15 research outputs found

    Observation of O+ (4P-4D0) lines in electron aurora over Svalbard

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    This work reports on observations of O+ lines in aurora over Svalbard, Norway. The Spectrographic Imaging Facility measures auroral spectra in three wavelength intervals (H, N+2 1N(0,2) and N+2 1N(1,3)). The oxygen ion 4P-4D0 multiplet (4639–4696 A° ) is blended with the N+2 1N(1,3) band. It is found that in electron aurora, the brightness of this multiplet, is on average, about 0.1 of the N+2 1N(0,2) total brightness. A joint optical and incoherent scatter radar study of an electron aurora event shows that the ratio is enhanced when the ionisation in the upper E-layer (140–190 km) is significant with respect to the E-layer peak below 130 km. Rayed arcs were observed on one such occasion, whereas on other occasions the auroral intensity was below the threshold of the imager. A one-dimensional electron transport model is used to estimate the cross section for production of the multiplet in electron collisions, yielding 0.18×10-18 cm2

    Observation of O<sup>+</sup> (<sup>4</sup>P-<sup>4</sup>D<sup>0</sup>) lines in electron aurora over Svalbard

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    This work reports on observations of O+ lines in aurora over Svalbard, Norway. The Spectrographic Imaging Facility measures auroral spectra in three wavelength intervals (H&beta;, N+2 1N(0,2) and N+2 1N(1,3)). The oxygen ion multiplet (4639-4696&#197;) is blended with the band. It is found that in electron aurora, the brightness of this multiplet, is on average, about 0.1 of the total brightness. A joint optical and incoherent scatter radar study of an electron aurora event shows that the ratio is enhanced when the ionisation in the upper E-layer (140-190km) is significant with respect to the E-layer peak below 130km. Rayed arcs were observed on one such occasion, whereas on other occasions the auroral intensity was below the threshold of the imager. A one-dimensional electron transport model is used to estimate the cross section for production of the multiplet in electron collisions, yielding 0.18x10-18cm2

    Increased circulating normal and BCR-ABL+Ve progenitor numbers in Philadelphia chromosome-positive acute myeloid leukaemia

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    We recorded elevated numbers of circulating myeloid and erythroid colony-forming cells in 15 adult patients with acute myeloid leukaemia (AML) who presented with high blood white cell counts. Since leukaemic blasts from three of these patients were Philadelphia chromosome-positive (Ph+), we were able to determine if blood progenitors from these particular patients arose from the leukaemic clone or from residual normal progenitors. Blasts and colonies were intensively investigated using a combination of cell surface marker analysis by flow cytometry, RT-PCR and interphase fluorescence in situ hybridization (FISH). FISH detected rearrangements within the major breakpoint BCR (M-BCR) region in blasts and in some myeloid and erythroid colonies from patients 1 and 2. The minor breakpoint (m-BCR) region was detected in blasts and in some myeloid and erythroid colonies from patient 3. RT-PCR detected long b2a2 BCR-ABL transcripts in blasts from patients 1 and 2, although misspliced short e1a2 transcripts were also seen in patient 1. Only e1a2 transcripts were found in blasts from patient 3. Flow sorting demonstrated the B-cell marker CD19 on blasts and on a proportion of myeloid and erythroid progenitors from patients 1 and 3. RT-PCR also detected IgH rearrangements, further evidence of B-cell differentiation, in blasts from these two patients. We conclude that both normal and clonal circulating progenitor numbers can be raised in both M-BCR and m-BCR Ph+ AML. The underlying cause, perhaps efflux from a congested marrow, may be common to AML patients with a high blood white cell count. © 2002 Elsevier Science Ltd. All rights reserved
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