HOUSEHOLD INVESTMENTS INTO SOLAR PV AND BATTERY STORAGE: AN ANALYSIS OF PROFITABILITY AND IMPACT. ESRI Research Bulletin 2017/07

Many countries worldwide have adopted policies to support the expansion of renewable energy sources (RES) aimed at reducing greenhouse gas emissions and combating climate change. These support schemes have led to rapidly increased RES capacities. The installed solar photovoltaic (PV) capacity, for instance, has reached more than 300 GW globally at the beginning of 2017. This resulted in strong cost reductions for new PV systems and subsequently in reductions of the PV subsidies. At the same time, electricity retail prices increased in most countries depending on how the different governments decided to levy the RES subsidies. As a result, the consumption of self-generated electricity (the so-called self-consumption) from solar PV became more attractive than feeding the electricity into the grid and getting paid the subsidy. With strongly decreasing battery storage costs, more and more battery storages are deployed along with PV systems in several countries, further fostering self-consumption. In order to explore the main drivers of self-consumption and the resulting costs in different countries, we therefore compare and contrast two EU countries which differ strongly in terms of their solar energy policy as well as their geographical and meteorological conditions and solar PV potential: Germany and Ireland

What drives the profitability of household PV investments, self-consumption and self-sufficiency?

Many countries introduced subsidy schemes that were successful in incentivising investments into residential solar PV. The resulting growth of the global PV market was accompanied by cost reductions for PV systems, reductions of PV subsidies and, often, increasing electricity retail prices. Along with decreasing costs for battery storages, these developments made self-consumption and self-sufficiency continuously more attractive. However, the profitability of PV-storage systems depends on many factors, including technological, political and geographical aspects. We present a simulation model to identify the most profitable sizes of PV and storage systems from a household perspective and explore what drives the profitability of self-consumption and self-sufficiency. We compare and contrast Germany and Ireland to account for regulatory and geographical differences. Our results show that PV-storage systems are generally profitable in Germany and that, after minor technology cost reductions, this result holds even in the absence of subsidies. In Ireland, such systems are not yet profitable but this may change soon with expected technology costs reductions. The share of electricity demand that will be required from the grid may be reduced to 25-35%. Implications for the electricity retail business and policy makers are discussed including distributional concerns and system efficiency considerations

New age constraints for the Saalian glaciation in northern central Europe: Implications for the extent of ice sheets and related proglacial lake systems

A comprehensive palaeogeographic reconstruction of ice sheets and related proglacial lake systems for the older Saalian glaciation in northern central Europe is presented, which is based on the integration of palaeo-ice flow data, till provenance, facies analysis, geomorphology and new luminescence ages of ice-marginal deposits. Three major ice advances with different ice-advance directions and source areas are indicated by palaeo-ice flow directions and till provenance. The first ice advance was characterised by a southwards directed ice flow and a dominance of clasts derived from southern Sweden. The second ice advance was initially characterised by an ice flow towards the southwest. Clasts are mainly derived from southern and central Sweden. The latest stage in the study area (third ice advance) was characterised by ice streaming (Hondsrug ice stream) in the west and a re-advance in the east. Clasts of this stage are mainly derived from eastern Fennoscandia. Numerical ages for the first ice advance are sparse, but may indicate a correlation with MIS 8 or early MIS 6. New pIRIR290 luminescence ages of ice-marginal deposits attributed to the second ice advance range from 175 ± 10 to 156 ± 24 ka and correlate with MIS 6. The ice sheets repeatedly blocked the main river-drainage pathways and led to the formation of extensive ice-dammed lakes. The formation of proglacial lakes was mainly controlled by ice-damming of river valleys and major bedrock spillways; therefore the lake levels and extends were very similar throughout the repeated ice advances. During deglaciation the lakes commonly increased in size and eventually drained successively towards the west and northwest into the Lower Rhine Embayment and the North Sea. Catastrophic lake-drainage events occurred when large overspill channels were suddenly opened. Ice-streaming at the end of the older Saalian glaciation was probably triggered by major lake-drainage events

The Relation between Interests and Grades : Path Analyses in Primary School Age

Within the school context substantial correlations between interests and grades are well documented, but the causal ordering still remains unclear. The paper examines how the relation between interests and grades over several measurement waves in elementary school age can be characterized, whether gender differences in the pattern of effects can be shown, and whether the effects are school-subject-specific. The present analysis follows N = 1.199 students in the 3rd Grade over a year and a half. It can be shown that grading determines the level of future interests but not vice versa. Thereby, the pattern of results concerning interests and grades is similar for boys and girls. The effects of grades on subsequent interests are mostly school-subject-specific

