The initial mass function of early-type galaxies

We determine an absolute calibration of the initial mass function (IMF) of early-type galaxies, by studying a sample of 56 gravitational lenses identified by the SLACS Survey. Under the assumption of standard Navarro, Frenk & White dark matter halos, a combination of lensing, dynamical, and stellar population synthesis models is used to disentangle the stellar and dark matter contribution for each lens. We define an "IMF mismatch" parameter \alpha=M*(L+D)/M*(SPS) as the ratio of stellar mass inferred by a joint lensing and dynamical models (M*(L+D)) to the current stellar mass inferred from stellar populations synthesis models (M*(SPS)). We find that a Salpeter IMF provides stellar masses in agreement with those inferred by lensing and dynamical models (=0.00+-0.03+-0.02), while a Chabrier IMF underestimates them (=0.25+-0.03+-0.02). A tentative trend is found, in the sense that \alpha appears to increase with galaxy velocity dispersion. Taken at face value, this result would imply a non universal IMF, perhaps dependent on metallicity, age, or abundance ratios of the stellar populations. Alternatively, the observed trend may imply non-universal dark matter halos with inner density slope increasing with velocity dispersion. While the degeneracy between the two interpretations cannot be broken without additional information, the data imply that massive early-type galaxies cannot have both a universal IMF and universal dark matter halos.Comment: 10 pages 4 figures. Resubmitted to ApJ taking into account referee's comment

The non-evolving internal structure of early-type galaxies: the case study SDSS J0728+3835 at z = 0.206

We study the internal dynamical structure of the early-type lens galaxy SDSS J0728+3835 at z = 0.206. The analysis is based on two-dimensional kinematic maps extending out to 1.7 effective radii obtained from Keck spectroscopy, on lensing geometry and on stellar mass estimates obtained from multiband Hubble Space Telescope imaging. The data are modelled under the assumptions of axial symmetry supported by a two-integral distribution function (DF), by applying the combined gravitational lensing and stellar dynamics code CAULDRON, and yielding high-quality constraints for an early-type galaxy at cosmological redshifts. Modelling the total density profile as a power-law of the form rho_tot ~ 1/r^{gamma}, we find that it is nearly isothermal (logarithmic slope gamma = 2.08^{+0.04}_{-0.02}), and quite flattened (axial ratio q = 0.60^{+0.08}_{-0.03}). The galaxy is mildly anisotropic (delta = 0.08 +/- 0.02) and shows a fair amount of rotational support, in particular towards the outer regions. We determine a dark matter fraction lower limit of 28 per cent within the effective radius. The stellar contribution to the total mass distribution is close to maximal for a Chabrier initial mass function (IMF), whereas for a Salpeter IMF the stellar mass exceeds the total mass within the galaxy inner regions. We find that the combination of a NFW dark matter halo with the maximally rescaled luminous profile provides a remarkably good fit to the total mass distribution over a broad radial range. Our results confirm and expand the findings of the SLACS survey for early-type galaxies of comparable velocity dispersion (sigma_SDSS = 214 +/- 11 km/s). The internal structure of J0728 is consistent with that of local early-type galaxies of comparable velocity dispersion as measured by the SAURON project, suggesting lack of evolution in the past two billion years.Comment: 13 pages, 10 figures. MNRAS in press. Revised to match accepted versio

Visualization of Allostery in P-Selectin Lectin Domain Using MD Simulations

Allostery of P-selectin lectin (Lec) domain followed by an epithelial growth factor (EGF)-like domain is essential for its biological functionality, but the underlying pathways have not been well understood. Here the molecular dynamics simulations were performed on the crystallized structures to visualize the dynamic conformational change for state 1 (S1) or state 2 (S2) Lec domain with respective bent (B) or extended (E) EGF orientation. Simulations illustrated that both S1 and S2 conformations were unable to switch from one to another directly. Instead, a novel S1' conformation was observed from S1 when crystallized B-S1 or reconstructed “E-S1” structure was employed, which was superposed well with that of equilibrated S1 Lec domain alone. It was also indicated that the corresponding allosteric pathway from S1 to S1' conformation started with the separation between residues Q30 and K67 and terminated with the release of residue N87 from residue C109. These results provided an insight into understanding the structural transition and the structure-function relationship of P-selectin allostery

Two-dimensional kinematics of SLACS lenses: II. Combined lensing and dynamics analysis of early-type galaxies at z = 0.08 - 0.33

