Speciális tulajdonságokkal rendelkező nanostrukturált vékonyrétegek előállítása nedves kolloidkémiai eljárásokkal. = Preparation of functionalized nanostructured thin layers by wet colloid chemical methods

Eljárásokat fejlesztettünk ki nanostrukturált, anorganikus (SiO2, ZnO, TiO2) vékonyrétegek különböző anyagú (fém, szilícium, üveg, kvarc) hordozók felületén történő előállítására. Tanulmányoztuk ezeknek a bevonatoknak optikai, fotokatalitikus, valamint nedvesedési tulajdonságait. Igazoltuk, hogy a vékonyrétegek multifunkcionalitása a szerkezet és összetétel megfelelő tervezésével kialakítható. Pásztázó szögű reflektometriai, valamint UV-Vis spektroszkópiai módszereken alapuló optikai modelleket fejlesztettünk ki a Langmuir-Blodgett-technikával előállított filmek törésmutatójának, törésmutató gradiensének és vastagságának meghatározására, amelyek közvetett információt adtak a filmek szerkezetéről. Reflektometriai, valamint termodinamikai eljárások felhasználásával új módszereket dolgoztunk ki nanoméretű szilárd részecskék nedvesedésének (gömb-ekvivalens peremszögének) meghatározására víz-levegő határfelületen. Számítógépes szimulációt alkalmazva elemeztük a részecskék polidiszperzitásának Langmuir-filmjeik szerkezetére gyakorolt hatását, ami új ismeretekkel szolgált a határrétegbeli filmek tömörödésének mechanizmusáról. Fontos eredményeket nyertünk továbbá a szol-gél-technikával kialakított ón-dioxid filmek vastagságát és morfológiáját meghatározó paraméterekeről. | New methods were developed for fabrication of thin coatings of inorganic (SiO2, ZnO, TiO2) nanoparticles on different (metal, silicon, glass, quartz) substrates. We studied optical, photocatalytical and wetting behaviours of the solid supported films that revealed multifunctional properties, which could be controlled by the composition and the structure of the films. Novel optical models were developed for the characterization of nanoparticulate Langmuir-Blodgett films by scanning angle reflectometry and UV-Vis spectroscopy methods. Refractive index, refractive index gradient and thickness of those transparent coatings were calculated which provided information about the film structure. Novel optical and thermodynamic approaches to the determination of sphere-equivalent contact angles of nanoparticles at water-air interface were suggested. Applying computer simulations we analyzed the effect of particle polydispersity on the structure formation of their Langmuir films that provided new findings about the mechanism of two-dimensional ordering of particles. Additionally, novel information was obtained about the experimental parameters which control the morphology and thickness of tin-dioxide sol-gel coatings

Plasticity analysis by synchrotron radiation in a Mg97Y2Zn1 alloy with bimodal grain structure and containing LPSO phase

© 2015 Acta Materialia Inc. All rights reserved. Deformation behaviour has been examined by synchrotron radiation diffraction in an extruded magnesium - long-period-stacking-order phase alloy comprising three components of microstructure. The variation of internal strains and intensities of the important crystallographic planes of the two phases has been examined during compression at several temperatures. The long-period-stacking-order phase remains elastic to stresses beyond the macroscopic yield stress while deformation in the magnesium matrix is dominated by twinning and basal slip, with the coarse-grained regions deforming plastically at stresses well below the macroscopic yield stress while regions with fine grain size deform plastically only at much higher stresses.We would like to acknowledge financial support of the Spanish Ministry of Education and Science under project number MAT2012-34135. We would like to acknowledge the expert support of Miguel Acedo and Edurne Laurin for assistance with the extrusion processing and the metallographical preparation, respectively.Peer Reviewe

Phase formation during solidification of Mg-Nd-Zn alloys: An in situ synchrotron radiation diffraction study

Mg-4Nd base alloys with Zn additions of 3, 5 and 8 wt % were investigated with in situ synchrotron radiation diffraction during solidification. This method enabled the investigation of phase formation and transformation in the alloys. The diffraction results were supported with TEM observations on the as-solidified samples. The results show the effect of increased Zn addition on stabilizing the Mg3RE phase (RE—rare earth). The experimental results agree only partially with the theoretical calculations indicating the need to improve the existing thermodynamic database on the alloy syste

Scaling behavior in crackle sound during lung inflation

During slow inflation of lung lobes, we measure a sequence of short explosive transient sound waves called "crackles," each consisting of an initial spike followed by ringing. The crackle time series is irregular and intermittent, with the number of spikes of size s following a power law, n(s)proportional to s(-alpha), with alpha = 2.77 +/- 0.05. We develop a model of crackle wave generation and propagation in a tree structure that combines the avalanchelike opening of airway segments with the wave propagation of crackles in a tree structure. The agreement between experiments and simulations suggests that (i) the irregularities are a consequence of structural heterogeneity in the lung, (ii) the intermittent behavior is due to the avalanchelike opening, and (iii) the scaling is a result of successive attenuations acting on the sound spikes as they propagate through a cascade of bifurcations along the airway tree. [S1063-651X(99)13810-8]

