2D and 3D Analysis of a Torus-unstable Quiet-Sun Prominence Eruption

The role of ideal-MHD instabilities in a prominence eruption is explored through 2D and 3D kinematic analysis of an event observed with the Solar Dynamics Observatory and the Solar Terrestrial Relations Observatory between 22:06 UT on 2013 February 26 and 04:06 UT on 2013 February 27. A series of 3D radial slits are used to extract height–time profiles ranging from the midpoint of the prominence leading edge to the southeastern footpoint. These height–time profiles are fit with a kinematic model combining linear and nonlinear rise phases, returning the nonlinear onset time (t nl) as a free parameter. A range (1.5–4.0) of temporal power indices (i.e., β in the nonlinear term ${(t-{t}_{\mathrm{nl}})}^{\beta }$) are considered to prevent prescribing any particular form of nonlinear kinematics. The decay index experienced by the leading edge is explored using a radial profile of the transverse magnetic field from a PFSS extrapolation above the prominence region. Critical decay indices are extracted for each slit at their own specific values of height at the nonlinear phase onset (h(t nl)) and filtered to focus on instances resulting from kinematic fits with ${\chi }_{\mathrm{red}}^{2}\lt 2$ (restricting β to 1.9–3.9). Based on this measure of the critical decay index along the prominence structure, we find strong evidence that the torus instability is the mechanism driving this prominence eruption. Defining any single decay index as being "critical" is not that critical because there is no single canonical or critical value of decay index through which all eruptions must succeed

Thinking territory historically.

BACKGROUND: While the randomised controlled trial (RCT) is generally regarded as the design of choice for assessing the effects of health care, within the social sciences there is considerable debate about the relative suitability of RCTs and non-randomised studies (NRSs) for evaluating public policy interventions. // OBJECTIVES: To determine whether RCTs lead to the same effect size and variance as NRSs of similar policy interventions; and whether these findings can be explained by other factors associated with the interventions or their evaluation. // METHODS: Analyses of methodological studies, empirical reviews, and individual health and social services studies investigated the relationship between randomisation and effect size of policy interventions by: 1) Comparing controlled trials that are identical in all respects other than the use of randomisation by 'breaking' the randomisation in a trial to create non-randomised trials (re-sampling studies). 2) Comparing randomised and non-randomised arms of controlled trials mounted simultaneously in the field (replication studies). 3) Comparing similar controlled trials drawn from systematic reviews that include both randomised and non-randomised studies (structured narrative reviews and sensitivity analyses within meta-analyses). 4) Investigating associations between randomisation and effect size using a pool of more diverse RCTs and NRSs within broadly similar areas (meta-epidemiology). // RESULTS: Prior methodological reviews and meta-analyses of existing reviews comparing effects from RCTs and nRCTs suggested that effect sizes from RCTs and nRCTs may indeed differ in some circumstances and that these differences may well be associated with factors confounded with design. Re-sampling studies offer no evidence that the absence of randomisation directly influences the effect size of policy interventions in a systematic way. No consistent explanations were found for randomisation being associated with changes in effect sizes of policy interventions in field trials

Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells

During inflammation, myeloperoxidase (MPO) released by circulating leukocytes accumulates within the subendothelial matrix by binding to and transcytosing the endothelium. Oxidative reactions catalyzed by subendothelial-localized MPO are implicated as a key cause of endothelial dysfunction in inflammatory vascular diseases. Whilst the subendothelial matrix is a reactive target for MPO-derived oxidants in disease, the functional implications of oxidative matrix modification for the endothelium are largely unknown. Here we show that hypochlorous acid (HOCl) produced by endothelial-transcytosed MPO oxidizes the subendothelial matrix, involving covalent crosslinking of the adhesive matrix protein fibronectin. Real-time biosensor and live cell imaging studies showed that HOCl-mediated matrix oxidation triggers rapid membrane retraction from the substratum and adjacent cells (de-adhesion). This de-adhesion was linked with the alteration of Tyr-118 phosphorylation of paxillin, a key focal adhesion-dependent signaling process, as well as Rho kinase-dependent myosin light chain-2 phosphorylation. De-adhesion dynamics were dependent on the contractile state of cells, with myosin II inhibition with blebbistatin markedly attenuating the rate of membrane retraction. Rho kinase inhibition with Y-27632 also conferred protection, but not during the initial phase of membrane retraction, which was driven by pre-existing actomyosin tensile stress. Notably, diversion of MPO from HOCl production by thiocyanate and nitrite attenuated de-adhesion and associated signaling responses, despite the latter substrate supporting MPO-catalyzed fibronectin nitration. This study indicates that HOCl-mediated matrix oxidation by subendothelial MPO deposits may play an important and previously unrecognized role in altering endothelial adhesion, signaling and integrity during inflammatory vascular disorders

