A Six-Planet System Around the Star HD 34445

We present a new precision radial velocity dataset that reveals a multi-planet system orbiting the G0V star HD 34445. Our 18-year span consists of 333 precision radial velocity observations, 56 of which were previously published, and 277 which are new data from Keck Observatory, Magellan at Las Campanas Observatory, and the Automated Planet Finder at Lick Observatory. These data indicate the presence of six planet candidates in Keplerian motion about the host star with periods of 1057, 215, 118, 49, 677, and 5700 days, and minimum masses of 0.63, 0.17, 0.1, 0.05, 0.12 and 0.38 Jupiter masses respectively. The HD 34445 planetary system, with its high degree of multiplicity, its long orbital periods, and its induced stellar radial velocity half-amplitudes in the range $2 \,{\rm m\, s^{-1}} \lesssim K \lesssim 5\,{\rm m\, s^{-1}}$ is fundamentally unlike either our own solar system (in which only Jupiter and Saturn induce significant reflex velocities for the Sun), or the Kepler multiple-transiting systems (which tend to have much more compact orbital configurations)Comment: 10 pages, 11 figure

Methane and Nitrogen Abundances On Pluto and Eris

We present spectra of Eris from the MMT 6.5 meter telescope and Red Channel Spectrograph (5700-9800 angstroms; 5 angstroms per pix) on Mt. Hopkins, AZ, and of Pluto from the Steward Observatory 2.3 meter telescope and Boller and Chivens spectrograph (7100-9400 angstroms; 2 angstroms per pix) on Kitt Peak, AZ. In addition, we present laboratory transmission spectra of methane-nitrogen and methane-argon ice mixtures. By anchoring our analysis in methane and nitrogen solubilities in one another as expressed in the phase diagram of Prokhvatilov and Yantsevich (1983), and comparing methane bands in our Eris and Pluto spectra and methane bands in our laboratory spectra of methane and nitrogen ice mixtures, we find Eris' bulk methane and nitrogen abundances are about 10% and about 90%, and Pluto's bulk methane and nitrogen abundances are about 3% and about 97%. Such abundances for Pluto are consistent with values reported in the literature. It appears that the bulk volatile composition of Eris is similar to the bulk volatile composition of Pluto. Both objects appear to be dominated by nitrogen ice. Our analysis also suggests, unlike previous work reported in the literature, that the methane and nitrogen stoichiometry is constant with depth into the surface of Eris. Finally, we point out that our Eris spectrum is also consistent with a laboratory ice mixture consisting of 40% methane and 60% argon. Although we cannot rule out an argon rich surface, it seems more likely that nitrogen is the dominant species on Eris because the nitrogen ice 2.15 micron band is seen in spectra of Pluto and Triton.Comment: The manuscript has 44 pages, 15 figures, and four tables. It will appear in the Astrophysical Journa

Development of a robust protocol for gene expression analysis using formalin-fixed, paraffin-embedded liver transplant biopsy specimens

Liver transplant biopsies are routinely archived following formalin fixation and paraffin embedding and may provide an additional source of diagnostic information following transcriptomic biomarker analysis. This study was designed to compare gene transcription between resting and stressed biliary cells in culture, these cells after fixation and embedding and archival liver transplant biopsy tissue. The transcription of p21/WAF1 and transforming growth factor (TGF)-β1 showed similar changes in the fresh and embedded liver cells. However, the expression of TGF-β2 was markedly different between the fresh and embedded samples, suggesting that fixation can produce sequence-specific artefacts. Sufficient quantities of pure RNA were recovered from all the liver transplant biopsies to allow complementary DNA production. Measurement of the transcription of all three genes showed variability between the cases. Although the results for individual transcripts should be interpreted with care, these data do suggest the feasibility of performing a larger biomarker discovery studies using archival tissue.Emily Thompson, Alastair D Burt, Catriona E Barker, John A Kirby, John G Brai

Wheat Landrace Genome Diversity

Understanding the genomic complexity of bread wheat (Triticum aestivum L.) is a cornerstone in the quest to unravel the processes of domestication and the following adaptation of domesticated wheat to a wide variety of environments across the globe. Additionally, it is of importance for future improvement of the crop, particularly in the light of climate change. Focussing on the adaptation after domestication, a nested association mapping (NAM) panel of 60 segregating bi-parental populations were developed mainly involving landrace accessions from the core set of the Watkins hexaploid wheat collection optimized for genetic diversity (WINGEN et al. 2014). A modern spring elite variety, ’Paragon’, was used as common reference parent. Genetic maps were constructed following identical rules to make them comparable. In total, 1,611 linkage groups were identified, based on recombination from an estimated 126,300 crossover events over the whole NAM panel. A consensus map, named landrace consensus map (LRC) was constructed and contained 2,498 genetic loci. These newly developed genetics tools were used to investigate the rules underlying genome fluidity or rigidity, e.g. by comparing at marker distances and marker orders. In general, marker order was highly correlated, which provides support for strong synteny between bread wheat accessions. However, many exceptional cases of incongruent linkage groups and increased marker distances were also found. Segregation distortion was detected for many markers, sometimes as hot-spots present in different populations. Furthermore, evidence for translocations in at least 36 of the maps was found. These translocations fell, in general, into many different translocation classes, but a few translocation classes were found in several accessions, the most frequent one being the well known T5B:7B translocation. Loci involved in recombination rate, which is an interesting trait for plant breeding, were identified by QTL analyses using the crossover counts as a trait. In total, 114 significant QTL were detected, nearly half of them with increasing effect from the non-reference parents

