Minidoka Memorial Hospital Expansion

The Minidoka Memorial Hospital is the main hospital serving Minidoka County. Due to an increase in farming and traffic accidents, the emergency facilities are no longer adequate and require expansion

The power of symbolic capital in patient and public involvement in health research

Print-Electronic This research was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust and University of Oxford. LL is supported by an NIHR Oxford Biomedical Research Centre Fellowship. AMB is supported by the NIHR Collaboration for Leadership in Applied Health Research and Care Oxford at Oxford Health NHS Foundation Trust. SS is supported by the NIHR Collaboration for Leadership in Applied Health Research and Care West Midlands. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. AbstractPeer reviewedPublisher PD

Performance of a new coaxial ion-molecule reaction region for low-pressure chemical ionization mass spectrometry with reduced instrument wall interactions

Chemical ionization mass spectrometry (CIMS) techniques have become prominent methods for sampling trace gases of relatively low volatility. Such gases are often referred to as being &ldquo;sticky&rdquo;, i.e., having measurement artifacts due to interactions between analyte molecules and instrument walls, given their tendency to interact with wall surfaces via absorption or adsorption processes. These surface interactions can impact the precision, accuracy, and detection limits of the measurements. We introduce a low-pressure ion&ndash;molecule reaction (IMR) region primarily built for performing iodide-adduct ionization, though other adduct ionization schemes could be employed. The design goals were to improve upon previous low-pressure IMR versions by reducing impacts of wall interactions at low pressure while maintaining sufficient ion&ndash;molecule reaction times. Chamber measurements demonstrate that the IMR delay times (i.e., magnitude of wall interactions) for a range of organic molecules spanning 5 orders of magnitude in volatility are 3 to 10 times lower in the new IMR compared to previous versions. Despite these improvements, wall interactions are still present and need to be understood. To that end, we also introduce a conceptual framework for considering instrument wall interactions and a measurement protocol to accurately capture the time dependence of analyte concentrations. This protocol uses short-duration, high-frequency measurements of the total background (i.e., fast zeros) during ambient measurements as well as during calibration factor determinations. This framework and associated terminology applies to any instrument and ionization technique that samples compounds susceptible to wall interactions.</p

Energy input is primary controller of methane bubbling in subarctic lakes

Emission of methane (CH4) from surface waters is often dominated by ebullition (bubbling), a transport mode with high‐spatiotemporal variability. Based on new and extensive CH4 ebullition data, we demonstrate striking correlations (r2 between 0.92 and 0.997) when comparing seasonal bubble CH4 flux from three shallow subarctic lakes to four readily measurable proxies of incoming energy flux and daily flux magnitudes to surface sediment temperature (r2 between 0.86 and 0.94). Our results after continuous multiyear sampling suggest that CH4 ebullition is a predictable process, and that heat flux into the lakes is the dominant driver of gas production and release. Future changes in the energy received by lakes and ponds due to shorter ice‐covered seasons will predictably alter the ebullitive CH4 flux from freshwater systems across northern landscapes. This finding is critical for our understanding of the dynamics of radiatively important trace gas sources and associated climate feedback

Effects of Feeding a Novel Alfalfa Leaf Pellet Product (ProLEAF MAX) and Alfalfa Stems (ProFiber Plus) on Performance in the Feedlot and Carcass Quality of Beef Steers

Alfalfa is often included in the diets of beef animals; however, the nutrient content of alfalfa is variable depending on the region in which it is grown, climate, soil, and many other factors. The leaf portion of alfalfa has a less variable nutrient composition than the stem portion of the plant. The variability that is present in the alfalfa plant can make the development of total mixed rations of consistent nutrient content difficult. As such, the purpose of this study was to determine how the inclusion of fractionated alfalfa leaves and alfalfa stems impacts performance and carcass quality of finishing beef steers. Twenty-four steers were allocated to one of three treatments: a control group fed a typical finishing diet with alfalfa as the forage (CON; n = 8), a typical diet that replaced alfalfa with fractionated alfalfa leaf pellets and alfalfa stems (ProLEAF MAX™ + ProFiber Plus™; PLM+PFP; n = 8), or a typical diet that replaced alfalfa with alfalfa stems (PFP; n = 8) for 63 days. Steers were fed individually once daily, weighed every 14 days and ultrasound images were collected every 28 days. At the end of the feeding trial, steers were harvested at a commercial facility and carcass data was obtained. Analysis of dry matter intake demonstrated that steers receiving the PFP and CON diets consumed more feed (P \u3c 0.001) than steers consuming the PLM+PFP diet. Steers receiving the PLM+PFP diet gained less (P \u3c 0.001) weight than the steers receiving the other two dietary treatments. No differences (P \u3e 0.10) in feed efficiency or carcass characteristics were observed. Steers receiving the PFP diet had improved (P = 0.016) cost of gain ($0.93 per kg) when compared with steers receiving PLM+PFP ($1.08 per kg) diet. Overall, our findings demonstrate that the inclusion of PFP in place of alfalfa hay in a finishing diet has the potential to improve cost of gain, without negatively affecting growth, performance, or carcass characteristics of finishing feedlot steers

