Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT)

The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT and colonoscopy were analyzed. After the findings of PET/CT and colonoscopy were determined independently, the results were compared in each of the six colonic sites examined in all patients. The efficacy of PET/CT was determined using colonoscopic examination as the gold standard. In all, 270 colorectal lesions 5 mm or more in size, including 70 pathologically confirmed malignant lesions, were found in 172 patients by colonoscopy. The sensitivity and specificity of PET/CT for detecting any of the colorectal lesions were 36 and 98%, respectively. For detecting lesions 11 mm or larger, the sensitivity was increased to 85%, with the specificity remaining consistent (97%). Moreover, the sensitivity for tumors 21 mm or larger was 96% (48/50). Tumors with malignant or high-grade pathology were likely to be positive with PET/CT. A size of 10 mm or smaller [odds ratio (OR) 44.14, 95% confidence interval (95% CI) 11.44-221.67] and flat morphology (OR 7.78, 95% CI 1.79-36.25) were significant factors that were associated with false-negative cases on PET/CT. The sensitivity of PET/CT for detecting colorectal lesions is acceptable, showing size- and pathology-dependence, suggesting, for the most part, that clinically relevant lesions are detectable with PET/CT. However, when considering PET/CT for screening purposes caution must be exercised because there are cases of false-negative results

Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.

Recent studies have suggested possible adverse effects of thiazolidinediones on bone metabolism. However, the detailed mechanism by which the activity of PPAR affects bone formation has not been elucidated. Impaired osteoblastic function due to cytokines is critical for the progression of inflammatory bone diseases. In the present study, we investigated the cellular mechanism by which PPAR actions interact with osteoblast differentiation regulated by BMP and TNF-alpha using mouse myoblastic C2C12 cells. BMP-2 and -4 potently induced the expression of various bone differentiation markers including Runx2, osteocalcin, type-1 collagen and alkaline phosphatase (ALP) in C2C12 cells. When administered in combination with a PPAR alpha agonist (fenofibric acid) but not with a PPAR gamma agonist (pioglitazone), BMP-4 enhanced osteoblast differentiation through the activity of PPAR alpha. The osteoblastic changes induced by BMP-4 were readily suppressed by treatment with TNF-alpha. Interestingly, the activities of PPAR alpha and PPAR gamma agonists reversed the suppression by TNF-alpha of osteoblast differentiation induced by BMP-4. Furthermore, TNF-alpha-induced phosphorylation of MAPKs, NF kappa B, I kappa B and Stat pathways was inhibited in the presence of PPAR alpha and PPAR gamma agonists with reducing TNF-alpha receptor expression. In view of the finding that inhibition of SAPK/JNK. Stat and NF kappa B pathways reversed the TNF-alpha suppression of osteoblast differentiation, we conclude that these cascades are functionally involved in the actions of PPARs that antagonize TNF-alpha-induced suppression of osteoblast differentiation. It was further discovered that the PPAR alpha agonist enhanced BMP-4-induced Smad1/5/8 signaling through downregulation of inhibitory Smad6/7 expression, whereas the PPAR gamma agonist impaired this activity by suppressing BMPRII expression. On the other hand, BMPs increased the expression levels of PPAR alpha and PPAR gamma in the process of osteoblast differentiation. Thus, PPAR alpha actions promote BMP-induced osteoblast differentiation, while both activities of PPAR alpha and PPAR gamma suppress TNF-alpha actions. Collectively, our present data establishes that PPAR activities are functionally involved in modulating the interaction between the BMP system and TNF-alpha receptor signaling that is crucial for bone metabolism

幼児を持つ母親の就業状況別家族機能とソーシャルサポート

調査報告Report幼児を持つ母親の就業状況による家族機能とソーシャルサポートの特徴を明らかにし、育児支援のありかたについて示唆を得ることを目的に、質問紙調査を実施した。その結果、正職員は,家庭内でのサポートが得られ、情緒機能は恵まれているが夫と話す時間が少ない。自営業は、夫以外の家族のサポートが得られている。間食は不規則であるが、生活リズムのしつけはなされている。パートは、正職員、自営業などの勤労婦人と比較し、夫・家庭内のサポートが得られていない。主婦は、情緒、教育、健康保持機能が高い。家庭内に夫以外で子育てのことで相談できる人は少ない。無職は、健康保持機能が高く、夫と話す時間がある等の特徴が見られた

Discussion on regional revitalization using woody biomass resources as renewable energy

Expanding the use of renewable energy is a matter of concern in many countries. Many Japanese local municipalities are attempting to promote business creation using renewable energy as an opportunity for regional revitalization based on the policy of the Japanese government. Renewable energy makes significant contributions to the region in terms of energy security, stable energy supply, and job creation. However, the most important contribution is enhancing residents' attachment to their community and supporting actions that appeal to the community through renewable energy utilization. Residents should actively participate in regional revitalization, which leads to sustainable prosperity of the region. However, the current measures of local municipalities seem to be lacking such a viewpoint. This study aims to analyse the environmental and economic aspects as well as the social acceptance of establishing a bathing business that utilizes woody biomass as its heat source. This study also discussed how the generation of heat from woody biomass contributes to regional revitalization. The case study area was Kobe and Mt. Rokko, Japan. First, heat production and utilization was assumed for the forest resources in Mt. Rokko, and the annual biomass energy production potential was estimated. The annual costs of lumber cutting, transportation, and chipping, and the annual CO2 reduction by substituting bunker A with woody biomass for heat production were also estimated. A questionnaire survey was conducted to determine community awareness of energy production using woody biomass from Mt. Rokko. Principal component analysis, contingent valuation method, and path analysis were used to quantify respondents' awareness