We present the first detailed analysis of the mass and dynamical structure of a sample of six early-type lens galaxies, selected from the Sloan Lens ACS Survey, in the redshift range 0.08 < z < 0.33. Both Hubble Space Telescope (HST)/ACS high-resolution imaging and VLT VIMOS integral field spectroscopy are available for these systems. The galaxies are modelled - under the assumptions of axial symmetry and two-integral stellar distribution function - by making use of the CAULDRON code, which self-consistently combines gravitational lensing and stellar dynamics, and is fully embedded within the framework of Bayesian statistics. The principal results of this study are: (i) all galaxies in the sample are well described by a simple axisymmetric power-law profile for the total density, with a logarithmic slope gamma very close to isothermal ( = 1.98 +/- 0.05 and an intrinsic spread close to 5 per cent) showing no evidence of evolution over the probed range of redshift; (ii) the axial ratio of the total density distribution is rounder than 0.65 and in all cases, except for a fast rotator, does not deviate significantly from the flattening of the intrinsic stellar distribution; (iii) the dark matter fraction within the effective radius has a lower limit of about 15 to 30 per cent; (iv) the sample galaxies are only mildly anisotropic, with delta <= 0.16; (v) the physical distinction among slow and fast rotators, quantified by the v/sigma ratio and the intrinsic angular momentum, is already present at z > 0.1. Altogether, early-type galaxies at z = 0.08 - 0.33 are found to be markedly smooth and almost isothermal systems, structurally and dynamically very similar to their nearby counterparts. (Abridged)Comment: MNRAS, in press. 17 pages, 18 figure

The Bacterial Fimbrial Tip Acts as a Mechanical Force Sensor

The subunits that constitute the bacterial adhesive complex located at the tip of the fimbria form a hook-chain that acts as a rapid force-sensitive anchor at high flow

Do público e do privado: uma perspectiva de género sobre uma dicotomia moderna

Neste texto propomos uma interpretação crítica da dicotomia histórica entre público e privado como dinâmica fundamental da modernidade. A partir de uma perspectiva de género, discutimos as fronteiras construídas entre espaço coletivo de cidadania e de sociabilidade e espaço individual de intimidade e desigualdade. Argumentamos a favor de uma relação de cumplicidade, ainda que tensa, entre as duas esferas, observando que a vida privada foi, em grande medida, moldada pelas mudanças operadas na vida pública. Recorrendo a diferentes definições de "público", notamos que, à medida que as sociabilidades tradicionais, essencialmente masculinas, estudadas entre outros por Ariès ou Sennett, sofriam uma erosão, crescia o sentimento de intimidade, aumentando igualmente a inclusão do privado no público através do alargamento da cidadania, em consequência das lutas travadas na esfera pública por vários movimentos de emancipação, como o operário ou o feminista. À medida que a pessoa era retirada da comunidade, do clã, do grupo de parentesco, em que eram "naturais" as desigualdades, no sentido aristotélico do termo, ia-se reencontrando progressivamente como indivíduo portador de cidadania. Se o espaço privado se tornou central na definição de uma identidade, ele é também crescentemente atravessado por mecanismos públicos de regulação. Nesse sentido, o movimento de ascensão do privado, que nas últimas décadas tem ocupado espaço de debate, deve ser cuidadosamente reinterpretado

Medical conditions in autism spectrum disorders

Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical conditions that are best established as probable causes of ASD include Fragile X syndrome, Tuberous Sclerosis and abnormalities of chromosome 15 involving the 15q11-13 region. Various other single gene mutations, genetic syndromes, chromosomal abnormalities and rare de novo copy number variants have been reported as being possibly implicated in etiology, as have several ante and post natal exposures and complications. However, in most instances the evidence base for an association with ASD is very limited and largely derives from case reports or findings from small, highly selected and uncontrolled case series. Not only therefore, is there uncertainty over whether the condition is associated, but the potential basis for the association is very poorly understood. In some cases the medical condition may be a consequence of autism or simply represent an associated feature deriving from an underlying shared etiology. Nevertheless, it is clear that in a growing proportion of individuals potentially causal medical conditions are being identified and clarification of their role in etio-pathogenesis is necessary. Indeed, investigations into the causal mechanisms underlying the association between conditions such as tuberous sclerosis, Fragile X and chromosome 15 abnormalities are beginning to cast light on the molecular and neurobiological pathways involved in the pathophysiology of ASD. It is evident therefore, that much can be learnt from the study of probably causal medical disorders as they represent simpler and more tractable model systems in which to investigate causal mechanisms. Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele