132 research outputs found
The essence and driving forces of competition
В статье рассмотрено понятие конкурентоспособности предприятия, раскрыта ее экономическая сущность, выявлены факторы движущих сил, влияющие на уровень конкурентной борьбы предприятий.The article considers the concept of enterprise competitiveness discloses its economic essence, identifies the factors of driving forces that influence the level of competitiveness of enterprises
Разработка состава и способа получения пористого стеклокомпозита на основе жидкого стекла
Разработка состава и способа получения пористого стеклокомпозита на основе жидкого стекла. Анализ характеристик исходных материалов, использование различных методов исследования, таких как определение вязкости и модуля жидкого стекла, а так же рентгенофазовый анализ и электронная микроскопия.Development of a composition and a method for producing a porous glass composite based on water glass. Analysis of the characteristics of raw materials, the use of various research methods, such as determination of the viscosity and modulus of liquid glass, as well as X-ray phase analysis and electron microscopy
FACT - The First G-APD Cherenkov Telescope: Status and Results
The First G-APD Cherenkov telescope (FACT) is the first telescope using
silicon photon detectors (G-APD aka. SiPM). It is built on the mount of the
HEGRA CT3 telescope, still located at the Observatorio del Roque de los
Muchachos, and it is successfully in operation since Oct. 2011. The use of
Silicon devices promises a higher photon detection efficiency, more robustness
and higher precision than photo-multiplier tubes. The FACT collaboration is
investigating with which precision these devices can be operated on the
long-term. Currently, the telescope is successfully operated from remote and
robotic operation is under development. During the past months of operation,
the foreseen monitoring program of the brightest known TeV blazars has been
carried out, and first physics results have been obtained including a strong
flare of Mrk501. An instantaneous flare alert system is already in a testing
phase. This presentation will give an overview of the project and summarize its
goals, status and first results
Інформаційна технологія для класифікації наукових текстів на основі методу модифікованої логістичної регресії
Об’єкт дослідження: процес класифікації наукових текстів та практичне використання технологій обробки природної мови в освітніх додатках, з метою підвищення ефективності освітнього процесу.
Предмет дослідження: методи, моделі машинного навчання та обробки природньої мови у задачах класифікації наукових текстів.
Мета магістерської роботи: вдосконалення та пришвидшення процесу класифікації текстів з допомогою моделі логістичної регресії, з метою застосування її у освітніх додатках для покращення освітнього процесу.
Методи дослідження. Для створення рекомендаційного та навчального асистента були використані засоби та методи машинного навчання, теорії множин, лінейної алгебри й обробки природної мови.
Наукова новизна полягає у тому, що вдосконалено та розширено можливості методу логістичної регресії на основі комбінування його з методом ранжування, що в результаті дозволило використати метод логістичної регресії для навчального асистенті.
Практична цінність полягає у тому, що в результаті роботи, було створено прототип навчального асистента, що використовує скомбіновану з методом ранжування модель логістичної регресії для класифікації текстів. Використані методи та підходи у прототипі можуть застосовуватись як при розробці «інтелектуальних» навчальних систем, так й в практиці викладання дисциплін, пов’язаних з обробкою природної мови
Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19 convalescent subjects
Background
The immune response to COVID-19-vaccination differs between naïve vaccinees and those who were previously infected with SARS-CoV-2. Longitudinal quantitative and qualitative serological differences in these two distinct immunological subgroups in response to vaccination are currently not well studied.
Methods
We investigate a cohort of SARS-CoV-2-naïve and COVID-19-convalescent individuals immediately after vaccination and 6 months later. We use different enzyme-linked immunosorbent assay (ELISA) variants and a surrogate virus neutralization test (sVNT) to measure IgG serum titers, IgA serum reactivity, IgG serum avidity and neutralization capacity by ACE2 receptor competition.
Results
Anti-receptor-binding domain (RBD) antibody titers decline over time in dually vaccinated COVID-19 naïves whereas titers in single dose vaccinated COVID-19 convalescents are higher and more durable. Similarly, antibody avidity is considerably higher among boosted COVID-19 convalescent subjects as compared to dually vaccinated COVID-19-naïve subjects. Furthermore, sera from boosted convalescents inhibited the binding of spike-protein to ACE2 more efficiently than sera from dually vaccinated COVID-19-naïve subjects.
Conclusions
Long-term humoral immunity differs substantially between dually vaccinated SARS-CoV-2-naïve and COVID-19-convalescent individuals. Booster vaccination after COVID-19 induces a more durable humoral immune response in terms of magnitude and quality as compared to two-dose vaccination in a SARS-CoV-2-naïve background
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
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