Deletion of the Ca2+ Channel Subunit α2δ3 Differentially Affects Cav2.1 and Cav2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing

Voltage-gated Ca2+ channels are composed of a pore-forming α1 subunit and auxiliary β and α2δ subunits, which modulate Ca2+ current properties and channel trafficking. So far, the partial redundancy and specificity of α1 for α2δ subunits in the CNS have remained largely elusive. Mature spiral ganglion (SG) neurons express α2δ subunit isoforms 1, 2, and 3 and multiple Ca2+ channel subtypes. Differentiation and in vivo functions of their endbulb of Held synapses, which rely on presynaptic P/Q channels (Lin et al., 2011), require the α2δ3 subunit (Pirone et al., 2014). This led us to hypothesize that P/Q channels may preferentially co-assemble with α2δ3. Using a dissociated primary culture, we analyzed the effects of α2δ3 deletion on somatic Ca2+ currents (ICa) of SG neurons isolated at postnatal day 20 (P20), when the cochlea is regarded to be mature. P/Q currents were the dominating steady-state Ca2+ currents (54% of total) followed by T-type, L-type, N-type, and R-type currents. Deletion of α2δ3 reduced P/Qand R-type currents by 60 and 38%, respectively, whereas L-type, N-type, and T-type currents were not altered. A subset of ICa types was also analyzed in SG neurons isolated at P5, i.e., before the onset of hearing (P12). Both L-type and N-type current amplitudes of wildtype SG neurons were larger at P5 compared with P20. Deletion of α2δ3 reduced L-type and N-type currents by 23 and 44%, respectively. In contrast, small P/Q currents, which were just being up-regulated at P5, were unaffected by the lack of α2δ3. In summary, α2δ3 regulates amplitudes of L- and N-type currents of immature cultured SG neurons, whereas it regulates P/Q- and R-type currents at P20. Our data indicate a developmental switch from dominating somatic N- to P/Q-type currents in cultured SG neurons. A switch from N- to P/Q-type channels, which has been observed at several central synapses, may also occur at developing endbulbs of Held. In this case, reduction of both neonatal N- (P5) and more mature P/Q-type currents (around/after hearing onset) may contribute to the impaired morphology and function of endbulb synapses in α2δ3-deficient mice

Reflexion und Reflexivität. Alltägliche pädagogische Praxis und Forschungsstrategie

Der Beitrag entfaltet am Beispiel empirischer Studien in pädagogischen Handlungsfeldern (Hochschullernwerkstatt, Demokratische Schule, Gedenkstätte) eine ethnomethodologische Perspektive auf die Erforschung von Reflexion und Reflexivität. Die Untersuchung pädagogischer Reflexion wird mit der erkenntnistheoretischen Prämisse, alles Handeln als reflexiv zu kennzeichnen, verbunden. In den untersuchten pädagogischen Handlungsfeldern reflektieren die Akteur:innen in etablierter Weise sichtbar und beobachtbar ihr Tun und bringen dies als alltägliche pädagogische Praxis zur Darstellung. Es geht darum, diese pädagogischen Praktiken der Reflexion zu identifizieren und dabei gleichzeitig die Eingebundenheit der Forscher:innen in diese reflexiven Forschungsfelder aufzuzeigen. Dieser Zugang zu Reflexion und Reflexivität wird damit gleichzeitig forschungsstrategische Ressource und Thema. (DIPF/Orig.

Biomarker alterations associated with distinct patterns of metastatic spread in colorectal cancer

