Networks : On the relation of bi- and multivariate measures

Date of Acceptance: 28/04/2015 Acknowledgement The article processing charge was funded by the German Research Foundation (DFG) and the Albert Ludwigs University Freiburg in the funding programme Open Access PublishingPeer reviewedPublisher PD

The IL-17 pathway as a target in giant cell arteritis

The network of IL-17 cytokines is considered a key component of autoimmune and inflammatory processes. Blocking IL-17 showed great success in psoriasis as well as psoriatic arthritis, and in patients with axial spondyloarthritis. Secukinumab is one of the approved IL-17A inhibitors for these diseases and is now routinely used. In giant cell arteritis, a large vessel vasculitis, there is accumulating evidence for a pathogenic role of IL-17 and Th17 cells, which are part of the CD4+ T-cell subset. Giant cell arteritis occurs in individuals over 50 years of age and many have relative contraindications to glucocorticoid therapy, which today still represents the mainstay therapy. Despite the approval of tocilizumab, which targets the IL-6 receptor, a high demand for glucocorticoid-sparing agents remains that combine the effective suppression of the acute inflammation observed in giant cell arteritis with a safety profile that matches the needs of an older patient population. The first results from a phase II proof-of-principle study (TitAIN) support an optimistic outlook on a potential new treatment option with secukinumab in giant cell arteritis

Assessing the strength of directed influences among neural signals : An approach to noisy data

Acknowledgements This work was supported by the German Science Foundation (Ti315/4-2), the German Federal Ministry of Education and Research (BMBF grant 01GQ0420), and the Excellence Initiative of the German Federal and State Governments. B.S. is indebted to the Kosterlitz Centre for the financial support of this research project.Peer reviewedPreprin

Carlo Lejeune / Christoph Brüll / Peter M. Quadflieg (Hrsg.), Grenzerfahrungen. Eine Geschichte der Deutschsprachigen Gemeinschaft Belgiens. Bd. 4: Staatenwechsel, Identitätskonflikte, Kriegserfahrungen (1919–1945). Mit Karten v. Klaus-Dieter Klauser. Eupen, Grenz-Echo-Verlag 2019

Dieser Beitrag ist mit Zustimmung des Rechteinhabers (De Gruyter) frei zugänglich.Peer Reviewe

Distinguishing Direct from Indirect Interactions in Oscillatory Networks with Multiple Time Scales

Peer reviewedPublisher PD

Effects of reproduction and environmental factors on body temperature and activity patterns of wolverines

publishedVersio

Open sub-granting radio resources in overlay D2D-based V2V communications

Capacity, reliability, and latency are seen as key requirements of new emerging applications, namely vehicle-to-everything (V2X) and machine-type communication in future cellular networks. D2D communication is envisaged to be the enabler to accomplish the requirements for the applications as mentioned earlier. Due to the scarcity of radio resources, a hierarchical radio resource allocation, namely the sub-granting scheme, has been considered for the overlay D2D communication. In this paper, we investigate the assignment of underutilized radio resources from D2D communication to device-to-infrastructure communication, which are moving in a dynamic environment. The sub-granting assignment problem is cast as a maximization problem of the uplink cell throughput. Firstly, we evaluate the sub-granting signaling overhead due to mobility in a centralized sub-granting resource algorithm, dedicated sub-granting radio resource (DSGRR), and then a distributed heuristics algorithm, open sub-granting radio resource (OSGRR), is proposed and compared with the DSGRR algorithm and no sub-granting case. Simulation results show improved cell throughput for the OSGRR compared with other algorithms. Besides, it is observed that the overhead incurred by the OSGRR is less than the DSGRR while the achieved cell throughput is yet close to the maximum achievable uplink cell throughput

Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis

Background. The incidence of bacterial sepsis during the neonatal period is high. Mannan-binding lectin (MBL), L-ficolin, and H-ficolin recognize microorganisms and activate the complement system viaMBL-associated serine proteases (MASPs). This study investigated whether cord blood concentrations of the lectin pathway proteins are associated with neonatal sepsis. >Methods. This was a case-control study including 47 infants with culture-proven sepsis during the first month of life and 94 matched controls. MBL, L-ficolin, H-ficolin, MASP-2, and MASP-3 levels were measured in cord blood with use of enzyme-linked immunosorbent assay and time-resolved immunofluorometric assay. Multivariate logistic regression was performed. Results. Infants with gram-positive sepsis had significantly lower H-ficolin cord blood concentrations than controls (multivariate odds ratio [OR], 4.00; 95% confidence interval [CI], 1.51-10.56; P=.005), whereas infants with gram-negative sepsis had lower MBL cord blood concentrations (OR, 2.99; 95% CI, 0.86-10.33; P=.084). When excluding patients with postoperative sepsis, multivariate analysis confirmed that low H-ficolin was associated with a significantly higher risk of gram-positive sepsis (OR, 3.71; 95% CI, 1.26-10.92; P=.017) and late-onset sepsis (OR, 3.14; 95% CI, 1.07-9.21; P=.037). In contrast, low MBL was associated with a significantly higher risk of gram-negative sepsis (OR, 4.39; 95% CI, 1.10-17.45; P=.036) and early-onset sepsis (OR, 3.87; 95% CI, 1.05-14.29; P=.042). The concentrations of all the lectin pathway proteins increased with gestational age (P<.01). Conclusions. These preliminary results indicate that low MBL concentrations are a susceptibility factor for gram-negative sepsis, and low H-ficolin concentrations indicate susceptibility to gram-positive sepsis. The decreased expression of lectin pathway proteins in neonates must be considered to be an additional form of neonatal immunodeficienc