548 research outputs found
On modeling and measuring viscoelasticity with dynamic Atomic Force Microscopy
The interaction between a rapidly oscillating atomic force microscope tip and
a soft material surface is described using both elastic and viscous forces with
a moving surface model. We derive the simplest form of this model, motivating
it as a way to capture the impact dynamics of the tip and sample with an
interaction consisting of two components: interfacial or surface force, and
bulk or volumetric force. Analytic solutions to the piece-wise linear model
identify characteristic time constants, providing a physical explanation of the
hysteresis observed in the measured dynamic force quadrature curves. Numerical
simulation is used to fit the model to experimental data and excellent
agreement is found with a variety of different samples. The model parameters
form a dimensionless impact-rheology factor, giving a quantitative physical
number to characterize a viscoelastic surface that does not depend on the tip
shape or cantilever frequency.Comment: 13 pages, 7 figure
Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack. Human KIR haplotypes comprise genes encoding mainly inhibitory receptors (KIR A) or activating and inhibitory receptors (KIR B). A substantial fraction of humans lack ligands for inhibitory KIRs (iKIRs), that is, a 'missing ligand' genotype. KIR B/x and missing ligand genotypes may thus give rise to potentially autoreactive, unlicensed NK cells. Little is known regarding the impact of such genotypes in untransplanted acute myeloid leukemia (AML). For this study, NK cell phenotypes and KIR/HLA genotypes were determined in 81 AML patients who received immunotherapy with histamine dihydrochloride and low-dose IL-2 for relapse prevention (NCT01347996). We observed that presence of unlicensed NK cells impacted favorably on clinical outcome, in particular among patients harboring functional NK cells reflected by high expression of the natural cytotoxicity receptor (NCR) NKp46. Genotype analyses suggested that the clinical benefit of high NCR expression was restricted to patients with a missing ligand genotype and/or a KIR B/x genotype. These data imply that functional NK cells are significant anti-leukemic effector cells in patients with KIR/HLA genotypes that favor NK cell autoreactivity
Does postoperative orbital volume predict postoperative globe malposition after blow-out fracture reconstruction? A 6-month clinical follow-up study
Purpose: The aim of this study was to investigate the relationship between intraorbital volume change caused by orbital fracture and globe malposition (GMP) in blow-out fracture patients undergoing surgery and to clarify the significance of different radiologically detected predictors associated with GMP.Patients and methods: A 6-month prospective follow-up study of unilateral isolated orbital fractures was designed and implemented. The main outcome variable was GMP (present or absent); the secondary outcome was orientation of GMP (horizontal or vertical). The primary predictor variable was postoperative orbital volume difference determined as the difference between the fractured and non-fractured orbit (measured in milliliter and analyzed in milliliter and percentages). The explanatory variables were gender, age, treatment delay from trauma to surgery, fracture site, horizontal depth of the fracture, fracture area, maximum vertical dislocation of the fracture, and preoperative volume difference.Results: A total of 15 patients fulfilled the inclusion criteria and were followed for 6months from a larger cohort. GMP was detected in 6/15 patients (40.0%). GMP was more often present in large (2.5cm(2)) fractures (55.6%), in combined orbital fractures (50.0%), and in fractures with preoperative volume difference 2.5ml (62.5%) regardless of the postoperative volume correction. Postoperatively, patients with and without GMP displayed overcorrection of orbital volume; 4.15% corresponded to 1.15ml (with GMP) and 7.6% corresponded to 1.9ml (without GMP).Conclusion: GMP was present in large and combined orbital fractures. Clinically detectable postoperative GMP occurred despite satisfactory orbital reconstruction and overcorrection. Mild GMP, however, is not significant for the patient.</div
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Modeling and Measuring Viscoelasticity with Dynamic Atomic Force Microscopy
The interaction between a rapidly oscillating atomic-force-microscope tip and a soft-material surface is described with use of both elastic and viscous forces in a moving-surface model. We present the simplest form of this model, motivating our derivation with the models ability to capture the impact dynamics of the tip and sample with an interaction consisting of two components: interfacial or surface force, and bulk or volumetric force. Analytic solutions to the piecewise linear model identify characteristic time constants, providing a physical explanation for the hysteresis observed in the measured dynamic-force-quadrature curves. Numerical simulation is used to fit the model to experimental data, and excellent agreement is found with a variety of different samples. The model parameters form a dimensionless impact-rheology factor, giving a quantitative physical number to characterize a viscoelastic surface that does not depend on the tip shape or cantilever frequency
Spectroscopic Detection of Carbon Monoxide in Two Late-type T Dwarfs
M band spectra of two late-type T dwarfs, 2MASS J09373487+2931409, and Gliese
570D, confirm evidence from photometry that photospheric CO is present at
abundance levels far in excess of those predicted from chemical equilibrium.
