinichi
- Arino Torn
- Armaganijan Luciana Vidal
- Arriaga Nava Roberto
- Arriagada German
- Arstall Margaret
- Asano Hiroshi
- Ashida Ko
- Astridge Penny
- Astudillo Carlos
- Atar Dan
- Atsuchi Yoshihiko
- Avino Maria D.
- Axthelm Christoph
- Ayala-Paredes Felix
- Aydinlar Ali
- Aylward Martin
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babyesiza Adyeri
- Balthazar Yohan
- Bantwal Ganapathi
- Barbarash Olga
- Barreda Gonzalez Maria
- Barrow Susan
- Bassand Jean-Pierre
- Baszak Jacek
- Baumbach Sylvia
- Bayat Junaid
- Bayo i Llibre Joan
- Bazargani Nooshin
- Bazzoni Ruiz Alberto Esteban
- Beach Scott
- Bearez Etienne
- Beattie Andre
- Beaudry Philippe
- Beer Juerg H.
- Belenky Dmitry
- Ben Frankel Ben Frankel
- Benavides Gonzalez Mario
- Bennett James
- Benson Lars
- Berg-Johansen Jan
- Berge Eivind
- Berlingieri Joseph
- Berneau Jean-Baptiste
- Bernhardt Peter
- Bernsten Fredrik
- Bet-suyaku Tetsuo
- Beutels Michel
- Bhargava Kartikeya
- Biedrzycka Malgorzata
- Bilas Roman
- Bilo Grzegorz
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bisatt John
- Bisne Vikas
- Blankoff Ivan
- Blenkhorn Adam
- Blombery Peter
- Blumberg Edwin
- Boda Zoltan
- Bodanese Luiz
- Boersma L. V. A.
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonnefoy Marc
- Boon Mark
- Boonyapisit Warangkana
- Borger Jan
- Borjesson Ulf
- Botelho Roberto Vieira
- Bothin Claes
- Boussy Tim
- Bowen-Simpkins Emma
- Boyes Jean-Paul
- Bradshaw Colin
- Bramley Matthew
- Brauer Gunter
- Bremmelgaard Arne
- Brodmann Marianne
- Broilo Franca Cesar Cassio
- Bromham Catherine
- Bronisz Marek
- Brotons Cuixart Carles
- Brugnaux Jean Philippe
- Bruun Michael
- Buchner Thomas
- Bugueno Gutierrez Claudio
- Buiks Cees
- Bulla Claudio
- Bunyapipat Thanita
- Burianova Hana
- Burns D.
- Butler Amy
- Butter Keith
- Cabrera Jardines Ricardo
- Cader Cas
- Caimi Teresa Maria
- Cairns John
- Cameron Alex
- Camm A. John
- Canosa Roddy
- Cantu Brito Carlos Gerardo
- Cao Shiping
- Capiau Luc
- Cappelli Roberto
- Capucci Alessandro
- Cardona Munoz Ernesto
- Carmo Borges Ney Carter
- Carroll Patrick
- Cartwright Simon
- Casassus Frederic
- Caspar Andreas
- Catanchin Andrei
- Cebron Jean-Pierre
- Centurion Nestor
- Cesar Ingaramo Adrian
- Cha James
- Cha Tae-Joon
- Chandwani Prakash
- Charme Vilches Gustavo
- Chatlaong Boonsert
- Chattranukulchai Pairoj
- Chauhan Naresh
- Chawanadelert Seksan
- Chawla Kamaldeep
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Moshui
- Chen Ping
- Chen Yingmin
- Cheng Xiaoshu
- Cheol Sang
- Cheung Stephen
- Chiba Kei
- Chibana Hidetoshi
- Ching Chi Keong
- Chizhov Petr
- Chmielnicka-Pruszczynska Malgorzata
- Cho Myeong-Chan
- Choi Dong Ju
- Choi Henry
- Cholsaringkarl Doungrat
- Chopada Manojkumar
- Choudhary Fiaz
- Choudhary Ulka
- Chowan Hasan
- Christersson Peter
- Chuquiure Valenzuela Eduardo Julian Jose Roberto
- Churet Jean-Baptiste
- Clark M.
- Coates Richard
- Coates Steven
- Colquhoun David
- Conde Diego
- Conejeros Carlos
- Conn Paul
- Connolly Stuart J.
