5 research outputs found
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Models for quality improvement and assurance in English and Welsh primary care
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/10/2007
- Field of study
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
- Author
- Aarøe Jens
- Abbass Hakam
- Abella-Ovalle Luis
- Adam Zul
- Agyemang Michael
- Ahlehof Ole
- Ahlehoff Ole
- Ahmad Yousif
- Al-Lamee Rasha
- Alberdi Lucía
- Aleti Shilpa
- Ali Danish
- Allen Kezia
- Alvares Wilson
- Alzuhairi Karam
- Amed Nadifa
- Anantharam Brijesh
- Andersen Grethe
- Andersen Henning Rud
- Anderson Michelle
- Andiapen Mervyn
- Andrews Michelle
- Ankersen Jens Peter
- Ansell Valerie
- Arango Amalia
- Armstrong Elissa
- Astarci Josenir
- Atkinson Emma
- Austin Rosalynn
- Avanzas Pablo
- Aziz Ahmed
- Azkhalil Mohammed
- Bales Emily
- Banerjee Prithwish
- Barclay Justin
- Barker Deborah
- Barker Joann
- Barmby David
- Bates Rachel
- Baucutt Karen
- Been Martin
- Beirnes Charmaine
- Bell Sheila
- Bennett Amy
- Bennett Lorraine
- Bernardo-Alba Pablo
- Berry Alan
- Berry Colin
- Besana Rissa
- Bhatre Gurbir
- Bhatti Rishma
- Bidle Amanda
- Bijsterveld Petra
- Bose Tuhina
- Boyle Georgina
- Brady Rebecca
- Braybrook Christine
- Breeze Jonathan
- Brennan Oliver
- Brett Sarah
- Brogan Richard
- Brown Janette
- Bucciarelli-Ducci Chiara
- Buchanan Louise
- Buelga-Díaz Covadonga
- Bueno Hector
- Bulluck Heerajnarain
- Burd Amanda
- Burnett Gillian
- Burtonwood Natalie
- Burunsuzoglu Senem
- Butler Robert
- Butler Robert
- Byrne Jean
- Bøtker Hans Erik
- Capel Robert
- Cappelen Helle
- Carruthers Gayle
- Carstensen Steen
- Castro Rafael
- Champney Felicity
- Chant Nicholas
- Charles Thabitha
- Chester Emma
- Chong Jun
- Christensen Erika Frischknecht
- Christiansen Evald Høj
- Christiansen Martin Kirk
- Christmas Natasha
- Chu Rebecca
- Chung Alan
- Cimas Teodorna
- Clapp Brian
- Clare Thomas
- Clarke Millie
- Clayton Tim
- Clifford Piers
- Cockayne Laura
- Colicchia Martina
- Collier Lucy
- Cooper Theresa
- Copas Andrew
- Copestick Jane
- Corps Ellie
- Corrigan Julie
- Cottam Victoria
- Cotton James
- Coward Paul
- Cox Emily
- Crause Jacolene
- Cruden Nick
- Cunliffe Denise
- Cunnington Michael
- Cuxton Josephine
- Dana Ali
- Dana Ali
- Darby Damaris
- Davies John
- Davies Justin
- Davies Nina
- de Cima Sara
- de la Hera Galarza Jesus Maria
- de la Roz Manuel
- De Mance Gianluigi
- De Sousa Phillipa
- Deen Zakhira
- del Valle Raquel
- Delaney Jane
- Denman Joanne
- Dias Priyanthi
- Dillon Angela
- Dimond Kirsty
- Din J.
- Dockerty Francesca
- Dodd Matthew
- Douglas James
- Douthwaite Rebecca
- Drew Martin
- Díaz-González Eloy
- East Clare
- Eaton Michelle
- Ellert Julia
- Elliott Rebecca
- Ellis Howard
- Elshiekh Dr Mohamed
- Elston Ruth
- Emery Lisa
- Engstrom Thomas
- Erntgaard Dennis
- Evans Richard
- Fahrai Gregor
- Farag Mohamed
- Fath-Orboubadi DR Fazin
- Fati Pene
- Fayed Hossam
- Fente Ana I.
