Electronic Health Records: An International Perspective on "Meaningful Use"

Examines the extent of meaningful use of electronic health records in Denmark, New Zealand, and Sweden, including sharing information with organizations, health authorities, and patients. Outlines challenges of and insights into encouraging U.S. adoption

Social-science research and the general social surveys

'Social-science research has been transformed over the last generation by the advent and expansion of the general social surveys (GSS). The GSS model of research has created a infrastructure for the social sciences designed to address the interests and research agenda of scholars and their students; cover a wide range of topics; utilize reliable, valid, and generalizable measurement; and provide data both across nations and across time. This design in turn has generated widespread analysis and notably contributed to our understanding of social processes and societal change.' (author's abstract)

O papel da engenharia de túneis na tomada de decisão de alternativas em projetos rodoferroviários

TCC (graduação) - Universidade Federal de Santa Catarina. Centro Tecnológico. Engenharia Civil.A infraestrutura de um país tem grande importância em seu desenvolvimento e as decisões cabem principalmente aos tomadores de decisão do setor público, os quais muitas vezes não possuem conhecimento técnico de engenharia. Devido a isso, as tomadas de decisão tendem a passar por uma análise financeira apenas, visando a alternativa mais barata e desprezando possíveis alternativas como a de traçados rodoferroviários com túneis, por exemplo. Mesmo que as obras de túneis tendam a ser mais onerosas, elas trazem resultados únicos como redução de acidentes de trânsito, redução do tempo de viagem, redução de manutenção, redução do impacto ambiental entre outros. Este trabalho tem por objetivo explorar a visão técnica da engenharia de túneis nas tomadas de decisão de alternativas em projetos rodoferroviários. Explora-se métodos de construção de túneis, métodos de tomada de decisão, traz-se cinco exemplos de casos representativos e duas análises de custo-benefício de obras reais. Conclui-se que as tomadas de decisão de projeto rodoferroviários englobam uma série de fatores que muitas vezes são extremamente complicados de se contabilizar através de valores monetários.A country's infrastructure is of great importance in its development. However, decisions are mainly made by decision makers from the public sector, who often do not have technical engineering knowledge. Due to this fact, decision-making tends to go through a financial analysis only, focusing on the cheapest alternative and ignoring possible alternatives such as tunneling for road-rail projects. Even though tunneling works tend to be more costly, they bring unique results such as reducing traffic accidents, reducing travel time, reducing maintenance, reducing environmental impact, among others. This paper aims to explore the technical vision of tunnel engineering in decision-making for alternatives in road-rail projects. It explores tunnel construction methods, decision-making methods, five representative case examples and two cost benefit analyses of real works. It is concluded that the road-railway project decision-making involves a series of factors that are often extremely complicated to account through monetary values

A Combined Score of Circulating miRNAs Allows Outcome Prediction in Critically Ill Patients

Background and aims: Identification of patients with increased risk of mortality represents an important prerequisite for an adapted adequate and individualized treatment of critically ill patients. Circulating micro-RNA (miRNA) levels have been suggested as potential biomarkers at the intensive care unit (ICU), but none of the investigated miRNAs displayed a sufficient sensitivity or specificity to be routinely employed as a single marker in clinical practice. Methods and results: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. In this study, we re-analyzed these previously published data and performed a combined analysis of these markers to unravel their potential as a prognostic scoring system in the context of critical illness. Based on the Youden’s index method, cut-off values were systematically defined for dysregulated miRNAs, and a “miRNA survival score” was calculated. Patients with high scores displayed a dramatically impaired prognosis compared to patients with low values. Additionally, the predictive power of our score could be further increased when the patient’s age was additionally incorporated into this score. Conclusions: We describe the first miRNA-based biomarker score for prediction of medical patients’ outcome during and after ICU treatment. Adding the patients’ age into this score was associated with a further increase in its predictive power. Further studies are needed to validate the clinical utility of this score in risk-stratifying critically ill patients