Does a PBL-based medical curriculum predispose training in specific career paths? A systematic review of the literature

Background North American medical schools have used problem-based learning (PBL) structured medical education for more than 60 years. However, it has only recently been introduced in other medical schools outside of North America. Since its inception, there has been the debate on whether the PBL learning process predisposes students to select certain career paths. Objectives To review available evidence to determine the predisposition of specific career paths when undertaking a PBL-based medical curriculum. The career path trajectory was determined as measured by official Matching Programs, self-reported questionnaires and surveys, and formally defined career development milestones. Methods A systematic literature review was performed. PubMed, Medline, Cochrane and ERIC databases were analysed in addition to reference lists for appropriate inclusion. Results Eleven studies fitting the inclusion criteria were identified. The majority of studies showed that PBL did not predispose a student to a career in a specific speciality (n = 7 out of 11 studies, 64%). However, three studies reported a significantly increased number of PBL graduates working in primary care compared to those from a non-PBL curriculum. Conclusions PBL has been shown not to predispose medical students to a career in General Practice or any other speciality. Furthermore, a greater number of similar studies are required before a definitive conclusion can be made in the future

Reliability of Synaptic Transmission at the Synapses of Held In Vivo under Acoustic Stimulation

BACKGROUND:The giant synapses of Held play an important role in high-fidelity auditory processing and provide a model system for synaptic transmission at central synapses. Whether transmission of action potentials can fail at these synapses has been investigated in recent studies. At the endbulbs of Held in the anteroventral cochlear nucleus (AVCN) a consistent picture emerged, whereas at the calyx of Held in the medial nucleus of the trapezoid body (MNTB) results on the reliability of transmission remain inconsistent. In vivo this discrepancy could be due to the difficulty in identifying failures of transmission. METHODS/FINDINGS:We introduce a novel method for detecting unreliable transmission in vivo. Based on the temporal relationship between a cells' waveform and other potentials in the recordings, a statistical test is developed that provides a balanced decision between the presence and the absence of failures. Its performance is quantified using simulated voltage recordings and found to exhibit a high level of accuracy. The method was applied to extracellular recordings from the synapses of Held in vivo. At the calyces of Held failures of transmission were found only rarely. By contrast, at the endbulbs of Held in the AVCN failures were found under spontaneous, excited, and suppressed conditions. In accordance with previous studies, failures occurred most abundantly in the suppressed condition, suggesting a role for inhibition. CONCLUSIONS/SIGNIFICANCE:Under the investigated activity conditions/anesthesia, transmission seems to remain largely unimpeded in the MNTB, whereas in the AVCN the occurrence of failures is related to inhibition and could be the basis/result of computational mechanisms for temporal processing. More generally, our approach provides a formal tool for studying the reliability of transmission with high statistical accuracy under typical in vivo recording conditions

Fluid challenges in intensive care: the FENICE study A global inception cohort study

Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC.2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response.The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account

Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study

Background Dental disease is more extensive in adults with chronic kidney disease, but whether dental health and behaviors are associated with survival in the setting of hemodialysis is unknown. Study Design Prospective multinational cohort. Setting & Participants 4,205 adults treated with long-term hemodialysis, 2010 to 2012 (Oral Diseases in Hemodialysis [ORAL-D] Study). Predictors Dental health as assessed by a standardized dental examination using World Health Organization guidelines and personal oral care, including edentulousness; decayed, missing, and filled teeth index; teeth brushing and flossing; and dental health consultation. Outcomes All-cause and cardiovascular mortality at 12 months after dental assessment. Measurements Multivariable-adjusted Cox proportional hazards regression models fitted with shared frailty to account for clustering of mortality risk within countries. Results During a mean follow-up of 22.1 months, 942 deaths occurred, including 477 cardiovascular deaths. Edentulousness (adjusted HR, 1.29; 95% CI, 1.10-1.51) and decayed, missing, or filled teeth score ≥ 14 (adjusted HR, 1.70; 95% CI, 1.33-2.17) were associated with early all-cause mortality, while dental flossing, using mouthwash, brushing teeth daily, spending at least 2 minutes on oral hygiene daily, changing a toothbrush at least every 3 months, and visiting a dentist within the past 6 months (adjusted HRs of 0.52 [95% CI, 0.32-0.85], 0.79 [95% CI, 0.64-0.97], 0.76 [95% CI, 0.58-0.99], 0.84 [95% CI, 0.71-0.99], 0.79 [95% CI, 0.65-0.95], and 0.79 [95% CI, 0.65-0.96], respectively) were associated with better survival. Results for cardiovascular mortality were similar. Limitations Convenience sample of clinics. Conclusions In adults treated with hemodialysis, poorer dental health was associated with early death, whereas preventive dental health practices were associated with longer survival