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Greater V˙O2peak is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise.
It is axiomatic that greater aerobic fitness (V˙O2peak) derives from enhanced perfusive and diffusive O2 conductances across active muscles. However, it remains unknown how these conductances might be reflected by regional differences in fractional O2 extraction (i.e., deoxy [Hb+Mb] and tissue O2 saturation [StO2]) and diffusive O2 potential (i.e., total[Hb+Mb]) among muscles spatially heterogeneous in blood flow, fiber type, and recruitment (vastus lateralis, VL; rectus femoris, RF). Using quantitative time-resolved near-infrared spectroscopy during ramp cycling in 24 young participants (V˙O2peak range: ~37.4-66.4 mL kg-1 min-1), we tested the hypotheses that (1) deoxy[Hb+Mb] and total[Hb+Mb] at V˙O2peak would be positively correlated with V˙O2peak in both VL and RF muscles; (2) the pattern of deoxygenation (the deoxy[Hb+Mb] slopes) during submaximal exercise would not differ among subjects differing in V˙O2peak Peak deoxy [Hb+Mb] and StO2 correlated with V˙O2peak for both VL (r = 0.44 and -0.51) and RF (r = 0.49 and -0.49), whereas for total[Hb+Mb] this was true only for RF (r = 0.45). Baseline deoxy[Hb+Mb] and StO2 correlated with V˙O2peak only for RF (r = -0.50 and 0.54). In addition, the deoxy[Hb+Mb] slopes were not affected by aerobic fitness. In conclusion, while the pattern of deoxygenation (the deoxy[Hb+Mb] slopes) did not differ between fitness groups the capacity to deoxygenate [Hb+Mb] (index of maximal fractional O2 extraction) correlated significantly with V˙O2peak in both RF and VL muscles. However, only in the RF did total[Hb+Mb] (index of diffusive O2 potential) relate to fitness
VLT FORS2 comparative transmission spectroscopy: Detection of Na in the atmosphere of WASP-39b from the ground
We present transmission spectroscopy of the warm Saturn-mass exoplanet
WASP-39b made with the Very Large Telescope (VLT) FOcal Reducer and
Spectrograph (FORS2) across the wavelength range 411-810nm. The transit depth
is measured with a typical precision of 240 parts per million (ppm) in
wavelength bins of 10nm on a V = 12.1 magnitude star. We detect the sodium
absorption feature (3.2-sigma) and find evidence for potassium. The
ground-based transmission spectrum is consistent with Hubble Space Telescope
(HST) optical spectroscopy, strengthening the interpretation of WASP-39b having
a largely clear atmosphere. Our results demonstrate the great potential of the
recently upgraded FORS2 spectrograph for optical transmission spectroscopy,
obtaining HST-quality light curves from the ground.Comment: 11 pages, 5 figures, accepted for publication in Ap
Greater (V)over dotO(2peak) is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise
Citation: Okushima, D., Poole, D. C., Barstow, T. J., Rossiter, H. B., Kondo, N., Bowen, T. S., . . . Koga, S. (2016). Greater (V)over dotO(2peak) is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise. Physiological Reports, 4(23), 12. doi:10.14814/phy2.13065It is axiomatic that greater aerobic fitness ((V)over dotO(2peak)) derives from enhanced perfusive and diffusive O-2 conductances across active muscles. However, it remains unknown how these conductances might be reflected by regional differences in fractional O-2 extraction (i.e., deoxy [Hb+Mb] and tissue O-2 saturation [StO2]) and diffusive O-2 potential (i.e., total[Hb+Mb]) among muscles spatially heterogeneous in blood flow, fiber type, and recruitment (vastus lateralis, VL; rectus femoris, RF). Using quantitative time-resolved near-infrared spectroscopy during ramp cycling in 24 young participants ((V)over dotO(2peak) range: similar to 37.4-66.4 mL kg(-1) min(-1)), we tested the hypotheses that (1) deoxy [Hb+Mb] and total[Hb+Mb] at (V)over dotO(2peak) would be positively correlated with (V)over dotO(2peak) in both VL and RF muscles; (2) the pattern of deoxygenation (the deoxy[Hb+Mb] slopes) during submaximal exercise would not differ among subjects differing in (V)over dotO(2peak). Peak deoxy [Hb+Mb] and StO2 correlated with (V)over dotO(2peak) for both VL (r = 0.44 and -0.51) and RF (r = 0.49 and -0.49), whereas for total[Hb+Mb] this was true only for RF (r = 0.45). Baseline deoxy[Hb+Mb] and StO2 correlated with (V)over dotO(2peak) only for RF (r = -0.50 and 0.54). In addition, the deoxy[Hb+Mb] slopes were not affected by aerobic fitness. In conclusion, while the pattern of deoxygenation (the deoxy[Hb+Mb] slopes) did not differ between fitness groups the capacity to deoxygenate [Hb+Mb] (index of maximal fractional O-2 extraction) correlated significantly with (V)over dotO(2peak) in both RF and VL muscles. However, only in the RF did total [Hb+Mb] (index of diffusive O-2 potential) relate to fitness
Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise
Citation: Smith, J. R., Broxterman, R. M., Ade, C. J., Evans, K. K., Kurti, S. P., Hammer, S. M., . . . Harms, C. A. (2016). Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise. Physiological Reports, 4(7), 1-10. doi:10.14814/phy2.12748N-acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe-intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation characteristics during severe-intensity exercise. Eight healthy nonendurance trained men (21.8 ± 1.2 years) were recruited and completed two constant power handgrip exercise tests at 80% peak power until exhaustion. Subjects orally consumed either placebo (PLA) or NAC (70 mg/kg) 60 min prior to handgrip exercise. Immediately prior to exercise, venous blood samples were collected for determination of plasma redox balance. Brachial artery blood flow (BABF) was measured via Doppler ultrasound and flexor digitorum superficialis oxygenation characteristics were measured via near-infrared spectroscopy. Following NAC supplementaiton, plasma cysteine (NAC: 47.2 ± 20.3 ?mol/L vs. PLA: 9.6 ± 1.2 ?mol/L; P = 0.001) and total cysteine (NAC: 156.2 ± 33.9 ?mol/L vs. PLA: 132.2 ± 16.3 ?mol/L; P = 0.048) increased. Time to exhaustion was not significantly different (P = 0.55) between NAC (473.0 ± 62.1 sec) and PLA (438.7 ± 58.1 sec). Resting BABF was not different (P = 0.79) with NAC (99.3 ± 31.1 mL/min) and PLA (108.3 ± 46.0 mL/min). BABF was not different (P = 0.42) during exercise or at end-exercise (NAC: 413 ± 109 mL/min; PLA: 445 ± 147 mL/min). Deoxy-[hemoglobin+myoglobin] and total-[hemoglobin+myoglobin] were not significantly different (P = 0.73 and P = 0.54, respectively) at rest or during exercise between conditions. We conclude that acute NAC supplementation does not alter oxygen delivery during exercise in men. © 2016 Published by the American Physiological Society and The Physiological Society
The Very Low Albedo of WASP-12b From Spectral Eclipse Observations with
We present an optical eclipse observation of the hot Jupiter WASP-12b using
the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope.
These spectra allow us to place an upper limit of (97.5%
confidence level) on the planet's white light geometric albedo across 290--570
nm. Using six wavelength bins across the same wavelength range also produces
stringent limits on the geometric albedo for all bins. However, our
uncertainties in eclipse depth are 40% greater than the Poisson limit and
may be limited by the intrinsic variability of the Sun-like host star --- the
solar luminosity is known to vary at the level on a timescale of
minutes. We use our eclipse depth limits to test two previously suggested
atmospheric models for this planet: Mie scattering from an aluminum-oxide haze
or cloud-free Rayleigh scattering. Our stringent nondetection rules out both
models and is consistent with thermal emission plus weak Rayleigh scattering
from atomic hydrogen and helium. Our results are in stark contrast with those
for the much cooler HD 189733b, the only other hot Jupiter with spectrally
resolved reflected light observations; those data showed an increase in albedo
with decreasing wavelength. The fact that the first two exoplanets with optical
albedo spectra exhibit significant differences demonstrates the importance of
spectrally resolved reflected light observations and highlights the great
diversity among hot Jupiters.Comment: 8 pages, 4 figures, 1 table, published in ApJL, in pres
Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans
We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen
uptake (VO2) were associated with a greater initial rise in VO2 (ΔVO2/ΔW, where W is work rate) following the
onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these
results were true only for heavy exercise, or if the association between fibre type and/or fitness and ΔVO2/ΔW
would also be seen for moderate (< LT) exercise. The purpose of the present study was to compare the
relationships between fibre type or peak VO2 and ΔVO2/ΔW determined for moderate ( LT)
exercise intensities during incremental exercise. Nine healthy subjects performed an incremental ramp test on
a cycle ergometer. The VO2/W slope was calculated for the domain of power outputs up to the LT (S1), from the
LT towards peak VO2 (S2), and over the entire linear portion of the ΔVO2/ΔW response (S
T), and compared to
fibre type distribution determined from biopsy of the vastus lateralis, and to peak VO2 (as ml kg-1 min-1).