- Fernandez Olga
- Fernández Elena
- Fernández-Carral Marcos Fernández-Carral
- Fernández-Gonzalo David
- Fernández-Mallo Francisco J.
- Finch Amanda
- Fleming Catherine
- Fofie Joyce
- Foundun Aboo
- Francis Rohin
- Francis Rohin
- Frank Emma
- Freeman Philip
- Freestone Beth
- Fuentes María D.
- Gale Joanne
- Gale Joanne
- Gallagher Ian
- Galván-Núñez Pablo
- Gamma Reto
- Garcia-Ruiz José Manuel
- García-Alonso María
- García-Castro Alfonso
- Gaughran Lisa
- Germon Rachel
- Gibson Kirsty
- Giebner Matthias
- Gill Abby
- Gill Simrat
- Giuffrida Gaia
- Given Rachel
- Glen James
- Goitia-Martín Javier
- Gomes Sara
- Gorog Diana
- Gorog Diana A
- Gowing Anne
- Gracey Jay
- Grech Ever
- Greenwood John
- Greenwood John P
- Gregory Sally
- Gregson Lisa
- Griffiths Huw
- Grosser Konrad
- Gue Ying
- Guinea Rocío
- Gunn Julian
- Guyatt Samantha
- Hall Charlotte
- Hall Ian
- Hall Lorna
- Hamid Mahmood
- Hansen Henrik Steen
- Hansen Knud Nørregård
- Hansen Poul Anders
- Hansen Troels Martin Hansen
- Harfield Scott
- Harkins Ruth
- Harland Charlotte
- Hartley Amy
- Hausenloy Derek J
- Haworth Peter
- Hayes Michelle
- Hedegaard Kim Witting
- Hedrera Segundo A.
- Helqvist Steffen
- Henderson Rob
- Hendry Cara
- Heppell Richard
- Hermosa Francisco J.
- Hernández Ernesto
- Hetherington Daniel
- Hetherington Simon
- Hildick-Smith David
- Hindle Julia
- Hjort Jakob
- Hoare Amy
- Hobson Alex
- Hodgson Adrian
- Hodierne Jeremy
- Hogrefe Kai
- Holloway Rachael
- Holmvang Lene
- Hoole Stephen
- Hopper Oliver
- Horler Stephanie
- Horner Victoria
- Horwood Carol
- Houghton Richard F
- Housley Kay
- Howe Serena
- Hudson Karen
- Hussein Jodie
- Hyndman Samantha
- Ibanez Borja
- Iglesias-Llaca Fernando
- Ilsley Mary
- Ingoldby Fiona
- Iqbal , Javid
- Iversen Allan
- Jack Pearse
- Jackson-Lawrence Karen
- Jakobsen Lars
- Jamal Zahra
- Jamieson-Leadbitter Caroline
- Jennison Alan
- Jensen Lisette Okkels
- Jensen Svend Eggert
- Johnstone Donna
- Jones Leslie
- Jones Sophie
- Joshi Francis
- Joyce Joan
- Junker Anders
- Jørgensen Erik
- Kaeng Lee
- Kaltoft Anne
- Kanji Rahim
- Kaur Ramandeep
- Kaur-Babooa Priya
- Kaus Henning
- Keate Kirstie
- Kelbæk Henning
- Kelly Julie
- Kelsall Nicci
- Kempel John
- Kennard Sarah
- Khan Arif
- Kharbanda Rajesh
- Kharbanda Rajesh K
- Khawaja Muhammed Zeeshan
- Knight Rosemary
- Knighton Abigail
- Kobson Barbara
- Kodoth Vivek
- Kolakaluri Laurel
- Koothoor Raiji
- Korsgaard Mette Tidemand
- Kotecha Tushar
- Krishnamoorthy Suresh
- Krishnamurthy Arvindra
- Kristensen Steen Dalby
- Laca Sonia I.