Rat cities and beehive worlds: density and design in the modern city

Nestled among E. M. Forster's careful studies of Edwardian social mores is a short story called "The Machine Stops." Set many years in the future, it is a work of science fiction that imagines all humanity housed in giant high-density cities buried deep below a lifeless surface. With each citizen cocooned in an identical private chamber, all interaction is mediated through the workings of "the Machine," a totalizing social system that controls every aspect of human life. Cultural variety has ceded to rigorous organization: everywhere is the same, everyone lives the same life. So hopelessly reliant is humanity upon the efficient operation of the Machine, that when the system begins to fail there is little the people can do, and so tightly ordered is the system that the failure spreads. At the story's conclusion, the collapse is total, and Forster's closing image offers a condemnation of the world they had built, and a hopeful glimpse of the world that might, in their absence, return: "The whole city was broken like a honeycomb. [⋯] For a moment they saw the nations of the dead, and, before they joined them, scraps of the untainted sky" (2001: 123). In physically breaking apart the city, there is an extent to which Forster is literalizing the device of the broken society, but it is also the case that the infrastructure of the Machine is so inseparable from its social structure that the failure of one causes the failure of the other. The city has-in the vocabulary of present-day engineers-"failed badly.

Microscopic Dynamics in a Strongly Interacting Bose-Einstein Condensate

An initially stable 85Rb Bose-Einstein condensate (BEC) was subjected to a carefully controlled magnetic field pulse in the vicinity of a Feshbach resonance. This pulse probed the strongly interacting regime for the condensate, with calculated values for the diluteness parameter (na^3) ranging from 0.01 to 0.5. The field pulse was observed to cause loss of atoms from the condensate on remarkably short time scales (>=10 microsec). The dependence of this loss on magnetic field pulse shape and amplitude was measured. For triangular pulses shorter than 1 ms, decreasing the pulse length actually increased the loss, until extremely short time scales (a few tens of microseconds) were reached. Such time scales and dependencies are very different from those expected in traditional condensate inelastic loss processes, suggesting the presence of new microscopic BEC physics.Comment: 4 pages in latex2E, 4 eps figures; revised Fig.1, revised scatt.lengths, added discussion, new refs., resubmitted to PR

Search for Nearby Earth Analogs. II. detection of five new planets, eight planet candidates, and confirmation of three planets around nine nearby M dwarfs

© 2020 The American Astronomical Society. This is an author-created, un-copyedited version of an article accepted for publication in Astrophysical Journal Supplement Series. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://doi.org/10.3847/1538-4365/ab5e7c.Zechmeister et al. surveyed 38 nearby M dwarfs from 2000 to 2007 March with VLT2 and the Ultraviolet and Visual Echelle Spectrograph (UVES) spectrometer. These data have recently been reanalyzed, yielding a significant improvement in the Doppler velocity precision. Spurred by this, we have combined the UVES data with velocity sets from High Accuracy Radial velocity Planet Searcher, Magellan/Planet Finder Spectrograph, and Keck/High Resolution Echelle Spectrometer. Sixteen planet candidates have been uncovered orbiting nine M dwarfs. Five of them are new planets corresponding to radial velocity signals, which are not sensitive to the choice of noise models and are identified in multiple data sets over various time spans. Eight candidate planets require additional observation to be confirmed. We also confirm three previously reported planets. Among the new planets, GJ 180 d and GJ 229A c are super-Earths located in the conservative habitable zones of their host stars. We investigate their dynamical stability using the Monte Carlo approach and find both planetary orbits are robust to the gravitational perturbations of the companion planets. Due to their proximity to the Sun, the angular separation between the host stars and the potentially habitable planets in these two systems is 25 and 59 mas, respectively. They are thus good candidates for future direct imaging by James Webb Space Telescope and E-ELT. In addition, we find GJ 433 c, a cold super-Neptune belonging to an unexplored population of Neptune-like planets. With a separation of 0.″5 from its host star, GJ 433 c is probably the first realistic candidate for the direct imaging of cold Neptunes. A comprehensive survey of these planets is important for the studies of planet formation.Peer reviewedFinal Published versio