Legacy and current pesticide residues in Syr Darya, Kazakhstan: Contamination status, seasonal variation and preliminary ecological risk assessment

The Syr Darya is one of two major rivers in Central Asia supplying critical fresh water to the Aral Sea. In spite of the river’s importance and agriculturally-intensive history, few studies have provided a modern evaluation of and the occurrence of pesticide residues potential effects to aquatic life. The primary goal of this investigation was to determine seasonal variations in ambient concentrations of modern and legacy pesticides in bottom sediment and water of the Syr Darya in Kazakhstan (KZ) downstream from an agriculturally-intensive watershed in Uzbekistan. Grab samples and passive samplers were used at five remote sampling stations during June 2015 to provide a baseline for ecotoxicological evaluation. Results were compared with samples collected during and after the agricultural growing season. Polar organic chemical integrative samplers (POCIS) were used in June and calibrated for time-weighted average concentrations of current use pesticides. Among legacy chlorinated pesticides measured in grab samples from the river, lindane (γ-HCH) was detected most frequently with the highest concentrations occurring during June. For all the sampling events, residues of lindane (γ-HCH) ranged from 0.014 to 0.24 μg/L detected in water samples, are among the highest concentrations reported for rivers globally. Concentrations of γ-HCH, p,p’-DDE and dieldrin were highest in October when dieldrin concentrations approached 0.4 μg/L. Sources of legacy pesticides may be either illicit upstream use or evidence of previous atmospheric contamination of glacial meltwater. Chronic exposure to these residues may lead to ecological risk to lower order organisms in both the sediment and water column. Includes Supplementary Material

An improved model for linking phosphorus loads in runoff to climate, soil and agricultural management

Abstract: Soil phosphorus (P) is one of the nutrients that contribute to eutrophication of waterways, algal blooms and damage to coral reefs. Reducing P movement from farm paddock to the broader environment often requires comprehensive, catchment-wide approaches to management. The substantial complexity of the physical and managerial causes of P pollution has led to a role for simulation models in evaluating the efficacy of regulations and management changes. In Queensland, the Reef Plan program (http://www.reefplan.qld.gov.au) addresses issues of sediment, nutrient and pesticide impact on the health and future of the Great Barrier Reef. Some of the associated regulations are concerned with the use of P fertilizer. The HowLeaky? model is one of few biophysical models that represent agricultural management, biophysical conditions and P exports. As reported at MODSIM07, information about P export was added to an existing model of water balance and sediment export (HowLeaky?) to create a useful model of P export from agriculture. However, the predictive power of the model was modest, especially over short periods (e.g. individual days). To improve the predictive power of the model, several changes have been made, including (i) additional empirical functions for estimating the enrichment of total P in sediment, and (ii) additional functions for estimating concentration of soluble P in runoff (mg P/L). Soil adsorption of P (P buffering), which affects the soluble P concentration in runoff, is now estimated from the widely available phosphorus buffering index test (PBI) rather than phosphorus buffering capacity (PBC). Large, high-quality datasets are used to evaluate these relationships. A case study is presented where HowLeaky? has been used to estimate P loads generated at a site in the GBR catchment. The Brigalow Catchment Study is a long-term study of the effects of land clearing and agriculture on the water balance and water quality. It is located in central Queensland, has a subcatchment that is cropped, has representative soils, and is part of the Fitzroy Catchment. HowLeaky? reproduced daily runoff amounts very well, and the revised P model in HowLeaky? was acceptably accurate at predicting daily P loads. Modelling predicted the long-term totals (6 years) of soluble and particulate P export from the field site with less than 50% error. This is a better-than-expected result with an un-calibrated model, as P exports are notoriously difficult to predict

