Ground state hyperfine structures of 43K and 44K measured by atomic beam magnetic resonance coupled with laser optical pumping

The ground state hyperfine structures of 43 K and 44K have been measured by an atomic beam magnetic resonance method in which the atoms are spin-polarized by laser optical pumping. The spectroscopic results are : Δv43( 2S1/2) = 192.648 4 (30) MHz and Δν44( 2S1/2) = - 946.718 (3) MHz. The sensitivity of our method is compared to the one achieved in classical ABMR apparatus

Precision mass measurements of very short-lived, neutron-rich Na isotopes using a radiofrequency spectrometer

Mass measurements of high precision have been performed on sodium isotopes out to $^{30}$Na using a new technique of radiofrequency excitation of ion trajectories in a homogeneous magnetic field. This method, especially suited to very short-lived nuclides, has allowed us to significantly reduce the uncertainty in mass of the most exotic Na isotopes: a relative error of 5x10$^{-7}$ was achieved for $^{28}$Na having a half-life of only 30.5 ms and 9x10$^{-7}$ for the weakly produced $^{30}$Na. Verifying and minimizing binding energy uncertainties in this region of the nuclear chart is important for clarification of a long standing problem concerning the strength of the $N$=20 magic shell closure. These results are the fruit of the commissioning of the new experimental program Mistral

UniFHy v0.1.1: a community modelling framework for the terrestrial water cycle in Python

The land surface, hydrological, and groundwater modelling communities all have expertise in simulating the hydrological processes at play in the terrestrial component of the Earth system. However, these communities, and the wider Earth system modelling community, have largely remained distinct with limited collaboration between disciplines, hindering progress in the representation of hydrological processes in the land component of Earth system models (ESMs). In order to address key societal questions regarding the future availability of water resources and the intensity of extreme events such as floods and droughts in a changing climate, these communities must come together and build on the strengths of one another to produce next-generation land system models that are able to adequately simulate the terrestrial water cycle under change. The development of a common modelling infrastructure can contribute to stimulating cross-fertilisation by structuring and standardising the interactions. This paper presents such an infrastructure, a land system framework, which targets an intermediate level of complexity and constrains interfaces between components (and communities) and, in doing so, aims to facilitate an easier pipeline between the development of (sub-)community models and their integration, both for standalone use and for use in ESMs. This paper first outlines the conceptual design and technical capabilities of the framework; thereafter, its usage and useful characteristics are demonstrated through case studies. The main innovations presented here are (1) the interfacing constraints themselves; (2) the implementation in Python (the Unified Framework for Hydrology, unifhy); and (3) the demonstration of standalone use cases using the framework. The existing framework does not yet meet all our goals, in particular, of directly supporting integration into larger ESMs, so we conclude with the remaining limitations of the current framework and necessary future developments.</p

Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma

Protein families encoded by transcripts that are differentially spliced in various types of HCC. Table S2. Bioinformatical prediction of functional changes caused by some of ASEs identified. Table S3. List of tumor suppressors for which AS is dysregulated in various types of HCC. Table S4. List of oncogenes for which AS is dysregulated in various types of HCC. Table S5. List of kinases for which AS is dysregulated in various types of HCC. Table S6. List of transcription factors for which AS is dysregulated in various types of HCC. Table S7. List of genes for which AS is dysregulated in all types of HCC. Table S8. List of genes uniquely dysregulated in HBV-associated HCC. Table S9. List of genes uniquely dysregulated in HCV-associated HCC. Table S10. List of genes uniquely dysregulated in HBV&HCV-associated HCC. Table S11. List of genes uniquely dysregulated in virus-free HCC. Figure S1. Characterization of splicing mysregulation in HCC. Figure S2. Characterization of ASEs that are modified in HBV- and HCV-associated HCC. Figure S3. AS modifications in transcripts encoded by kinases and transcriptions factores in HBV- and HCV-associated HCC. Figure S4. Global profiling of ASE modifications in both HBV&HCV-associated HCC and virus-free-associated HCC. Figure S5. RNA splicing factors in HCC. Figure S6. Modifications to AS of 96 transcripts in response to knockdown of splicing factors with specific siRNAs (PDF 6675 kb

The surface composition of six newly discovered chemically peculiar stars. Comparison to the HgMn stars μ\mu Lep and β\beta Scl and the superficially normal B star ν\nu Cap

We report on a detailed abundance study of six bright, mostly southern, slowly rotating late B stars: HD~1279 (B8III), HD~99803 (B9V), HD~123445 (B9V), HD~147550 (B9V), HD~171961 (B8III) and HD~202671 (B5II/III), hitherto reported as normal stars. We compare them to the two classical HgMn stars $\mu$ Lep and $\beta$ Scl and to the superficially normal star, $\nu$ Cap. In the spectra of the six stars, the \ion{Hg}{2} line at 3984 \AA\ line is clearly seen and numerous lines of P, Ti, Mn, Fe, Ga, Sr, Y, and Zr appear to be strong absorbers. A comparison of newly acquired and archival spectra of these objects with a grid of synthetic spectra for selected unblended lines reveals large overabundances of P, Ti, Cr, Mn, Sr, Y, Zr, Ba, Pt and Hg and underabundances of He, Mg, Sc and Ni. The effective temperatures, surface gravities, low projected rotational velocities and the peculiar abundance patterns of the six investigated stars show that they are new chemically peculiar stars, mostly new HgMn stars, and are reclassified as such. The evolutionary status of these stars has been inferred and their ages and masses estimated. The two most massive objects, HD~1279 and HD~202671, might have evolved away from the main-sequence recently, the other stars are main-sequence objects. HD~99803A is a sharp lined HgMn star with grazing eclipses; from TESS and MASCARA photometry we determine an orbital period of $P_{\rm orb} = 26.12022 \pm 0.00004$\,d.Comment: 54 pages, accepted in The Astronomical Journal. arXiv admin note: substantial text overlap with arXiv:1908.0502

Accurate mass measurements of short-lived isotopes with the MISTRAL rf spectrometer

The MISTRAL experiment has measured its first masses at ISOLDE. Installed in May 1997, this radiofrequency transmission spectrometer is to concentrate on nuclides with particularly short half-lives. MISTRAL received its first stable beam in October and first radioactive beam in November 1997. These first tests, with a plasma ion source, resulted in excellent isobaric separation and reasonable transmission. Further testing and development enabled first data taking in July 1998 on neutron-rich Na isotopes having half-lives as short as 31 ms

Scalability of Incompressible Flow Computations on Multi-GPU Clusters Using Dual-Level and Tri-Level Parallelism

High performance computing using graphics processing units (GPUs) is gaining popularity in the scientific computing field, with many large compute clusters being augmented with multiple GPUs in each node. We investigate hybrid tri-level (MPI-OpenMP-CUDA) parallel implementations to explore the efficiency and scalability of incompressible flow computations on GPU clusters up to 128 GPUS. This work details some of the unique issues faced when merging fine-grain parallelism on the GPU using CUDA with coarse-grain parallelism using OpenMP for intra-node and MPI for inter-node communication. Comparisons between the tri-level MPI-OpenMP-CUDA and dual-level MPI-CUDA implementations are shown using computationally large computational fluid dynamics (CFD) simulations. Our results demonstrate that a tri-level parallel implementation does not provide a significant advantage in performance over the dual-level implementation, however further research is needed to justify our conclusion for a cluster with a high GPU per node density or when using software that can utilize OpenMP’s fine-grain parallelism more effectively

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p &lt; 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM &gt; 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM &gt; 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015