A quick guide for student-driven community genome annotation

High quality gene models are necessary to expand the molecular and genetic tools available for a target organism, but these are available for only a handful of model organisms that have undergone extensive curation and experimental validation over the course of many years. The majority of gene models present in biological databases today have been identified in draft genome assemblies using automated annotation pipelines that are frequently based on orthologs from distantly related model organisms. Manual curation is time consuming and often requires substantial expertise, but is instrumental in improving gene model structure and identification. Manual annotation may seem to be a daunting and cost-prohibitive task for small research communities but involving undergraduates in community genome annotation consortiums can be mutually beneficial for both education and improved genomic resources. We outline a workflow for efficient manual annotation driven by a team of primarily undergraduate annotators. This model can be scaled to large teams and includes quality control processes through incremental evaluation. Moreover, it gives students an opportunity to increase their understanding of genome biology and to participate in scientific research in collaboration with peers and senior researchers at multiple institutions

Order-by-disorder in the antiferromagnetic Ising model on an elastic triangular lattice

Geometrically frustrated materials have a ground-state degeneracy that may be lifted by subtle effects, such as higher order interactions causing small energetic preferences for ordered structures. Alternatively, ordering may result from entropic differences between configurations in an effect termed order-by-disorder. Motivated by recent experiments in a frustrated colloidal system in which ordering is suspected to result from entropy, we consider in this paper, the antiferromagnetic Ising model on a deformable triangular lattice. We calculate the displacements exactly at the microscopic level, and contrary to previous studies, find a partially disordered ground state of randomly zigzagging stripes. Each such configuration is deformed differently and thus has a unique phonon spectrum with distinct entropy, thus lifting the degeneracy at finite temperature. Nonetheless, due to the free-energy barriers between the ground-state configurations, the system falls into a disordered glassy state.Comment: Accepted to PNA

Optimal storage of a single photon by a single intra-cavity atom

We theoretically analyse the efficiency of a quantum memory for single photons. The photons propagate along a transmission line and impinge on one of the mirrors of a high-finesse cavity. The quantum memory is constituted by a single atom within the optical resonator. Photon storage is realised by the controlled transfer of the photonic excitation into a metastable state of the atom and occurs via a Raman transition with a suitably tailored laser pulse, which drives the atom. Our study is supported by numerical simulations, in which we include the modes of the transmission line and we use the experimental parameters of existing experimental setups. It reproduces the results derived using input-output theory in the corresponding regime and can be extended to compute dynamics where the input-output formalism cannot be straightforwardly applied. Our analysis determines the maximal storage efficiency, namely, the maximal probability to store the photon in a stable atomic excitation, in the presence of spontaneous decay and cavity parasitic losses. It further delivers the form of the laser pulse that achieves the maximal efficiency by partially compensating parasitic losses. We numerically assess the conditions under which storage based on adiabatic dynamics is preferable to non-adiabatic pulses. Moreover, we systematically determine the shortest photon pulse that can be efficiently stored as a function of the system parameters.Comment: 13 pages, 8 figure

Target-Specificity in Scorpions; Comparing Lethality of Scorpion Venoms across Arthropods and Vertebrates

ABSTARCT: Scorpions use their venom in defensive situations as well as for subduing prey. Since some species of scorpion use their venom more in defensive situations than others, this may have led to selection for differences in effectiveness in defensive situations. Here, we compared the LD50 of the venom of 10 species of scorpions on five different species of target organisms; two insects and three vertebrates. We found little correlation between the target species in the efficacy of the different scorpion venoms. Only the two insects showed a positive correlation, indicating that they responded similarly to the panel of scorpion venoms. We discuss the lack of positive correlation between the vertebrate target species in the light of their evolution and development. When comparing the responses of the target systems to individual scorpion venoms pairwise, we found that closely related scorpion species tend to elicit a similar response pattern across the target species. This was further reflected in a significant phylogenetic signal across the scorpion phylogeny for the LD50 in mice and in zebrafish. We also provide the first mouse LD50 value for Grosphusgrandidieri