- Lakeman Nicki
- Langrish Jeremy
- Lasica Ratko
- Lassen Jens Flensted
- Laurence Julia
- Lazar Nicoleta
- Leathers Chris
- Lee Dr Kaeng
- Lee Kelvin
- Lee Sandra
- Lenzi Valentina
- Leonard Gerry
- Lippert Freddy K
- Llorente-Álvarez Susana
- Lloyd Steph
- Loder Chris
- Longbottom Colin
- Longman Kristel
- Lozano Iñigo
- Lucking Andrew
- Ludman Andrew
- Lønborg Jacob T
- Maart Clint
- Mackenzie Ailie
- Mackie Sarah
- Madsen Morten
- Maeng Michael
- Malik Iqbal
- Marber Michael
- Mark Bettina Løjmand
- Markham-Jones Helene
- Martin Katherine
- Martinez-González Eugenio
- Martins Joe
- Martínez-Bastida Ginés
- Martínez-Fernández César M.
- Martínez-Pérez Polácido J.
- Martínez-Valle Marta
- Massey Ian
- Mathur Anthony
- Matic Dragan
- Mcarthy Rachel
- McCormick Louise
- McFarlane-Henry Eleanor
- McGregor Andrew
- McLeod Jane
- McSkeane Anna
- Meade Tom
- Meadows Deborah
- Medina-Cameán Ana B.
- Mehmedbegovic Zlatko
- Merrick Angela
- Metherell Stella
- Middle Janet
- Milasinovic Dejan
- Milgate Sarah
- Mohiddin Saidi
- Mojela Idah
- Moon Angela
- Moore Donna
- Moore Roger
- More Ranjit
- More Ranjit
- Moreby Berni
- Moreira Silvia
- Morgan Maureen
- Morris Steve
- Morís César
- Mota Paula
- Mudd Alexandra
- Munir Shahzad
- Muriel-Velasco Ana
- Musa Anntoniette
- Musselwhite Janine
- Møller Ulla Kristine
- Nair Sunil
- Naves María C.
- Neal Debbie
- Nelthorpe Faye
- Neubauer Stephen
- Newman Hannah
- Nicholas Jennifer M
- Nicholson Anne
- Nicholson Susan
- Nonide Marta
- Norfolk Derek
- O'Connor John
- O'Donnell Joshua
- O'Kane Peter
- O'Neill James
- Oakes Trevor
- Ocampo Madelaine
- Odedra Toral
- Oliveira Joana
- Oliver Victoria
- Oommen Anu
- Orr Sarah
- Paddy Loveth
- Padrón Remigio
- Panicker Abeesh Sadasiva
- Parsons Georgina
- Pascual Isaac
- Pascual Susana
- Patale Sheetal
- Pavlidis Antonis
- Pedersen Danny Mejsner
- Pedersen Frants
- Pedersen Karin Møller
- Pedersen Knud Erik
- Pedley Lauren
- Pejic Marijana
- Peláez María C.
- Pemberton Chris
- Pengelley Clare
- Penney Lucy
- Pepper Stacey
- Perara Divaka
- Perkins Alexander
- Phillips Hannah
- Phuyal Urmila
- Pine Amy
- Pitcher Louise
- Pitt Mike
- Polokova Karin
- Polwarth Gary
- Pomar-Amillo Ángeles
- Pozo-López Mónica
- Prendergast Bernard
- prentice Scott
- Preston Stephen
- Prodanovic Maja
- Prossora Mary
- Pulikal George
- Quintana Rosa B.