These new and unambiguous detections of CO, together with an earlier
spectroscopic detection of CO in Gliese 229B and existing M band photometry of
a large selection of T dwarfs, suggest that vertical mixing in the photosphere
drives the CO abundance out of chemical equilibrium and is a common, and likely
universal feature of mid-to-late type T dwarfs. The M band spectra allow
determinations of the time scale of vertical mixing in the atmosphere of each
object, the first such measurements of this important parameter in late T
dwarfs. A detailed analysis of the spectral energy distribution of 2MASS
J09373487+2931409 results in the following values for metallicity, temperature,
surface gravity, and luminosity: [M/H]~-0.3, T_eff=925-975K, log g=5.20-5.47,
log L/L_sun=-5.308 +/- 0.027. The age is 3-10 Gyr and the mass is in the range
45-69 M_Jup.Comment: 36 pages incl. 12 figures and 3 tables, accepted by Ap
Comments on alternative calculations of the broadening of spectral lines of neutral sodium by H-atom collisions
With the exception of the sodium D-lines recent calculations of line
broadening cross-sections for several multiplets of sodium by Leininger et al
(2000) are in substantial disagreement with cross-sections interpolated from
the tables of Anstee and O'Mara (1995) and Barklem and O'Mara (1997). The
discrepancy is as large as a factor of three for the 3p-4d multiplet. The two
theories are tested by using the results of each to synthesize lines in the
solar spectrum. It is found that generally the data from the theory of Anstee,
Barklem and O'Mara produce the best match to the observed solar spectrum. It is
found, using a simple model for reflection of the optical electron by the
potential barrier between the two atoms, that the reflection coefficient is too
large for avoided crossings with the upper states of subordinate lines to
contribute to line broadening, supporting the neglect of avoided ionic
crossings by Anstee, Barklem and O'Mara for these lines. The large
discrepancies between the two sets of calculations is a result of an
approximate treatment of avoided ionic crossings for these lines by Leininger
et al (2000).Comment: 18 pages, 5 ps figures included, to appear in J Phys B: At. Mol. Opt.
Phy
Basic physical parameters of a selected sample of evolved stars
We present the detailed spectroscopic analysis of 72 evolved stars, including
the [Fe/H] determination for the whole sample. These metallicities, together
with the Teff values and the absolute V magnitude derived from Hipparcos
parallaxes, are used to estimate basic stellar parameters (ages, masses, radii,
(B-V)o and log g using theoretical isochrones and a Bayesian estimation method.
The (B-V)o values so estimated turn out to be in excellent agreement with the
observed (B-V), confirming the reliability of the (Teff,(B-V)o) relation used
in the isochrones. The estimated diameters have been compared with limb
darkening-corrected ones measured with independent methods, finding an
agreement better than 0.3 mas within the 1-10 mas interval. We derive the
age-metallicity relation for the solar neighborhood; for the first time such a
relation has been derived from observations of field giants rather than from
open clusters and field dwarfs and subdwarfs. The age-metallicity relation is
characterized by close-to-solar metallicities for stars younger than ~4 Gyr,
and by a large [Fe/H] spread with a trend towards lower metallicities for
higher ages. We find that the [Fe/H] dispersion of young stars (less than 1
Gyr) is comparable to the observational errors, indicating that stars in the
solar neighbourhood are formed from interstellar matter of quite homogeneous
chemical composition. The three giants of our sample which have been proposed
to host planets are not metal rich, what is at odds with those for main
sequence stars. However, two of these stars have masses much larger than a
solar mass so we may be sampling a different stellar population from most
radial velocity searches for extrasolar planets. We also confirm that the
radial velocity variability tends to increase along the RGB.Comment: 17 pgs, 19 fig
MASEP gamma knife radiosurgery for secretory pituitary adenomas: experience in 347 consecutive cases
<p>Abstract</p> <p>Background</p> <p>Secretory pituitary adenomas are very common brain tumors. Historically, the treatment armamentarium for secretory pituitary adenomas included neurosurgery, medical management, and fractionated radiotherapy. In recent years, MASEP gamma knife radiosurgery (MASEP GKRS) has emerged as an important treatment modality in the management of secretory pituitary adenomas. The goal of this research is to define accurately the efficacy, safety, complications, and role of MASEP GKRS for treatment of secretory pituitary adenomas.</p> <p>Methods</p> <p>Between 1997 and 2007 a total of 347 patients with secretory pituitary adenomas treated with MASEP GKRS and with at least 60 months of follow-up data were identified. In 47 of these patients some form of prior treatment such as transsphenoidal resection, or craniotomy and resection had been conducted. The others were deemed ineligible for microsurgery because of body health or private choice, and MASEP GKRS served as the primary treatment modality. Endocrinological, ophthalmological, and neuroradiological responses were evaluated.</p> <p>Results</p> <p>MASEP GKRS was tolerated well in these patients under the follow-up period ranged from 60 to 90 months; acute radioreaction was rare and 17 patients had transient headaches with no clinical significance. Late radioreaction was noted in 1 patient and consisted of consistent headache. Of the 68 patients with adrenocorticotropic hormone-secreting(ACTH) adenomas, 89.7% showed tumor volume decrease or remain unchanged and 27.9% experienced normalization of hormone level. Of the 176 patients with prolactinomas, 23.3% had normalization of hormone level and 90.3% showed tumor volume decrease or remain unchanged. Of the 103 patients with growth hormone-secreting(GH) adenomas, 95.1% experienced tumor volume decrease or remain unchanged and 36.9% showed normalization of hormone level.</p> <p>Conclusion</p> <p>MASEP GKRS is safe and effective in treating secretory pituitary adenomas. None of the patients in our study experienced injury to the optic apparatus or had other neuropathies related with gamma knife. MASEP GKRS may serve as a primary treatment method in some or as a salvage treatment in the others. However, treatment must be tailored to meet the patient's symptoms, tumor location, tumor morphometry, and overall health. Longer follow-up is required for a more complete assessment of late radioreaction and treatment efficacy.</p
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