Prevalence of overweight among Dutch primary school children living in JOGG and non-JOGG areas

BACKGROUND: One of the most influential integrated approaches towards reducing childhood obesity is EPODE, a program that has been translated to over 20 different countries worldwide. AIM: The goal of this study was to explore how JOGG–the Dutch EPODE adaptation–might reduce overweight prevalence among children. METHODS: To compare whether overweight prevalence was different in JOGG areas vs. non-JOGG areas, in long-term JOGG areas vs. short-term JOGG areas, and in low SES JOGG areas vs. middle/high SES JOGG areas, secondary anthropometric and personal data of 209,565 Dutch children were mapped onto publicly available JOGG data. RESULTS: Findings showed that overweight prevalence decreased from 25.17% to 16.08% in JOGG-areas, and from 32.31% to 18.43% in long-term JOGG areas. However, when taking into account SES, the decrease in prevalence was mainly visible in low SES long-term JOGG areas. CONCLUSION: JOGG appeared to be successful in targeting areas where overweight was most prevalent. Low SES areas that had implemented JOGG for a longer period of time, i.e., six years, appeared to be successful in decreasing overweight prevalence

“We Say ‘Mothers’ But Mean ‘Parents’”:Qualitative Perceptions and Experiences With Father Absence Among Curaçaoan, Curaçaoan-Dutch, and Dutch Young People

Perceptions and experiences with biological father absence might vary depending on the extent to which father absence constitutes a common family form, like it does in many Caribbean countries. The goal of this qualitative study was to better understand what it means to grow up without a father for Curaçaoan (n = 19; 15–24 years), Curaçaoan-Dutch (n = 15; 14–29 years), and Dutch (n = 16; 16–26 years) young men and women. Findings from thematic analyses of ethically approved in-depth interviews revealed that most interviewees from all three cultural groups perceived no bond with and upbringing from their absent father. The interviewees noted emotional pain, but also mentioned that (m)others compensated for their father’s absence. Dutch interviewees were more negative about their absent father, and both Dutch and Curaçaoan-Dutch interviewees experienced more difficulties with respect to their father’s absence compared with Curaçaoan interviewees. Studying the similarities and differences between perceptions and experiences with father absence enriches our knowledge of what it means to grow up without a father. Doing so from young people’s point of view and across cultures has important practical value by providing a fuller understanding of the meaning of father absence for young people across cultures

“We Say ‘Mothers’ But Mean ‘Parents’”:Qualitative Perceptions and Experiences With Father Absence Among Curaçaoan, Curaçaoan-Dutch, and Dutch Young People

Perceptions and experiences with biological father absence might vary depending on the extent to which father absence constitutes a common family form, like it does in many Caribbean countries. The goal of this qualitative study was to better understand what it means to grow up without a father for Curaçaoan (n = 19; 15–24 years), Curaçaoan-Dutch (n = 15; 14–29 years), and Dutch (n = 16; 16–26 years) young men and women. Findings from thematic analyses of ethically approved in-depth interviews revealed that most interviewees from all three cultural groups perceived no bond with and upbringing from their absent father. The interviewees noted emotional pain, but also mentioned that (m)others compensated for their father’s absence. Dutch interviewees were more negative about their absent father, and both Dutch and Curaçaoan-Dutch interviewees experienced more difficulties with respect to their father’s absence compared with Curaçaoan interviewees. Studying the similarities and differences between perceptions and experiences with father absence enriches our knowledge of what it means to grow up without a father. Doing so from young people’s point of view and across cultures has important practical value by providing a fuller understanding of the meaning of father absence for young people across cultures

“We Say ‘Mothers’ But Mean ‘Parents’”:Qualitative Perceptions and Experiences With Father Absence Among Curaçaoan, Curaçaoan-Dutch, and Dutch Young People

Perceptions and experiences with biological father absence might vary depending on the extent to which father absence constitutes a common family form, like it does in many Caribbean countries. The goal of this qualitative study was to better understand what it means to grow up without a father present in the household for Curaçaoan (n = 19; 15-24 years), Curaçaoan-Dutch (n = 15; 14-29 years), and Dutch (n = 16; 16-26 years) young men and women. Findings from thematic analyses of ethically approved structured in-depth interviews revealed that most young people from all three cultural groups perceived no bond with and upbringing from their absent father. They noted emotional pain, but also mentioned that (m)others compensated for their father’s absence. Dutch young people were more negative about their absent father and both Dutch and Curaçaoan-Dutch young people experienced more difficulties with respect to their father’s absence compared to Curaçaoan young people. Studying the similarities and differences between perceptions and experiences with father absence enriches our knowledge of what it means to grow up without a father. Doing so from young people’s point of view and across cultures has important practical value by providing a fuller understanding of the meaning of father absence for young people across cultures

Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases.