The genotype of barley cultivars influences multiple aspects of their associated microbiota via differential root exudate secretion

Plant-associated microbe play vital roles in promoting plant growth and health, with plants secreting root exudates into the rhizosphere to attract beneficial microbes. Exudate composition defines the nature of microbial recruitment, with different plant species attracting distinct microbiota to enable optimal adaptation to the soil environment. To more closely examine the relationship between plant genotype and microbial recruitment, we analysed the rhizosphere microbiomes of landrace (Chevallier) and modern (NFC Tipple) barley (Hordeum vulgare) cultivars. Distinct differences were observed between the plant associated microbiomes of the 2 cultivars, with the plant-growth promoting rhizobacterial genus Pseudomonas substantially more abundant in the Tipple rhizosphere. Striking differences were also observed between the phenotypes of recruited Pseudomonas populations, alongside distinct genotypic clustering by cultivar. Cultivar-driven Pseudomonas selection was driven by root exudate composition, with the greater abundance of hexose sugars secreted from Tipple roots attracting microbes better adapted to growth on these metabolites and vice versa. Cultivar-driven selection also operates at the molecular level, with both gene expression and the abundance of ecologically relevant loci differing between Tipple and Chevallier Pseudomonas isolates. Finally, cultivar-driven selection is important for plant health, with both cultivars showing a distinct preference for microbes selected by their genetic siblings in rhizosphere transplantation assay

Diffusion MRI of the facial-vestibulocochlear nerve complex: a prospective clinical validation study

Objectives: Surgical planning of vestibular schwannoma surgery would benefit greatly from a robust method of delineating the facial-vestibulocochlear nerve complex with respect to the tumour. This study aimed to optimise a multi-shell readout-segmented diffusion-weighted imaging (rs-DWI) protocol and develop a novel post-processing pipeline to delineate the facial-vestibulocochlear complex within the skull base region, evaluating its accuracy intraoperatively using neuronavigation and tracked electrophysiological recordings./ Methods: In a prospective study of five healthy volunteers and five patients who underwent vestibular schwannoma surgery, rs-DWI was performed and colour tissue maps (CTM) and probabilistic tractography of the cranial nerves were generated. In patients, the average symmetric surface distance (ASSD) and 95% Hausdorff distance (HD-95) were calculated with reference to the neuroradiologist-approved facial nerve segmentation. The accuracy of patient results was assessed intraoperatively using neuronavigation and tracked electrophysiological recordings./ Results: Using CTM alone, the facial-vestibulocochlear complex of healthy volunteer subjects was visualised on 9/10 sides. CTM were generated in all 5 patients with vestibular schwannoma enabling the facial nerve to be accurately identified preoperatively. The mean ASSD between the annotators’ two segmentations was 1.11 mm (SD 0.40) and the mean HD-95 was 4.62 mm (SD 1.78). The median distance from the nerve segmentation to a positive stimulation point was 1.21 mm (IQR 0.81–3.27 mm) and 2.03 mm (IQR 0.99–3.84 mm) for the two annotators, respectively./ Conclusions: rs-DWI may be used to acquire dMRI data of the cranial nerves within the posterior fossa./ Clinical relevance statement: Readout-segmented diffusion-weighted imaging and colour tissue mapping provide 1–2 mm spatially accurate imaging of the facial-vestibulocochlear nerve complex, enabling accurate preoperative localisation of the facial nerve. This study evaluated the technique in 5 healthy volunteers and 5 patients with vestibular schwannoma./ Key Points: • Readout-segmented diffusion-weighted imaging (rs-DWI) with colour tissue mapping (CTM) visualised the facial-vestibulocochlear nerve complex on 9/10 sides in 5 healthy volunteer subjects./ • Using rs-DWI and CTM, the facial nerve was visualised in all 5 patients with vestibular schwannoma and within 1.21–2.03 mm of the nerve’s true intraoperative location./ • Reproducible results were obtained on different scanners