Esquinas do Tempo : contributos para uma (re)construção da memória educativa portuguesa

O presente trabalho procura revisitar o passado, numa tentativa de perscrutar a evolução do ensino entre os anos de 1930 e 1980, época singular da história de Portugal, dado o seu carácter fortemente ideológico. A investigação procura igualmente reflectir sobre a concepção de profissão do ponto de vista histórico/sociológico, analisando as questões de género, de forma a compreender o processo de feminização do corpo docente. A problemática que originou este estudo partiu da intersecção de vários questionamentos, em especial perceber a representação da profissão docente no universo feminino do século XX, compreender a visão de classe e de identidade profissional, interpretar a relevância das experiências das professoras no universo pessoal e profissional local e, por fim, auscultar a forma como a acção pedagógica é influenciada pelos percursos de vida dos professores e pelas suas características pessoais. A metodologia seguida é de carácter qualitativo, numa abordagem biográfica com recurso a narrativas de vida. O estudo analisa os percursos de vida de quatro docentes, “desvendando a singularidade e totalidade da pessoa do actor biografada” (Afonso, 2005:99), com vista a perceber como as mesmas interpretaram as suas vivências e que sentidos conferiram às suas experiências, formação e conquistas profissionais.This work aims to revisit the past, in an attempt at analyzing the evolution of education between 1930 and 1980, a singular era in the history of Portugal, due to its strongly ideological character. The research also seeks to reflect on the design of the profession in a historical/sociological point of view, analyzing gender issues, in order to understand the process of feminization of the teaching force. The problem that originated this study came from the intersection of several questions, in particular perceive the representation of the teaching profession in the feminine universe of the 20th century, understand the vision of class and professional identity, infer the relevance of the experiences of teachers in professional and personal universe and, finally, find how the pedagogical action is influenced by journeys of life of teachers and their personal characteristics. The methodology used is a biographical approach using life narratives. The study analyzes life journeys of four teachers, "unweaving the singularity and totality of the person of actor in study" (Afonso, 2005:99), in order to realize how they interpreted their experiences and what they think about their training and professional achievements

DON\u27T BLAME THE VACCINE

Background: The mRNA COVID vaccine is a rare cause of myocarditis in young patients. We describe a case of cardiogenic shock with extensive workup ruling out COVID vaccine induced myocarditis. Case: 42-year-old female who drinks 5 Monster energy drinks and 3-4 cups of coffee daily presented to the hospital with palpitations two weeks following her mRNA COVID vaccine. EKG showed atrial tachycardia with heart rates of 160 beats per minute. Adenosine and Lopressor were administered resulting in hemodynamic instability requiring norepinephrine. An echocardiogram showed dilated cardiomyopathy with ejection fraction of 15%. Right heart catheterization was performed, and the cardiac index was 1.22 L/min/m², systemic vascular resistance was 1918 dynes*sec*cm-5 and wedge pressure was 31 mm Hg. The patient was started on nitroprusside, furosemide, and milrinone drips and she began to improve. The patient was adamant the vaccine is what triggered her heart failure and extensive testing was performed to rule out COVID vaccine induced myocarditis. Workup showed normal coronary arteries and no evidence of infiltrative disease or myocarditis on cardiac MRI. The etiology was from tachycardia induced cardiomyopathy triggered by excessive stimulants and the patient had successful atrial tachycardia ablation of the right superior pulmonary vein. She was discharged on medical therapy for heart failure and advised to stop drinking energy drinks. Decision-making: Once the patient did not respond to the rate controlling agents an echocardiogram showed reduced ejection fraction. Right heart catheterization confirmed cardiogenic shock and nitroprusside and milrinone were started to help reduce afterload and improve contractility. Workup to exclude COVID induced myocarditis lead to the diagnosis of tachycardia induced cardiomyopathy and atrial tachycardia ablation was performed. Conclusion: We report a case of cardiogenic shock with workup diagnosing tachycardia induced cardiomyopathy induced from a combination of excessive monster energy drinks and coffee. She was treated successfully with afterload reduction, inotrope support, and atrial tachycardia ablation

The Transmuted Exponentiated Additive Weibull Distribution: Properties and Applications