- Radford Elizabeth
- Radosavljevic-Radovanovic Mina
- Radovanovic Nebojsa
- Rai Amrit
- Raju Prashanth
- Rakhit Roby
- Rakhit Roby D
- Ramlall Manish
- Ramos Angelo
- Ratcliffe Amanda
- Raungaard Bent
- Ravkilde Jan
- Redington Andrew
- Redman Emily
- Redwood Simon
- Redwood Simon
- Reed Helen
- Reeve Christy
- Relph Chris
- Richardson James
- Riches Joanne
- Riddervold Ingunn Skogstad
- Riedel Ella
- Roberts Josh
- Robertson Steven
- Rodil-Díaz Juan A.
- Rondán Juan
- Ross David
- Roy Liby
- Roza César L.
- Rozado José
- Ryan Tony
- Ryding Alisdair
- Ryding Alisdair D
- Saclot Louie
- Samaniego Beatriz
- Sanchez-Vidal Ruth
- Sandhu Kully
- Sarti Charlotte
- Saunamäki Kari
- Saunders Heidi
- Savic Lidija
- Schmidt Michael R
- Schumacher Natasha
- Scott Kerry
- Sebastian Deepa
- Sebastian Deepti
- Segovia Eduardo
- Sevillano Annaliza
- Shaw Caroline
- Shelton Rhidian
- Shepherd Lucy
- Sherwood Martin
- Sidgwick Sian
- Simpson Holly
- Skipper Nicola
- Skov Charlotte Schmidt
- Smallwood Andrew
- Smee Joanna
- Smit Angelique
- Smith Bethany
- Smith Clare
- Smith Ian
- Smith Jan
- Smith Megan
- Smith Trevor
- Snow Tom
- Solieri Ashley
- Somers Kathryn
- Spence Sharon
- Spickett Helen
- Spinthakis Nicholas
- Stables Rod
- Staines Jocasta
- Stankovic Goran
- Stimson Leah
- Storey Robert F.
- Strike Philip
- Subotic Ida
- Suttling Anne
- Suárez Alfonso
- Suárez-Coto Raquel
- Suárez-Noriega Raquel
- Sørensen Henrik Toft
- Sørensen Rikke
- Tapp Luke
- Tawiah Cecilia
- Taylor Rebecca
- Terkelsen Christian Juhl
- Thambi Sunil
- Theodorou Nana
- Thim Troels
- Thomas Isobel
- Thompson Rebecca
- Thornborough Lauren
- Thornton Emma
- Thuesen Leif
- Thygesen Kristian
- Tilsted Hans Henrik
- Tipping Aoife
- Tomlinson Lucy
- Tomlinson Sharon
- Topic Dragan
- Tresguerres Jose M.
- Turner Charlotte
- Turner Jenny
- Turney Sharon
- Upton Robert
- Uscumlic Ana
- Van Dyck Laura
- Varma Madhusudhan
- Varma Madhusudhan
- Veerapen Jessry
- Vega-Fernández José L.
- Vegas-Valle Jose M.
- Veien Karsten
- Venugopal Vinod
- Vertue Mark
- Victor Saji
- Villadsen Anton Boel
- Villanueva María J.
- Villar-Fernández Lara
- Vinagrero María S.
- Viribay Fernando M.
- Vlad Ionela
- von Weitzel-Mudersbach Paul
- Vukcevic Vladan
- Vázquez-Suárez María
- Waddington Natalia
- Wain Jill
- Waitrak Paulina
- Waldron Molly
- Wallace Lauren
- Walshe Siobhan
- Walvin Tom
- Warner Karen
- Watkins Richard
- Watkinson Oliver
- Weatherlley Louise
- Webb Ian
- Webb Ian
- Wells Nicki
- Westwood Mark
- Wheeldon Nigel
- Whitehead Helena
- Whiteside Charlene
- Wilkinson Conor
- Wilson Karen
- Wittrock Daniel
- Wolyrum Mathias
- Woods Sarah
- Wragg Christopher
- Yellon Derek M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Professional Executive Committees: What Do They Do?
