On the investigations of galaxy redshift periodicity

In this article we present a historical review of study of the redshift periodicity of galaxies, starting from the first works performed in the seventies of the twentieth century until the present day. We discuss the observational data and methods used, showing in which cases the discretization of redshifts was observed. We conclude that galaxy redshift periodisation is an effect which can really exist. We also discussed the redshift discretization in two different structures: the Local Group of galaxies and the Hercules Supercluster. Contrary to the previous studies we consider all galaxies which can be regarded as a structure member disregarding the accuracy of velocity measurements. We applied the power spectrum analysis using the Hann function for weighting, together with the jackknife error estimator. In both the structures we found weak effects of redshift periodisation.Comment: 10 pages, 4 figures, to be published in Part. and Nucl. Lett. 200

Ca II Triplet Spectroscopy of Giants in SMC Star Clusters: Abundances, Velocities and the Age-Metallicity Relation

We have obtained spectra at the Ca II triplet of individual red giants in seven SMC star clusters whose ages range from ~4 to 12 Gyr. The spectra have been used to determine mean abundances for six of the star clusters to a typical precision of 0.12 dex. When combined with existing data for other objects, the resulting SMC age-metallicity relation is generally consistent with that for a simple model of chemical evolution, scaled to the present-day SMC mean abundance and gas mass fraction. Two of the clusters (Lindsay 113 and NGC 339), however, have abundances that ~0.5 dex lower than that expected from the mean age-metallicity relation. It is suggested that the formation of these clusters, which have ages of ~5 Gyr, may have involved the infall of uneriched gas, perhaps from the Magellanic Stream. The spectra also yield radial velocities for the seven clusters. The resulting velocity dispersion is 16 +/- 4 km/sec, consistent with those of the SMC planetary nebula and carbon star populations.Comment: 28 pages including 4 figure

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation

Sandhoff disease, one of the GM2 gangliosidoses, is a lysosomal storage disorder characterized by the absence of beta-hexosaminidase A and B activity and the concomitant lysosomal accumulation of its substrate, GM2 ganglioside. It features catastrophic neurodegeneration and death in early childhood. How the lysosomal accumulation of ganglioside might affect the early development of the nervous system is not understood. Recently, cerebral organoids derived from induced pluripotent stem (iPS) cells have illuminated early developmental events altered by disease processes. To develop an early neurodevelopmental model of Sandhoff disease, we first generated iPS cells from the fibroblasts of an infantile Sandhoff disease patient, then corrected one of the mutant HEXB alleles in those iPS cells using CRISPR/Cas9 genome-editing technology, thereby creating isogenic controls. Next, we used the parental Sandhoff disease iPS cells and isogenic HEXB-corrected iPS cell clones to generate cerebral organoids that modeled the first trimester of neurodevelopment. The Sandhoff disease organoids, but not the HEXB-corrected organoids, accumulated GM2 ganglioside and exhibited increased size and cellular proliferation compared with the HEXB-corrected organoids. Whole-transcriptome analysis demonstrated that development was impaired in the Sandhoff disease organoids, suggesting that alterations in neuronal differentiation may occur during early development in the GM2 gangliosidoses

HI asymmetry in the isolated galaxy CIG 85 (UGC 1547)

We present the results from the Giant Metrewave Radio Telescope (GMRT) interferometric HI and 20 cm radio continuum observations of CIG 85, an isolated asymmetric galaxy from the AMIGA (Analysis of the Interstellar Medium of Isolated GAlaxies) sample. Despite being an isolated galaxy, CIG 85 showed an appreciable optical and HI spectral asymmetry and therefore was an excellent candidate for resolved HI studies to understand the reasons giving rise to asymmetries in isolated galaxies. The galaxy was imaged in HI and 20 cm radio continuum using the GMRT. For a detailed discussion of the results we also made use of multi-wavelength data from archival SDSS, GALEX and Halpha imaging. We find the HI in CIG 85 to have a clumpy, asymmetric distribution which in the NW part is correlated with optical tail like features, but the HI velocity field displays a relatively regular rotation pattern. Evaluating all the observational evidence, we come to a conclusion that CIG 85 is most likely a case of a disturbed spiral galaxy which now appears to have the morphology of an irregular galaxy. Although it is currently isolated from major companions, the observational evidence is consistent with HI asymmetries, a highly disturbed optical disk and recent increase in star formation having been caused by a minor merger, remnants of which are now projected in front of the optical disk. If this is correct, the companion will be fully accreted by CIG 85 in the near future.Comment: 10 pages, 9 figures, accepted in A&