- Cooke Philip
- Cools Frank
- Corbalan Ramon
- Cornelius David
- Corros Vicente Cecilia
- Cosmi Franco
- Costabel Juan Pablo
- Coulshed David
- Coulson Warwick
- Coutu Benoit
- Cox Michael
- Crisby Milita
- Cristina Leone Maria
- Crousillat Bernard
- Cymerman Krzysztof
- Danielsen Mark
- Dario Dran Ricardo
- Darius Harald
- Date Haruhiko
- Davies Emyr
- Davies Richard
- Davies Sarah
- de Almeida Roberto Simoes
- de Aranjo Gilson Roberto
- De Blasio Angelo
- De Cristofaro Raimondo
- de los Rios Ibarra Manuel
- de Moura Xavier Moraes Junior Joao Batista
- de Souza Neto Joao David
- De Wolf Axel
- De-Sousa Nigel
- Deacon Melanie
- Debrunner Johann
- Dedek Vratislav
- Del Carlo Carlos Henrique
- Delarche Nicolas
- Delforge Marc
- Demir Mesut
- Desfontaines Philippe
- Destrac Sylvain
- Dhillon Ripple
- Di Minno Giovanni
- Dobson Simon
- Doi Hideo
- Doiuchi Junji
- Domanska Ewa
- Dominguez Helena
- Dooldeniya Chaminda
- Dorsch Wilfried
- Doucet Bernard
- Douglas Kevin
- Dragotto Pablo
- Drapkina Oksana
- Dres Praxis
- Drexel Heinz
- Dshabrailov Janna
- du Preez Miranda
- Duffy Peter
- Durdil Vaclav
- Durgaprasad Rajashekhar
- Ebert Hans-Holger
- Eccleston David
- Eden Jane
- Eder Wolfgang
- Edin Anton
- Eggers German
- Egido Javier
- Egilsson Arnor
- Egorova Liudmila
- Egyutt Mihaly
- Eichinger-Hasenauer Sabine
- Eikelboom John
- Eissfeller Enno
- Eissing Volker
- El Din Mohamed Gamal
- El-Etreby Adel
- Elbahry Atef
- Elkhadem Magdi
- Ellie Emmanuel
- Elmersson Micael
- Eltishcheva Vera
- Emura Yoko
- Endo Masato
- Engdahl Johan
- Engelbrecht Johannes
- Engelthaler Gabriella
- Epelde Gonzalo Francisco
- Erdle Werner
- Erga Knut
- Ericsson Marianne
- Eriksen Ebbe
- Ersanli Murat
- Esheiba Ehab M.
- Espinola Zavaleta Nilda
- Estifanos Salah
- Eto Takuma
- Evans Paul
- Evans Phil
- Faes Dirk
- Fairhead Sue
- Fajardo Campos Pedro
- Falkowski Stephen
- Fanelli Raffaele
- Fattore Luciano
- Fedorowsky Alain
- Feola Mauro
- Ferdinand Keith
- Ferenczi Judit
- Ferkl Richard
- Fernandez Caputi Vanina
- Fernandez Escobar Esther
- Ferreira Braga Joao Carlos
- Ferrick Kevin
- Ferroni Fabian
- Fierro Fierro Omar
- Figueiredo Estevao Lanna
- Fikry Sameh
- Finimundi Helius Carlos
- Fisher E.
- Fitzmaurice David
- Fitzmaurice David A.
- Flores Martinez David
- Flynn Ann
- Foechterle Johannes
- Fontoura Tavares Claudio Munhoz
- Foo David
- Fooks Tim
- Forero Alejandro
- Forshaw Karen
- Fournier Pierre-Yves
- Fox Keith A. A.
- Fox Robin
- Frack Costantini Costantino Roberto
- Franco Miguel
- Franklin Simon
- French John
- Fu Guosheng
- Fudo Tetsuro
- Fujii Masako
- Fujiki Rei
- Fujimoto Shunichi
- Fujisawa Akinori
- Fujisawa Kazuaki
- Fujisawa Yasuaki
- Fujito Tsuneo
- Fujiura Yoshihisa
- Fujiura Yoshitake
- Fukuda Tsuyoshi
- Fukui Takayuki
- Fukuoka Shuji
- Furukawa Nobufusa
- Furukawa Toshiyuki
- Furukawa Yoshiyuki
- Furumoto Wataru
- Fushtey Ivan
- Galbas Krzysztof
- Galinier Michel
- Gallagher Andrew
- Galloway Sophia
- Gaona Rodriguez Rodolfo
- Garcia Hernandez Norberto
- Garcia Pavia Pablo
- Garcia Jorge
- Garda Riaz
- Gaszner Balazs
- Geatch Diane
- Gegenhuber Alfons
- Gerbaulet Uwe
- Germini Fabrizio
- Gersh Bernard J.
- Ghezai Beraki
- Giacomi Guillermo
- Gibbons Lisa
- Gibbs Harry
- Gieroba Andrzej
- Giles Claire
- Gilliand A.