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Second asymptomatic carotid surgery trial (ACST-2) : a randomised comparison of carotid artery stenting versus carotid endarterectomy
- Author
- \u160ercl Miroslav
- \u160koloud\uedk David
- \u160tekl\ue1cov\ue1 Anna
- Abd-Allah Foad
- Abdul-Hamiq Ahmed
- Abdulamit Timur
- Accrocca Federico
- Acosta Stefan
- Ahlhelm Frank J
- Aidashova Balzhan
- Akyea-Mensah Joyce
- Albuquerque e Castro Jo\ue3o
- Aleksic Nikola
- Allaire Eric
- Almekhlafi Mohammed A
- Alonso Angelika
- Alves Gon\ue7alo
- Alwis Lanka
- Amatucci Giovanni
- Ambrogi Cesare
- Amis Deborah
- Anderson Dawn
- Andonova Silva
- Andziak Piotr
- Angiletta Domenico
- Angus Jane
- Antonopoulos Constantine N
- Aparici Robles Fernando
- Argentieri Angelo
- Arnold Sebastian
- Ashleigh Ray
- Ashley Simon
- Asokanathan Asaipillai
- Astarci Parla
- Babic Srdan
- Bachvarov Chavdar
- Baht Hardeep
- Bajardi Guido
- Bajoriene Milda
- Baker Lucy
- Bakke S\uf8ren
- Bal Simerpreet
- Ball Stephen
- Balogun Ibrahim
- Barbazza Renzo
- Barber Phillip A
- Barer David
- Bari Vasha
- Barlinn Jessica
- Bartko Daniel
- Barwell James
- Barz\uf3 P\ue1l
- Bastos Gon\ue7alves Frederico
- Bausback Yvonne
- Beard Jonathan
- Becquemin Jean-Pierre
- Belcastro Fernando
- Bellenis Ion
- Belli Anna
- Bellini Dalio Marcelo
- Belyasnik Andrey
- Bene\u161 III Vladim\uedr
- Benevento Domenico
- Beno Peter
- Berekoven B\ue4rbel
- Berg Bengt
- Berger Hermann
- Bergeron Patrice
- Bernardini Giulia
- Berry Clive
- Beyar Rafi
- Bialek Pawel
- Bianchi Paolo
- Bicknell Colin
- Biejat Zbigniew
- Biermaier Bernhard
- Bir\uf3 G\ue1bor
- Birt Angela
- Bj\uf6rses Katarina
- Blackham Kristine
- Blanco Ca\uf1ibano Estrella
- Blanes Orti Paula
- Bodosi Mihaly
- Bombic Martin
- Bonati Leo H
- Bonati Leo H
- Borger Franka
- Bosiers Marc
- Botsios Spiridon
- Br\ue4unlich Sven
- Bradshaw S
- Brandt Kerstin
- Branzan Daniela
- Briley Dennis
- Brountzos Elias
- Brown Andrew
- Brown Ellen
- Brown Ellen
- Brown James
- Brown Pauline
- Brudlo Wojciech
- Bryce Jenny
- Buchvald Pavel
- Bulbulia Richard
- Bulbulia Richard
- Burger Ilse
- Burzotta Francesco
- Butterfield Stephen
- C\uf6ster Andreas
- Callaert Joren
- Campbell Erik
- Campos Jr Walter
- Cannizzaro Alfredo
- Cao Piergiorgio
- Capoccia Laura
- Cappelli Alessandro
- Cardon Jean-Marie
- Carimati Federico
- Casana Renato
- Casella Ivan B
- Caso Valeria
- Catterson Martin
- Cernetti Carlo
- Chamorro \uc1ngel
- Chataway Jeremy
- Chatzinikou Eleni
- Chechulov Pavel
- Chernyavsky Mikhail A
- Cheshire Nicholas
- Chester Johanna
- Chester Johanna
- Chetter Ian
- Chiarandini Stefano
- Chisci Emiliano
- Chlouba Vladim\uedr
- Chrisopoulou Angela
- Cieri Enrico
- Cirelli Silvana
- Cireni Lea
- Civilini Efrem
- Clarke Alison
- Clarke Mike
- Clarke Sandra
- Cleveland Trevor
- Clifton Andrew
- Clifton Andrew