For the first time in Europe hundreds of rare disease (RD) experts team up to actively share and jointly analyse existing patient's data. Solve-RD is a Horizon 2020-supported EU flagship project bringing together >300 clinicians, scientists, and patient representatives of 51 sites from 15 countries. Solve-RD is built upon a core group of four European Reference Networks (ERNs; ERN-ITHACA, ERN-RND, ERN-Euro NMD, ERN-GENTURIS) which annually see more than 270,000 RD patients with respective pathologies. The main ambition is to solve unsolved rare diseases for which a molecular cause is not yet known. This is achieved through an innovative clinical research environment that introduces novel ways to organise expertise and data. Two major approaches are being pursued (i) massive data re-analysis of >19,000 unsolved rare disease patients and (ii) novel combined -omics approaches. The minimum requirement to be eligible for the analysis activities is an inconclusive exome that can be shared with controlled access. The first preliminary data re-analysis has already diagnosed 255 cases form 8393 exomes/genome datasets. This unprecedented degree of collaboration focused on sharing of data and expertise shall identify many new disease genes and enable diagnosis of many so far undiagnosed patients from all over Europe

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Fundamentals of software integration

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Prevalence of overweight among Dutch primary school children living in JOGG and non-JOGG areas

Background: One of the most influential integrated approaches towards reducing childhood obesity is EPODE, a program that has been translated to over 20 different countries worldwide. Aim The goal of this study was to explore how JOGG – the Dutch EPODE adaptation – might reduce overweight prevalence among children. Methods: To compare whether overweight prevalence was different in JOGG areas vs. non-JOGG areas, in long-term JOGG areas vs. short-term JOGG areas, and in low SES JOGG areas vs. middle/high SES JOGG areas, secondary anthropometric and personal data of 209,565 Dutch children were mapped onto publicly available JOGG data. Results: Findings showed that overweight prevalence decreased from 25.17% to 16.08% in JOGG-areas, and from 32.31% to 18.43% in long-term JOGG areas. However, when taking into account SES, the decrease in prevalence was mainly visible in low SES long-term JOGG areas. Conclusion: JOGG appeared to be successful in targeting areas where overweight was most prevalent. Low SES areas that had implemented JOGG for a longer period of time, i.e., six years, appeared to be successful in decreasing overweight prevalence

The association between obesity-related legislation in the United States and adolescents’ weight

Effective obesity prevention requires intervening at all levels of society, including the governmental level. Policy interventions at the governmental level are especially promising as they tend to involve minimal individual effort while, at the same time, reach many people. The amount of state-level obesity-related legislation in the United States has increased over the years, and several laws were installed in contexts that reach young people, such as schools. Given this increase in state-level obesity-related legislation targeting youth, we tested whether the quantity of obesity-related legislation in U.S. states was associated with adolescent BMI and overweight/obesity prevalence. Linear and multilevel analyses showed that the quantity of physical activity-related legislation was associated with lower overweight/obesity prevalence yet with very modest effect size (b = -0.002, p = .042). Our results underline the likely importance of obesity-related legislation. In addition, the value of examining both BMI and overweight/obesity prevalence when evaluating interventions is demonstrated

Interventions aimed at preventing and reducing overweight/obesity among children and adolescents: a meta-synthesis

The prevalence of childhood and adolescent obesity has been a major worldwide problem for decades. To stop the number of children and adolescents with overweight or obesity from increasing, numerous interventions focusing on improving children’s weight status have been designed and implemented. This vastly growing body of research on weight-related interventions for children and adolescents has been summarized by several meta-analyses that aim to provide an overview of the effectiveness of these interventions. Yet, the number of meta-analyses is expanding so quickly and overall results differ, making a comprehensive synopsis of the literature difficult. To tackle this problem, a meta- synthesis was conducted to draw informed conclusions about the state of the effectiveness of interventions targeting child and adolescent overweight. The results of the quantitative synthesis of 26 meta-analyses resulted in a standardized mean difference of -0.12 (95%CI: -0.16;-0.08). Several moderator analyses (e.g., gender, age, duration of the intervention, parental involvement) showed that participant and intervention characteristics had little impact on the overall effect size. Overall, the results of this meta-synthesis suggest that interventions result in statistically significant effects albeit of relatively little clinical relevance