A new generalization of the transmuted additive Weibull distribution is proposed by using the quadratic rank transmutation map, the so-called transmuted exponentiated additive Weibull distribution. It retains the characteristics of a good model. It is more flexible, being able to analyze more complex data; it includes twenty-seven sub-models as special cases and it is interpretable. Several mathematical properties of the new distribution as closed forms for ordinary and incomplete moments, quantiles, and moment generating function are presented, as well as the MLEs. The usefulness of the model is illustrated by using two real data sets

Participação, informação e comunicação nos processos de decisão pública – o caso de Alqueva

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Gestão e Políticas AmbientaisAs barragens têm sido promovidas como um importante meio de atender a necessidades efectivas de água e energia e como investimentos estratégicos de longo prazo capazes de oferecer múltiplos benefícios. O desenvolvimento regional, a criação de emprego e o fomento de novo tecido industrial ou ainda o turismo, são frequentemente referidos como objectivos adicionais a atingir com a construção de grandes barragens. Os grandes investimentos envolvidos e os impactes gerados pelas grandes barragens provocam conflitos acerca da localização e impactes dessas infra-estruturas, tornando-se actualmente uma das questões mais controversas na área do desenvolvimento sustentável. O Empreendimento de Fins Múltiplos de Alqueva corresponde a uma aspiração com várias décadas. Ao longo de todos estes anos, foram expostas e controvertidas na comunicação social posições diversas a respeito de Alqueva. Houve sempre a exposição de posições contrárias, mas nunca, como hoje, se terá assistido a uma tão grande prevalência da expressão de posições desfavoráveis ao Empreendimento. O estudo deste conflito pretende, através de uma análise da imprensa publicada em dois períodos distintos, identificar os aspectos dominantes e os interesses, valores e posições dos actores envolvidos. Um dos principais objectivos visa extrair ensinamentos que permitam desenvolver abordagens mais adequadas para situações controversas que frequentemente acabam em impasse. Neste caso, verifica-se que o conflito opõe dois grupos dominantes de actores: por um lado,estão a EDIA, as autarquias da região, as populações locais e os partidos políticos. No segundo grande grupo encontram-se as Organizações Não Governamentais de Ambiente – ONGA - e de Arqueologia

National Landscape of Hospitalizations in Patients with Left Ventricular Assist Device. Insights from the National Readmission Database 2010-2015

The number of patients with left ventricular assist devices (LVAD) has increased over the years and it is important to identify the etiologies for hospital admission, as well as the costs, length of stay and in-hospital complications in this patient group. Using the National Readmission Database from 2010 to 2015, we identified patients with a history of LVAD placement using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code V43.21. We aimed to identify the etiologies for hospital admission, patient characteristics, and in-hospital outcomes. We identified a total of 15,996 patients with an LVAD, the mean age was 58 years and 76% were males. The most common cause of hospital readmission after LVAD was heart failure (HF, 13%), followed by gastrointestinal (GI) bleed (11.8%), device complication (11.5%), and ventricular tachycardia/fibrillation (4.2%). The median length of stay was 6 days (3-11 days) and the median hospital costs was $12,723 USD. The in-hospital mortality was 3.9%, blood transfusion was required in 26.8% of patients, 20.5% had acute kidney injury, 2.8% required hemodialysis, and 6.2% of patients underwent heart transplantation. Interestingly, the most common cause of readmission was the same as the diagnosis for the preceding admission. One in every four LVAD patients experiences a readmission within 30 days of a prior admission, most commonly due to HF and GI bleeding. Interventions to reduce HF readmissions, such as speed optimization, may be one means of improving LVAD outcomes and resource utilization

Detection of mild cognitive impairment in people older than 65 years of age and its relationship to cardiovascular risk factors (DECRIVAM)

[ENG]Background: Studies centered on the detection of cognitive impairment and its relationship to cardiovascular risk factors in elderly people have gained special relevance in recent years. Knowledge of the cardiovascular risk factors that may be associated to cognitive impairment could be very useful for introducing treatments in early stagesthereby possibly contributing to improve patient quality of life. The present study explores cognitive performance in people over 65 years of age in Salamanca (Spain), with special emphasis on the identification of early symptoms of cognitive impairment, with the purpose of detecting mild cognitive impairment and of studying the relationships between this clinical situation and cardiovascular risk factors. Methods/Design: A longitudinal study is contemplated. The reference population will consist of 420 people over 65 years of age enrolled through randomized sampling stratified by healthcare area, and who previously participated in another study. Measurement: a) Sociodemographic variables; b) Cardiovascular risk factors; c) Comorbidity; d) Functional level for daily life activities; and e) Study of higher cognitive functions based on a neuropsychological battery especially adapted to the evaluation of elderly people. Discussion: We hope that this study will afford objective information on the representative prevalence of cognitive impairment in the population over 65 years of age in Salamanca. We also hope to obtain data on the relationship between cognitive impairment and cardiovascular risk factors in this specific population group. Based on the results obtained, we also will be able to establish the usefulness of some of the screening tests applied during the study, such as the Mini-Mental State Examination and the 7 Minute Screen test. Trial registration: ClinicalTrials.gov: NCT0132719

Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure

<p>Abstract</p> <p>Introduction</p> <p>Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinone administration is not well established.</p> <p>Methods</p> <p>Ten patients with severe HF and reduced cardiac output who were to receive milrinone were studied. Blood samples were taken just before initiation of milrinone and after 24 hours of infusion. Dosing was at the discretion of the patient's attending physician (range 0.25–0.5 mcg/kg/min). Plasma measurements of troponin, myoglobin, N-terminal-pro-BNP, interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand were performed at both time points.</p> <p>Results</p> <p>Troponin was elevated at baseline in all patients (mean 0.1259 ± 0.17 ng/ml), but there was no significant change after 24 hours of milrinone (mean 0.1345 ± 0.16 ng/ml, p = 0.44). There were significant improvements in interleukin-6, tumor necrosis factor-α, soluble Fas, and soluble Fas-ligand (all p < 0.05) indicative of reduced inflammatory and apoptotic signaling compared to baseline.</p> <p>Conclusion</p> <p>In conclusion, among patients with severe HF and low cardiac output, ongoing myocardial injury is common, and initiation of milrinone did not result in exacerbation of myocardial injury but instead was associated with salutary effects on other biomarkers.</p

Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that the rare complex allele [G576V;R668C] is associated with a milder disease via a gain-of-function mechanism. Conversely, CFTR ultra-rare alleles with reduced function are associated with disease severity either alone (dominant disorder) or with another hypomorphic allele in the second chromosome (recessive disorder) with a global residual CFTR activity between 50 to 91%. Furthermore, we characterized novel CFTR complex alleles, including [A238V;F508del], [R74W;D1270N;V201M], [I1027T;F508del], [I506V;D1168G], and simple alleles, including R347C, F1052V, Y625N, I328V, K68E, A309D, A252T, G542*, V562I, R1066H, I506V, I807M, which lead to a reduced CFTR function and thus, to more severe COVID-19. In conclusion, CFTR genetic analysis is an important tool in identifying patients at risk of severe COVID-19

Gestión del proceso de innovación de las prácticas de enseñanza en instituciones educativas. Un estudio prospectivo a diez años

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Maine, Claudia Amelia. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Abram, Liliana Alejandra. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Barrionuevo Vidal, María Belén. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Etchegorry, Mariana. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Perfumo, María Soledad. Universidad Católica de Córdoba. Facultad de Educación; Argentin

An explainable model of host genetic interactions linked to COVID-19 severity

We employed a multifaceted computational strategy to identify the genetic factors contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing (WES) dataset of a cohort of 2000 Italian patients. We coupled a stratified k-fold screening, to rank variants more associated with severity, with the training of multiple supervised classifiers, to predict severity based on screened features. Feature importance analysis from tree-based models allowed us to identify 16 variants with the highest support which, together with age and gender covariates, were found to be most predictive of COVID-19 severity. When tested on a follow-up cohort, our ensemble of models predicted severity with high accuracy (ACC = 81.88%; AUCROC = 96%; MCC = 61.55%). Our model recapitulated a vast literature of emerging molecular mechanisms and genetic factors linked to COVID-19 response and extends previous landmark Genome-Wide Association Studies (GWAS). It revealed a network of interplaying genetic signatures converging on established immune system and inflammatory processes linked to viral infection response. It also identified additional processes cross-talking with immune pathways, such as GPCR signaling, which might offer additional opportunities for therapeutic intervention and patient stratification. Publicly available PheWAS datasets revealed that several variants were significantly associated with phenotypic traits such as "Respiratory or thoracic disease", supporting their link with COVID-19 severity outcome.A multifaceted computational strategy identifies 16 genetic variants contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing dataset of a cohort of Italian patients