In Search of Possible Associations between Planetary Nebulae and Open Clusters

We consider the possibility of cluster membership for 13 planetary nebulae that are located in close proximity to open clusters lying in their lines of sight. The short lifetimes and low sample size of intermediate-mass planetary nebulae with respect to nearby open clusters conspire to reduce the probability of observing a true association. Not surprisingly, line of sight coincidences almost certainly exist for 7 of the 13 cases considered. Additional studies are advocated, however, for 6 planetary nebula/open cluster coincidences in which a physical association is not excluded by the available evidence, namely M 1-80/Berkeley 57, NGC 2438/NGC 2437, NGC 2452/NGC 2453, VBRC 2 & NGC 2899/IC 2488, and HeFa 1/NGC 6067. A number of additional potential associations between planetary nebulae and open clusters is tabulated for reference purposes. It is noteworthy that the strongest cases involve planetary nebulae lying in cluster coronae, a feature also found for short-period cluster Cepheids, which are themselves potential progenitors of planetary nebulae.Comment: Accepted for publication in PASP (December 2007

Revisiting special relativity: A natural algebraic alternative to Minkowski spacetime

Minkowski famously introduced the concept of a space-time continuum in 1908, merging the three dimensions of space with an imaginary time dimension $i c t$, with the unit imaginary producing the correct spacetime distance $x^2 - c^2 t^2$, and the results of Einstein's then recently developed theory of special relativity, thus providing an explanation for Einstein's theory in terms of the structure of space and time. As an alternative to a planar Minkowski space-time of two space dimensions and one time dimension, we replace the unit imaginary $i = \sqrt{-1}$, with the Clifford bivector $\iota = e_1 e_2$ for the plane that also squares to minus one, but which can be included without the addition of an extra dimension, as it is an integral part of the real Cartesian plane with the orthonormal basis $e_1$ and $e_2$. We find that with this model of planar spacetime, using a two-dimensional Clifford multivector, the spacetime metric and the Lorentz transformations follow immediately as properties of the algebra. This also leads to momentum and energy being represented as components of a multivector and we give a new efficient derivation of Compton's scattering formula, and a simple formulation of Dirac's and Maxwell's equations. Based on the mathematical structure of the multivector, we produce a semi-classical model of massive particles, which can then be viewed as the origin of the Minkowski spacetime structure and thus a deeper explanation for relativistic effects. We also find a new perspective on the nature of time, which is now given a precise mathematical definition as the bivector of the plane.Comment: 29 pages, 2 figure

The MACHO Project 9 Million Star Color-Magnitude Diagram of the Large Magellanic Cloud

We present a 9 million star color-magnitude diagram (9M CMD) of the LMC bar. The 9M CMD reveals a complex superposition of different age and metallicity stellar populations, with important stellar evolutionary phases occurring over 3 orders of magnitude in number density. First, we count the non-variable supergiants, the associated Cepheids, and measure the effective temperatures defining the instability strip. Lifetime predictions of stellar evolution theory are tested, with implications for the origin of low-luminosity Cepheids. The highly-evolved AGB stars have a bimodal distribution in brightness, which we interpret as discrete old populations (>1 Gyr). The faint AGB may be metal-poor and very old. We identify the clusters NGC 411 and M3 as templates for the admixture of old stellar populations. However, there are indications that the old and metal-poor field population has a red HB morphology: the RR Lyraes lie on the red edge of the instability strip, the AGB-bump is very red, and the ratio of AGB-bump stars to RR Lyraes is quite large. If the HB second parameter is age, the old and metal-poor field population likely formed after the oldest clusters. Lifetime predictions of stellar evolution theory lead us to associate a significant fraction of the red HB clump giants with the same old and metal-poor population producing the RR Lyraes and the AGB-bump. In this case, compared to the age-dependent luminosity predictions of stellar evolution theory, the red HB clump is too bright relative to the RR Lyraes and AGB-bump. Last, the surface density profile of RR Lyraes is fit by an exponential, favoring a disk-like rather than spheroidal distribution. We conclude that the age of the LMC disk is probably similar to the age of the Galactic disk. (ABRIDGED)Comment: to appear in the Astronomical Journal, 49 pages, 12 figures, aaspp4.st