Significant correlations between ΔVO2/ΔW and the proportion of type I fibres were found for each exercise
domain (r is 0.69, 0.71 and 0.84 for S1, S2 and ST, respectively, P <0.05). S1 ranged between about
9 ml min-1 W-1 for a low proportion of type I fibres and 11 ml min-1 W-1 for a high proportion of type I
fibres. Similar correlations were also found between S2 (r = 0.70) and ST (r = 0.76) and peak VO2. These results
are consistent with our previous findings during >LT constant power output exercise, and suggest that the
proportion of type I fibres, and possibly fitness as indicated by peak VO2, is associated with greater ΔVO2/ΔW
during the initial adjustment to LT exercise. These results do not appear to be explained by
classical descriptions of the kinetics of adjustment of VO2 following the onset of ramp or constant power output
exercise. They might reflect enhanced motor unit recruitment in subjects with a greater percentage of type I
fibres, and/or who are more aerobically fit. However, the underlying mechanism for these findings must await
further study
A JWST NIRSpec Phase Curve for WASP-121b: Dayside Emission Strongest Eastward of the Substellar Point and Nightside Conditions Conducive to Cloud Formation
We present the first exoplanet phase curve measurement made with the JWST
NIRSpec instrument, highlighting the exceptional stability of this
newly-commissioned observatory for exoplanet climate studies. The target,
WASP-121b, is an ultrahot Jupiter with an orbital period of 30.6 hr. We analyze
two broadband light curves generated for the NRS1 and NRS2 detectors, covering
wavelength ranges of 2.70-3.72 micron and 3.82-5.15 micron, respectively. Both
light curves exhibit minimal systematics, with approximately linear drifts in
the baseline flux level of 30 ppm/hr (NRS1) and 10 ppm/hr (NRS2). Assuming a
simple brightness map for the planet described by a low-order spherical
harmonic dipole, our light curve fits suggest that the phase curve peaks
coincide with orbital phases deg (NRS1) and deg
(NRS2) prior to mid-eclipse. This is consistent with the strongest dayside
emission emanating from eastward of the substellar point. We measure
planet-to-star emission ratios of ppm (NRS1) and
ppm (NRS2) for the dayside hemisphere, and ppm (NRS1) and ppm (NRS2) for the nightside hemisphere. The latter nightside emission
ratios translate to planetary brightness temperatures of K (NRS1)
and K (NRS2), which are low enough for a wide range of
refractory condensates to form, including enstatite and forsterite. A nightside
cloud deck may be blocking emission from deeper, hotter layers of the
atmosphere, potentially helping to explain why cloud-free 3D general
circulation model simulations systematically over-predict the nightside
emission for WASP-121b.Comment: Accepted for publication in Astrophysical Journal Letters on December
29, 202
Abundance measurements of H<sub>2</sub>O and carbon-bearing species in the atmosphere of WASP-127b confirm its super-solar metallicity
The chemical abundances of exoplanet atmospheres may provide valuable information about the bulk compositions, formation pathways, and evolutionary histories of planets. Exoplanets with large, relatively cloud-free atmospheres, and which orbit bright stars provide the best opportunities for accurate abundance measurements. For this reason, we measured the transmission spectrum of the bright (V∼10.2), large (), sub-Saturn mass () exoplanet WASP-127b across the near-UV to near-infrared wavelength range (0.3–5 μm), using the Hubble and Spitzer Space Telescopes. Our results show a feature-rich transmission spectrum, with absorption from Na, , and , and wavelength-dependent scattering from small-particle condensates. We ran two types of atmospheric retrieval models: one enforcing chemical equilibrium, and the other which fit the abundances freely. Our retrieved abundances at chemical equilibrium for Na, O and C are all super-solar, with abundances relative to solar values of , , and respectively. Despite giving conflicting C/O ratios, both retrievals gave super-solar volume mixing ratios, which adds to the likelihood that WASP-127b’s bulk metallicity is super-solar, since abundance is highly sensitive to atmospheric metallicity. We detect water at a significance of 13.7 σ. Our detection of Na is in agreement with previous ground-based detections, though we find a much lower abundance, and we also do not find evidence for Li or K despite increased sensitivity. In the future, spectroscopy with JWST will be able to constrain WASP-127b’s C/O ratio, and may reveal the formation history of this metal-enriched, highly observable exoplanet
Transiting Exoplanet Studies and Community Targets for JWST's Early Release Science Program
The James Webb Space Telescope will revolutionize transiting exoplanet
atmospheric science due to its capability for continuous, long-duration
observations and its larger collecting area, spectral coverage, and spectral
resolution compared to existing space-based facilities. However, it is unclear
precisely how well JWST will perform and which of its myriad instruments and
observing modes will be best suited for transiting exoplanet studies. In this
article, we describe a prefatory JWST Early Release Science (ERS) program that
focuses on testing specific observing modes to quickly give the community the
data and experience it needs to plan more efficient and successful future
transiting exoplanet characterization programs. We propose a multi-pronged
approach wherein one aspect of the program focuses on observing transits of a
single target with all of the recommended observing modes to identify and
understand potential systematics, compare transmission spectra at overlapping
and neighboring wavelength regions, confirm throughputs, and determine overall
performances. In our search for transiting exoplanets that are well suited to
achieving these goals, we identify 12 objects (dubbed "community targets") that
meet our defined criteria. Currently, the most favorable target is WASP-62b
because of its large predicted signal size, relatively bright host star, and
location in JWST's continuous viewing zone. Since most of the community targets
do not have well-characterized atmospheres, we recommend initiating preparatory
observing programs to determine the presence of obscuring clouds/hazes within
their atmospheres. Measurable spectroscopic features are needed to establish
the optimal resolution and wavelength regions for exoplanet characterization.
Other initiatives from our proposed ERS program include testing the instrument
brightness limits and performing phase-curve observations.(Abridged)Comment: This is a white paper that originated from an open discussion at the
Enabling Transiting Exoplanet Science with JWST workshop held November 16 -
18, 2015 at STScI (http://www.stsci.edu/jwst/science/exoplanets). Accepted
for publication in PAS
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