Metastatic spread is the most important life-threatening feature of colorectal cancer and is supposed to be mainly driven by alterations in different carcinogenic pathways. The present study compared mutation and expression profiles of distinctive biomarkers in colorectal cancer patients with different clinical metastatic patterns. As for a case-control study, patients were matched according to T category, grading and primary tumour site. Overall, 246 patients with either exclusive lung metastasis (N = 82), exclusive liver metastasis (N = 82) or non-metastatic colorectal cancer (N = 82) were identified. Paraffin-embedded specimens were examined for mutations in the RAS and RAF genes and for the expression of β-catenin and CD133. Clinical endpoints were presence or absence of distant metastasis, formation of metastasis in lungs versus the liver and survival. MAPK pathway mutations in either the KRAS, NRAS or BRAF gene were associated with the development of lung metastasis (63.4%) compared to the control group (47.6%; p = 0.04). MAPK pathway alterations plus high β-catenin expression were associated with metastasis to the lungs but not to the liver (28.0% vs. 13.4%; p = 0.02). High CD133 expression correlated with the development of liver metastasis compared to the control group (30.5% vs. 14.6%; p = 0.02). This data indicates that different patterns of distant spread are associated with specific biomarker alterations and may represent different molecular subtypes of colorectal cancer. However, underlying mechanisms of metastasis formation in different anatomic sites remains unclear. Since knowledge of the anticipated site of distant spread would substantially impact clinical management, further research is needed to identify solid biomarkers for different metastatic patterns

Robotic observation pipeline for small bodies in the solar system based on open-source software and commercially available telescope hardware

The observation of small bodies in the Space Environment is an ongoing important task in astronomy. While nowadays new objects are mostly detected in larger sky surveys, several follow-up observations are usually needed for each object to improve the accuracy of orbit determination. In particular objects orbiting close to Earth, so called Near-Earth Objects (NEOs) are of special concern as a small but not negligible fraction of them can have a non-zero impact probability with Earth. Additionally, the observation of manmade space debris and tracking of satellites falls in the same class measurements. Telescopes for these follow-up observations are mainly in a aperture class between 1 m down to approximately 25 cm. These telescopes are often hosted by amateur observatories or dedicated companies like 6ROADS specialized on this type of observation. With upcoming new NEO search campaigns by very wide field of view telescopes, like the Vera C. Rubin Observatory, NASA’s NEO surveyor space mission and ESA’s Flyeye telescopes, the number of NEO discoveries will increase dramatically. This will require an increasing number of useful telescopes for follow-up observations at different geographical locations. While well-equipped amateur astronomers often host instruments which might be capable of creating useful measurements, both observation planning and scheduling, and also analysis are still a major challenge for many observers. In this work we present a fully robotic planning, scheduling and observation pipeline that extends the widely used open-source cross-platform software KStars/Ekos for Instrument Neutral Distributed Interface (INDI) devices. The method consists of algorithms which automatically select NEO candidates with priority according to ESA’s Near-Earth Object Coordination Centre (NEOCC). It then analyses detectable objects (based on limiting magnitudes, geographical position, and time) with preliminary ephemeris from the Minor Planet Center (MPC). Optimal observing slots during the night are calculated and scheduled. Immediately before the measurement the accurate position of the minor body is recalculated and finally the images are taken. Besides the detailed description of all components, we will show a complete robotic hard- and software solution based on our methods.TS-R acknowledges funding from the NEO-MAPP project (H2020-EU-2-1-6/870377). This work was (partially) funded by the Spanish MICIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” by the “European Union” through grant RTI2018-095076-B-C21, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia “María de Maeztu”) through grant CEX2019-000918-M

Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B

In the frame of studies on secondary metabolites produced by fungi from deep-sea environments we have investigated inhibitors of enzymes playing key roles in signaling cascades of biochemical pathways relevant for the treatment of diseases. Here we report on a new inhibitor of the human protein tyrosine phosphatase 1B (PTP1B), a target in the signaling pathway of insulin. A new asperentin analog is produced by an Aspergillus sydowii strain isolated from the sediment of the deep Mediterranean Sea. Asperentin B (1) contains an additional phenolic hydroxy function at C-6 and exhibits an IC50 value against PTP1B of 2 μM in vitro, which is six times stronger than the positive control, suramin. Interestingly, asperentin (2) did not show any inhibition of this enzymatic activity. Asperentin B (1) is discussed as possible therapeutic agents for type 2 diabetes and sleeping sickness

Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β

The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling pathways of type 2 diabetes, neurological disorders, cancer, and other diseases. Therefore, inhibitors of GSK-3 are promising drug candidates for the treatment of a broad range of diseases. Here we report pannorin (1), alternariol (2), and alternariol-9-methylether (3) to be promising inhibitors of the isoform GSK-3β showing sub-μM IC50 values. The in vitro inhibition is in the range of the known highly active GSK-3β inhibitor TDZD-8. Compounds 1–3 have a highly oxygenated benzocoumarin core structure in common, which suggests that this may be a new structural feature for efficient GSK-3β inhibitio