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of understanding of the in vivo functions of the putative causative genes. We addressed this by investigating a key pair of endocytic adaptor proteins, PH domain-containing endocytic trafficking adaptor 1 and 2 (PHETA1/2; also known as FAM109A/B, Ses1/2, IPIP27A/B), which interact with the protein product of OCRL, the causative gene for Lowe syndrome. Here, we conducted the first study of PHETA1/2 in vivo, utilizing the zebrafish system. We found that impairment of both zebrafish orthologs, pheta1 and pheta2, disrupted endocytosis and ciliogenesis in renal tissues. In addition, pheta1/2 mutant animals exhibited reduced jaw size and delayed chondrocyte differentiation, indicating a role in craniofacial development. Deficiency of pheta1/2 resulted in dysregulation of cathepsin K, which led to an increased abundance of type II collagen in craniofacial cartilages, a marker of immature cartilage extracellular matrix. Cathepsin K inhibition rescued the craniofacial phenotypes in the pheta1/2 double mutants. The abnormal renal and craniofacial phenotypes in the pheta1/2 mutant animals were consistent with the clinical presentation of a patient with a de novo arginine (R) to cysteine (C) variant (R6C) of PHETA1. Expressing the patient-specific variant in zebrafish exacerbated craniofacial deficits, suggesting that the R6C allele acts in a dominant-negative manner. Together, these results provide insights into the in vivo roles of PHETA1/2 and suggest that the R6C variant is contributory to the pathogenesis of disease in the patient

Compound heterozygosity for lossâ ofâ function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation

Aminoacylâ tRNA synthetases (ARSs) are ubiquitously expressed enzymes that ligate amino acids onto tRNA molecules. Genes encoding ARSs have been implicated in myriad dominant and recessive disease phenotypes. Glycylâ tRNA synthetase (GARS) is a bifunctional ARS that charges tRNAGly in the cytoplasm and mitochondria. GARS variants have been associated with dominant Charcotâ Marieâ Tooth disease but have not been convincingly implicated in recessive phenotypes. Here, we describe a patient from the NIH Undiagnosed Diseases Program with a multisystem, developmental phenotype. Wholeâ exome sequence analysis revealed that the patient is compound heterozygous for one frameshift (p.Glu83Ilefs*6) and one missense (p.Arg310Gln) GARS variant. Using in vitro and in vivo functional studies, we show that both GARS variants cause a lossâ ofâ function effect: the frameshift variant results in depleted protein levels and the missense variant reduces GARS tRNA charging activity. In support of GARS variant pathogenicity, our patient shows striking phenotypic overlap with other patients having ARSâ related recessive diseases, including features associated with variants in both cytoplasmic and mitochondrial ARSs; this observation is consistent with the essential function of GARS in both cellular locations. In summary, our clinical, genetic, and functional analyses expand the phenotypic spectrum associated with GARS variants.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138288/1/humu23287-sup-0001-text.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138288/2/humu23287.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138288/3/humu23287_am.pd

The Palomar Testbed Interferometer Calibrator Catalog

The Palomar Testbed Interferometer (PTI) archive of observations between 1998 and 2005 is examined for objects appropriate for calibration of optical long-baseline interferometer observations - stars that are predictably point-like and single. Approximately 1,400 nights of data on 1,800 objects were examined for this investigation. We compare those observations to an intensively studied object that is a suitable calibrator, HD217014, and statistically compare each candidate calibrator to that object by computing both a Mahalanobis distance and a Principal Component Analysis. Our hypothesis is that the frequency distribution of visibility data associated with calibrator stars differs from non-calibrator stars such as binary stars. Spectroscopic binaries resolved by PTI, objects known to be unsuitable for calibrator use, are similarly tested to establish detection limits of this approach. From this investigation, we find more than 350 observed stars suitable for use as calibrators (with an additional $\approx 140$ being rejected), corresponding to $\gtrsim 95$ sky coverage for PTI. This approach is noteworthy in that it rigorously establishes calibration sources through a traceable, empirical methodology, leveraging the predictions of spectral energy distribution modeling but also verifying it with the rich body of PTI's on-sky observations.Comment: 100 pages, 7 figures, 7 tables; to appear in the May 2008ApJS, v176n