Self-Generated Magnetic Fields in Galactic Cooling Flows

Interstellar magnetic fields in elliptical galaxies are assumed to have their origin in stellar fields that accompany normal mass loss from an evolving population of old stars. The seed fields are amplified by interstellar turbulence driven by stellar mass loss and supernova events. These disordered fields are further amplified by time-dependent compression in the inward moving galactic cooling flow and are expected to dominate near the galactic core. Under favorable circumstances, fields similar in strength to those observed $B \sim 1-10~(r/10~kpc)^{-1.2}\mu$G can be generated solely from these natural galactic processes. In general the interstellar field throughout elliptical galaxies is determined by the outermost regions in the interstellar gas where the turbulent dynamo process can occur. Because of the long hydrodynamic flow times in galactic cooling flows, currently observed magnetic fields may result from periods of intense turbulent field amplification that occurred in the outer galaxy in the distant past. Particularly strong fields in ellipticals may result from ancient galactic mergers or shear turbulence introduced at the boundary between the interstellar gas and ambient cluster gas.Comment: 21 pages in AASTEX LaTeX with 2 figures; accepted by Astrophysical Journa

Global Environmental Change: What Can Health Care Providers and the Environmental Health Community Do About It Now?

The debate about whether global environmental change is real is now over; in its wake is the realization that it is happening more rapidly than predicted. These changes constitute a profound challenge to human health, both as a direct threat and as a promoter of other risks. We call on health care providers to inform themselves about these issues and to become agents of change in their communities. It is our responsibility as clinicians to educate patients and their communities on the connections between regressive policies, unsustainable behaviors, global environmental changes, and threats to health and security. We call on professional organizations to assist in educating their members about these issues, in helping clinicians practice behavior change with their patients, and in adding their voices to this issue in our statehouses and Congress. We call for the development of carbon- and other environmental-labeling of consumer products so individuals can make informed choices; we also call for the rapid implementation of policies that provide tangible economic incentives for choosing environmentally sustainable products and services. We urge the environmental health community to take up the challenge of developing a global environmental health index that will incorporate human health into available “planetary health” metrics and that can be used as a policy tool to evaluate the impact of interventions and document spatial and temporal shifts in the healthfulness of local areas. Finally, we urge our political, business, public health, and academic leaders to heed these environmental warnings and quickly develop regulatory and policy solutions so that the health of populations and the integrity of their environments will be ensured for future generations

Green and High Performance Factory Crafted Housing

In the U.S., factory-built housing greater than 400 square feet is built either to the U.S. Department of Housing and Urban Development (HUD) code for mobile homes or site-built codes for modular housing. During the last few years, as the production of HUD code housing has dwindled, many leading edge factory builders have started building modular homes to compete with site-built housing and stay in business. As part of the Building America Industrialized Housing Partnership (BAIHP) we have assisted in the design and construction of several “green” and high performance modular homes that Palm Harbor Homes, Florida Division (PHH) has built for the International Builders’ Show (IBS) in 2006, 2007, and 2008. This paper will summarize the design features and the “green” and energy-efficient certification processes conducted for the 2008 show homes, one of which received the very first E-Scale produced by BAIHP for the U.S. Department of Energy (DOE) Builders Challenge program

A Cosmological Framework for the Co-Evolution of Quasars, Supermassive Black Holes, and Elliptical Galaxies: II. Formation of Red Ellipticals

(Abridged) We develop and test a model for the cosmological role of mergers in the formation and quenching of red, early-type galaxies. Making the ansatz that star formation is quenched after a gas-rich, spheroid-forming major merger, we demonstrate that this naturally predicts the turnover in the efficiency of star formation at ~L_star, as well as the observed mass functions/density of red galaxies as a function of redshift, the formation times of spheroids as a function of mass, and the fraction of quenched galaxies as a function of galaxy and halo mass, environment, and redshift. Comparing to a variety of semi-analytic models in which quenching is primarily driven by halo mass considerations or secular/disk instabilities, we demonstrate that our model and different broad classes of models make unique and robust qualitative predictions for a number of observables, including the red fraction as a function of galaxy and halo mass, the density of passive galaxies and evolution of the color-morphology-density relations at high z, and the fraction of disky/boxy spheroids as a function of mass. In each case, the observations favor a model in which galaxies quench after a major merger builds a massive spheroid, and disfavor quenching via secular or pure halo processes. We discuss a variety of physical possibilities for this quenching, and propose a mixed scenario in which traditional quenching in hot, massive halos is supplemented by the feedback associated with star formation and quasar activity in a major merger, which temporarily suppress cooling and establish the conditions of a dynamically hot halo in the central regions of the host, even in low mass halos.Comment: 29 pages, 21 figures, submitted to ApJ. Replacement fixes comparison of models in Figures 6 &