- Gjertsen Erik
- Glanowska Grazyna
- Glatzel Dirk
- Glencross Janet
- Go Yoshinori
- Goda Toshihiro
- Godart Pascal
- Goldhaber Samuel Z.
- Golino Paolo
- Gomes Ferreira Luis Gustavo
- Gomez Pajuelo Casimiro
- Gomez Vilamajo Oscar
- Gonzalez Juanatey Jose Ramon
- Gooding Trevor
- Goodwin Daryl
- Goram Jane
- Goto Kazuo
- Goto Shinya
- Goto Tsutomu
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- Yan Xiaowei
- Yang Ping
- Yang Yuejin
- Yang Zhiming
- Yasui Kiyoshi
- YILMAZ MEHMET BİRHAN
- Yilmaz Ozcan
- Yin Yuehui
- Yokota Naoto
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yousef Ghazi
- Yuyang Tan
- Zaitsu Ryuji
- Zaluska Roman
- Zaman Kashif
- Zapata Gerardo
- Zateyshchikov Dmitry
- Zateyshchikova Anna
- Zauzig Heinz-Dieter
- Zemlianskaia Oksana
- Zhang Huaiqin
- Zhao Ruiping
- Zhao Yusheng
- Zhurba Svitlana
- Zidkova Eva
- Zimny Hans-Hermann
- Zinka Elzbieta
- Zrazhevskiy Konstantin
- Zuber Mathieu
- Zutz Stefan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2019
- Field of study
BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
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- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
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- Atkociunas Aivaras
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- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
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- Babirye Lilian
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- Badr Helmy
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- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
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- Barrera López Francisco Javier
- Barsic Neven
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- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
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- Belal qadomi Asef
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- Belvedere Angela
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- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
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- Blunnie Eimear
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- Bogusevicius Algirdas
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- Bondurri Andrea
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- Bono Lorenzo
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- Borghi Felice
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- Borowski David W
- Bortolasi Luca
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- Clements Joshua Michael
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- Dollie Qaasim
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- Dominguez Joaquina
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- Eldeep Mostafa
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- Eldoseuky mohammed Amany
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- Elewaily Mohamed Ibrahim Elsayed
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- Elfallal Ahmed
- Elfanty Mahmoud
- ElFayoumy Ahmed Moustafa
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- Elghareeb Nourhan
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine
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- Elmahdy Marwa
- Elmeslemany Nehal
- Elmokadem Aya
- Elqadi Muawiyah
- Elrais Safa
- Elsayed Mai
- Elsayed Mohammad
- Elshafei Houssein
- Elshafey Ahmed
- Elshaibani Mahmoud
- Elshatby Bassant
- Elshawy Mohamed Elemam
- Elsherbeny Mohammed Yasser
- Elsherif Fawzia
- Elshimy Ahmed
- Elsobky Hager
- Elteir Hana
- Eltoum Ruba
- Elzanfaly Ali Abdelazez
- Emara Eman
- Emeghara Okechukwu
- Emile Sameh
- Enumah Zachary
- Eraslan Huseyin
- Eray Ismail Cem
- Erkul Oguz
- Esbaga Fatima
- Escobar Dennis
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- Eskander John
- Eslam Sara
- Esmat Nourhan Ahmed
- Esper Asil
- Espin-Basany Eloy
- Espina Perez Beatriz
- Espinosa-Bravo Martin
- Esposito Giovanni
- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
- Essam Eman
- Estalagem Inês
- Estevez Tesouro José
- Eswaye Haitem
- Etchill Eric
- Etonyeaku Amarachukwu
- Eusebio Zegarra Ivan Edward
- Ezzat Helmy
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- Fahira Alessa
- Fahmawee Toqa
- Fairfield Cameron J
- Falato Armando
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- Fernandez-Hevia Maria
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- Fernández Veiga Maria Pilar
- Ferrari Guglielmo
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- Ferreira Andreia
- Ferreira Pedro
- Ferrero Esther
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- Figueiredo Ana Gabriela
- Finlay Ben
- Fitchat Nicolas
- Fitzgerald J Edward
- Flamey Nicolas
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- Forero-Torres Alexander
- Fortuna Martins Sónia
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- Foster Deshka S
- Fox Benjamin
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- French James
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- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
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- Wong Jane J
- Wong Jeremy
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- Wong Sui-Weng
- Wong Tsz Lun Ernest
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- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
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- Xanthopoulou Georgia
- Yabut Kenneth
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- Yaghi Nadine
- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
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- Yang P Zichu
- Yanikoglu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
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- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- You Lucia
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- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
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- Dominguez Joaquina
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- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
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- Ghonaim Mennatullah
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- Yeoh Andrea
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- Yoong Andrel
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- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research