- Cochennec-Paliwoda Fr\ue9d\ue9ric
- Codispoti Francesco Alberto
- Colgan Mary P
- Colic Momcilo
- Colston Amanda
- Coppi Elisabetta
- Coppi Gioacchino
- Corbetta Riccardo
- Cosier Tracy
- Coutts Shelagh B
- Cowie Linda
- Cox Robin
- Cradduck-Bamford Andrea
- Cradduck-Bamford Andrea
- Cras Patrick
- Crawford Susan
- Crinnion Jamie
- Csobay-Nov\ue1k Csaba
- Cuenoud Larissa
- Cura Fernando
- Cvetic Vladimir
- Cvjetko Ivan
- Czepel Wojciech
- Czlonkowska Anna
- D'Angelo Costantino L
- D'Oria Mario
- D'Souza Stephen
- D\uf3sa Edit
- da Silva Erasmo S
- Dabek Pawel
- Darby Chris
- Davey Philip
- Davidovic Lazar
- Davies Paul
- Davis Michelle
- de Arag\ue3o Morais Jos\ue9
- de Borst Gert J
- De Donato Gianmarco
- De Koster Guy
- de Luccia Nelson
- Debus Eike S
- Dei Negri Massimo
- Delle Martin
- Delodovici Maria Luisa
- Deloose Koen
- DeMarco Ester
- Demchuk Andrew M
- DeRango Paola
- Desantis Claudio
- Desgranges Pascal
- Desiron Quentin
- Di Lazzaro Vincenzo
- Dias Nuno
- Dienel Cora
- Dieng Mortalla
- Diepers Michael
- Dix Francis
- Dixit Anand
- Donnelly Mary
- Dormal Pol
- Dorman Paul
- Dowzenko Anatol
- Dratwicki Maciej
- Drelichowski Stanislaw
- Dunlop Paul
- Durairajan Ragunath
- Dutta Dipankar
- Dyker Alexander
- Dzieciuchowicz Lukasz
- Eckstein Hans-Henning
- Eesa Muneer
- Egun Anselm A
- Eldessoki Mohamed H
- Eley Caroline
- Eliot-Jones Bekky
- Emerson Lorraine
- Endo Hidenori
- Endrych Ladislav
- Enevoldson Peter
- Engelhardt Andreas
- Engelter Stefan
- Entz L\ue1szl\uf3
- Esisi Bernard
- Estenssoro Andr\ue9 E V
- Ettles Duncan
- Eugster Thomas
- Ezura Masayuki
- F\ue1k\uf3 Eniko
- F\ufcl\uf6p B\ue9la
- Fadda Gian Franco
- Faggioli Gianluca
- Farchioni Luca
- Farrell Barbara
- Fathers Susan
- Ferrante Angela
- Ferrero Emanuele
- Ferri Michelangelo
- Fiedler Jir\ued
- Flather Marcus
- Flis Vojko
- Fontana Federico
- Ford Gary
- Formgren Johan
- Fornolles Caroline
- Fraedrich Gustav
- Frerker Klaus
- Furui Eisuke
- G\ufcnther Albrecht
- G\ufcrke Lorenz
- G\ufcrke Lorenz
- Gaba Kamran
- Gabriel Marcin
- Gaggiano Andrea
- Gaines Peter
- Galeotti Roberto
- Gamble Ed
- Garc\ueda Dominguez Luis
- Garc\ueda Fresnillo Beatriz
- Garcia Ana C
- Gargiulo Mauro
- Gasbarro Vincenzo
- Gasparini Mladen
- Geenens Mia
- Gemper Janine
- Gensicke Henrik
- George Jim
- Gerber Johannes
- Ghosh Jonathan
- Giannoukas Athanasios
- Giaquinta Alessia
- Gibbs Richard
- Gil Robert
- Gillgren Peter
- Gillies Michelle
- Gissler Hans Martin
- Gizewski Elke
- Golovkova Maria S
- Gordon Vera
- Gotts\ue4ter Anders
- Gough Michael
- Goyal Mayank
- Gr\uf6chenig Ernst
- Grad Anton
- Graham Anne
- Gramizadeh Gita
- Grassi Viviana
- Gray Mo
- Gray Richard
- Gregary Bindu
- Grimaldi Luigi
- Grimonprez Annelies
- Griselli Filippo
- Groden Christoph
- Gruber Ingrid
- Gruber Philipp
- Grunwald Iris
- Grzyska Ulrich
- Guerra Requena Mercedes
- Gunathilagan Gunaratnam
- Guyler Paul
- H\uf6lzer Henryk
- Haase Kathrin
- Haider Syed N
- Halliday Alison
- Halliday Alison
- Halu\u17ean Damir
- Hamady Mohammad
- Hammer Frank
- Hands Linda
- Harbison Joe
- Hardy Diana
- Hargroves David
- Harman Paula
- Hartmann Christian
- Hayter Elizabeth
- Hazel Beth
- Heiling Bianka
- Hemelsoet Dimitri
- Hendriks Jeroen
- Henning Eckstein Hans
- Herrington Will
- Hes Karel
- Heshmat Kassem Hussein
- Hill Michael D
- Hilltout Paula
- Hoffman Aaron
- Holliday Constance
- Holst Jan
- Hoppenbrouwers Mieke
- Hosseini Hassan
- Howard Dominic
- Hrb\ue1c Tom\ue1\u161
- Hudon Mark E
- Hughes Andrea
- Humphreys John
- Hunte Sophy
- Ignatenko Pavel
- Ilijevski Nenad
- Inoue Takashi
- Insall Robert
- Ioannou Nikolaos
- Irsara Sandro
- Isaak Andrej
- Isernia Giacomo
- Iwanowski Wojciech
- Jackson Ralph
- Jahrome Ommid
- Jakeways Matthew
- Jambula Anitha
- James Alex
- Jarl Lotta
- Jedrzejewska Julia
- Jenkins Alison
- Jenkins Michael
- Jochmann Elisabeth
- Jones Deborah
- Jones Sally
- Jonker Leon
- Joseph Thomas
- Joseph Thomas
- Jovanovic Dejana R
- Joviliano Edwaldo E
- Judge Parminder
- Justin Frances
- Juszynski Michal
- K\uf6lbel Tilo
- K\ufchme Tobias
- Kahles Timo
- Kakisis John D
- Kall Torbj\uf6rn B
- Kallmayer Michael
- Kandyba Dmitry
- Kappadath Sreevalsan
- Kappelle Jaap L
- Karathanos Christos
- Karpenko Andrey
- Karram Tony
- Karvouniari Panagiota
- Kasemi Holta
- Kazan Viviane
- Keene Elizabeth
- Keese Michael
- Kelly Christine
- Kelsall Nicci
- Kenney Carol
- Kerner Arthur
- Keunen Rudolf W M
- Khanom Nyma
- Khuoge Christopher
- Kiechl Stefan
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- Zalunardo Beniamino
- Zanow J\ufcrgen
- Zdanowski Zbigniew
- Zelen\ue1k Kamil
- Zherdev Nikolay N
- Ziani Barbara
- Zielinski Maciej
- Zimmel L
- Zimmermann Alexander
- Zini Andrea
- Zuromskis Tadas
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence.
Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362.
Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86-1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91-1·32; p=0·21).
Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
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- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
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- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
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- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
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- Bartkowiak Radoslaw
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- Mantovani Lorenzo G.
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- Yang Lingli
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- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes